Lipoxin A4 Regulates Lipopolysaccharide-Induced BV2 Microglial Activation and Differentiation via the Notch Signaling Pathway

Combined administration of resolvin E1 and lipoxin A4 resolves inflammation in a murine model of Alzheimer's disease

(2018) Alpdogan Kantarci et al.   EXPERIMENTAL NEUROLOGY

XQ-1H protects against ischemic stroke by regulating microglia polarization through PPARγ pathway in mice

(2018) Rui Liu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Simvastatin alters M1/M2 polarization of murine BV2 microglia via Notch signaling

(2018) Fei Wu et al.   JOURNAL OF NEUROIMMUNOLOGY

Notch signaling inhibitor DAPT provides protection against acute craniocerebral injury

(2018) Hong-Mei Zhang et al.   PLoS One

Lipoxin A 4 and its analog suppress hepatocarcinoma cell epithelial-mesenchymal transition, migration and metastasis via regulating integrin-linked kinase axis

(2018) Fen Xu et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Erythropoietin ameliorates early brain injury after subarachnoid haemorrhage by modulating microglia polarization via the EPOR/JAK2-STAT3 pathway

(2017) Shanwu Wei et al.   EXPERIMENTAL CELL RESEARCH

Lipoxin A4 Attenuates Bronchopulmonary Dysplasia via Upregulation of Let-7c and Downregulation of TGF-β1 Signaling Pathway

(2017) Xiao-Qing Chen et al.   INFLAMMATION

Inhibition of AGEs/RAGE/Rho/ROCK pathway suppresses non-specific neuroinflammation by regulating BV2 microglial M1/M2 polarization through the NF-κB pathway

(2017) Jingkao Chen et al.   JOURNAL OF NEUROIMMUNOLOGY

Fingolimod Protects Against Ischemic White Matter Damage by Modulating Microglia Toward M2 Polarization via STAT3 Pathway

(2017) Chuan Qin et al.   STROKE

Early and Late CNS Inflammation in Alzheimer’s Disease: Two Extremes of a Continuum?

(2017) A. Claudio Cuello   TRENDS IN PHARMACOLOGICAL SCIENCES

The Role of Microglia in Retinal Neurodegeneration: Alzheimer's Disease, Parkinson, and Glaucoma

(2017) Ana I. Ramirez et al.   Frontiers in Aging Neuroscience

Microglia preconditioned by oxygen-glucose deprivation promote functional recovery in ischemic rats

(2017) Masato Kanazawa et al.   Scientific Reports

Formyl-Peptide Receptor 2/3/Lipoxin A4Receptor Regulates Neutrophil-Platelet Aggregation and Attenuates Cerebral InflammationCLINICAL PERSPECTIVE

(2016) Shantel A. Vital et al.   CIRCULATION

Neuronal Soluble Fas Ligand Drives M1-Microglia Polarization after Cerebral Ischemia

(2016) Hai-Lan Meng et al.   CNS Neuroscience & Therapeutics

Cyclic AMP is a key regulator of M1 to M2a phenotypic conversion of microglia in the presence of Th2 cytokines

(2016) Mousumi Ghosh et al.   Journal of Neuroinflammation

Lipoxin A4 Preconditioning Attenuates Intestinal Ischemia Reperfusion Injury through Keap1/Nrf2 Pathway in a Lipoxin A4 Receptor Independent Manner

(2016) Xue Han et al.   Oxidative Medicine and Cellular Longevity

Functions and mechanisms of microglia/macrophages in neuroinflammation and neurogenesis after stroke

(2016) Xiao-Yi Xiong et al.   PROGRESS IN NEUROBIOLOGY

Lipoxin A4 Reduces Inflammation Through Formyl Peptide Receptor 2/p38 MAPK Signaling Pathway in Subarachnoid Hemorrhage Rats

(2016) Zongduo Guo et al.   STROKE

Role of Notch signaling in regulating innate immunity and inflammation in health and disease

