Article
Agriculture, Dairy & Animal Science
Wei Zhao, Luo-Dong Huang, Jin-Niu
Summary: This study investigated the function and molecular mechanism of astaxanthin-enriched Oedocladium sp. in attenuating liver damage and fat deposition caused by a high-fat diet. The findings showed that supplementation with Oedocladium sp. improved digestibility, reduced serum cholesterol and triglycerides, and alleviated inflammation and oxidative stress in fish fed a high-fat diet. The study also revealed that Oedocladium sp. activated the AMPK/ACC/CPT1 signal and suppressed the AMPK/SREBP1/FAS signal, promoting fat catabolism and transport while inhibiting fat synthesis. These results suggest that Oedocladium sp. can be a promising source of astaxanthin to enhance the health and productivity of farmed fish.
ANIMAL FEED SCIENCE AND TECHNOLOGY
(2023)
Article
Nutrition & Dietetics
Ting Zhang, Shiu-Lun Au Yeung, C. Mary Schooling
Summary: The study found bi-directional associations between arachidonic acid synthesis and cardiovascular disease risk factors, with some lipid indicators showing positive associations. Genetically predicted arachidonic acid was positively associated with ApoB and LDL-C, but not with other traits. The association of arachidonic acid with ischemic heart disease may be mediated through ApoB.
Article
Endocrinology & Metabolism
Teresa Buckner, Lauren A. Vanderlinden, Brian C. DeFelice, Patrick M. Carry, Katerina Kechris, Fran Dong, Oliver Fiehn, Brigitte I. Frohnert, Michael Clare-Salzler, Marian Rewers, Jill M. Norris
Summary: The study found that some oxylipins are associated with an increased risk of type 1 diabetes, while others are associated with a decreased risk. Higher levels of linoleic acid and alpha-linolenic acid-related oxylipins demonstrate a protective association in reducing the risk of type 1 diabetes.
Article
Chemistry, Medicinal
Samaneh Azizi, Reza Mahdavi, Majid Mobasseri, Soghra Aliasgharzadeh, Fatemeh Abbaszadeh, Mehrangiz Ebrahimi-Mameghani
Summary: The study suggests that L-citrulline supplementation may improve glucose homeostasis, certain lipid factors, and inflammatory markers in overweight and obese patients with type 2 diabetes (T2D).
PHYTOTHERAPY RESEARCH
(2021)
Article
Nutrition & Dietetics
Marzieh Heidari, Maryam Chaboksafar, Mohammad Alizadeh, Bahram Sohrabi, Sorayya Kheirouri
Summary: The study analyzed the effects of Astaxanthin (AX) supplementation on cardiometabolic risk factors in patients with coronary artery disease (CAD). The results showed that AX supplementation did not significantly affect body composition, glycemic indices, TNF-alpha, and Sirtuin1 levels. However, it did lead to a significant reduction in total cholesterol and LDL-C levels. More clinical investigations are needed to establish conclusive findings.
FRONTIERS IN NUTRITION
(2023)
Review
Medicine, Research & Experimental
Zeynab Kohandel, Tahereh Farkhondeh, Michael Aschner, Ali Mohammad Pourbagher-Shahri, Saeed Samarghandian
Summary: This study summarizes the anti-inflammatory efficacy of astaxanthin in various chronic and acute disorders, as well as the pathways through which it mediates its effects. Further experimental and clinical studies are needed to confirm the anti-inflammatory and protective effects of astaxanthin in humans. The review suggests that astaxanthin, with its demonstrated anti-inflammatory properties, may be a suitable candidate for drug design with novel technology.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Integrative & Complementary Medicine
Hadi Emamat, Ali Zahedmehr, Sanaz Asadian, Javad Nasrollahzadeh
Summary: Consumption of purple-black barberry can decrease plasma levels of CRP and improve lipid profile in subjects with cardiovascular risk factors.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2022)
Review
Medicine, General & Internal
Melanie Bailey, Dermot Linden, Hong Guo-Parke, Olivia Earley, Tunde Peto, Danny F. F. McAuley, Clifford Taggart, Joseph Kidney
Summary: SARS-CoV-2 binds to ACE2 receptors in the lungs, leading to endothelial pathology and activation of the contact-kinin pathway, resulting in clotting and inflammatory lung disease. Blood tests of hospitalized patients show prolonged APTT, decreased platelet counts, and lymphopenia, indicating consumption and emergence of lymphocytic pneumonitis. Bradykinin is involved in the development of edema and release of IL-6, contributing to thrombosis and lymphocytic pneumonitis. Measurements of platelets, lymphocytes, and APTT can help stratify the risk of developing ARDS.
