Article
Oncology
Changying Shi, Yong Li, Li Geng, Weifeng Shen, Chengjun Sui, Binghua Dai, Jiongjiong Lu, Mianshun Pan, Jiamei Yang
Summary: This study aimed to investigate the efficacy of SBRT targeting suboptimal resection margin as adjuvant therapy in MVI-positive HCC. The results showed that SBRT group had significantly better DFS and OS compared to the surgery alone group.
EUROPEAN JOURNAL OF CANCER
(2022)
Article
Medicine, General & Internal
Joonho Jeong, Jung Gu Park, Kwang Ill Seo, Ji Hyun Ahn, Jae Chun Park, Byung Cheol Yun, Sang Uk Lee, Jin Wook Lee, Jong Hyouk Yun
Summary: This study aimed to investigate factors affecting tumor necrosis with TACE and evaluate factors associated with early hepatocellular carcinoma recurrence after curative hepatectomy. Microvascular invasion (MVI) was found to be the strongest factor influencing TACE-induced tumor necrosis and recurrence-free survival rate within 2 years. MVI could play a crucial role in determining TACE as an initial treatment for hepatocellular carcinoma and predicting recurrence after curative hepatic resection.
Article
Medicine, Research & Experimental
Kai Zhang, Changcheng Tao, Tana Siqin, Jianxiong Wu, Weiqi Rong
Summary: This study successfully developed and validated a predictive model for early relapse after R0 resection in HCC patients with MVI, incorporating preoperative blood markers, hepatitis status, tumor characteristics, and other factors, with higher predictive accuracy in the validation cohort.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Review
Oncology
Anwei Mo, Biquan Lin, Denglin Chen
Summary: This study aims to investigate the impact of sequential transcatheter arterial chemoembolization (TACE) on the prognosis of patients with hepatocellular carcinoma (HCC) and microvascular invasion (MVI) following radical resection. Thirteen articles were included in the study, and the results showed that TACE after radical hepatectomy resection (HR) significantly improved the recurrence-free survival (RFS) and overall survival (OS) rates at 1 year, 2 years, 3 years, and 5 years compared to HR alone. The findings suggest that postoperative sequential TACE treatment can benefit patients with HCC and MVI in terms of long-term survival.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Cyrille Feray, Loic Campion, Philippe Mathurin, Isabelle Archambreaud, Xavier Mirabel, Jean Pierre Bronowicki, Emmanuel Rio, Christophe Perret, Laurent Mineur, Frederic Oberti, Yann Touchefeu, Jerome Gournay, Helen Regnault, Julien Edeline, Agnes Rode, Patrick Hillion, Jean Frederic Blanc, Eric Nguyen Khac, Daniel Azoulay, Alain Luciani, Athena Galetto Preglisasco, Elodie Faurel-Paul, Helene Auble, Francoise Mornex, Philippe Merle
Summary: This study compared the efficacy and safety of the combination of a single TACE and external CRT vs. classical TACE. The results showed that the combination of TACE + CRT failed to improve liver PFS or overall survival and led to more frequent liver-related adverse effects.
Article
Gastroenterology & Hepatology
Hanyu Jiang, Jingwei Wei, Fangfang Fu, Hong Wei, Yun Qin, Ting Duan, Weixia Chen, Kunlin Xie, Jeong Min Lee, Mustafa R. Bashir, Meiyun Wang, Bin Song, Jie Tian
Summary: This study aimed to develop and validate a scoring system for predicting microvascular invasion (MVI) in hepatocellular carcinoma (HCC). The results showed that the preoperative MVI score, which integrated five EOB-MRI features and serum alpha-fetoprotein level, accurately predicted MVI and postoperative survival in HCC. This score could be useful in making individualized treatment decisions.
LIVER INTERNATIONAL
(2022)
Article
Oncology
Yun Yang, Kongying Lin, Lei Liu, Youwen Qian, Yuan Yang, Shengxian Yuan, Peng Zhu, Jian Huang, Fuchen Liu, Fangming Gu, Siyuan Fu, Beige Jiang, Hui Liu, Zeya Pan, Wan Yee Lau, Weiping Zhou
Summary: The study found that preoperative TACE did not impact the incidence of MVI and long-term survival outcomes in HCC patients undergoing curative liver resection. After propensity score matching, preoperative TACE was not associated with Disease-Free Survival (DFS) and Overall Survival (OS).
