Editorial Material
Medicine, General & Internal
Michael McDermott, David E. Newby
Summary: In this study, Fuchs et al. analyzed the outcomes of 9533 adults who underwent coronary computed tomography angiography. The unique data provided by this study on the natural history of coronary artery disease will be valuable for informing prevention strategies.
ANNALS OF INTERNAL MEDICINE
(2023)
Review
Engineering, Biomedical
Junsong Guo, Hao Wang, Ying Li, Shuang Zhu, Houxiang Hu, Zhanjun Gua
Summary: Coronary heart disease (CHD) is a leading cause of death and disability worldwide, particularly in low-income and middle-income countries and among older populations. Conventional diagnostic and therapeutic approaches have limitations, but nanotechnology offers promising alternatives for the diagnosis and treatment of CHD by utilizing the unique properties of nanomaterials. Nanomaterials can enhance early detection of CHD, facilitate targeted drug delivery and tissue engineering, and modulate inflammation and oxidative stress, addressing multiple aspects of CHD pathophysiology.
ACTA BIOMATERIALIA
(2023)
Article
Multidisciplinary Sciences
Takao Konishi, Saikat Kumar B. Ghosh, Yu Sato, Rika Kawakami, Kenji Kawai, Aimee E. Vozenilek, Weili Xu, Arielle Bellissard, Robert Giasolli, Diljon Chahal, Renu Virmani, Aloke V. V. Finn
Summary: This study investigated the thickness of the coronary medial and found that it varies depending on the coronary artery itself, its segments, and branches. The findings are important for coronary intervention and product development.
Article
Medicine, General & Internal
Sadiya S. Khan, Wendy S. Post, Xiuqing Guo, Jingyi Tan, Fang Zhu, Daniel Bos, Bahar Sedaghati-Khayat, Jeroen van Rooij, Aaron Aday, Norrina B. Allen, Maxime M. Bos, Andre G. Uitterlinden, Matthew J. Budoff, Donald M. Lloyd-Jones, Jonathan D. Mosley, Jerome I. Rotter, Philip Greenland, Maryam Kavousi
Summary: Coronary artery calcium score and polygenic risk score were evaluated for their ability to predict risk of coronary heart disease (CHD) in two population-based studies. The results showed that coronary artery calcium score had better discrimination and improved risk prediction when added to traditional risk factors compared to the polygenic risk score.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Review
Cardiac & Cardiovascular Systems
Reza Hajhosseiny, Camila Munoz, Gastao Cruz, Ramzi Khamis, Won Yong Kim, Claudia Prieto, Rene M. Botnar
Summary: Cardiovascular disease is a leading cause of mortality worldwide, with atherosclerotic coronary artery disease being the most common type. Traditional imaging methods have limitations, and there is a need for an alternative method for early identification and long-term monitoring of CAD. Coronary magnetic resonance angiography (CMRA) may offer a potential solution without radiation or contrast agents, but its clinical utilization remains limited.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Chuan Wang, Wei-Guo Ma, Yang Yu, Jing-Xing Li, Cheng-Xiong Gu
Summary: The alternative technique involving a Foley catheter and polypropylene suture for dealing with calcified ascending aorta during coronary artery bypass grafting showed favorable outcomes, with no early or late deaths, and a graft patency rate of 93% at mean follow-up of 1.6 ± 0.5 years.
ANNALS OF THORACIC SURGERY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Marwa Daghem, Philip D. Adamson, Kang-Ling Wang, Mhairi Doris, Rong Bing, Edwin J. R. van Beek, Laura Forsyth, Michelle C. Williams, Evangelos Tzolos, Damini Dey, Piotr J. Slomka, Marc R. Dweck, David E. Newby, Alastair J. Moss
Summary: The study aimed to investigate the natural history of coronary F-18-fluoride uptake in patients with chronic coronary artery disease or recent myocardial infarction. The results showed that coronary F-18-fluoride uptake is associated with the severity and progression of coronary artery disease but does not undergo rapid dynamic changes in a short period of time.