(2016) Yingli Shang et al.   Protein & Cell

Macrophage polarization in experimental and clinical choroidal neovascularization

(2016) Yu Yang et al.   Scientific Reports

Telmisartan prevention of LPS-induced microglia activation involves M2 microglia polarization via CaMKKβ-dependent AMPK activation

(2015) Yuan Xu et al.   BRAIN BEHAVIOR AND IMMUNITY

Lipid mediator lipoxin A4 inhibits tumor growth by targeting IL-10-producing regulatory B (Breg) cells

(2015) Zheng Wang et al.   CANCER LETTERS

Lipoxin A4 Attenuates Obesity-Induced Adipose Inflammation and Associated Liver and Kidney Disease

(2015) Emma Börgeson et al.   Cell Metabolism

Scutellarin regulates the Notch pathway and affects the migration and morphological transformation of activated microglia in experimentally induced cerebral ischemia in rats and in activated BV-2 microglia

(2015) Yun Yuan et al.   Journal of Neuroinflammation

Lipoxin A4 activates alveolar epithelial sodium channel gamma via the microRNA-21/PTEN/AKT pathway in lipopolysaccharide-induced inflammatory lung injury

(2015) Wei Qi et al.   LABORATORY INVESTIGATION

Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases

(2015) Yu Tang et al.   MOLECULAR NEUROBIOLOGY

Neuroinflammation in Parkinson’s disease and its potential as therapeutic target

(2015) Qinqin Wang et al.   Translational Neurodegeneration

Lipoxin A4: The Double-edge Sword in Mice Pregnancy

(2014) Zhangye Xu et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Improvement of functional recovery by chronic metformin treatment is associated with enhanced alternative activation of microglia/macrophages and increased angiogenesis and neurogenesis following experimental stroke

(2014) Qin Jin et al.   BRAIN BEHAVIOR AND IMMUNITY

Microglial and macrophage polarization—new prospects for brain repair

(2014) Xiaoming Hu et al.   Nature Reviews Neurology

Aspirin-triggered Lipoxin A4 attenuates mechanical allodynia in association with inhibiting spinal JAK2/STAT3 signaling in neuropathic pain in rats

(2014) Z.-F. Wang et al.   NEUROSCIENCE

Microglial Dynamics and Role in the Healthy and Diseased Brain

(2014) Diego Gomez-Nicola et al.   NEUROSCIENTIST

Resolvin D1 and Lipoxin A4 Improve Alveolarization and Normalize Septal Wall Thickness in a Neonatal Murine Model of Hyperoxia-Induced Lung Injury

(2014) Camilia R. Martin et al.   PLoS One

Aspirin-triggered lipoxin A4 attenuates lipopolysaccharide induced inflammatory response in primary astrocytes

(2013) Chengye Yao et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Lipoxins Attenuate Renal Fibrosis by Inducing let-7c and Suppressing TGF R1

(2013) E. P. Brennan et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Lipoxin A4Preconditioning and Postconditioning Protect Myocardial Ischemia/Reperfusion Injury in Rats

(2013) Qifeng Zhao et al.   MEDIATORS OF INFLAMMATION

Neurogenic neuroinflammation: inflammatory CNS reactions in response to neuronal activity

(2013) Dimitris N. Xanthos et al.   NATURE REVIEWS NEUROSCIENCE

Lipoxin A4 ameliorates cerebral ischaemia/reperfusion injury through upregulation of nuclear factor erythroid 2-related factor 2

(2013) Le Wu et al.   NEUROLOGICAL RESEARCH

Lipoxin A4 Inhibits the Development of Endometriosis in Mice: The Role of Anti-Inflammation and Anti-Angiogenesis

(2012) Zhangye Xu et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Safety and Tolerability of the γ-Secretase Inhibitor Avagacestat in a Phase 2 Study of Mild to Moderate Alzheimer Disease

