Article
Biochemistry & Molecular Biology
Ibrahim S. S. Al Nasr, Waleed S. S. Koko, Tariq A. A. Khan, Nevin Gurbuz, Ismail Ozdemir, Naceur Hamdi
Summary: A series of RuCl2(p-cymene)(NHC) complexes were synthesized and their structures were determined. These complexes exhibited potent enzyme inhibitory, antioxidant, antimicrobial, anticancer, and antiparasitic properties. Among them, complex 3d showed the highest inhibitory activity against AchE, excellent antimicrobial activity, and promising cytotoxic and antiparasitic activities. Further research on its mode of action and in vivo evaluation is recommended.
Article
Chemistry, Inorganic & Nuclear
Guijie Li, Jianbing Zheng, Xiaoli Fang, Kewei Xu, Yun-Fang Yang, Jiang Wu, Linyu Cao, Jian Li, Yuanbin She
Summary: A series of N-heterocyclic carbene-based tetradentate Pd(II) complexes were designed and synthesized, which exhibited stability and high thermal decomposition temperature. The electrochemical and photophysical properties of these complexes were systematically investigated through experimental research and theoretical calculation.
Article
Chemistry, Inorganic & Nuclear
Jonas F. Schlagintweit, Christian H. G. Jakob, Kevin Meighen-Berger, Thomas F. Gronauer, Angela Weigert Munoz, Vanessa Weiss, Matthias J. Feige, Stephan A. Sieber, Joao D. G. Correia, Fritz E. Kuehn
Summary: Fluorescent Pd(II) and Pt(II) complexes with 4-methylene-7-methoxycoumarin (MMC) and 2,6-diisopropylphenyl (Dipp) substituted NHC/1,2,3-triazole hybrid ligands were described, showing antiproliferative activity against cervix and breast cancer cells, with the tetradentate coordination mode being notably more effective. The Pd(s) complex with bidentate coordination mode was only active against HeLa, exhibiting high selectivity for cancer cells compared to healthy skin cells. The compound is believed to be located in late endosomes or lysosomes according to fluorescence microscopy.
DALTON TRANSACTIONS
(2021)
Article
Biochemistry & Molecular Biology
Mehmet Esref Alkis, Kenan Buldurun, Nevin Turan, Yusuf Alan, Unzile Kelestemur Yilmaz, Asim Mantarci
Summary: In this study, a new Schiff base and its Ni(II) and Pd(II) complexes were synthesized and characterized. The antiproliferative activities of these compounds on liver cancer cells were evaluated, and it was found that the complexes exhibited stronger activity than the ligand. Electroporation was also shown to enhance the cytotoxicity of the complexes. These findings suggest that the Ni(II) and Pd(II) complexes have potential as anti-cancer agents, particularly in electrochemotherapy.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Chemistry, Inorganic & Nuclear
Matthew P. P. Sullivan, Muneebah Adams, Mie Riisom, Caitlin D. D. Herbert, Kelvin K. H. Tong, Jonathan W. W. Astin, Stephen M. F. Jamieson, Muhammad Hanif, David C. C. Goldstone, Christian G. G. Hartinger
Summary: Pt(terpyridine) complexes are known for their ability to intercalate with DNA. The addition of an NHC co-ligand significantly increased the anticancer activity of the complex compared to its chlorido derivative. While the compound showed high efficacy, it was well-tolerated by zebrafish embryos, especially when compared to cisplatin. DNA interaction studies suggest that the mode of action is related to intercalation.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Inorganic & Nuclear
M. Carcelli, S. Montalbano, D. Rogolino, V Gandin, F. Miglioli, G. Pelosi, A. Buschini
Summary: Complexes of nickel(II), palladium(II), and zinc(II) with thiosemicarbazone ligands were synthesized and evaluated for their antiproliferative and genotoxic activities. The nickel complexes showed the most promising results, particularly the nickel dimer [NiL](2), which exhibited both antiproliferative and genotoxic activities.
INORGANICA CHIMICA ACTA
(2022)
Article
Chemistry, Inorganic & Nuclear
Urszula K. Komarnicka, Sandra Koziel, Agnieszka Skorska-Stania, Agnieszka Kyziol, Francesco Tisato
Summary: In this study, new complexes based on ruthenium(II) and iridium(III) with phosphine ligands and phenyl rings with/without methoxy motifs were synthesized and characterized. The complexes showed high catalytic efficiency in the oxidation of NADH to NAD(+) and exhibited potential applications in biological and medical fields. Furthermore, they demonstrated redox activity and significant cytotoxicity against various cancer cell lines.
