Hydrostatic Pressure Studies Distinguish Global from Local Protein Motions in C−H Activation by Soybean Lipoxygenase-1

Emerging Concepts about the Role of Protein Motion in Enzyme Catalysis

(2015) Sharon Hammes-Schiffer et al.   ACCOUNTS OF CHEMICAL RESEARCH

Kinetic Detection of Orthogonal Protein and Chemical Coordinates in Enzyme Catalysis: Double Mutants of Soybean Lipoxygenase

(2015) Sudhir C. Sharma et al.   BIOCHEMISTRY

Nonadiabatic rate constants for proton transfer and proton-coupled electron transfer reactions in solution: Effects of quadratic term in the vibronic coupling expansion

(2015) Alexander V. Soudackov et al.   JOURNAL OF CHEMICAL PHYSICS

Temperature-Jump Fluorescence Provides Evidence for Fully Reversible Microsecond Dynamics in a Thermophilic Alcohol Dehydrogenase

(2015) Corey W. Meadows et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Protein Conformational Landscapes and Catalysis. Influence of Active Site Conformations in the Reaction Catalyzed by L-Lactate Dehydrogenase

(2015) Katarzyna Świderek et al.   ACS Catalysis

Network of Remote and Local Protein Dynamics in Dihydrofolate Reductase Catalysis

(2015) Priyanka Singh et al.   ACS Catalysis

Mapping the conformational landscape of a dynamic enzyme by multitemperature and XFEL crystallography

(2015) Daniel A Keedy et al.   eLife

Dynamically Achieved Active Site Precision in Enzyme Catalysis

(2014) Judith P. Klinman   ACCOUNTS OF CHEMICAL RESEARCH

Picosecond-Resolved Fluorescence Studies of Substrate and Cofactor-Binding Domain Mutants in a Thermophilic Alcohol Dehydrogenase Uncover an Extended Network of Communication

(2014) Corey W. Meadows et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Extremely Elevated Room-Temperature Kinetic Isotope Effects Quantify the Critical Role of Barrier Width in Enzymatic C–H Activation

(2014) Shenshen Hu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Engineering of Flexible Loops in Enzymes

(2014) Bettina M. Nestl et al.   ACS Catalysis

Importance of Protein Dynamics during Enzymatic C–H Bond Cleavage Catalysis

(2013) Judith P. Klinman   BIOCHEMISTRY

Automated identification of functional dynamic contact networks from X-ray crystallography

(2013) Henry van den Bedem et al.   NATURE METHODS

Active Site Hydrophobic Residues Impact Hydrogen Tunneling Differently in a Thermophilic Alcohol Dehydrogenase at Optimal versus Nonoptimal Temperatures

(2012) Zachary D. Nagel et al.   BIOCHEMISTRY

Pressure Effects on Enzyme-Catalyzed Quantum Tunneling Events Arise from Protein-Specific Structural and Dynamic Changes

(2012) Sam Hay et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cavity hydration as a gateway to unfolding: An NMR study of hen lysozyme at high pressure and low temperature

(2011) Yuji O. Kamatari et al.   BIOPHYSICAL CHEMISTRY

Impaired protein conformational landscapes as revealed in anomalous Arrhenius prefactors

(2011) Z. D. Nagel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of a canine homolog of hepatitis C virus

(2011) A. Kapoor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An integrated model for enzyme catalysis emerges from studies of hydrogen tunneling

(2009) Judith P. Klinman   CHEMICAL PHYSICS LETTERS

Long-timescale molecular dynamics simulations of protein structure and function

(2009) John L Klepeis et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Evidence To Support the Hypothesis That Promoting Vibrations Enhance the Rate of an Enzyme Catalyzed H-Tunneling Reaction

(2009) Christopher R Pudney et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enzymatic transition states and dynamic motion in barrier crossing

(2009) Steven D Schwartz et al.   Nature Chemical Biology

A 21st century revisionist's view at a turning point in enzymology

(2009) Zachary D Nagel et al.   Nature Chemical Biology

Enzyme structure and dynamics affect hydrogen tunneling: The impact of a remote side chain (I553) in soybean lipoxygenase-1

(2008) M. P. Meyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA