期刊
SMALL
卷 15, 期 11, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.201804575
关键词
candle soot; carbon nano-onion; photoacoustic imaging; photothermal therapy; theranostic agent
类别
资金
- National Natural Science Foundation of China [21673037]
- Natural Science Foundation of Jiangsu Province [BK20170078]
- Innovative and Entrepreneurial Talent Recruitment Program of Jiangsu Province
Herein, water-dispersible carbon nano-onion clusters (CNOCs) with an average hydrodynamic size of approximate to 90 nm are prepared by simply sonicating candle soot in a mixture of oxidizing acid. The obtained CNOCs have high photothermal conversion efficiency (57.5%), excellent aqueous dispersibility (stable in water for more than a year without precipitation), and benign biocompatibility. After polyethylenirnine (PEI) and poly(ethylene glycol) (PEG) modification, the resultant CNOCs-PEI-PEG have a high photothermal conversion efficiency (56.5%), and can realize after-wash photothermal cancer cell ablation due to their ultrahigh cellular uptake (21.3 pg/cell), which is highly beneficial for the selective ablation of cancer cells via light-triggered intracellular heat generation. More interestingly, the cellular uptake of CNOCs-PEI-PEG is so high that the internalized nanoagents can be directly observed under a microscope without fluorescent labeling. Besides, in vivo experiments reveal that CNOCs-PEI-PEG can be used for photothermal photoacoustic dual-modal imaging-guided photothermal therapy after intravenous administration. Furthermore, CNOCs-PEI-PEG can be efficiently cleared from the mouse body within a week, ensuring their excellent longterm biosafety. To the best of the authors' knowledge, the first example of using candle soot as raw material to prepare water-dispersible onion-like carbon nanomaterials for cancer theranostics is represented herein.
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