Article
Medicine, General & Internal
Xianchen Liu, Yanyun Yang, Zhenzhen Liu, Cunxian Jia
Summary: Insomnia, daytime sleepiness, and depressive symptoms are highly comorbid in adolescents. The associations between insomnia and daytime sleepiness, as well as insomnia and depression, are bidirectional. Depression predicts daytime sleepiness, but not vice versa.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Agata Gabryelska, Szymon Turkiewicz, Marta Ditmer, Filip Franciszek Karuga, Dominik Strzelecki, Piotr Bialasiewicz, Marcin Sochal
Summary: This study investigated differences in concentrations of BDNF and proBDNF in patients with OSA and healthy individuals, and found that the BDNF signaling pathway might be involved in the pathophysiology of depression and insomnia in patients with OSA.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
Blake K. Noyes, Douglas P. Munoz, Sarosh Khalid-Khan, Elisa Brietzke, Linda Booij
Summary: Subthreshold depression and major depressive disorder in adolescents share similarities in several aspects, including higher prevalence, functional impairment, comorbidity, genetic predisposition, and treatment response. However, the definition of subthreshold depression varies across studies, and adolescent-specific data are limited.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Gavin Brupbacher, Thea Zander-Schellenberg, Doris Straus, Hildburg Porschke, Denis Infanger, Markus Gerber, Roland von Kanel, Arno Schmidt-Trucksaess
Summary: This study investigated the effects of a single bout of aerobic exercise performed after 2:00 pm on subsequent night's sleep in patients with depression. While the exercise did not affect sleep efficiency, it had a strong beneficial effect on mood states, including depressiveness.
Article
Clinical Neurology
Gavin Brupbacher, Thea Zander-Schellenberg, Doris Straus, Hildburg Porschke, Denis Infangerl, Markus Gerber, Roland von Kaenel, Arno Schmidt-Trucksaess
Summary: The study aimed to investigate the effects of a single bout of aerobic exercise on sleep in patients with depression. The results showed that aerobic exercise had no effect on sleep efficiency but had a strong beneficial effect on mood and did not increase adverse outcomes. These findings suggest that exercise after 02:00 pm is not detrimental for sleep, contrary to sleep hygiene recommendations.
Article
Medicine, General & Internal
Marine Thieux, Min Zhang, Agathe Marcastel, Alice Poitrinal, Fanny Vassias, Aurore Guyon, Olivier Revol, Stephanie Mazza, Anne Guignard-Perret, Patricia Franco
Summary: Adequate intellectual abilities serve as a protective factor for psychosocial adjustments in chronic disorders. This study found that children with narcolepsy and high intellectual potential had lower perceptual reasoning index and fewer conduct disorders compared to controls, while children with narcolepsy and normal intellectual range reported more school difficulties.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Carolin F. Reichert, Simon Veitz, Miriam Buhler, Georg Gruber, Gunnar Deuring, Sophia S. Rehm, Katharina Rentsch, Corrado Garbazza, Martin Meyer, Helen Slawik, Yu-Shiuan Lin, Janine Weibel
Summary: The study found that caffeine can reduce subjective sleepiness but has individual variability in its effects on sleep. Particularly, teenagers with a higher need for deep sleep may experience a loss of slow-wave sleep at night.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Clinical Neurology
Oyunsuren Munkhjargal, Yasunori Oka, Sakurako Tanno, Hiroshi Shimizu, Yoko Fujino, Tomoko Kira, Akiko Ooe, Mariko Eguchi, Takashi Higaki
Summary: Discrepancy between subjective and objective sleepiness is common, with subjective sleepiness being more prevalent. Age, bedtime, and neurodevelopmental disorders are significant factors associated with subjective sleepiness without objective sleepiness.
Article
Engineering, Environmental
Yun Liu, Richa Gairola, Jordan R. Kuiper, George D. Papandonatos, Karl T. Kelsey, Scott M. Langevin, Jessie P. Buckley, Aimin Chen, Bruce P. Lanphear, Kim M. Cecil, Kimberly Yolton, Joseph M. Braun
Summary: Per- and polyfluoroalkyl substance (PFAS) exposure has been linked to DNA methylation changes in neonates and adults. We previously reported that prenatal PFAS exposure may have a durable impact on DNA methylation from birth to adolescence. However, few studies have examined the association of postnatal PFAS exposure with alterations in DNA methylation.
ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS
(2023)
Article
Medicine, General & Internal
Hsin-Hao Tseng, Sheng-Wei Hwang, Shang-Rung Hwang, Juen-Haur Hwang
Summary: This study aimed to investigate the impact of common diseases and habits on daytime sleepiness in adults. The findings revealed that dyslipidemia, acute myocardial infarction (AMI), liver cirrhosis, alcohol drinking, and tea consumption were significantly associated with daytime sleepiness in adults, with differences observed in terms of sex and age.
Article
Health Care Sciences & Services
Geetha Kandasamy, Tahani Almeleebia
Summary: This study aimed to assess OSA and the relationship between AHI and polysomnographic characteristics in OSA patients. The results showed a significant prevalence of obesity and high frequency of OSA in men, with polysomnography being the primary method for early detection and treatment of the condition.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Psychiatry
Ingeborg Bolstad, Anni-Emilia Alakokkare, Jorgen G. Bramness, Eline B. Rognli, Jonna Levola, Antti Mustonen, Jouko Miettunen, Solja Niemela
Summary: The study found that cigarette smoking and alcohol consumption during adolescence were associated with an increased risk of subsequent bipolar disorder, while the association between smoking and major depression weakened after adjusting for emotional and behavioral problems. No association was observed between adolescent coffee consumption and subsequent mood disorders.
ACTA PSYCHIATRICA SCANDINAVICA
(2022)
Article
Clinical Neurology
Hiba Bilal, Ian H. Harding, Julie C. Stout
Summary: Huntington's disease (HD) is a neurodegenerative disorder characterized by motor abnormalities, cognitive decline, and neuropsychiatric disturbances. Depression is common in HD, but the short-term dynamics of mood and its relationship with depression in HD have not been studied. This study found that depression severity was associated with average mood across 28 days, but not with day-to-day mood variability or inertia. It also revealed that female HD carriers experienced more day-to-day mood variability compared to males.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Behavioral Sciences
Yuan Shen, Haicun Shi, JianGuo Zhong, PingLei Pan, ShuFang Wang, MingZhu Chen, ZhiPeng Chen, ChunFeng Liu
Summary: This study aimed to explore the factors correlated with excessive daytime sleepiness (EDS) in patients with Parkinson's disease (PD). The findings revealed that fatigue and respiratory-related microarousal index were independent risk factors for EDS in PD patients. Fragmented sleep and pathological abnormalities of the central nervous system resulting in changes in arousal are speculated to be major influencing factors of EDS in PD.
BRAIN AND BEHAVIOR
(2023)
Article
Multidisciplinary Sciences
Basma Radwan, Gloria Jansen, Dipesh Chaudhury
Summary: The study reveals that mice susceptible to chronic social stress show an increased tendency towards wakefulness, lower stability in NREM, and higher probability of transitioning to wakefulness in the sleep-wake sequences.
Article
Multidisciplinary Sciences
Laura S. Korhonen, Minna Lukkarinen, Katri Kantojarvi, Panu Raty, Hasse Karlsson, Tiina Paunio, Ville Peltola, Linnea Karlsson
Summary: The study found that the IL6 minor allele G may increase the risk of children developing RRIs, while prenatal maternal distress did not interact with child genotype. Exploratory analyses suggest that the variant type of IL6 may be associated with the risk of RRIs in males and dependent on prenatal exposure to maternal distress.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Marja-Liisa Nuotio, Heini Sanez Tahtisalo, Alexandra Lahtinen, Kati Donner, Frej Fyhrquist, Markus Perola, Kimmo K. Kontula, Timo P. Hiltunen
Summary: Essential hypertension remains a leading factor in global disease burden, with treatment goals often unmet. Research on DNA methylation and antihypertensive drug responses identified potential associations, particularly near the ACY3 TSS. However, robust associations between DNA methylation and BP responses to different antihypertensive drugs were not found, suggesting a need for further exploration.