JOURNAL OF NUCLEAR MEDICINE
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Beth Whittington, Marc R. R. Dweck, Edwin J. R. van Beek, David Newby, Michelle C. C. Williams
Summary: PET-MRI combines MRI's anatomical detail and tissue characterization with PET's functional information, allowing for the identification of biological activity and high-risk plaque features within the coronary arteries. It can also provide information on myocardial perfusion, viability, and function, characterizing the downstream effects of coronary artery disease on the myocardium.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Review
Biochemistry & Molecular Biology
Marios Sagris, Panagiotis Theofilis, Alexios S. Antonopoulos, Evangelos Oikonomou, Christina Paschaliori, Nikolaos Galiatsatos, Kostas Tsioufis, Dimitris Tousoulis
Summary: Chronic low-grade inflammation plays a role in coronary atherosclerosis, leading to a range of clinical manifestations. Microvascular dysfunction in the coronary arteries can reduce oxygen supply to the myocardium. Anti-inflammatory agents may offer new treatment approaches for reducing cardiovascular events.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Manqing Luo, Xiaowei Xie, Jieyu Wu, Liwei Zhang, Xi Zheng, Mengying Xie, Na Lin, Huazhen Xiao, Jilang Zeng, Guohui Lan, Xiaoli Lu, Xiaoying Ye, Zelin Huang, Tingting Xu, Tinggui Wang, Kaiyang Lin, Yansong Guo, Xiaoxu Xie
Summary: This study investigated the association between long-term exposure to ambient particulate matter (PM10 and PM2.5) and coronary stenosis. The study found a significant correlation between chronic exposure to PM10 and PM2.5 and coronary stenosis. Each 10 μg/m3 increase in PM10 exposure was associated with a 33% increased risk of coronary stenosis, while each 10 μg/m3 increase in PM2.5 exposure was associated with an 87% increased risk. The study also identified potential mediators.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Cardiac & Cardiovascular Systems
Maria G. Hauge, Peter Damm, Klaus F. Kofoed, Anne S. Ersboll, Marianne Johansen, Per E. Sigvardsen, Mathias B. Moller, Andreas Fuchs, Jorgen T. Kuhl, Borge G. Nordestgaard, Lars Kober, Finn Gustafsson, Jesper J. Linde
Summary: This study found that younger women with previous preeclampsia had a slightly higher prevalence of coronary atherosclerosis compared to women from the general population. Preeclampsia remained an independent risk factor for coronary atherosclerosis after adjusting for traditional cardiovascular risk factors.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Tjerk S. J. Opstal, Aernoud T. L. Fiolet, Amber van Broekhoven, Arend Mosterd, John W. Eikelboom, Stefan M. Nidorf, Peter L. Thompson, Michiel Duyvendak, J. W. Martijn van Eck, Eugene A. van Beek, Frank den Hartog, Charley A. Budgeon, Willem A. Bax, Jan G. P. Tijssen, Saloua El Messaoudi, Jan H. Cornel
Summary: This study found that the benefits of colchicine in reducing major adverse cardiovascular events are consistent regardless of the history and timing of prior acute coronary syndrome (ACS).
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Review
Medicine, General & Internal
Alyssa L. S. Chow, Saad D. Alhassani, Andrew M. Crean, Gary R. Small
Summary: The article discusses the roles of CCTA and CAC-scoring in subclinical atherosclerosis, as well as their applications in screening and guiding therapy, suggesting that CCTA plays an essential role in the detection and management of clinical coronary artery disease.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Bo Li, Zhijun Lei, You Wu, Bingyu Li, Ming Zhai, Yuan Zhong, Peinan Ju, Wenxin Kou, Yefei Shi, Xianling Zhang, Wenhui Peng
Summary: Plasma SERPINA3 levels were found to be associated with CAD, potentially affecting the pathogenesis of atherosclerosis by increasing inflammatory factors expression in HUVECs, regulating VSMCs proliferation and migration, and influencing the NF-kappa B signaling pathway.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Medicine, Research & Experimental
Lexun Wang, Dongxing Zhang, Wenjing Zhan, Zhihuan Zeng, Jianying Yin, Ke Wang, Hong Wang, Lixia Song, Zhanhui Gu, Caijuan Guo, Qin Zhong, Weixuan Wang, Xianglu Rong, Weijian Bei, Jiao Guo
Summary: The study aims to investigate the unique mechanism of FTZ in the treatment of DM-CHD minipigs with coronary atherosclerosis. The results showed that FTZ significantly improved disordered glycolipid metabolism, reduced coronary stenosis and myocardial injury in DM-CHD minipigs. FTZ also reversed the abnormal protein expressions in the DM-CHD coronary artery and ameliorated the damage and high migration activity of HUVECs induced by high glucose.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Cardiac & Cardiovascular Systems
Koen M. van der Sluijs, Esmee A. Bakker, Tim J. Schuijt, Jayaraj Joseph, Maryam Kavousi, Geert-Jan Geersing, Frans H. Rutten, Yvonne A. W. Hartman, Dick H. J. Thijssen, Thijs M. H. Eijsvogels
Summary: It is reported that COVID-19 has long-term effects on cardiovascular health and physical functioning. This study compared cardiovascular risk factors, arterial stiffness, and physical functioning in nonhospitalized COVID-19 patients at 6 months post-infection. The study found that one in three nonhospitalized patients with COVID-19 reported residual symptoms, especially fatigue, at a median of 6 months post-infection, but no differences in cardiovascular risk factors or arterial stiffness were observed between the COVID-19 group and the control group.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Vincent L. Aengevaeren, Arend Mosterd, Esmee A. Bakker, Thijs L. Braber, Hendrik M. Nathoe, Sanjay Sharma, Paul D. Thompson, Birgitta K. Velthuis, Thijs M. H. Eijsvogels
Summary: According to the study, the intensity rather than the volume of exercise is associated with the progression of coronary atherosclerosis in middle-aged and older male athletes. Vigorous intensity exercise is associated with less coronary artery calcification (CAC) progression, while very vigorous intensity exercise is associated with greater CAC and calcified plaque progression.
Article
Cardiac & Cardiovascular Systems
Yasina B. Somani, Laween Uthman, Vincent L. Aengevaeren, Laura Rodwell, Gregory Y. H. Lip, Maria T. E. Hopman, Niels Van Royen, Thijs M. H. Eijsvogels, Dick H. J. Thijssen
Summary: Prolonged exercise can lead to the release of cardiac troponin. The magnitude of troponin release decreases with successive days of exercise in healthy individuals and those with cardiovascular risk factors, but not in patients with established cardiovascular disease.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Hematology
Giuseppe Ciliberti, Joseph Westaby, Michael Papadakis, Elijah R. Behr, Sanjay Sharma, Gherardo Finocchiaro, Mary N. Sheppard