Article
Gastroenterology & Hepatology
Liming Wang, Yunhe Liu, Weiqi Rong, Fan Wu, Weibo Yu, Kan Liu, Shengtao Lin, Yiling Zheng, Kai Zhang, Tana Siqin, Changcheng Tao, Mei Liu, Bo Chen, Qinfu Feng, Jianxiong Wu
Summary: The study demonstrates that IOERT in combination with narrow-margin hepatectomy for centrally located HCCs is feasible and safe, with a significantly better recurrence-free survival rate observed in the IOERT group compared to the control group, particularly beneficial for patients with MVI (+).
HEPATOBILIARY SURGERY AND NUTRITION
(2022)
Article
Oncology
Xuqi Sun, Ziliang Yang, Jie Mei, Ning Lyu, Jinfa Lai, Minshan Chen, Ming Zhao
Summary: For HCC patients with MVI (+) and early small recurrence, TACE-RFA could achieve better prognosis than hepatectomy or RFA alone, while RFA alone provided comparable survival benefits compared with hepatectomy or TACE-RFA in other HCC patients with small recurrence.
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2021)
Article
Pharmacology & Pharmacy
Li Chen, Chen-Xi Yu, Bin-Yan Zhong, Hai-Dong Zhu, Zhi-Cheng Jin, Guang-Yu Zhu, Qi Zhang, Cai-Fang Ni, Gao-Jun Teng
Summary: This study aimed to identify the independent risk factors for transarterial embolization (TACE) refractoriness in hepatocellular carcinoma (HCC) patients. The study found that the number of tumors and bilobular invasion of HCC were independent risk factors for TACE refractoriness. The TACE refractoriness score was developed as an effective tool for predicting the risk of TACE refractoriness.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Gastroenterology & Hepatology
Zhen-Hua Chen, Xiu-Ping Zhang, Jin-Kai Feng, Le-Qun Li, Fan Zhang, Yi-Ren Hu, Cheng-Qian Zhong, Jie Shi, Wei-Xing Guo, Meng-Chao Wu, Wan Yee Lau, Shu-Qun Cheng
Summary: One-third of HCC patients with MVI achieved the long-term survival milestone of 5 years after resection. Anatomical hepatectomy, controlling intraoperative blood loss, a wide resection margin, and postoperative adjuvant TACE should be considered to improve long-term survival outcomes.
HEPATOLOGY INTERNATIONAL
(2021)
Article
Oncology
Yuling Xiong, Peng Cao, Xiaohua Lei, Weiping Tang, Chengming Ding, Shuo Qi, Guodong Chen
Summary: This study compared the clinical prognosis of HCC patients with or without tumor microvascular invasion (MVI) after radical surgical treatment and found that MVI is an independent risk factor for a poor prognosis after surgery. A prediction model based on preoperative AFP, tumor diameter, and TNM stage showed good predictive efficacy and clinical practicability.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Surgery
Xubiao Wei, Yabo Jiang, Shuang Feng, Chongde Lu, Lei Huo, Bin Zhou, Yan Meng, Wan Yee Lau, Yaxin Zheng, Shuqun Cheng
Summary: For patients with a resectable single and small hepatitis B virus-related HCC predicted to have high risks of MVI, neoadjuvant RT gave a promising response rate with mild toxicity. Nevertheless, neoadjuvant RT yielded similar long-term DFS and OS rates compared with patients who underwent upfront surgery.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Article
Surgery
Xin-Fei Xu, Yong-Kang Diao, Yong-Yi Zeng, Chao Li, Feng-Wei Li, Li-Yang Sun, Han Wu, Kong-Ying Lin, Lan-Qing Yao, Ming-Da Wang, Cheng-Wu Zhang, Wan Yee Lau, Feng Shen, Tian Yang
Summary: This study investigated the relationship between the severity in the grading of microvascular invasion (MVI) and long-term oncological outcomes in patients with early-stage hepatocellular carcinoma (HCC). The results showed that the severity in MVI grading was independently associated with recurrence and survival after HCC resection. Patients with a more severe MVI grading (M2) require more stringent recurrence surveillance and/or active adjuvant therapy against recurrence.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Article
Medicine, Research & Experimental
Yi Wang, Gui-Qi Zhu, Rui Yang, Cheng Wang, Wei-Feng Qu, Tian-Hao Chu, Zheng Tang, Chun Yang, Li Yang, Chang-Wu Zhou, Geng-Yun Miao, Wei-Ren Liu, Ying-Hong Shi, Meng-Su Zeng
Summary: This study revealed the interactions of cell subpopulations and distinct metabolism profiles in MVI+ HCC, and discovered the radiomics features related to the infiltration of APOE(+) macrophages and iCAFs. Furthermore, the study developed Radscore for predicting MVI and HCC prognostication, which could predict the level of infiltration of APOE(+) macrophages and iCAFs.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Education & Educational Research
Chunping Zheng, Lili Wang, Ching Sing Chai
Summary: This study explores and explains the effects of different sequences of video-based formative assessment on English language learners' public speaking anxiety and performance. The findings show that learners who engaged in self-assessment first had lower public speaking anxiety, while those who engaged in peer-assessment first had better public speaking performance. Therefore, the sequence of formative assessment should be adjusted based on learners' anxiety levels and language proficiency in public speaking courses.