Article
Nursing
Tiina Putkuri, Mari Lahti, Camilla Laaksonen, Anna S. Sarvasmaa, Rauno Huttunen, Anna Axelin
Summary: The study aims to describe the variation in stakeholders' perceptions related to desirable mental health services in school environments, construct alternative future visions based on these perceptions, and describe stakeholders' perceptions about the actions needed to reach such an ideal state. The study identified four alternative future visions based on stakeholders' perceptions and emphasized the importance of considering micro-, mezzo-, and macro-level changes. The study is relevant to clinical practice as it provides alternative future visions and helps clarify the future role of school nurses.
JOURNAL OF CLINICAL NURSING
(2022)
Article
Endocrinology & Metabolism
Jani Kajanoja, Saara Nolvi, Katri Kantojarvi, Linnea Karlsson, Tiina Paunio, Hasse Karlsson
Summary: Maternal prenatal stress may have long-term adverse consequences for child development. The oxytocin-receptor genotype may moderate the association between maternal stress during pregnancy and child social-emotional development. Infants with risk genotypes are more susceptible to the negative effects of maternal prenatal anxiety, while those with fewer or no risk genotypes are less affected.
PSYCHONEUROENDOCRINOLOGY
(2022)
Article
Psychology, Developmental
Helene Vulser, Herve S. Lemaitre, Stella Guldner, Pauline Bezivin-Frere, Martin Loffler, Anna S. Sarvasmaa, Jessica Massicotte-Marquez, Eric Artiges, Marie-Laure Paillere Martinot, Irina Filippi, Ruben Miranda, Argyris Stringaris, Betteke Maria van Noort, Jani Penttila, Yvonne Grimmer, Andreas Becker, Tobias Banaschewski, Arun L. W. Bokde, Sylvane Desrivieres, Juliane H. Frohner, Hugh Garavan, Antoine Grigis, Penny A. Gowland, Andreas Heinz, Dimitri Papadopoulos Orfanos, Luise Poustka, Michael N. Smolka, Philip A. Spechler, Henrik Walter, Robert Whelan, Gunter Schumann, Herta Flor, Jean-Luc Martinot, Frauke Nees
Summary: Adolescence is a critical period for circadian rhythm, with a shift toward eveningness. Eveningness in adolescence predicts later onset of depressive symptoms. This study investigates the structural variations associated with chronotype in early adolescence and its contribution to the development of depressive symptoms.
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2023)
Meeting Abstract
Oncology
J. Oikkonen, A. Virtanen, Y. Li, V-M. Isoviita, K. Zhang, S. Jamalzadeh, G. Marchi, A. Hakkinen, T. A. Muranen, A. Lahtinen, S. Hietanen, K. Huhtinen, J. Hynninen, S. Hautaniemi
ANNALS OF ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Fredrik Aberg, Katri Kantojarvi, Ville Mannisto, Anna But, Veikko Salomaa, Teemu Niiranen, Martti Farkkila, Panu Luukkonen, Satu Mannisto, Annamari Lundqvist, Markus Perola, Antti Jula
Summary: This study found that both hypertension and genetic predisposition to hypertension are associated with liver-related outcomes. However, the initiation of antihypertensive medication can attenuate this association in individuals with a higher genetic risk for hypertension.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Jaana Simola, Felix Siebenhuhner, Vladislav Myrov, Katri Kantojarvi, Tiina Paunio, J. Matias Palva, Elvira Brattico, Satu Palva
Summary: Genetic polymorphisms in neuromodulatory genes, such as COMT and BDNF, contribute to inter-individual variability in neuronal oscillation dynamics. These polymorphisms influence local oscillation amplitudes, temporal correlations, and large-scale synchronization, with the modulation of excitation-inhibition balance playing a role in their effects.
