Review
Immunology
Elisa Gremese, Barbara Tolusso, Dario Bruno, Stefano Alivernini, Gianfranco Ferraccioli
Summary: Multiple Sclerosis (MS) is associated with Epstein Barr Virus (EBV) infection, and there may be a link between other autoimmune inflammatory diseases and infection. In the study of Rheumatoid Arthritis (RA), various infectious agents have been considered, but only a few meet the criteria for possible pathogenic causes of autoimmune diseases. This article discusses the breakdown of immune tolerance and the role of infectious agents in triggering arthritis in animal models. Additionally, preventive measures are described.
AUTOIMMUNITY REVIEWS
(2022)
Review
Immunology
Tue Bjerg Bennike
Summary: Proteomics is a scientific study of protein composition in biological samples, involving the identification and quantification of proteins, peptides, and post-translational modifications. Recent developments in mass spectrometry-based proteomics, including sample preparation, have improved the sensitivity and coverage. It finds applications in immunology and cancer research, providing insights into disease mechanisms and potential markers for diagnosis and treatment.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Ziqiang Shuai, Shuang Zheng, Kang Wang, Jian Wang, Patrick S. C. Leung, Bin Xu
Summary: Researchers are actively exploring new approaches to treat rheumatoid arthritis through methods such as stem cell transplantation, tolerogenic dendritic cells, and antigen-based tolerogenic vaccines. Current clinical trials show promising results in terms of safety and effectiveness in restoring immune balance and improving symptoms through stem cell transplantation and tolerogenic dendritic cell therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Nan Zhang, Mengru Li, Ziye Hou, Lan Ma, Ayesha Younas, Ziyi Wang, Xinchi Jiang, Jianqing Gao
Summary: Rheumatoid arthritis (RA) is a difficult-to-cure joint-related autoimmune disease, and novel strategies targeting the root causes are needed. Nanotechnology is closely linked to vaccine development, offering potential for revolutionizing RA treatment.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Immunology
Qi Jiang, Guocan Yang, Qi Liu, Shengjun Wang, Dawei Cui
Summary: Rheumatoid arthritis is a systemic and heterogeneous autoimmune disease characterized by symmetrical polyarthritis, with dysfunction of regulatory T (Treg) cells potentially contributing to the breakdown of self-tolerance. The ideal treatment strategy for RA should focus on re-inducing self-tolerance to prevent obvious tissue injury.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Qi-Hai Wang, Shu Pan, Xiu-Ping Cheng, Opeyemi Joshua Olatunji, Qingcheng Mao, Jian Zuo
Summary: This study found that rheumatoid arthritis conditions can increase the oral absorption of MTX, and this is related to changes in MTX absorption-related transporters in the intestines. Additionally, glycolysis-driven high energy metabolism can increase the absorption of MTX in rheumatic subjects, leading to exacerbated toxicity.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Chemistry, Multidisciplinary
Xiaoyan Chen, Guangsheng Du, Shuting Bai, Liu Dijia, Chenglong Li, Yingying Hou, Yuandong Zhang, Zhirong Zhang, Tao Gong, Yao Fu, Massimo Bottini, Xun Sun
Summary: The study aimed at exploring the therapeutic effects and tolerogenic mechanism of a novel tolerogenic polypeptide vaccine, showing synergistic effects on regulatory T cells, promotion of IL-10 secretion, reduction of pro-inflammatory cytokines, and antibodies in experimental arthritis. This work could shed light on the development of tolerogenic therapeutics as novel immunotherapies for rheumatoid arthritis.