DALTON TRANSACTIONS
(2022)
Article
Biochemistry & Molecular Biology
Rinku Malhi, Jerry P. Jasinski, Manpreet Kaur, Kamaldeep Paul, Rekha Sharma
Summary: A variety of selenosemicarbazones were synthesized through reactions with different aldehydes and ketones. Reactions with aldehydes containing a single aromatic ring resulted in the formation of other compounds instead of selenosemicarbazones. The synthesized compounds were characterized using IR and NMR spectroscopy, and some were found to exhibit excellent anti-TB activity.
BIOORGANIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Franco Bisceglie, Giorgio Pelosi, Nicolo Orsoni, Marianna Pioli, Mauro Carcelli, Paolo Pelagatti, Silvana Pinelli, Peter J. Sadler
Summary: We synthesized and characterized three half-sandwich Ru(II) arene complexes with different ligands, where one of the complexes exhibited good phototoxicity towards lung cancer cells upon blue light irradiation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Arezoo Saadati, Mahnaz Aryaeifar, Olivier Blacque, Rui Cabral, Luis R. R. Raposo, Alexandra R. R. Fernandes, Hadi Amiri Rudbari, Jose V. Cuevas-Vicario
Summary: This study investigated the effect of structure, halogen substitution, metal ions, and ligand flexibility on the antiproliferative activity of Cu(II) and Pt(II) complexes. The results showed that these complexes exhibited different structures depending on the ligand used and the presence of a base during preparation. All complexes demonstrated a reduction in cancer cell viability, but only complexes with iodo-substituted ligands showed low cytotoxicity in normal cells. Further analysis revealed that the I-2-H2L2-Cu complex induced cell death through apoptosis and autophagy mechanisms in the A2780 cell line.
BIOORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Carolina Rivera, Hector A. Bacilio-Beltran, Ana M. Puebla-Perez, Irma I. Rangel-Salas, Jose G. Alvarado-Rodriguez, Roberto Flores-Moreno, Gilberto Velazquez-Juarez, A. Aaron Peregrina-Lucano, Elvia Becerra-Martinez, Jaime Valdez-Ruvalcaba, Jose E. Rubio, Sara A. Cortes-Llamas
Summary: The synthesis of cis and trans isomers of platinum complexes with a symmetric N-heterocyclic carbene ligand has been reported. These complexes were obtained from a masked N-heterocyclic carbene precursor. Their cytotoxicity, oxidative nature, and antibacterial behavior were investigated, and the cis-[Pt((NHC)-N-Me)(2)Cl-2] complex exhibited the highest cytotoxic effect in the HeLa cervical cancer cell line.
NEW JOURNAL OF CHEMISTRY
(2022)
Review
Chemistry, Inorganic & Nuclear
Gabrieli L. Parrilha, Raquel G. dos Santos, Heloisa Beraldo
Summary: Metallic radionuclides have diverse applications as diagnostic and therapeutic agents. This study reports the behavior of different radiometal complexes with mono(thiosemicarbazones) and bis(thiosemicarbazones) as potential radiopharmaceuticals. The application of bis(thiosemicarbazonato)copper(II) complexes as diagnostic radiopharmaceuticals has been successful, while other radioisotopes such as Ga-67/68, (111/114)mIn, and Tc-99m have also been used to obtain mono- and bis(thiosemicarbazone) complexes for potential diagnosis and therapy.
COORDINATION CHEMISTRY REVIEWS
(2022)
Article
Chemistry, Multidisciplinary
Heba M. Fahmy, Fatma M. Abdel-Rahman, Anwar A. El-Sayed, Ahmed A. El-Sherif
Summary: Novel metallic antitumor drugs with heterocyclic ligands were synthesized and characterized. The cytotoxicity, oxidative stress, antioxidant activity, DNA damage, and antimicrobial activity of these drugs were evaluated. The results showed that one of the drugs exhibited strong anticancer activity against breast and cervical cancer cells.