Review
Oncology
Aikaterini Skorda, Marie Lund Bay, Sampsa Hautaniemi, Alexandra Lahtinen, Tuula Kallunki
Summary: Ovarian cancer is the deadliest gynecological cancer, especially the high-grade serous ovarian carcinoma (HGSC). Despite recent advancements in therapeutics, the overall survival rate of HGSC patients has not significantly improved. This article discusses the potential use of small molecule kinase inhibitors as personalized treatments for platinum and taxane resistant ovarian cancer, with a focus on HGSC.
Article
Oncology
Alexandra Lahtinen, Kari Lavikka, Anni Virtanen, Yilin Li, Sanaz Jamalzadeh, Aikaterini Skorda, Anna Rossberg Lauridsen, Kaiyang Zhang, Giovanni Marchi, Veli-Matti Isoviita, Valeria Ariotta, Oskari Lehtonen, Taru A. Muranen, Kaisa Huhtinen, Olli Carpen, Sakari Hietanen, Wojciech Senkowski, Tuula Kallunki, Antti Hakkinen, Johanna Hynninen, Jaana Oikkonen, Sampsa Hautaniemi
Summary: Ovarian HGSC is often diagnosed at an advanced stage, with genetically diverse clones existing prior to treatment. This study analyzed whole-genome sequencing data from 510 samples of 148 HGSC patients, revealing three evolutionary states with distinct genomic features, pathways, and phenotypes, which showed significant association with treatment response. Pathway analysis suggested two potential evolutionary trajectories, and experiments with tumor organoids supported targeted therapy for tumors with enriched PI3K/AKT pathway. Heterogeneity analysis indicated more unique clones in samples from the site of origin compared to metastatic tumors or ascites. These findings highlight the importance of integrative tumor evolution analysis for identifying patient subtypes.
Article
Clinical Neurology
Johanna Liuhanen, Katri Kantojarvi, Henriette Acosta, Johanna T. Pietikainen, Saara Nolvi, Minna Savukoski, Anneli Kylliainen, Pirjo Polkki, Hasse Karlsson, Linnea Karlsson, E. Juulia Paavonen, Tiina Paunio
Summary: Recent advances in genome-wide association studies have allowed for the estimation of genetic risk of complex traits, such as neuroticism, using polygenic risk scores (PRS). While previous studies have shown associations between neuroticism PRS and psychiatric disorders in adults, research on children is limited. This study aimed to explore the associations between neuroticism PRS and its subscales, worry PRS and depressive affect PRS, with externalizing and internalizing symptoms in 2-year-old children. Additionally, the study investigated whether parental neuroticism PRS and maternal depressive symptoms mediated the effects on children's symptoms.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)
Article
Clinical Neurology
Anna Perkio, Ilona Merikanto, Katri Kantojarvi, Tiina Paunio, Nasa Sinnott-Armstrong, Samuel E. Jones, Hanna M. Ollila
Summary: Polygenic risk scores (PRSs) for sleep traits were generated using summary data from genome-wide association studies and tested in two independent Finnish population cohorts. The PRSs were found to be associated with their respective sleep traits, and there was a significant difference in reported sleep duration between the extremes of the PRS. These findings suggest that sleep-related PRSs are portable across cohorts and can be useful in studying disease and trait associations.
Article
Biochemical Research Methods
Aikaterini Skorda, Anna Rossberg Lauridsen, Kaisa Huhtinen, Alexandra Lahtinen, Wojciech Senkowski, Jaana Oikkonen, Johanna Hynninen, Sampsa Hautaniemi, Tuula Kallunki
Summary: Patient-derived organoids (PDOs) are ideal ex vivo model systems for studying cancer progression and drug resistance mechanisms. This study presents a protocol for measuring drug efficacy in three-dimensional (3D) high-grade serous ovarian cancer PDO cultures through quantification of cytotoxicity and analyzing proliferation using the Ki67 biomarker.