Article
Immunology
Liam J. O'Neil, Christopher B. Oliveira, Donavon Sandoval-Heglund, Ana Barrera-Vargas, Javier Merayo-Chalico, Eduardo Aguirre-Aguilar, Mariana J. Kaplan, Carmelo Carmona-Rivera
Summary: Anti-CarP antibodies are linked to poor prognosis and bone erosion in rheumatoid arthritis (RA). Neutrophils in RA release modified autoantigens via NETs, including carbamylated LL37. Elevated levels of carbamylated LL37 were found in RA patients' plasma and synovial fluid, and could lead to autoantibody responses and bone damage in RA.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Sha Wu, Xiao-Feng Li, Yuan-Yuan Wu, Su-Qin Yin, Cheng Huang, Jun Li
Summary: Rheumatoid arthritis is characterized by immune cell infiltration and destruction of cartilage and bone. Studies have shown that m(6)A modification is related to the pathogenesis of RA, providing evidence for the development of new therapies. The relationship between m(6)A enzymes, immune cells, and RA is important for understanding and treating this autoimmune disease.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Yuanhao Zhao, Xiaoyan Chen, Penghui He, Xuanyu Wang, Yanhua Xu, Rui Hu, Yangsen Ou, Zhihua Zhang, Zhibing Zhang, Guangsheng Du, Xun Sun
Summary: This study investigated the use of a transdermal microneedle patch to deliver CII peptide autoantigen and rapamycin for the treatment of rheumatoid arthritis. The microneedles effectively recruited antigen-presenting cells and induced tolerogenic dendritic cells, leading to the activation of Treg cells and the suppression of proinflammatory cytokines, ultimately eliminating RA symptoms. Low dose of rapamycin was found to be crucial for successful immune tolerance induction. This rationally designed microneedle patch shows promise for immune balance restoration and improved patient compliance.
Article
Immunology
Tanglin Ouyang, Liyu Song, Huiling Fang, Ji Tan, Yue Zheng, Jinping Yi
Summary: Rheumatoid arthritis is a chronic autoimmune disease that primarily affects synovial joints, leading to synovial inflammation and joint damage. Timely and effective treatment is crucial for disease control, but misdiagnosis or delayed treatment often results in worsened condition and poor prognosis, significantly impacting patients' quality of life.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Haruki Matsumoto, Yuya Fujita, Michio Onizawa, Kenji Saito, Yuya Sumichika, Shuhei Yoshida, Jumpei Temmoku, Naoki Matsuoka, Makiko Yashiro-Furuya, Tomoyuki Asano, Shuzo Sato, Eiji Suzuki, Takeshi Machida, Hiroshi Watanabe, Kiyoshi Migita
Summary: The expression of CEACAM1 is elevated in peripheral blood neutrophils of patients with RA and is associated with rheumatoid inflammation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Katarina Barbaric Starcevic, Nina Lukac, Mislav Jelic, Alan Sucur, Danka Grcevic, Natasa Kovacic
Summary: This study analyzed the cellular composition of synovial tissue from RA and control patients and found higher proportions of lymphocytes and myeloid cells in RA synovial tissue compared to controls. Additionally, there was a decrease in the proportion of CD200(+)CD105(-) cells and an increase in CD200(-)CD105(+) cells in RA synovial tissue. These cell populations were associated with inflammatory activity and could differentiate between RA and control patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Chenglong Li, Xiaoyan Chen, Xianjin Luo, Hairui Wang, Yining Zhu, Guangshen Du, Wenfei Chen, Zhengjun Chen, Xinyan Hao, Zhirong Zhang, Xun Sun
Summary: This study developed an engineered nanoemulsion for targeted co-delivery of self-antigens and an immunomodulator to inflamed joints in rheumatoid arthritis. The nanoemulsion showed satisfactory accumulation in the inflamed paws and provided enhanced anti-inflammatory effects in various experimental murine models of RA, offering a promising targeting strategy for immune tolerance induction in RA treatment.
Review
Biochemistry & Molecular Biology
Alexander Blagov, Andrey Grechko, Nikita G. Nikiforov, Alexander D. Zhuravlev, Nikolay K. Sadykhov, Alexander N. Orekhov
Summary: This article discusses the connection between metabolism and inflammation in rheumatoid arthritis, exploring the changes in metabolic processes and their immunomodulatory effects, as well as the metabolic features of synovial membrane cells during inflammation and potential targets for the therapy of rheumatoid arthritis.