期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 55, 期 5, 页码 1894-1898出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201510558
关键词
arenes; boron; copper; oxidation; synthetic methods
资金
- NSERC Canada
- Alberta Undergraduate Research Initiative, Canadian Foundation for Innovation
Reported is a versatile new oxidative method for the arylation of activated methylene species. Under mild reaction conditions (RT to 40 degrees C), Cu(OTf)(2) mediates the selective coupling of functionalized aryl boron species with a variety of stabilized sp(3)-nucleophiles. Tertiary malonates and amido esters can be employed as substrates to generate quaternary centers. Complementing either traditional cross-coupling or SNAr protocols, the transformation is chemoselective in the presence of halogen electrophiles, including aryl bromides and iodides. Substrates bearing amide, sulfonyl, and phosphonyl groups, which are not amenable to coupling under mild Hurtley-type conditions, are suitable reaction partners.
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