Article
Chemistry, Analytical
Yuan Gao, Yuyun Zhao, Le Xie, Guoyan Zheng
Summary: Using image overlay projection technology during surgery can help surgeons better understand anatomical structures and surgical targets, avoiding distractions. While projecting surgical navigation information precisely onto the target remains a challenge, our proposed projector-based surgical navigation system has shown good performance in terms of projection accuracy and accuracy.
Article
Computer Science, Interdisciplinary Applications
T. Collins, D. Pizarro, S. Gasparini, N. Bourdel, P. Chauvet, M. Canis, L. Calvet, A. Bartoli
Summary: The system presented in the research successfully performed markerless real-time registration and augmented reality of a mobile human organ with monocular laparoscopes in the operating room. The system addresses the challenges posed by the weakly-textured, highly mobile nature of the uterus through novel and robust solutions.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2021)
Article
Surgery
Philip C. Mueller, Caroline Haslebacher, Daniel C. Steinemann, Beat P. Mueller-Stich, Thilo Hackert, Matthias Peterhans, Benjamin Eigl
Summary: This study evaluated the feasibility and potential benefits of image-guided EPS using a computer-assisted navigation system in artificial pancreas silicon models. Results showed that this method successfully targeted pancreatic lesions with high accuracy and could facilitate complex minimally invasive and robotic pancreatic procedures in the clinical setting.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Review
Oncology
Fabio Giannone, Emanuele Felli, Zineb Cherkaoui, Pietro Mascagni, Patrick Pessaux
Summary: Robotic surgery for liver resection has gained attention for its potential to improve surgical dexterity in minimally invasive procedures. While there are promising results reported in the literature, there is still a lack of strong evidence. The robotic system allows for a hybrid interface that can utilize pre- and intra-operative imaging tools to guide surgical resection, aiming to enhance safety and oncological outcomes.
Article
Biology
Tao Zhu, Shan Jiang, Zhiyong Yang, Zeyang Zhou, Yuhua Li, Shixing Ma, Jie Zhuo
Summary: The study proposed an AR-based neuroendoscopic navigation system to assist surgeons in locating and clearing intracerebral hemorrhage. It has been validated to have high accuracy and feasibility.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Xin Huang, Xiaoguang Liu, Bin Zhu, Xiangyu Hou, Bao Hai, Shuiqing Li, Dongfang Yu, Wenhao Zheng, Ranyang Li, Junjun Pan, Youjie Yao, Zailin Dai, Haijun Zeng, Ryan Halter, Gary L. Bowlin
Summary: This study evaluated the feasibility and effectiveness of an augmented reality surgical navigation system in percutaneous endoscopic lumbar discectomy. The results showed that the system successfully superimposed radiographs and puncture needle in real-time, and significantly reduced the number of puncture attempts and fluoroscopies.
BIOENGINEERING-BASEL
(2023)
Article
Medicine, General & Internal
Seung Hyun Lee, Yu Hua Quan, Min Sub Kim, Ki Hyeok Kwon, Byeong Hyeon Choi, Hyun Koo Kim, Beop-Min Kim
Summary: This study developed an augmented reality-based near-infrared fluorescence imaging system to detect stable fluorescence images for tumor margin assessments in animal models. By utilizing commercial smart glasses and other components, the system showed good performance in laboratory evaluation and preclinical experiments, proving effective for tumor detection and lung lobectomy in the operating room. Even when the system itself was distorted, the fluorescence image consistently matched the actual site, highlighting its reliability for surgical workflows.
Article
Oncology
Santiago Ochandiano, David Garcia-Mato, Alba Gonzalez-Alvarez, Rafael Moreta-Martinez, Manuel Tousidonis, Carlos Navarro-Cuellar, Ignacio Navarro-Cuellar, Jose Ignacio Salmeron, Javier Pascau
Summary: Image-guided surgery, prosthetic-based virtual planning, 3D printing, and CAD/ CAM technology have revolutionized head and neck ablative and reconstructive surgical oncology, enabling accurate dental implant placement and improving quality of life. A learning curve exists for surgeons using guided methods, with dynamic navigation cases achieving the highest accuracy in implant placement. Smartphone-based augmented reality visualization is a valuable tool for intraoperative visualization and final verification, contributing to the success of free flap oncological reconstruction.