COMPUTER ASSISTED LANGUAGE LEARNING
(2023)
Review
Food Science & Technology
Zhao Deng, Zhipeng Yang, Jian Peng
Summary: This review discusses the impact of bioactive peptides on inflammatory diseases and cancer through regulating programmed cell deaths, and explores their potential and pathways in treatment.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Computer Science, Cybernetics
Ying Li, Fangzhou You, Ming Ji, Rui Jie Zhang, Xuqun You
Summary: This study evaluates the impact of gestures and smartphone sizes on the user experience during text entry. The results show that two-thumb text entry is more effective than one-thumb text entry, and different smartphone sizes also affect the user experience. QWERTY is suitable for two-thumb text entry, while T9 is suitable for one-thumb text entry.
UNIVERSAL ACCESS IN THE INFORMATION SOCIETY
(2023)
Article
Engineering, Electrical & Electronic
Lei Chen, Min Wang, Tian Tian Zhang, Jia Yi Peng, Feng Wei
Summary: A balanced second-order tri-band bandpass filter with high selectivity is proposed in this paper. Three differential-mode passbands are formed by using special resonators, and broadband common-mode suppression is achieved with a special structure, simplifying the design process.
Article
Mathematics
Bo Liu
Summary: This article proves the variation formula, embedding formula, and adiabatic limit formula for equivariant Bismut-Cheeger eta forms with a fiberwise compact Lie group action. The only condition required is that the kernels of the corresponding fiberwise Dirac operators form vector bundles.
INTERNATIONAL MATHEMATICS RESEARCH NOTICES
(2023)
Article
Environmental Sciences
Yaosheng Luo, Huixian Zeng, Yanshi Ye, Genfeng Yu, Cheng Song, Siyang Liu, Xingying Chen, Yuqi Jiang, Hualin Duan, Yue Li, Shengqing He, Zhi Chen, Lingling Liu, Yongqian Liang, Xu Lin, Heng Wan, Jie Shen
Summary: This study found that lower serum levels of magnesium and iron are associated with incremental positivity of thyroiditis antibodies, especially in women of reproductive age.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Correction
Chemistry, Physical
Hui Ding, Daji Wang, Haibing Huang, Xiaozhu Chen, Jie Wang, Jinjie Sun, Jianlin Zhang, Lu Lu, Beiping Miao, Yanjuan Cai, Kelong Fan, Yongtian Lu, Hongsong Dong, Xiyun Yan, Guohui Nie, Minmin Liang
Article
Computer Science, Artificial Intelligence
Xianghua Li, Xinyu Wu, Zheng Luo, Zhanwei Du, Zhen Wang, Chao Gao
Summary: Text classification is a fundamental problem in natural language processing. Graph-based models, such as GNN-based and GCN-based models, have recently been applied to this task and achieved excellent performance by modeling context from a global perspective. However, existing graph-based models often construct a corpus-level graph structure, leading to high memory consumption and overlooking local contextual information. To address these issues, this paper proposes a novel GNN-based model called TSW-GNN, which constructs a unique text-level graph for each text using two sliding windows. Extensive experiments on benchmark datasets demonstrate the improvement of TSW-GNN in classification accuracy compared to state-of-the-art models.
