A novel, efficient electrochemical sensor for the detection of isoniazid based on the B/N doped mesoporous carbon modified electrode

At present, B/N co-doped mesoporous carbon (BNDC) have been synthesized in one-step and employed for high sensitive electrochemical detection of Isoniazid (INZ). The synthetic procedure was simple and produced homogenous doping of heteroatoms with high elemental purity and mesoporous surface. Further, the surface and physiochemical properties of synthesized BNDC was analysis by Nitrogen (N-2) adsorption-desorption analysis, and spectroscopic studies. A high sensitive amperometric sensor of BNDC film modified electrode, towards INZ, delivered superior analytical performance with a broad dynamic range 0.02-1783 mu M and detection limit of 1.5 nM. Excellency of electrochemical sensor can be attributed to the large surface area, low pore size, abundant active sites, and enhanced electrical conductivity of synthesized BNDC electrocatalyst. Furthermore, the excellent chemical stability of BNDC advocates the long-term stability and reproducibility of the fabricated electrochemical assay. The practical applicability of the proposed sensor was assessed by detection of INZ in physiological fluids.