期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 55, 期 19, 页码 5837-5841出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201601351
关键词
arenes; cross-coupling; fluorine; ligand design; nickel
资金
- National Basic Research Program of China (973 Program) [2012CB821600, 2015CB931900]
- NSFC [21425208, 21421002, 21332010]
- SIOC
A nickel-catalyzed cross-coupling between (hetero)arylborons and unactivated 1-bromo-1,1-difluoroalkanes has been developed. The use of two ligands (a bidentate bipyridine-based ligand, 4,4-ditBu-bpy, and a monodentate pyridine-based ligand, DMAP) offers a highly efficient nickel-based catalytic system to prepare difluoroalkylated arenes which have important applications in medicinal chemistry.
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