FRONTIERS IN ONCOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Joelle Ackermann, Florentin Liebmann, Armando Hoch, Jess G. Snedeker, Mazda Farshad, Stefan Rahm, Patrick O. Zingg, Philipp Furnstahl
Summary: The study demonstrated the feasibility of AR-based execution of complex osteotomies, with high accuracy in osteotomy and room for improvement in fragment realignment navigation.
APPLIED SCIENCES-BASEL
(2021)
Article
Health Care Sciences & Services
Shin-Yan Chiou, Zhi-Yue Zhang, Hao-Li Liu, Jiun-Lin Yan, Kuo-Chen Wei, Pin-Yuan Chen
Summary: This paper introduces an augmented reality surgical navigation system that accurately superimposes the surgical target position, scalpel entry point, and scalpel direction on a patient's head and displays this data on a tablet. The designed system meets clinical requirements and provides a visual and intuitive guide for neurosurgeons.
Article
Dentistry, Oral Surgery & Medicine
Marton Kivovics, Anna Takacs, Dorottya Penzes, Orsolya Nemeth, Eitan Mijiritsky
Summary: This in vitro study compared the accuracy of implant placement in model surgeries using three different methods. The results showed that the accuracy of AR-based dynamic navigation was comparable to static CAIS and superior to the free-hand method in terms of implant positioning.
JOURNAL OF DENTISTRY
(2022)
Article
Medicine, General & Internal
Bernhard Remschmidt, Marcus Rieder, Christina Gsaxner, Jan Gaessler, Michael Payer, Juergen Wallner
Summary: This study evaluates the intraoperative feasibility and usability of HoloLens 2, an AR image guidance device, in apicoectomies. The results show that HoloLens has excellent usability and is suitable for apicoectomies.
Article
Cardiac & Cardiovascular Systems
Vincent Van den Bosch, Hizirwan Shukri Salim, Njin-Zu Chen, Otto Stroosma, Philipp Bruners, Christiane K. Kuhl, Federico Pedersoli, Peter Isfort
Summary: This study demonstrates the feasibility of a novel augmented reality system for CT-guided liver interventions. It shows that augmented reality can significantly reduce puncture time and partially improve puncture accuracy compared to free-hand interventions.
CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY
(2022)
Review
Engineering, Biomedical
Zhuo Zhao, Jasmin Poyhonen, Xin Chen Cai, Frances Sophie Woodley Hooper, Yangmyung Ma, Yihua Hu, Hongliang Ren, Wenzhan Song, Zion Tsz Ho Tse
Summary: In this review, 233 publications on augmented reality-based systems for image-guided therapy were considered, and 16 studies were selected for analysis. The engineering specifications and applications of these studies were summarized, and future directions and existing challenges in the field were discussed.
PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART H-JOURNAL OF ENGINEERING IN MEDICINE
(2021)
Article
Computer Science, Cybernetics
Yuwei Wang, Yimin Wu, Cheng Chen, Bohan Wu, Shu Ma, Duming Wang, Hongting Li, Zhen Yang
Summary: The study suggests that augmented reality head-up display technology can enhance driving safety but may also lead to inattentional blindness. High workload intensifies this relationship, highlighting the importance of considering the risk of inattentional blindness in the design of AR HUD assisted-driving systems.
INTERNATIONAL JOURNAL OF HUMAN-COMPUTER INTERACTION
(2022)
Article
Gastroenterology & Hepatology
Tanveer Singh, Prabhjot Bedi, Karandeep Bumrah, Darshan Gandhi, Tanureet Arora, Nikita Verma, Mary Schleicher, Manoj P. Rai, Rajat Garg, Beni Verma, Madhusudhan R. Sanaka
Summary: Fecal microbiota transplantation (FMT) is effective in the treatment of recurrent Clostridium difficile infection (CDI), but not significant in primary CDI.
