Article
Biochemistry & Molecular Biology
Andromachi Pouikli, Monika Maleszewska, Swati Parekh, Ming Yang, Chrysa Nikopoulou, Juan Jose Bonfiglio, Constantine Mylonas, Tonantzi Sandoval, Anna-Lena Schumacher, Yvonne Hinze, Ivan Matic, Christian Frezza, Peter Tessarz
Summary: This study reveals the impact of normal oxygen levels on the differentiation of bone-derived mesenchymal stem cells. High oxygen concentration promotes chromatin compaction and histone hypo-acetylation, resulting in osteogenic defects. Additionally, decreased activity of citrate carrier leads to the accumulation of acetyl-CoA inside mitochondria. Restoring cytosolic acetyl-CoA levels rescues the osteogenic defects.
Article
Oncology
Xu Zhou, Yu Zhou, Weiqing Shao, Liang Hong, Ming Lu, Wenwei Zhu
Summary: Acetyl-CoA metabolic aberration is associated with ICC metastasis, and down-regulation of ACOT12 promotes ICC metastasis, suggesting ACOT12 as a prognostic marker and potential therapeutic target for ICC metastasis.
Article
Biology
Ienglam Lei, Shuo Tian, Wenbin Gao, Liu Liu, Yijing Guo, Paul Tang, Eugene Chen, Zhong Wang
Summary: This study demonstrates that increasing acetyl-CoA improves heart function in rats with myocardial infarction by promoting histone acetylation, leading to activation of antioxidant genes and inhibition of cardiomyocyte apoptosis. The improvement in cardiac function is mainly mediated by metabolic enzyme MCAD and histone acetyltransferase Kat2a. These findings suggest an interlinked metabolic/epigenetic network involving acetyl-CoA, MCAD, and Kat2a in combating heart injury.
Review
Immunology
Monica Dominguez, Bernhard Bruene, Dmitry Namgaladze
Summary: Recent studies have shown the profound influence of metabolism on immune responses, particularly through epigenetic regulation of gene expression. ACLY plays a crucial role in the formation of cytosolic acetyl-CoA, supporting de novo lipogenesis and contributing to epigenetic regulation through histone acetylation. Alternative sources of acetyl-CoA also play a role in metabolic and epigenetic regulation in immune cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Weijing He, Qingguo Li, Xinxiang Li
Summary: Acetyl-CoA is an important molecule that participates in multiple intracellular metabolic reactions and affects protein post-translational modification, playing a key role in cell metabolism and epigenetic inheritance. In cancer, extensive lipid metabolism and histone acetylation are required for cancer cell growth and expression of cancer-promoting genes. Acetyl-CoA, as a raw material for lipid synthesis and histone acetylation, has a major impact on lipid metabolism and histone acetylation in cancer. Moreover, acetyl-CoA connects lipid metabolism with histone acetylation, forming a complex regulatory mechanism that influences cancer growth, proliferation, and metastasis.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2023)
Article
Multidisciplinary Sciences
Dongwen Que, Feimei Kuang, Rui Kang, Daolin Tang, Jiao Liu
Summary: Alkaliptosis is a newly discovered pH-dependent cell death used for tumor therapy. ACSS2, an acetate-activating enzyme, is identified as a positive regulator of alkaliptosis in human PDAC cells. ACSS2 expression is upregulated in response to the alkaliptosis activator JTC801, and knockdown of ACSS2 inhibits JTC801-induced cell death and alters cellular pH. These findings provide new insights into the metabolic basis of alkaliptosis and potential strategies for PDAC treatment.
SCIENTIFIC REPORTS
(2023)
Review
Biochemistry & Molecular Biology
Patrick C. Bradshaw
Summary: Acetyl-CoA plays important roles in regulating gene expression and promoting longevity, with decreased cytoplasmic levels potentially contributing to longevity and increased nuclear levels aiding in histone acetylation and lifespan extension. Future research should focus on the role of nuclear acetyl-CoA and histone acetylation in controlling hypothalamic inflammation, a key driver of organismal aging.
Article
Agriculture, Multidisciplinary
Xue-Ning Wang, Li-Li Hong, Jian-Qiang Kong
Summary: A stable acetyl-CoA-synthesizing biocatalyst was identified using maltose O-acetyltransferase (MAT) with diacerein as an acetyl donor, providing a promising and cost-effective alternative method for acetylation modifications. The mutant MAT-E125F showed the highest yield of acetyl-CoA production and could also synthesize glycosyl esters through acetylation or transesterification reactions. The multifunctional MAT displayed a potent capacity in synthesizing acetyl-CoA and glycosyl esters using diacerein as an acetyl donor.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Plant Sciences
Yue Lu, Qing Bu, Mingli Chuan, Xiaoyun Cui, Yu Zhao, Dao-Xiu Zhou
Summary: Chromatin modifications play a crucial role in shaping the epigenome and regulating gene expression during plant development and adaptation to environmental changes. The activities of chromatin modification enzymes are influenced by cellular metabolites, such as S-adenosyl-methionine, acetyl-CoA, alpha-ketoglutarate, and NAD(+). On the other hand, changes in the plant epigenome and activity of epigenetic regulators can impact cellular metabolism through regulation of metabolic enzymes. This review highlights recent advances in understanding the metabolic control of plant chromatin regulators and epigenomes, which contribute to plant adaptation to environmental stresses.