Summary: Spontaneous coronary artery dissection (SCAD) and myocardial infarction with nonobstructed coronary arteries (MINOCA) are rare causes of sudden cardiac death (SCD). SCAD is not associated with coronary fibromuscular dysplasia (FMD) in SCD victims, and compared to MINOCA, SCAD is more common in females, linked to pregnancy, and has a lower incidence of infarcted myocardium. SCAD victims also have a higher prevalence of premortem cardiac symptoms, while substance use or abuse is more common among MINOCA victims.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Neeltje A. E. Allard, Lando Janssen, Bart Lagerwaard, Malou A. H. Nuijten, Coen C. W. G. Bongers, Richard J. Rodenburg, Paul D. Thompson, Thijs M. H. Eijsvogels, Willem J. J. Assendelft, Tom J. J. Schirris, Silvie Timmers, Maria T. E. Hopman
Summary: This study aimed to determine the effect of prolonged moderate-intensity exercise on markers of muscle injury in statin users and whether statin-associated muscle symptoms exacerbate this injury. The results showed that statin use and the presence of statin-associated muscle symptoms do not aggravate exercise-induced muscle injury, and there is no relationship between muscle injury markers and leukocyte CoQ10 levels.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Letter
Cardiac & Cardiovascular Systems
Joyee Basu, Gherardo Finocchiaro, Christopher Miles, Gemma Parry-Williams, Hamish MacLachlan, Maria Teresa Tome Esteban, Sanjay Sharma, Michael Papadakis
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Alessia Paldino, Maddalena Rossi, Matteo Dal Ferro, Irena Tavcar, Elijah Behr, Sanjay Sharma, Michael Papadakis, Gianfranco Sinagra, Gherardo Finocchiaro
Summary: GEN+PHEN- individuals carry pathogenic genetic variants without phenotypic manifestation of the disease, which poses challenges in clinical management. The variable expressivity of genetic variants within the same family and the unpredictable conversion to overt phenotype complicate decision-making in sports participation. Current guidelines acknowledge the lack of evidence and uncertainties in managing GEN+PHEN- individuals.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Sport Sciences
Johannus Q. de Korte, Thijs M. H. Eijsvogels, Maria T. E. Hopman, Coen C. W. G. Bongers
Summary: Watching a football match in a simulated hot and humid environment does not cause significant thermal or cardiovascular strain, but it does result in an increase in skin temperature. The majority of spectators experience thermal discomfort, although age does not appear to affect the heat stress response.
Letter
Cardiac & Cardiovascular Systems
Raghav T. Bhatia, Gherardo Finocchiaro, Joseph Westaby, Nikhil Chatrath, Elijah R. Behr, Michael Papadakis, Sanjay Sharma, Mary N. Sheppard
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Manon Kloosterman, Machteld J. Boonstra, Rob W. Roudijk, Mimount Bourfiss, Iris van der Schaaf, Birgitta K. Velthuis, Thijs M. H. Eijsvogels, Feddo P. Kirkels, Peter M. van Dam, Peter Loh
Summary: This study used body surface potential mapping to identify abnormal QRS and STT patterns in variant carriers of PKP2 who had normal 12 lead ECGs. This helps in detecting early signs of the disease.
Editorial Material
Physiology
Thijs M. H. Eijsvogels, Vincent L. Aengevaeren
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Niels A. Stens, Esmee A. Bakker, Asier Manas, Laurien M. Buffart, Francisco B. Ortega, Duck-chul Lee, Paul D. Thompson, Dick H. J. Thijssen, Thijs M. H. Eijsvogels
Summary: According to the meta-analysis, daily step counts of approximately 2,600 and 2,800 already yield significant benefits in terms of reducing mortality and cardiovascular disease. Further increasing the step count up to approximately 8,800 and 7,200 steps per day leads to progressive risk reductions. There are additional mortality benefits from moderate to high step cadences.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Sport Sciences
Iris Apolonia de Koning, B. M. A. van Bakel, Hajar Rotbi, Robert-Jan M. Van Geuns, G. Etienne Cramer, Gheorghe A. M. Pop, Thijs Eijsvogels, Dick H. J. Thijssen
Summary: Regular exercise prior to myocardial infarction (MI) may lead to lower post-MI cardiac biomarker concentrations, indicating the cardiovascular health benefits of exercise.
BMJ OPEN SPORT & EXERCISE MEDICINE
(2023)
Letter
Allergy
Bernard N. Jukema, Thomas C. Pelgrim, Sylvan L. J. E. Janssen, Thijs M. H. Eijsvogels, Alma Mingels, Wim Vroemen, Nienke Vrisekoop, Leo Koenderman
CLINICAL AND TRANSLATIONAL ALLERGY
(2023)