JOURNAL OF CLINICAL GASTROENTEROLOGY
(2022)
Letter
Urology & Nephrology
Jeremy Yuen-Chun Teoh, Marcelo Langer Wroclawski, Steffi Yuen, Bryan Cheng, Riccardo Bertolo, Daniele Castellani, Vineet Gauhar, Thomas Herrmann
WORLD JOURNAL OF UROLOGY
(2022)
Review
Health Policy & Services
Dena Crozier, Amy Greene, Mary Schleicher, Johanna Goldfarb
Summary: This systematic review examined the structure of courses teaching spirituality to medical students and assessed their impact on reported student outcomes. The majority of curricula were taught in United States medical schools, with a mix of mandatory and elective courses, and evaluation methods included pre- and post-test designs.
JOURNAL OF HEALTH CARE CHAPLAINCY
(2022)
Letter
Urology & Nephrology
Riccardo Campi, Riccardo Bertolo, Andrea Minervini
Article
Urology & Nephrology
Riccardo Bertolo, Pierluigi Bove, Andrea Minervini, Alessandro Antonelli
INTERNATIONAL JOURNAL OF UROLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Gauranga Mahalwar, Ashwin Kumar, Ankit Agrawal, Abhilash Bhat, Muhammad Furqan, Abdullah Yesilyaprak, Beni Rai Verma, Nicholas Chan, Mary Schleicher, Manuel L. Ribeiro Neto, Bo Xu, Christine L. Jellis, Allan L. Klein
Summary: Pericardial disease secondary to sarcoidosis is a rare condition with limited research. This study reviewed previous case reports to understand the diagnosis and management of sarcoidosis-induced pericarditis. The majority of patients presented with dyspnea and lung involvement was commonly observed. Pericardial effusion was the most frequently encountered manifestation, and corticosteroids were the main treatment option. Overall, most patients showed clinical improvement after treatment.
AMERICAN JOURNAL OF CARDIOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Dania Kallas, Navroop Sandhu, Christina Gandilo, Mary Schleicher, Laura Banks, Mariam Jabara, Luiz Alberto Cerqueira Batista Filho, Tracey J. F. Colella, Kim Connelly, Varinder Kaur Randhawa
Summary: The use of digital health technologies (DHT) in chronic disease management is increasing. This study evaluated the impact of DHT on clinical outcomes in patients with heart failure (HF) and diabetes mellitus (DM). The findings suggest limited data on randomized controlled trials (RCTs) evaluating DHT in patients with both HF and DM. Further research is needed to define standardized clinical endpoints and platforms for managing patients with multiple comorbidities.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2023)
Review
Medicine, General & Internal
Stijn Muselaers, Selcuk Erdem, Riccardo Bertolo, Alexandre Ingels, Onder Kara, Nicola Pavan, Eduard Roussel, Angela Pecoraro, Michele Marchioni, Umberto Carbonara, Laura Marandino, Daniele Amparore, Riccardo Campi
Summary: PSMA PET/Computed Tomography has the potential to be an important imaging tool for staging and monitoring renal cell carcinoma, as it is highly expressed in the microvasculature of solid tumors.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Aldo Brassetti, Giovanni E. Cacciamani, Andrea Mari, Juan D. Garisto, Riccardo Bertolo, Chandru P. Sundaram, Ithaar Derweesh, Ahmet Bindayi, Prokar Dasgupta, James Porter, Alexander Mottrie, Luigi Schips, Koon Ho Rah, David Y. T. Chen, Chao Zhang, Kenneth Jacobsohn, Umberto Anceschi, Alfredo M. Bove, Manuela Costantini, Mariaconsiglia Ferriero, Riccardo Mastroianni, Leonardo Misuraca, Gabriele Tuderti, Alexander Kutikov, Wesley M. White, Stephen T. Ryan, Francesco Porpiglia, Jihad Kaouk, Andrea Minervini, Inderbir Gill, Riccardo Autorino, Giuseppe Simone
Summary: Robot-assisted partial nephrectomy is a viable option for treating tumors larger than 7 cm, but the risk of postoperative renal function deterioration should be considered. Off-clamp robotic partial nephrectomy has shorter operation times and may improve perioperative outcomes.