Meeting Abstract
Oncology
Alexandra Lahtinen, Kari Lavikka, Yilin Li, Sanaz Jamalzadeh, Anni Virtanen, Rainer Lehtonen, Olli Carpen, Sakari Hietanen, Kaisa Huhtinen, Antti Hakkinen, Johanna Hynninen, Jaana Oikkonen, Sampsa Hautaniemi
Meeting Abstract
Oncology
Alexandra Lahtinen, Kari Lavikka, Yilin Li, Sanaz Jamalzadeh, Anni Virtanen, Rainer Lehtonen, Olli Carpen, Sakari Hietanen, Kaisa Huhtinen, Antti Hakkinen, Johanna Hynninen, Jaana Oikkonen, Sampsa Hautaniemi
Article
Clinical Neurology
Melanie Strauss, Lucie Griffon, Maxime Elbaz, Isabelle Arnulf, Mounir Chennaoui, Damien Leger
Summary: This study examines decision-making impairments in individuals with central disorders of hypersomnolence (CDH), specifically narcolepsy type 1 (NT1). The results suggest that both NT1 and other CDH patients have decreased learning abilities to avoid losses, which is associated with alterations in vigilance. The study provides new insights into the nature of decision-making impairments in CDH and suggests the potential for minimizing these alterations by restoring adequate vigilance.
Article
Clinical Neurology
Kyriakos Dimitriadis, Christina Stathakopoulou, Nikolaos Pyrpyris, Eirini Beneki, Elena Adamopoulou, Stergios Soulaidopoulos, Ioannis Leontsinis, Alexandros Kasiakogias, Aggelos Papanikolaou, Panagiotis Tsioufis, Konstantinos Aznaouridis, Dimitris Tsiachris, Konstantina Aggeli, Konstantinos Tsioufis
Summary: This review provides a comprehensive analysis of the common pathophysiology between sleep disordered breathing (SDB) and mitral regurgitation (MR), and discusses the effects of SDB treatment on MR and the effects of mitral valve surgery or transcatheter repair on obstructive and central sleep apnea (OSA and CSA).
Article
Clinical Neurology
Szu-Yu Hou, Ching-Ju Chiu, Jeanne Laraine Shea, Chih-Liang Wang, Hsiao-Han Tang, Po-Ching Kuo, Yi-Chieh Yang, Chih-Hsing Wu
Summary: The study aimed to examine the effects of age, menopausal status, and symptoms on sleep patterns and circadian rhythms in midlife women. Premenopausal women had the most unstable day-to-day rhythms, and women with more severe symptoms experienced greater sleep problems. Psychological symptoms were the strongest predictors for all sleep parameters.
Article
Clinical Neurology
Ya-Wen Hsiao, Wei-Lun Lin, Yu-Hui Chou, Shin-Huei Liu, Ting-Wei Ernie Liao, Shih-Ann Chen, Li-Wei Lo
Summary: This study aimed to investigate the effects of RDN on heart inflammation associated with COSA. The results suggest that RDN treatment may prevent COSA-associated heart inflammation through the JAK2-STAT3 signaling pathway.
Article
Clinical Neurology
Amy C. Reynolds, Kelly A. Loffler, Nicole Grivell, Brandon W. J. Brown, Robert J. Adams
Summary: This study aimed to understand the experience of sleep disorder diagnosis and treatment in shift workers and propose patient-informed solutions to improve access to health services. The findings showed that there were varied experiences with diagnosis and management, often taking a long time to seek help from healthcare providers after noticing symptoms. The study also identified the need for education and awareness initiatives, convenient screening and referral pathways, and tailored models of care.
Article
Clinical Neurology
Hsi -Chung Chen, Nai-Wei Hsu, Ching-Heng Lin
Summary: This study found a relationship between daytime sleepiness and mortality risk among older adults. The moderating effects of sex and physical function were examined. Specifically, the passive factor predicted mortality risk in women with good muscle power, while the active factor predicted mortality risk in men with good muscle power.
Article
Clinical Neurology
Sean P. A. Drummond, Bei Bei
Summary: This study proposes a parsimonious two-stage model for defining stages of Cognitive Behavioural Therapy for Insomnia (CBT-I) based on Sleep Restriction Therapy (SRT). Using data from a randomized clinical trial, the model helps identify patterns of treatment progression and their association with baseline insomnia severity. The model holds potential for further research on various CBT-I processes that are currently not fully understood.
