Review
Biochemistry & Molecular Biology
Hanns Ulrich Zeilhofer, Karolina Werynska, Jacinthe Gingras, Gonzalo E. Yevenes
Summary: Restoring proper synaptic inhibition in the spinal cord, particularly through targeting the alpha 3 subtype of glycine receptors, may help reduce deleterious side effects and increase tolerability in chronic pain states. This review provides an update on the physiological properties and functions of alpha 3 subtype GlyRs and related drug discovery programs.
Article
Multidisciplinary Sciences
Kevin J. Pollard, Devon A. Bowser, Wesley A. Anderson, Mostafa Meselhe, Michael J. Moore
Summary: Chronic pain is on the rise due to genetic predisposition, injury, or acquired neuropathy. Opioid analgesics, while effective, have led to an epidemic of prescription drug abuse. Screening drug candidates in a microphysiological system can efficiently identify therapeutics with analgesic potential.
Article
Neurosciences
Hourong Wang, Zhifeng Liu, Tianyuan Yu, Yingqi Zhang, Yajing Xu, Yi Jiao, Qian Guan, Di Liu
Summary: This study analyzed the changes in gene expression in the dorsal root ganglia (DRG) and spinal dorsal horn (SDH) after tuina treatment and investigated the immediate analgesic mechanism of tuina. The results showed that tuina improved nociceptive behavior in rats with minor chronic constriction injury (CCI), especially in thermal hyperalgesia. Additionally, analysis of differentially expressed genes (DEGs) revealed that the immediate analgesic mechanism of tuina is associated with the calcium signaling pathway, thermogenesis, and regulation of lipolysis in adipocytes.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Ghanshyam P. Sinha, Pranav Prasoon, Bret N. Smith, Bradley K. Taylor
Summary: The firing patterns of Neuropeptide Y Y1 receptor-expressing neurons in the spinal cord dorsal horn play a crucial role in chronic pain, predominantly controlled by T-type calcium channels. These neurons exhibit rapid adaptation, rebound spiking, and delayed firing, with an adaptation speed higher than other neurons.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Multidisciplinary Sciences
Jacqueline A. Iredale, Jeremy G. Stoddard, Hannah R. Drury, Tyler J. Browne, Augustus Elton, Jessica F. Madden, Robert J. Callister, James S. Welsh, Brett A. Graham
Summary: The use of microelectrode arrays (MEAs) and mouse spinal cord slices allows the study of dorsal horn (DH) activity induced by chemical stimulation of DH circuits. This research provides a platform to investigate DH circuit activity and can be used to study different animal models and mice with genetically altered nociceptive function.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2022)
Article
Pharmacology & Pharmacy
Mariacristina Mazzitelli, Kendall Marshall, Andrew Pham, Guangchen Ji, Volker Neugebauer
Summary: The amygdala plays a crucial role in modulating spinal cord neuron activity and inducing pain-like behaviors under normal conditions and in a pain model.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Neurosciences
Laszlo Ducza, Andrea Gajtko, Krisztina Hegedus, Erzsebet Bakk, Greta Kis, Botond Gaal, Roland Takacs, Peter Szucs, Klara Matesz, Krisztina Hollo
Summary: This study provides new evidence for the involvement of neuronal and glial P2X4 receptors in the development of inflammatory pain.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Engineering, Biomedical
Mara Evany de Oliveira, Joyce Teixeira Da Silva, Marcos Leal Brioschi, Marucia Chacur
Summary: Nerve injury triggers the release of peptides and the upregulation of receptors contributing to chronic pain, while PBMT has shown to reduce nociceptive mediators and temperature in a rodent model of neuropathic pain, suggesting its potential therapeutic role in modulating thermoregulation and inflammation associated with peripheral nerve injuries.
LASERS IN MEDICAL SCIENCE
(2021)
Article
Neurosciences
Mariana Pereira, Sofia Rita Fernandes, Pedro Cavaleiro Miranda, Mamede de Carvalho
Summary: The study aims to define the optimal tsDCS montage for maximizing the electric field in the lumbar spinal cord through computer modeling, and to measure its effect on LMN excitability and SSEPs.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Sathish Kumar Singaravelu, Alexander Dawit Goitom, Akseli Petteri Graf, Handan Moerz, Andreas Schilder, Ulrich Hoheisel, Rainer Spanagel, Rolf-Detlef Treede
Summary: Adversity in adolescence increases the risk of non-specific low back pain, leading to persistent muscle hyperalgesia, which is associated with morphological changes in spinal cord microglia.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Yingying Miao, Guifeng Liu, Lin Liu
Summary: Our study found that SUV39H2 and LSD1 were highly expressed, while CDH1 was downregulated in OS tissues and cells. SUV39H2 expression correlated inversely with overall survival of OS patients. SUV39H2 positively regulated LSD1 expression, which in turn negatively regulated CDH1 expression, thereby promoting the progression of OS.