Review
Education, Scientific Disciplines
Lisa Umphrey, Nora Lenhard, Suet Kam Lam, Nathaniel E. Hayward, Shaina Hecht, Priya Agrawal, Amy Chambliss, Jessica Evert, Heather Haq, Stephanie M. Lauden, George Paasi, Mary Schleicher, Megan S. McHenry
Summary: This study synthesized recent virtual global health education activities for graduate medical trainees, highlighting important drivers and challenges, the need for future research on activity preferences, and considerations for educators and learners in low-to-middle income countries. These findings may inform global health educators in planning and implementing virtual activities.
INTERNATIONAL JOURNAL OF MEDICAL EDUCATION
(2022)
Article
Medicine, General & Internal
Riccardo Bertolo, Chiara Cipriani, Matteo Vittori, Riccardo Campi, Juan Garisto, Michele Di Dio, Filippo Annino, Pierluigi Bove
Summary: Robotic technology allows beginner surgeons to perform minimally-invasive partial nephrectomy with a shorter learning curve compared to pure laparoscopy. This video-article presents the surgical technique and outcomes of the first 11 cases performed by a young surgeon using robotic PN. The off-clamp approach and simple enucleation technique were successfully employed, yielding comparable results to existing literature.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biology
Xue Yang, Ying Wang, Valentina Rovella, Eleonora Candi, Wei Jia, Francesca Bernassola, Pierluigi Bove, Mauro Piacentini, Manuel Scimeca, Giuseppe Sica, Giuseppe Tisone, Alessandro Mauriello, Lixin Wei, Gerry Melino, Yufang Shi
Summary: Natural ageing of organisms and age-related diseases are mainly caused by stem cell ageing and inflammaging. Mesenchymal stem cells (MSCs) have high immune-regulating capacity and are potential candidates for immune-related disease treatment. However, MSC application is not satisfactory for some patients, especially the elderly, possibly due to changes in MSCs with ageing, including reduced cell population and differentiation ability, decreased migratory and homing capacity, and defective immunosuppression. It is important to explore the relationship between inflammaging and aged MSCs in order to prevent age-related diseases and improve the therapeutic effects of MSCs. This review discusses the changes in naturally ageing MSCs mainly from an inflammation perspective and proposes ideas for rejuvenating aged MSCs in future treatments.
Review
Medicine, General & Internal
Alfredo Distante, Laura Marandino, Riccardo Bertolo, Alexandre Ingels, Nicola Pavan, Angela Pecoraro, Michele Marchioni, Umberto Carbonara, Selcuk Erdem, Daniele Amparore, Riccardo Campi, Eduard Roussel, Anna Calio, Zhenjie Wu, Carlotta Palumbo, Leonardo D. D. Borregales, Peter Mulders, Constantijn H. J. Muselaers
Summary: Renal cell carcinoma (RCC) presents histopathological challenges for accurate diagnosis and prognosis. This literature review explores recent advancements in AI applications in RCC pathology, with the aim of improving precision, efficiency, and objectivity in histopathological analysis. AI-powered approaches demonstrate effective identification and classification abilities, enabling accurate diagnosis, grading, and prognosis prediction. Challenges include standardization, generalizability, performance benchmarking, and data integration into clinical workflows. Accurate interpretation of AI decisions by pathologists and robust validation workflows are crucial for enhancing patient care.
Article
Education, Scientific Disciplines
Colleen Y. Colbert, Cecile M. Foshee, Allison Prelosky-Leeson, Mary Schleicher, Rachel King
Summary: "Differentiated Instruction in Health Professions Education" discusses the importance of differentiated instruction in medical education and provides implementation strategies suitable for various healthcare educational settings.
MEDICAL SCIENCE EDUCATOR
(2023)
Article
Urology & Nephrology
Riccardo Bertolo, Pierluigi Bove, Marco Sandri, Luca Cindolo, Filippo Annino, Costantino Leonardo, Paolo Parma, Roberto Nucciotti, Angelo Porreca, Mario Falsaperla, Domenico Veneziano, Antonio Celia, Luigi Schips, Claudio Simeone, Marco Carini, Andrea Minervini, Alessandro Antonelli
MINERVA UROLOGY AND NEPHROLOGY
(2022)