Article
Endocrinology & Metabolism
Emma J. Verwaaijen, Jinhui Ma, Hester A. de Groot-Kruseman, Rob Pieters, Inge M. van der Sluis, Jenneke E. van Atteveld, Jacqueline Halton, Conrad Fernandez, Annelies Hartman, Robert de Jonge, Maarten H. Lequin, Mariel L. Te Winkel, Nathalie Alos, Stephanie A. Atkinson, Ronald Barr, Ronald M. Grant, John Hay, Adam M. Huber, Josephine Ho, Jacob Jaremko, Khaldoun Koujok, Bianca Lang, Mary-Ann Matzinger, Nazih Shenouda, Frank Rauch, Celia Rodd, Marry M. Van den Heuvel-Eibrink, Saskia M. F. Pluijm, Leanne M. Ward
Summary: A prediction model for identifying pediatric ALL patients with low LS BMD at diagnosis, as an important indicator for bone fragility, was successfully developed and validated, facilitating the identification of future bone fragility in individual pediatric ALL patients.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Geriatrics & Gerontology
C. -l. Wu, O. N. Nfor, W. -y. Lu, D. Manli Tantoh, Yung-Po Liaw
Summary: This study found a relationship between coffee consumption and a lower risk of osteoporosis in individuals in Taiwan with the ESR1 rs2982573 gene, particularly for those with the TC+CC genotype.
JOURNAL OF NUTRITION HEALTH & AGING
(2022)
Article
Genetics & Heredity
Laila M. Sherief, Mohamed Beshir, Nermin Raafat, Elhamy R. Abdelkhalek, Wesam A. Mokhtar, Khaled M. Elgerby, Basma K. Soliman, Hosam E. Salah, Ghada A. Mokhtar, Naglaa M. Kamal, Heba ELsayed, Marwa Zakaria
Summary: The study found a high incidence of ON in children with ALL, with older age and insufficient vitamin D levels being important risk factors for ON development. Polymorphisms in the PAI-1 and VDR genes may play a genetic risk factor in the pathogenesis of ON.
MOLECULAR GENETICS & GENOMIC MEDICINE
(2021)
Article
Genetics & Heredity
Yi-Ming Guo, Jian-Hao Cheng, Hao Zhang, Jin-Wei He, Hua Yue, Wei-Wei Hu, Jie-Mei Gu, Yun-Qiu Hu, Wen-Zhen Fu, Chun Wang, Zhen-Lin Zhang
Summary: This study investigated the association between genetic variation of the POSTN gene and the prevalence of vertebral fractures and bone mineral density (BMD) in Chinese postmenopausal women. The study found that the rs9603226 variant of POSTN was significantly associated with vertebral fractures, while the rs3923854 variant was associated with serum periostin levels. These findings suggest that genetic variation of the POSTN gene may be a predicting factor for the risk of vertebral fractures, and serum periostin levels could be a potential biochemical parameter for osteoporosis in Chinese postmenopausal women.
Article
Endocrinology & Metabolism
Melody Kasher, Maxim B. Freidin, Frances Mk Williams, Stacey S. Cherny, Ida Malkin, Gregory Livshits
Summary: This study investigated the genetic association between rheumatoid arthritis (RA) and osteoporosis (OP), and found evidence of pleiotropy. Shared genetic variants associated with both RA and OP were identified.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Jacqueline Halton, Jinui Ma, Paul Babyn, Mary Ann C. Matzinger, Sue Kaste, Maya V. Scharke, Conrad Fernandez, Paivi Miettunen, Josephine Ho, Nathalie Alos, Sharon Abish, Ronald Barr, Elizabeth B. Cairney, David M. Dix, Ronald Grant, Sara Israels, Victor Lewis, Beverly Wilson, Stephanie Atkinson, David Cabral, Elizabeth Cummings, Celia Rodd, Robert Stein, Anne Marie L. Sbrocchi, Jacob Jaremko, Khaldoun Koujok, Nazih Shenouda, Frank Rauch, Kerry M. Siminoski, Leanne Ward, Canadian STOPP Consortium
Summary: Osteonecrosis is a common complication in children with acute lymphoblastic leukemia after therapy. A study evaluated the prevalence of osteonecrotic lesions in 86 children using multisite magnetic resonance imaging and found that 35% of the children had ON. Clinical factors such as bone mineral density changes were also considered in the analysis.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Review
Hematology
Yannis K. Valtis, Andrew E. Place, Lewis B. Silverman, Lynda M. Vrooman, Daniel J. DeAngelo, Marlise R. Luskin
Summary: Osteonecrosis (ON) is a complication of acute lymphoblastic leukaemia (ALL) treatment, with patient and treatment-specific risk factors. Age is consistently identified as a key risk factor, with adolescents at higher risk. Limited studies on adults suggest that adolescents and young adults (AYAs) treated with specific regimens are more at risk. Effective strategies for prevention and management of osteonecrosis and other orthopaedic complications are lacking. Further research and evidence-based guidelines are needed, particularly for high-risk AYAs being treated with paediatric-inspired regimens.
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
Article
Nutrition & Dietetics
Pavel Marozik, Alena Rudenka, Katsiaryna Kobets, Ema Rudenka
Summary: This study demonstrated significant effects of VDR gene variants ApaI rs7975232, BsmI rs1544410, TaqI rs731236, and Cdx2 rs11568820 on bone mineral density, 25-hydroxyvitamin D level, and osteoporosis risk in Belarusian women. The findings suggest the importance of genetic markers for personalized medicine strategies.
Review
Endocrinology & Metabolism
Erika Kague, Carolina Medina-Gomez, Simeon A. Boyadjiev, Fernando Rivadeneira
Summary: The genetic overlap between osteoporosis and craniosynostosis provides valuable insights into molecular mechanisms and potential therapeutic approaches.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Genetics & Heredity
Wen-Jie Wang, Jin-Wei He, Wen-Zhen Fu, Chun Wang, Zhen-Lin Zhang
Summary: The study found a significant association between the NF-kappa B1 and RELA genes and bone response to zoledronic treatment in postmenopausal Chinese women with osteoporosis, with certain haplotypes being related to improvements in bone density.
Article
Hematology
Song Yao, Qianqian Zhu, Peter D. Cole, Kristen Stevenson, Marian H. Harris, Emily Schultz, Justine M. Kahn, Elena J. Ladas, Uma H. Athale, Luis A. Clavell, Caroline Laverdiere, Jean-Marie Leclerc, Bruno Michon, Marshall A. Schorin, Jennifer J. G. Welch, Stephen E. Sallan, Lewis B. Silverman, Kara M. Kelly
Summary: This study found that Black and Hispanic children treated for ALL have a lower risk of bone toxicities, partly due to the percentage of African ancestry in their genetic admixture. Meanwhile, patients with a higher percentage of Native American ancestry showed significantly poorer overall survival and event-free survival.
Article
Medicine, General & Internal
Thies Bartram, Peter Schuette, Anja Moericke, Richard S. Houlston, Eva Ellinghaus, Martin Zimmermann, Anke Bergmann, Britt-Sabina Loescher, Norman Klein, Laura Hinze, Stefanie Junk, Michael Forster, Claus R. Bartram, Rolf Koehler, Andre Franke, Martin Schrappe, Christian P. Kratz, Gunnar Cario, Martin Stanulla
Summary: Genetic variation in the ABCC4 gene was found to be associated with AP during ALL treatment, while no association was observed with the CFTR gene. Replication confirmed the ABCC4 variants but not the CFTR variant. Larger international studies are needed to more conclusively assess the risk of rare clinical phenotypes.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Oncology
Lilly Velentza, Farasat Zaman, Lars Savendahl
Summary: GCs are widely used in the treatment of childhood ALL but their long-term use is associated with bone-related morbidities. Unfortunately, there is currently no efficient treatment for bone health impairment in patients and survivors. The review aims to discuss how GCs impact bone health in pediatric ALL and efforts made to minimize these side effects.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2021)
Article
Oncology
Shlomit Barzilai-Birenboim, Joanne Yacobovich, Yair Zalcberg, Nira Arad-Cohen, Galia Avrahami, Gil Gilad, Naomi Litichever, Shai Izraeli, Sarah Elitzur
Summary: The study showed that osteonecrosis is a significant complication of ALL therapy in children, with a variety of risk factors identified. Despite the low rates of resolution, it is important to identify high-risk patients for further therapeutic adjustments.
PEDIATRIC BLOOD & CANCER
(2021)
Article
Biochemistry & Molecular Biology
Hussein Sakr, Zenat Khired, Marzieh Moghadas
Summary: This study examined the effect of a wheat grain diet on bone turnover markers in rats. The results showed that rats fed whole or refined grains had lower bone density and mineral content compared to the control group. Additionally, levels of bone turnover indicators in the blood were altered, indicating a decrease in bone turnover and mass with a grain diet.
Article
Infectious Diseases
Volkan Hazar, Gulsun Tezcan Karasu, Vedat Uygun, Gulyuz Ozturk, Suar Caki Kilic, Alphan Kupesiz, Hayriye Daloglu, Serap Aksoylar, Didem Atay, Elif Unal Ince, Musa Karakukcu, Namik Ozbek, Funda Tayfun, Savas Comma Kansoy, Emel Ozyurek, Arzu Akcay, Orhan Gursel, Sule Haskologlu, Zuhre Kaya, Sebnem Yilmaz, Atila Tanyeli, Akif Yesilipek
Article
Hematology
Melek Erdem, Ozlem Tufekci, Sebnem Yilmaz, Inci Alacacioglu, Hale Oren
ACTA HAEMATOLOGICA
(2019)
Editorial Material
Oncology
Birsen Baysal, Ozlem Tufekci, Melek Erdem, Sebnem Yilmaz, Hale Oren
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
(2019)
Article
Hematology
Deniz Kizmazoglu, Seher Sari, Melike Evim Sezgin, Arzu Kantarcioglu, Ozlem Tufekci, Fatma Demir Yenigurbuz, Birol Baytan, Sebnem Yilmaz, Adalet Meral Gunes, Hale Oren
TURKISH JOURNAL OF HEMATOLOGY
(2019)
Meeting Abstract
Oncology
S. Vural, S. Karaman, S. Yilmaz, G. Sumlu Ozcelik, N. Akinci
Article
Oncology
Yuksel Olgun, Deniz Cakir Kizmazoglu, Dilek Ince, Hulya Ellidokuz, Enis A. Guneri, Nur Olgun, Gunay Kirkim
Summary: The study found that children between 5 and 12 years old, cranial irradiation and simultaneous treatment with cisplatin and carboplatin were associated with ototoxicity. These factors were identified as significant risk factors for ototoxicity in multivariate analysis.