CANCER CELL INTERNATIONAL
(2021)
Article
Cell Biology
Daniel Segelcke, Hanna K. Fischer, Meike Huette, Sven Dennerlein, Fritz Benseler, Nils Brose, Esther M. Pogatzki-Zahn, Manuela Schmidt
Summary: Tmem160 plays a significant role in the establishment of nerve injury-induced pain behaviors in male mice, but is dispensable for other pain modalities and entities. The findings reveal Tmem160 as a sexually dimorphic factor in the development of specific nerve-induced pain behaviors.
Article
Neurosciences
Yuto Ejiri, Daisuke Uta, Hiroki Ota, Kazue Mizumura, Toru Taguchi
Summary: This study investigates the pathological mechanisms of fibromyalgia (FM) using a rat reserpine-induced pain model. It finds that chemical stimuli can facilitate pain-related behaviors and that this hypersensitivity is associated with hyperactivation of spinal dorsal horn neurons.
NEUROSCIENCE RESEARCH
(2022)
Article
Multidisciplinary Sciences
Qian Xu, Neil C. Ford, Shaoqiu He, Qian Huang, Michael Anderson, Zhiyong Chen, Fei Yang, LaTasha K. Crawford, Michael J. Caterina, Yun Guan, Xinzhong Dong
Summary: Astrocytes were found to play an important role in pain gating, exerting nonneuronal control of pain by activating Aβ fibers.
Article
Anesthesiology
Luyao Zhang, Xiang Li, Xiaozhou Feng, Tolga Berkman, Ruining Ma, Shibin Du, Shaogen Wu, Congcong Huang, Akwasi Amponsah, Alex Bekker, Yuan-Xiang Tao
Summary: Nerve trauma-induced alternations of gene expression in the neurons of DRG participate in nerve trauma-caused nociceptive hypersensitivity. ELF1 plays a role in nerve trauma-caused nociceptive hypersensitivity by upregulating MMP9 in injured DRG. ELF1 may be a potential target for managing neuropathic pain.
Article
Neurosciences
Shaogen Wu, Brianna Marie Lutz, Xuerong Miao, Lingli Liang, Kai Mo, Yun-Juan Chang, Peicheng Du, Patricia Soteropoulos, Bin Tian, Andrew G. Kaufman, Alex Bekker, Yali Hu, Yuan-Xiang Tao
Article
Neurosciences
Lingli Liang, Jian-Yuan Zhao, Xiyao Gu, Shaogen Wu, Kai Mo, Ming Xiong, Brianna Marie Lutz, Alex Bekker, Yuan-Xiang Tao
Article
Anesthesiology
Linlin Sun, Jian-Yuan Zhao, Xiyao Gu, Lingli Liang, Shaogen Wu, Kai Mo, Jian Feng, Weixiang Guo, Jun Zhang, Alex Bekker, Xinyu Zhao, Eric J. Nestler, Yuan-Xiang Tao
Article
Multidisciplinary Sciences
Jian-Yuan Zhao, Lingli Liang, Xiyao Gu, Zhisong Li, Shaogen Wu, Linlin Sun, Fidelis E. Atianjoh, Jian Feng, Kai Mo, Shushan Jia, Brianna Marie Lutz, Alex Bekker, Eric J. Nestler, Yuan-Xiang Tao
NATURE COMMUNICATIONS
(2017)
Article
Neurosciences
Bo Xu, Jing Cao, Jun Zhang, Shushan Jia, Shaogen Wu, Kai Mo, Guihua Wei, Lingli Liang, Xuerong Miao, Alex Bekker, Yuan-Xiang Tao
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2017)
Article
Neurosciences
Kai Mo, Shaogen Wu, Xiyao Gu, Ming Xiong, Weihua Cai, Fidelis E. Atianjoh, Emily E. Jobe, Xinyu Zhao, Wei-Feng Tu, Yuan-Xiang Tao
JOURNAL OF NEUROSCIENCE
(2018)
Article
Anesthesiology
Jingjing Yuan, Jing Wen, Shaogen Wu, Yuanyuan Mao, Kai Mo, Zhisong Li, Songxue Su, Hanwen Gu, Yanqiu Ai, Alex Bekker, Wei Zhang, Yuan-Xiang Tao
Article
Multidisciplinary Sciences
Lingli Liang, Xiyao Gu, Jian-Yuan Zhao, Shaogen Wu, Xuerong Miao, Jifang Xiao, Kai Mo, Jun Zhang, Brianna Marie Lutz, Alex Bekker, Yuan-Xiang Tao
SCIENTIFIC REPORTS
(2016)
Article
Neurosciences
Kai Mo, Huali Xu, Hualei Gong, Hongyi Lei, Yongwei Wang, Wenjing Guo, Shiyuan Xu, Weifeng Tu
Article
Biochemistry & Molecular Biology
Zhisong Li, Yuanyuan Mao, Lingli Liang, Shaogen Wu, Jingjing Yuan, Kai Mo, Weihua Cai, Qingxiang Mao, Jing Cao, Alex Bekker, Wei Zhang, Yuan-Xiang Tao