Article
Chemistry, Inorganic & Nuclear
Alba Hernandez-Garcia, Lenka Markova, Maria Dolores Santana, Jitka Pracharova, Delia Bautista, Hana Kostrhunova, Vojtech Novohradsky, Viktor Brabec, Jose Ruiz, Jana Kasparkova
Summary: This study presents the synthesis and characterization of six new heteroleptic osmium(II) complexes with varying substituents in the R3 position of the phenyl ring of the cyclometalating C^N ligand. These complexes are highly kinetically inert and absorb a full-wavelength range of visible light. The antiproliferative activity of these complexes has been investigated using human cancer and noncancerous cell cultures, showing that they are more potent than conventional cisplatin. The mechanism of action involves the activation of the endoplasmic reticulum stress pathway and disruption of calcium homeostasis.
INORGANIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Maged S. Al-Fakeh, Maha A. Alsikhan, Jawza Sh Alnawmasi
Summary: A new class of biologically active mineral complexes were synthesized and characterized using various techniques. The complexes showed coordination between ligands and metal ions, with nano-sized structures. Molecular modeling was performed for Cu(II) complex, and the complexes exhibited significant antioxidant and anticancer activities, as well as antimicrobial effects.
Article
Chemistry, Organic
Ramaiah Konakanchi, Prashanth Jyothi, Laxma Reddy Kotha
Summary: In this study, the FT-Raman and FTIR spectra of synthesized molecules were characterized using density functional theory. The results showed that the Cu(II)APC complex exhibited significant anti-inflammatory activity and had good binding energy values against the target protein COX-2.
POLYCYCLIC AROMATIC COMPOUNDS
(2022)
Article
Biochemistry & Molecular Biology
Moideen Musthafa, Ramaiah Konakanchi, Rakesh Ganguly, Chandrasekar Balachandran, Shin Aoki, Anandaram Sreekanth
Summary: A series of aroyl selenourea ligands and their Ru(II) complexes were synthesized and characterized, with the molecular structures confirmed by single XRD crystal method. The cytotoxic study revealed that complexes 1 and 2 showed promising cytotoxic activity against HeLa S3 cells, while the in vitro DNA interaction studies indicated an intercalative mode of binding in the order of 1 > 2 > 3.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Article
Chemistry, Organic
Natte Kavitha, Munagala Alivelu, Ramaiah Konakanchi
Summary: The optimal structure and properties of 2-mercapto benzimidazole were calculated using density functional theory, and compared with experimental results. The compound shows higher drug-likeness and molecular docking affinity, suitable for Covid-19 treatment.
POLYCYCLIC AROMATIC COMPOUNDS
(2022)
Review
Chemistry, Medicinal
C. G. Arya, Ramesh Gondru, Yupeng Li, Janardhan Banothu
Summary: This study summarizes the improvement of pharmacokinetic and pharmacodynamic properties of coumarin and benzimidazole compounds through molecular hybridization, and highlights the biological properties and functions of different classes of their hybrids. These hybrids exhibit diverse biological activities, including anticancer, antiviral, antimicrobial effects.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Organic
Srikanth Mamidala, R. Kowshik Aravilli, Krishnaiah Vaarla, Sudhir Reddy Peddi, Ramesh Gondru, Vijjulatha Manga, Rajeswar Rao Vedula
Summary: In this study, a series of thiazolyl pyrazoles were synthesized using a conventional method and their structures were confirmed by spectral and analytical data. These compounds exhibited significant anticancer activity in vitro and were predicted to be potential candidates for anticancer drug development.
POLYCYCLIC AROMATIC COMPOUNDS
(2022)
Article
Chemistry, Organic
Rambabu Palabindela, Ramu Guda, Gondru Ramesh, Prabhakar Myadaraveni, Devendar Banothu, Gangalla Ravi, Rajashekar Korra, Himabindu Mekala, Mamatha Kasula
Summary: A series of novel tryptanthrin aminothiazole analogues with biologically active thiazole moiety were synthesized, and they exhibited excellent anticancer activity and good pharmacokinetic profile.
JOURNAL OF HETEROCYCLIC CHEMISTRY
(2022)
Article
Chemistry, Physical
K. Srishailam, K. Ramaiah, K. Laxma Reddy, B. Venkatram Reddy, G. Ramana Rao
Summary: The Fourier transform infrared spectra of two molecules and their Raman counterparts were measured and analyzed. The dihedral angles and barrier heights around various rotating bonds were computed for geometry optimization. The vibrational fundamentals, potential energy distribution, and intensities were determined using DFT/B3LYP/6-311++G(d,p) method. The measured spectra showed good agreement with the simulated spectra, and accurate assignments of vibrational frequencies were obtained.