Review
Endocrinology & Metabolism
Gonzalo Fernandez-Fuente, Michael J. Rigby, Luigi Puglielli
Summary: By regulating intracellular signaling molecules, especially the citrate/acetyl-CoA pathway, homeostatic responses in cells can be activated. The citrate/acetyl-CoA pathway plays important roles in various biological functions within cells and is associated with N epsilon-lysine acetylation. Specifically, in the acetylation machinery of the endoplasmic reticulum (ER), ER acetylation regulates metabolic communication and homeostasis between different cellular organelles, affecting cellular adaptive responses and specific disease states. Therefore, citrate and acetyl-CoA should be recognized as both metabolic substrates and important signaling molecules for cellular adaptation.
MOLECULAR METABOLISM
(2023)
Article
Immunology
Zhengguo Zhang, Ming Wang, Yu Zhang, Yiming Zhang, Marek Bartkuhn, Melanie Markmann, Hamid Hossain, Trinad Chakraborty, Sandra B. Hake, Zhankui Jia, Andreas Meinhardt, Sudhanshu Bhushan
Summary: UPEC infection manipulates host cell metabolism to inhibit inflammatory cytokine production by suppressing ATP citrate lyase, leading to reduced histone acetylation and decreased expression of immune response genes. This effect can be reversed by acetate supplementation and improves tissue recovery in a murine cystitis model.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Oncology
Peng Xiao, Qinghui Meng, Qi Liu, Qingfu Lang, Zhijie Yin, Guanqun Li, Zhibo Li, Yilin Xu, Ze Yu, Qi Geng, Yangyang Zhang, Liwei Liu, Yu Xie, Le Li, Hua Chen, Tiemin Pei, Bei Sun
Summary: IGF2BP1 plays a crucial role in the initiation and progression of intrahepatic cholangiocarcinoma (iCCA) through its regulation of the c-Myc/p16 and ZIC2/PAK4/AKT/MMP2 signaling pathways. Upregulation of IGF2BP1 is associated with poor clinicopathological characteristics and survival. Inhibition of IGF2BP1 using the inhibitor BTYNB shows promising anti-tumor efficacy in a patient-derived xenograft (PDX) model.
Article
Materials Science, Multidisciplinary
Dan Zhao, Wen Kang, Yiwen Wang, Jiuyu Ge, Jianfeng Huang, Jie Yang, Weidong Yang, Xuna Tang, Sijing Xie
Summary: The study reveals that during osteoblast differentiation of hDPSCs, the HDAC class III pathway is upregulated while STAT3 signaling is downregulated. SIRT1, a class III HDAC, counteracts STAT3 activation to promote osteogenic differentiation of hDPSCs. This research highlights the potential use of SIRT1 activators in hDPSC-based therapies for bone augmentation strategies.
Article
Genetics & Heredity
Wei Zheng, Luisa Tasselli, Tie-mei Li, Katrin F. Chua
Summary: The modulation of dynamic histone acetylation states is crucial for gene expression and chromatin structure. SIRT6 controls nuclear levels of ACLY and regulates the expression of tumor suppressive genes by affecting nuclear acetyl-CoA pools.
Article
Multidisciplinary Sciences
Sethu C. Nair, Justin T. Munro, Alexis Mann, Manuel Llinas, Sean T. Prigge
Summary: Coenzyme A (CoA) biosynthesis is a critical target for combating malaria. The study reveals the essential role of the mitochondrion in cellular acetyl-CoA biosynthesis and identifies a synthetic lethal relationship between two key ketoacid dehydrogenase enzymes. The lipoate attachment enzyme LipL2 is found to be crucial for the activity of these enzymes, which is indispensable for parasite survival due to its involvement in acetyl-CoA metabolism. Additionally, the study highlights the importance of mitochondrial-derived acetyl-CoA for protein acetylation outside the mitochondrion. Overall, these findings underscore the significance of the mitochondrion in cellular acetyl-CoA metabolism and protein acetylation crucial for parasite survival.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Cell & Tissue Engineering
Xian Li, Wenjuan Zhou, Xinyue Li, Ming Gao, Shufang Ji, Wenyu Tian, Guangyu Ji, Jingyi Du, Aijun Hao
STEM CELL RESEARCH & THERAPY
(2019)
Article
Medicine, Research & Experimental
Xu Wang, Wenjuan Zhou, Xian Li, Jun Ren, Guangyu Ji, Jingyi Du, Wenyu Tian, Qian Liu, Aijun Hao
JOURNAL OF TRANSLATIONAL MEDICINE
(2020)
Article
Cell Biology
Dongping Lyu, Guanjun Kou, Shiyang Li, Lixiang Li, Bing Li, Ruchen Zhou, Xiaoxiao Yang, Wenyu Tian, Yanqing Li, Xiuli Zuo
Summary: Enterochromaffin (EC) cells play a key role in ulcerative colitis (UC), and the study found that EC cells in patients with UC exhibit enhanced protein synthesis capacity and increased immunological functions, such as antigen processing and presentation, while chemical sensation is decreased.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)