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
(2021)
Article
Dermatology
Eda Ataseven, Deniz Kizmazoglu, Haldun Oniz
Summary: Juvenile xanthogranuloma (JXG) is a common form of non-Langerhans cell histiocytosis that usually presents with spontaneously regressing skin lesions. However, systemic involvement can be life-threatening and may require chemotherapy following the treatment protocol for Langerhans cell histiocytosis.
PEDIATRIC DERMATOLOGY
(2021)
Article
Oncology
Irem Ceren Erbas, Ozlem Tufekci, Sefika Akyol, Hatice Karaoglu Asrak, Ayse Cakil Guzin, Silem Ozdem Alatas, Sebnem Yilmaz, Hale Oren, Nursen Belet
Summary: This study investigated the impact of COVID-19 pandemic and prevention policies on febrile neutropenia episodes in children with acute leukemia. The findings showed that there were no significant differences in the incidence and etiology of FN episodes before and during the COVID-19 pandemic in children with acute leukemia.
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
(2022)
Review
Pediatrics
Seyran Bulut, Gonul Catli, Berna Eroglu Filibeli, Hayrullah Manyas, Ilkay Ayranci, Rabia Meral, Deniz Kizmazoglu, Bumin Nuri Dundar
Summary: Androgen-secreting adrenal tumors are aggressive cancers in childhood but rare in clinical practice. This article reports a case of pure androgen-secreting adrenal carcinoma, emphasizing the possibility of adrenal tumors in patients presenting with virilization.
JOURNAL OF PEDIATRIC RESEARCH
(2022)
Article
Oncology
Nur Olgun, Emre Cecen, Dilek Ince, Deniz Kizmazoglu, Birsen Baysal, Ayse Onal, Ozhan Ozdogan, Handan Guleryuz, Riza Cetingoz, Ayse Demiral, Mustafa Olguner, Ahmet Celik, Serra Kamer, Erdener Ozer, Zekiye Altun, Safiye Aktas
Summary: This study analyzed the efficacy and safety of combining immunotherapy with dinutuximab beta and chemotherapy in patients with relapsed/refractory high-risk neuroblastoma. The results showed that this treatment approach had promising response rates in these patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Serap Karaman, Rejin Kebudi, Hande Kizilocak, Zeynep Karakas, Bengu Demirag, Melike S. Evim, Nese Yarali, Zuhre Kaya, Barbaros S. Karagun, Selime Aydogdu, Umran Caliskan, Aylin C. Ayhan, Aysenur Bahadir, Betul Cakir, Burcak T. Guner, Canan Albayrak, Deniz Y. Karapinar, Elif G. Kazanci, Ekrem Unal, Emine Turkkan, Ferhan Akici, Ozcan Bor, Sema Vural, Sebnem Yilmaz, Hilmi Apak, Birol Baytan, Neryal M. Tahta, Zeliha Guzelkucuk, Ulker Kocak, Bulent Antmen, Huseyin Tokgoz, Tunc Fisgin, Nihal Ozdemir, Adalet M. Gunes, Canan Vergin, Aysegul Unuvar, Namik Ozbek, Deniz Tugcu, Sema B. Bay, Hikmet G. Tanyildiz, Tiraje Celkan
Summary: This multicenter retrospective study evaluated 51 pediatric patients with leukemia, 6 of whom had undergone bone marrow transplantation, and had proven or probable central nervous system fungal infections (CNSFI). The most common clinical findings were headaches and seizures. Antifungal therapy and surgery were the main treatment options. Early diagnosis and prompt management were crucial for improving clinical outcomes.
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY
(2022)
Meeting Abstract
Endocrinology & Metabolism
Kubra Yuksek Acinikli, Ozge Besci, Elif Yasar, Ozlem Tufekci, Zehra Karadag, Gizem Yildiz, Ruya Torun, Gozde Akin Kagizmanli, Meral Torun Bayram, Sebnem Yilmaz, Handan Guleryuz, Ayhan Abaci, Ece Bober, Korcan Demir
HORMONE RESEARCH IN PAEDIATRICS
(2022)
Meeting Abstract
Pediatrics
Ozge Besci, Kashyap A. Patel, Gizem Yildiz, Ozlem Tufekci, Kubra Yuksek Acinikli, Ibrahim Mert Erbas, Ayhan Abaci, Ece Bober, Meral Torun Bayram, Sebnem Yilmaz, Korcan Demir
PEDIATRIC NEPHROLOGY
(2021)