MOLECULAR SIMULATION
(2022)
Article
Chemistry, Physical
Ramaiah Konakanchi, Koya Prabhakara Rao, G. Naaresh Reddy, Jyothi Prashanth
Summary: The spectroscopic and physicochemical properties of a synthesized Zn(II)-2-amino-3-pyridinecarboxaldehyde complex were investigated in this article. The complex was optimized using various methods and its Fourier transform infrared and Raman spectra were compared to theoretical parameters. The compound exhibited significant anti-inflammatory potency and showed binding energy towards a protein receptor related to inflammation.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Organic
K. Fabitha, C. G. Arya, Perugu Shyam, Ramesh Gondru, Janardhan Banothu
Summary: The emergence of multi-drug resistant bacteria has led to the development of a new class of antimicrobials that have high selectivity, low toxicity, and a new mode of action. Researchers synthesized a new series of chalcone-morpholine hybrids using copper(I)-catalyzed reactions and found that several compounds exhibited broad-spectrum antibacterial activity, making them potential candidates for effective antibacterial agents.
POLYCYCLIC AROMATIC COMPOUNDS
(2023)
Article
Engineering, Electrical & Electronic
T. Ramesh, B. Sravanthi, G. Umadevi, K. Ramaiah, B. Anna Tanuja Safala, T. Suneetha
Summary: The aim of this study is to synthesize ZnO nanostructures and investigate their gas-sensing, cytotoxicity, and antibacterial activity. Three different synthesis methods were employed: sol-gel, chemical co-precipitation, and microwave heating. Structural, morphological, and optical features of the synthesized materials were analyzed using X-ray diffraction, field effective scanning electron microscopy, and UV-Visible spectroscopy. The synthesized samples exhibited a hexagonal wurtzite structure, and their morphology and absorption varied depending on the synthesis method. Gas-sensing tests showed that the synthesized powders had a strong capability to sense NH3. The compounds also exhibited antimicrobial and anticancer activity, with significant activity observed against certain cancer cell lines.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
(2023)
Article
Chemistry, Physical
Rambabu Palabindela, Ramu Guda, Gondru Ramesh, Ramakrishna Bodapati, Satheesh Kumar Nukala, Prabhakar Myadaraveni, Gangalla Ravi, Mamatha Kasula
Summary: A series of new curcumin pyrazole-thiazole hybrids were synthesized and characterized. The compounds C7, C2, and C5 showed potent antiproliferative activity against multiple cancer cell lines. The compound C7 exhibited double inhibitory potency towards EGFR compared to the reference drug erlotinib. Additionally, C5 and C2 demonstrated strong antioxidant activity.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Pharmacology & Pharmacy
H. Mundarinti Sudheer Kumar, Kothapalli Bannoth Chandrasekhar
Summary: A stability-indicating RP-HPLC method was developed and validated for the determination of ATO in bulk and tablet dosage forms. The proposed method showed good specificity, precision, accuracy, linearity, and robustness according to ICH standards. The method was reliable, reproducible, accurate, and sensitive for the quantification of ATO.
ASIAN JOURNAL OF PHARMACEUTICAL RESEARCH AND HEALTH CARE
(2022)
Review
Chemistry, Multidisciplinary
C. G. Arya, Munugala Chandrakanth, K. Fabitha, Neethu Mariam Thomas, Rakendu N. Pramod, Ramesh Gondru, Janardhan Banothu
Summary: The synthesis and biological applications of coumarin-benzimidazole hybrids have gained considerable attention globally. This review focuses on various synthetic strategies for these hybrids, along with their metal complexes, providing valuable insights for designing and developing drug candidates.
RESULTS IN CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
B. Swapna, K. B. Chandrasekhar, D. Madhuri, G. Sumathi
Summary: The development of nanotechnology and the synthesis of nanomedicine have shown great potential in the field of biomedicine. In this study, silver nanoparticles were successfully synthesized from Carica papaya seeds using an eco-friendly method, and these nanoparticles exhibited high antioxidant and antibacterial properties against various pathogens.
