Article
Biochemistry & Molecular Biology
Theresa Porst, Joerg Johannes, Hans Gluschke, Richard Koehler, Sebastian Mehl, Peter Kuehnen, Kostja Renko, Waldemar B. Minich, Susanna Wiegand, Lutz Schomburg
Summary: The study found that MCT8-aAb and MCT10-aAb are prevalent in thyroid disease and obesity, with the highest prevalence of MCT8-aAb in thyroid patients. Serum with positive MCT8-aAb can impact T4 uptake in cell culture.
Article
Gastroenterology & Hepatology
Paul Manka, Jason D. Coombes, Svenja Sydor, Marzena K. Swiderska-Syn, Jan Best, Karine Gauthier, Leo A. van Grunsven, Ye H. Oo, Cindy Wang, Anna M. Diehl, Georg S. Hoenes, Lars C. Moeller, Anja Figge, Rene J. Boosman, Klaas N. Faber, Andrea Tannapfel, Oliver Goetze, Patricia Aspichueta, Christian M. Lange, Ali Canbay, Wing-Kin Syn
Summary: Thyroid hormones play a crucial role in hepatic fibrogenesis by regulating the phenotype of hepatic stellate cells (HSC) via the TGF beta signaling pathway. In vitro experiments showed that T3 can inhibit the expression of fibrogenic genes and promote wound healing in HSC. In vivo experiments on TR alpha-deficient mice further confirmed the importance of the TH-TR axis in liver fibrosis.
LIVER INTERNATIONAL
(2023)
Article
Food Science & Technology
Yueting Ge, Yuhui Yang, Yuge Jiang, Chuanxing Feng, Bowen Li, Jin Sun, Xue Tang, Yonghui Shi, Guowei Le
Summary: Recent studies have found that high oxidative injury pork and Dityr intake induce oxidative stress and inflammation, impairing thyroid function and peripheral metabolism, leading to a decrease in circulating and liver thyroid hormones and induced hepatic steatosis.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Georg Sebastian Hoenes, Ramona Gowry Sivakumar, Christoph Hoppe, Joerg Koenig, Dagmar Fuehrer, Lars Christian Moeller
Summary: MGL-3196 is a new thyromimetic agent that activates TR beta with high efficacy through specific transport by OATP1B1, leading to its hepatic thyromimetic action.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Gregory A. Brent
Summary: Thyroid hormone plays a vital role in development and has diverse effects on various tissues and organs in the body. Early markers of thyroid hormone action included oxygen consumption, basal metabolic rate, serum cholesterol, and deep tendon reflex time. Research has focused on understanding the nuclear and cellular mechanisms of thyroid hormone action, including the role of thyroid hormone receptors, coactivators, DNA response elements, and transportation defects.
Article
Environmental Sciences
Xinwen Dong, Weidong Wu, Sanqiao Yao, Haibin Li, Zhichun Li, Li Zhang, Jing Jiang, Jie Xu, Fengquan Zhang
Summary: PM2.5 exposure induced pathological changes in the thyroid and liver of rats, decreased TH levels, and led to oxidative stress responses. Activation of the HPT axis and altered hepatic transthyretin levels appear to crucially contribute to PM2.5-induced thyroid dysfunction.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Biochemistry & Molecular Biology
Jiesi Chen, Eva Salveridou, Lutz Liebmann, Sivaraj M. Sundaram, Denica Doycheva, Boyka Markova, Christian A. Hubner, Anita Boelen, W. Edward Visser, Heike Heuer, Steffen Mayerl
Summary: Patients with inactive thyroid hormone transporter MCT8 show intellectual disability. The thyromimetic compounds Triac and Ditpa were compared for their potential therapeutic effects in a mouse model of MCT8 deficiency. Triac was found to be more effective in promoting CNS maturation and function in the mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Stefan Groeneweg, Ferdy S. van Geest, Zhongli Chen, Stefania Farina, Ramona E. A. van Heerebeek, Marcel E. Meima, Robin P. Peeters, Heike Heuer, Marco Medici, W. Edward Visser
Summary: The study demonstrates that SLC17A4 facilitates the transport of T3 and T4, as well as less efficiently rT3 and 3,3’-T2. Further research should reveal the physiological role of SLC17A4 in TH regulation.
Article
Endocrinology & Metabolism
Elisa Merchan-Ramirez, Guillermo Sanchez-Delgado, Cristina Arrizabalaga-Arriazu, Borja Martinez-Tellez, Andrea Mendez-Gutierrez, Manuel Munoz-Torres, Jose M. Llamas-Elvira, Jonatan R. Ruiz
Summary: The study found that cold exposure led to an increase in FT4 levels and a decrease in TSH levels, but had no effect on FT3 serum concentration. There were no associations between TSH and THs levels at thermoneutral or cold-induced conditions and BAT volume, F-18-FDG uptake, and mean radiodensity in young healthy euthyroid adults.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Carolina Chaves, Eveline Bruinstroop, Samuel Refetoff, Paul Yen, Joao Anselmo
Summary: The study found that mutations in the THRB gene causing resistance to thyroid hormone beta can lead to increased hepatic steatosis, particularly affecting intrahepatic TR beta signaling, independent of factors like age and obesity. This highlights the importance of thyroid hormone in liver lipid metabolism and provides a rationale for the development of TR beta-selective thyromimetics.