Article
Clinical Neurology
Janet Jezkova, Karel Sonka, Jakub Kreisinger, Petra Prochazkova, Helena Tlaskalova-Hogenova, Sona Nevsimalova, Jitka Buskova, Radana Merkova, Tereza Dvorakova, Iva Prihodova, Simona Dostalova, Radka Roubalova
Summary: In recent years, there has been a growing interest in the influence of gut microbiota on sleep physiology. The gut microbiota affects the central nervous system and circadian rhythms, and can be associated with sleep disorders. This study observed the gut microbiota composition of patients with different types of narcolepsy and idiopathic hypersomnia, and found changes in beta diversity in these patient groups compared to healthy controls. However, after adjusting for confounding factors, the differences were no longer statistically significant. The study suggests that using metabolomics and proteomics approaches to study the role of microbiota in sleep disorders may be beneficial.
Article
Clinical Neurology
Mauro Manconi, Linda C. van der Gaag, Francesca Mangili, Corrado Garbazza, Silvia Riccardi, Christian Cajochen, Susanna Mondini, Francesca Furia, Elena Zambrelli, Simone Baiardi, Alessandra Giordano, Nicola Rizzo, Cristina Fonti, Elsa Viora, Armando D'Agostino, Alessandro Cicolin, Fabio Cirignotta, Daniele Aquilino, Alessandra Barassi, Renata del Giudice, Giulia Fior, Orsola Gambini, Barbara Giordano, Alma Martini, Chiara Serrati, Rossana Stefanelli, Silvio Scarone, Mariapaola Canevini, Valentina Fanti, Hans-Christian Stein, Anna Maria Marconi, Erica Raimondo, Emanuela Viglietta, Rossella Santoro, Giuliana Simonazzi, Alessandra Bianconcini, Francesco Meani, Nicoletta Piazza, Filippos Filippakos, Thomas Gyr
Summary: The Life-ON study provides the largest polysomnographic dataset coupled with longitudinal subjective assessments of sleep quality in pregnant women to date. Sleep disorders are highly frequent and distributed differently during pregnancy and postpartum. Routine assessment of sleep disturbances in the perinatal period is necessary to improve early detection and clinical management.
Article
Clinical Neurology
Zhihua Huang, Anqi Duan, Zhihui Zhao, Qing Zhao, Yi Zhang, Xin Li, Sicheng Zhang, Luyang Gao, Chenhong An, Qin Luo, Zhihong Liu
Summary: This study aims to investigate pulmonary arterial hypertension (PAH) phenotypes and their prognostic implications by clustering overnight cardiorespiratory signals in PAH patients. Three distinct clusters were identified, with patients in Cluster 3 exhibiting worse clinical outcomes. The presence of nocturnal hypoxemia and obstructive sleep apnea (OSA) in PAH patients was associated with increased risk of clinical worsening. Tailored management strategies addressing both PAH and nocturnal hypoxemia may improve clinical outcomes.
Article
Clinical Neurology
Yudan Lv, Yujun Wen, Ramalingam Vetrivelan, Jun Lu
Summary: This study demonstrated that the projections from the pontine parabrachial nucleus (PB) to the basal forebrain (BF) and medial septum (MS) can activate the cerebral cortex and hippocampus, providing important insights into the activities of these brain regions during the sleep-wake cycle.
Article
Clinical Neurology
Annika M. Myers, Megan E. Rech, Bengi Baran, Cara Palmer, Dimitrios Mylonas, Candice A. Alfano
Summary: This study found that N2 sleep spindles are associated with emotional functioning in school-aged children. Higher spindle density is related to decreased state-based emotional arousal towards negative affective images, and higher spindle peak frequency is associated with greater use of the positive emotion regulatory strategy of savoring.
Article
Clinical Neurology
Hung Youl Seok, Yong Won Cho
Summary: This study investigated the long-term impact of dopamine agonist treatment on altered central sensory processing in restless legs syndrome (RLS) patients. The results showed that dopamine agonist treatment effectively reduced RLS symptoms but did not reverse the altered central sensory processing observed on testing. These findings suggest that RLS pathophysiology is multifactorial and not solely driven by dopaminergic dysfunction.