JOURNAL OF PHARMACEUTICAL NEGATIVE RESULTS
(2022)
Article
Pharmacology & Pharmacy
Hathibelagal Mundarinti Kumar, Kothapalli Chandrasekhar
Summary: A stability-indicating RP-high-performance liquid chromatography method for the simultaneous determination of olanzapine (OLA) and samidorphan (SAM) has been developed and validated. The method's specificity, precision, accuracy, linearity, and robustness were all confirmed according to International Conference on Harmonization guidelines. The method was found to be reliable, repeatable, accurate, and sensitive.
EGYPTIAN PHARMACEUTICAL JOURNAL
(2022)
Article
Chemistry, Organic
Dilek Isik Tasgin, Irem Bayraktar
Summary: We present a synthetic method for pyrrolizine-3-one derivatives and investigate their photophysical properties. These compounds are prepared through a series of reactions involving substituted pyrroles in one-pot, two-step oxidation, and intramolecular cyclization processes. The photophysical properties of the synthesized compounds are studied using UV-Vis and fluorescence spectroscopy in various solvents. The introduction of pyrrolyl substituents has a significant impact on Stokes shifts and quantum yield values.
SYNTHETIC COMMUNICATIONS
(2024)
Article
Chemistry, Organic
Satish Kumar Burra, Vaikunta Rao Lakinani, Raghunadh Akula, Chiranjeevi Yankkanti
Summary: A novel and green strategy for the construction of biologically relevant substituted indolyl-4H-chromenes scaffolds is reported, using L-proline as a catalyst and water as a promoter solvent. This catalytic system offers wider applicability, shorter reaction times, and high yields, making it an ideal condition for green chemistry.
SYNTHETIC COMMUNICATIONS
(2024)
Review
Chemistry, Organic
Abouelhaoul El Alami, Amine El Maraghi, Fatima Youssoufi, Assiya Atif, Hamid Sdassi
Summary: Nitrobenzimidazoles have become increasingly important in the design of new compounds in medicinal, therapeutic and chemical fields. This review provides an overview of the synthesis strategies and biological activities of nitrobenzimidazole derivatives.
SYNTHETIC COMMUNICATIONS
(2024)
Article
Chemistry, Organic
Nilesh Raghunath Khedkar, Alex Joseph, Milind Sindkhedkar
Summary: In this study, a new library of 3-(2-(pyrimidin-5-yl)thiazol-4-yl)-1,2,4-oxadiazole compounds was designed and synthesized as potential anticancer agents using in silico fragment-based drug design. The compounds were tested for their anticancer activity in vitro, and one compound exhibited excellent activity against multiple cancer cell lines.
SYNTHETIC COMMUNICATIONS
(2024)
Article
Chemistry, Organic
Terungwa H. Iorkula, Bryce A. Tolman, Scott R. Burt, Matt A. Peterson
Summary: A new method for synthesizing C-6 substituted products has been discovered in this study, which utilizes lower doses of fluoride and CsF as a catalyst, with high reaction yields and cost-effectiveness under suitable conditions.
SYNTHETIC COMMUNICATIONS
(2024)
Review
Chemistry, Organic
Ranjana Aggarwal, Swati Sharma
Summary: This review article mainly focuses on the synthesis of 3(5)-trifluoromethylpyrazoles via condensation reaction of trifluoromethyl-beta-diketones with hydrazines. It emphasizes the importance of fluorine-containing compounds and pyrazoles in the field of biology. The literature reported condensation reactions of trifluoromethyl-beta-diketones with hydrazines are covered.
SYNTHETIC COMMUNICATIONS
(2024)
Article
Chemistry, Organic
F. M. Alshareef, Sami A. Al-Harbi, Esam S. Allehyani, Omeima Abdullah, Magdy A. Ibrahim
Summary: This study aimed to construct a novel category of linear annulated chromeno[3',2':5,6]pyrido[2,3-d][1,3]thiazolo[3,2-a]pyrimidines. The chemical reactivity of the synthesized compounds was investigated, and they showed significant antimicrobial activity against various strains.
SYNTHETIC COMMUNICATIONS
(2024)
Article
Chemistry, Organic
Preethi Dhanapal, S. L. Manju
Summary: Thiazole based Schiff base scaffolds have become an integral part of drug development in recent years, playing a versatile role as building blocks for lead drug molecules. This study presents a facile one pot synthetic method for producing novel 4-aryl thiazoles with high yield, shorter reaction time, and milder conditions, without the need for catalysts or purification techniques.
SYNTHETIC COMMUNICATIONS
(2024)