NEURAL COMPUTING & APPLICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Lingmei Kong, Yaning Luo, Lyudmila Turyanska, Ting Zhang, Zhipeng Zhang, Guichuan Xing, Yingguo Yang, Chengxi Zhang, Xuyong Yang
Summary: This study develops a strategy for nucleation and growth of perovskite films with the assistance of spacer cations. The addition of guanidinium (GA(+)) spacer enhances the optical and electrical performance of perovskite films by providing more nucleation sites and reducing the crystallization rate. The strategy also promotes the formation of polydisperse domain distribution and interaction with perovskite defects through coordination bonding. The resulting perovskite LEDs exhibit high efficiency and brightness.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Energy & Fuels
Dengle Duan, Yongchuan Zhang, Juncheng Li, Liyin Huang, Zhimin Xu, Yayun Zhang, Weimin Sun, Qin Wang, Roger Ruan
Summary: The catalytic pyrolysis of low-density polyethylene over hierarchical HZSM-5 zeolite was studied to improve liquid oil quality. Nanocrystalline cellulose was used as a template to successfully synthesize the hierarchical zeolite, which showed ordered surface morphology and excellent porous structure. Compared to conventional HZSM-5, hierarchical HZSM-5 zeolite significantly increased bio-oil yield and altered the relative content of cycloalkanes and aromatics.
Article
Engineering, Civil
Guiping Nie, Ying Liu, Zhiyong Liu, Zhixuan Liang, Jianfeng Xue, Yaowei Liang
Summary: Drainage conditions and consolidation states can affect the deformation behavior of clayey soil under cyclic loading. The lateral deformation in soils under partially drained conditions is similar to those under undrained conditions with the increase of over consolidation ratio. Under undrained conditions, a large axial strain could accumulate with a small amount accumulation in excess pore water pressure, while under partially drained conditions, the resilient modulus of the soil decreases as the volumetric strain increases.
INTERNATIONAL JOURNAL OF CIVIL ENGINEERING
(2023)
Article
Obstetrics & Gynecology
Jiahui Wei, Baoyi Huang, Yingqi Nong, Qianyu Zhang, Wenjuan Liu, Yanni Xie, Tong Peng, Wei Wang, Xiangping Liang, Qiuyun Li, Fenghua Liu
Summary: This study reveals the suppression of cuproptosis and the involvement of PDHA1 and kinase activity in EMs, which may explain the cancer-like pathology in EMs.
REPRODUCTIVE SCIENCES
(2023)
Article
Environmental Sciences
Yanqi Wu, Shuai Song, Xinchuang Chen, Yajuan Shi, Haotian Cui, Ying Liu, Shengjie Yang
Summary: This study explores the variations in the ecological risks of pharmaceutical and personal care products (PPCPs) in surface water and identifies the critical sources. The research found that rural areas have a higher contamination level than urban areas. Medical wastewater contributes the highest proportion, while domestic sewage poses the greatest threat to aquatic ecosystems. The study highlights the importance of developing environmental management strategies to reduce PPCP contamination, with a focus on domestic sewage in urban areas and aquaculture in rural areas.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Hematology
Yu-Ce Wei, Wei-Xin Liu, Fei Qi, Chang-Gong Zhang, Bao-Min Zheng, Yan Xie, Bo Chen, Di Zhang, Wei-Ping Liu, Hui Fang, Yue Chai, Shu-Nan Qi, Ye-Xiong Li, Wei-Hu Wang, Yu-Qin Song, Jun Zhu, Mei Dong
Summary: This study aimed to investigate the clinical features, prognosis, and treatment of advanced-stage non-nasal type extranodal natural killer/T-cell lymphoma (ENKTCL). The results showed that non-nasal type ENKTCLs had higher Ki-67 expression levels compared to nasal type disease. The non-nasal group showed slightly inferior survival outcomes compared to the nasal group, but without statistically significant differences. Eastern Cooperative Oncology Group (ECOG) score >= 2 and lactic dehydrogenase (LDH) elevation were significantly correlated with worse overall survival in the non-nasal group.
ANNALS OF HEMATOLOGY
(2023)
Article
Medicine, Research & Experimental
Kunyu Wang, Yanan Zhang, Miao Ao, Haixia Luo, Wei Mao, Bin Li
Summary: In this study, researchers identified cuproptosis-related features associated with the prognosis of ovarian cancer patients and constructed a prognostic model that can accurately predict patient prognosis and immune characteristics. Among them, WASF2 is a cuproptosis-related gene that is associated with the promotion of ovarian cancer cell proliferation and resistance to platinum drugs, and is also associated with poor prognosis in patients.