FRONTIERS IN MEDICINE
(2023)
Article
Agricultural Engineering
Vaibhav Sunil Tambat, Anil Kumar Patel, Reeta Rani Singhania, Akash Pralhad Vadrale, Archana Tiwari, Chiu-Wen Chen, Cheng-Di Dong
Summary: This study focused on designing and optimizing a two-stage mixotrophic bioprocess using Chlorella zofingiensis to produce astaxanthin. Gradual increase in light intensity and micronutrient concentration during the first stage and stress conditions during the second stage were found to enhance biomass and astaxanthin yield. The study also showed the potential of using Chlorella zofingiensis for commercial production of astaxanthin and lipid, with promising sustainability features.
BIORESOURCE TECHNOLOGY
(2023)
Article
Biochemical Research Methods
Min Li, Pingping Zhou, Mingkai Chen, Hongwei Yu, Lidan Ye
Summary: This study successfully increased the production yield of astaxanthin by regulating genes related to lipid metabolism. The production yield was further enhanced by moderately upregulating lipid synthesis and balancing the expression of related enzymes.
ACS SYNTHETIC BIOLOGY
(2022)
Review
Medicine, Research & Experimental
Zeynab Kohandel, Tahereh Farkhondeh, Michael Aschner, Saeed Samarghandian
Summary: Astaxanthin (ATX) is a red pigment carotenoid found in shrimp, salmon, crab, and asteroidean, with proven antioxidant efficacy. Nrf2 plays a crucial role in mediating the various protective effects of ATX.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Fisheries
Emily Courtot, Dean Musson, Chris Stratford, David Blyth, Nicholas A. Bourne, Artur N. Rombenso, Cedric J. Simon, Xugan Wu, Nicholas M. Wade
Summary: Astaxanthin digestibility in salmonids is influenced by various factors, with algal carotenoids showing higher apparent digestibility than synthetic ones. Oils containing high levels of monounsaturated fatty acids, particularly 18:1n-9, can significantly improve the digestibility of algal carotenoids in Atlantic salmon.
AQUACULTURE RESEARCH
(2022)
Article
Immunology
Mehwish Younas, Christina Psomas, Christelle Reynes, Renaud Cezar, Lucy Kundura, Pierre Portales, Corinne Merle, Nadine Atoui, Celine Fernandez, Vincent Le Moing, Claudine Barbuat, Albert Sotto, Robert Sabatier, Audrey Winter, Pascale Fabbro, Thierry Vincent, Jacques Reynes, Pierre Corbeau
Summary: This study found that some HIV-1-infected patients under efficient treatment display low-level viremia and unique features of immune activation distinct from microbial translocation. Patients with Profile E exhibited high levels of CD4+ T cell, monocyte, and endothelium activation, while other patients had different profiles of immune activation. These findings suggest a potential causal link between low-level viremia and atherosclerosis in virologic responders.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Benedetta Perrone, Paola Ruffo, Giuseppina Augimeri, Diego Sisci, Maria Stefania Sinicropi, Giovanni Tripepi, Corrado Mammi, Daniela Bonofiglio, Francesca Luisa Conforti
Summary: This study aimed to explore the genetic factors related to the metabolic/inflammatory profile of adolescents, and identified significant associations between genetic polymorphisms and serum metabolic parameters. These findings provide evidence for the importance of genetic profiling in the prevention and management of chronic diseases.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Nutrition & Dietetics
Xiangyu Zhou, Qingming Cao, Caroline Orfila, Jian Zhao, Lin Zhang
Summary: Oral astaxanthin supplementation significantly improved skin moisture content and elasticity, but did not significantly decrease wrinkle depth compared to placebo. Open-label, prospective studies suggested slightly protective effects of topical and oral-topical astaxanthin applications on skin ageing.