Article
Pharmacology & Pharmacy
Kodai Nishi, Masato Kobayashi, Minori Kikuchi, Asuka Mizutani, Yuka Muranaka, Ikumi Tamai, Keiichi Kawai, Takashi Kudo
Summary: The study revealed that Tc-99m-TF is primarily transported by OCT1 and OCT2 in vitro, and the hepatic accumulation of Tc-99m-TF can be significantly reduced by using an OCT1 inhibitor, resulting in altered pharmacokinetics and improved SPECT image quality.
Article
Medicine, Research & Experimental
Chuangzhen Lin, Bingqing Yu, Xuelian Liu, Lixin Chen, Zhaohui Zhang, Weixiang Ye, Hui Zhong, Wenke Bai, Yuping Yang, Biao Nie
Summary: Objective: This study revealed a novel mechanism by which Obeticholic acid (OCA) improves nonalcoholic fatty liver disease (NAFLD) independent of farnesoid X receptor (FXR), suggesting a potential therapeutic effect of OCA through inhibiting hepatic long-chain fatty acids uptake mediated by FATP5.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Endocrinology & Metabolism
Doreen Braun, Simon Bohleber, Gad D. Vatine, Clive N. Svendsen, Ulrich Schweizer
Summary: This research found that the chemical chaperone sodium phenylbutyrate (NaPB) can stabilize MCT8 gene mutations in a human cell model and activate the transport of thyroid hormones (TH) through MCT10. This discovery provides a new direction for studying the use of NaPB in treating MCT8 deficiency cases.
Article
Endocrinology & Metabolism
Rutchanna M. S. Jongejan, Marcel E. Meima, W. Edward Visser, Tim I. M. Korevaar, Sjoerd A. A. van den Berg, Robin P. Peeters, Yolanda B. de Rijke
Summary: This study determined the distribution and binding affinity of thyroid hormone metabolites to thyroid hormone distributor proteins, and found that the distribution of metabolites differs from that of thyroid hormones. This has potential clinical importance for the interpretation of thyroid hormone metabolism.
Article
Chemistry, Medicinal
Yu Egashira, Tomoka Shimada, Kei Mayumi
Summary: In this study, a method was developed to evaluate the contribution of albumin-mediated hepatic uptake by considering the albumin binding fraction in plasma, leading to accurate prediction of human PK profiles. The findings suggest that the proposed PBPK approach is useful in scientific discussions with regulatory authorities.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Toxicology
Kathryn Page, Walter Westerink, Kristie Sullivan, Thomas McDonald, Clive Roper
Summary: This study developed a new method to assess the skin irritation of antimicrobial cleaning products. The method utilized a more human-like model and demonstrated its effectiveness through comparison with in vivo rabbit skin irritation data.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Arupam Patra, Thirukumaran Kandasamy, Siddhartha Sankar Ghosh, Gurvinder Kaur Saini
Summary: This study successfully produced recombinant anisoplin and demonstrated its significant anti-cancer effect and ability to induce apoptosis in breast cancer cells. The activation of related signaling pathways may be the key to cell death.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Thomas Haller, Alexander Jesacher, Alberto Hidalgo, Christina Schmidt
Summary: This study used live cell imaging to observe the accumulation of amiodarone in primary rat alveolar type II cells, and found that it specifically accumulates in lamellar bodies. The uptake is rapid, while storage is persistent. The main mechanisms for intracellular bioaccumulation of amiodarone are proposed to be passive diffusion, ion-trapping, and lipophilic interactions.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Filiz Bakar-Ates, Erva Ozkan
Summary: This study investigated the ferroptotic effect of CuB in breast cancer cells and evaluated its combination with erastin, a ferroptosis inducer. The results showed that the combination treatment significantly activated the ferroptotic pathways and altered the expression of iron-related proteins in breast cancer cells.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Rachel Z. Bennie, Ian C. Shaw
Summary: Estrogen mimics are synthetic and naturally occurring compounds that can interact with estrogen receptors in animals. In vitro transactivation reporter gene assay and in silico molecular modelling can be used to predict the mimicry of these compounds, reducing reliance on animal studies.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Sevda Isik, Semra Cicek
Summary: This study found that high doses of riboflavin can cause cytotoxicity in rainbow trout gonad cells and affect the transcriptional expressions of antioxidant enzymes and growth and reproductive genes, potentially leading to DNA damage and cell death.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Ying Wang, Jie Wu, Mengqi Wan, Dou Yang, Fasheng Liu, Kehao Li, Manxin Hu, Yuanyuan Tang, Huiqiang Lu, Shouhua Zhang, Yuanzhen Xiong
Summary: m-Cresol is commonly used as an intermediate for pesticides and other industrial applications. This study investigated the hepatotoxicity of m-cresol using zebrafish larvae and explored its molecular mechanisms. The results suggest that m-cresol may induce liver damage in zebrafish larvae through oxidative stress and cell apoptosis pathways.
TOXICOLOGY IN VITRO
(2024)
Article
Toxicology
Vincent J. Manna, Shannon Dwyer, Vanessa Pizutelli, Salvatore J. Caradonna
Summary: The widespread use of electronic cigarettes and the emergence of a new illness have raised concerns about the effects of e-cigarette vapor on respiratory tissues. Researchers have developed a simple device to mimic the response of human airway tissue after long-term exposure to e-cigarette vapor, and have identified differences in the effects of different vapor compositions on airway tissue.
TOXICOLOGY IN VITRO
(2024)