(2012) Vladimir Coric et al.   ARCHIVES OF NEUROLOGY

N9 microglial cells polarized by LPS and IL4 show differential responses to secondary environmental stimuli

(2012) Hong-Cui Liu et al.   CELLULAR IMMUNOLOGY

Macrophage plasticity and polarization in tissue repair and remodelling

(2012) Alberto Mantovani et al.   JOURNAL OF PATHOLOGY

Lipoxin A4 inhibits the production of proinflammatory cytokines induced by β-amyloid in vitro and in vivo

(2011) Jun Wu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Notch signaling: simplicity in design, versatility in function

(2011) E. R. Andersson et al.   DEVELOPMENT

Aspirin-triggered lipoxin A4 attenuates LPS-induced pro-inflammatory responses by inhibiting activation of NF-κB and MAPKs in BV-2 microglial cells

(2011) Yan-Ping Wang et al.   Journal of Neuroinflammation

Not(ch) just development: Notch signalling in the adult brain

(2011) Jessica L. Ables et al.   NATURE REVIEWS NEUROSCIENCE

Notch Activation Enhances the Microglia-Mediated Inflammatory Response Associated With Focal Cerebral Ischemia

(2011) Zelan Wei et al.   STROKE

Lipoxin A 4 analogue protects brain and reduces inflammation in a rat model of focal cerebral ischemia reperfusion

(2010) Xi-Hong Ye et al.   BRAIN RESEARCH

Notch Signaling Determines the M1 versus M2 Polarization of Macrophages in Antitumor Immune Responses

(2010) Yao-Chun Wang et al.   CANCER RESEARCH

Autoamplification of Notch Signaling in Macrophages by TLR-Induced and RBP-J-Dependent Induction of Jagged1

(2010) J. Foldi et al.   JOURNAL OF IMMUNOLOGY

Lipoxin A4and Its Analogue Suppress the Tumor Growth of Transplanted H22 in Mice: The Role of Antiangiogenesis

(2010) Ying Chen et al.   MOLECULAR CANCER THERAPEUTICS

The protective effects of Lipoxin A4during the early phase of severe acute pancreatitis in rats

(2010) Mengtao Zhou et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Lipoxin A4 inhibits IL-1β-induced IL-8 and ICAM-1 expression in 1321N1 human astrocytoma cells

(2009) Yann Decker et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Origin and evolution of the Notch signalling pathway: an overview from eukaryotic genomes

(2009) Eve Gazave et al.   BMC EVOLUTIONARY BIOLOGY

Heterogeneity of Microglial Activation in the Innate Immune Response in the Brain

(2009) Carol A. Colton   Journal of Neuroimmune Pharmacology

Lipoxin A4 Reduces Lipopolysaccharide-Induced Inflammation in Macrophages and Intestinal Epithelial Cells through Inhibition of Nuclear Factor- B Activation

(2009) I. Kure et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

NOTCH inhibition and glucocorticoid therapy in T-cell acute lymphoblastic leukemia

(2009) P J Real et al.   LEUKEMIA

Elevated Expressions of 15-Lipoxygenase and Lipoxin A4 in Children with Acute Poststreptococcal Glomerulonephritis

(2008) Sheng-Hua Wu et al.   AMERICAN JOURNAL OF PATHOLOGY

Alternative Activation of Macrophages: An Immunologic Functional Perspective

(2008) Fernando O. Martinez et al.   Annual Review of Immunology

Systemic infection, inflammation and acute ischemic stroke

(2008) B.W. McColl et al.   NEUROSCIENCE

Attenuation of Notch signaling promotes the differentiation of neural progenitors into neurons in the hippocampal CA1 region after ischemic injury

(2008) S. Oya et al.   NEUROSCIENCE

The role of inflammation in CNS injury and disease

(2006) Sian-Marie Lucas et al.   BRITISH JOURNAL OF PHARMACOLOGY