Article
Spectroscopy
Surisa Sa-nguanprang, Anukorn Phuruangrat, Opas Bunkoed
Summary: A hybrid fluorescent sensing probe was developed for the quantitative analysis of thiamphenicol, showing high sensitivity and selectivity. The accuracy of the optosensor was evaluated by analyzing spiked milk samples, which agreed well with HPLC analysis results, with recoveries in the range of 93.5 to 100.1% and good precision.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Chemistry, Analytical
Nuntanut Chaitong, Nutnicha Chansud, Naphatsakorn Orachorn, Warakorn Limbut, Opas Bunkoed
Summary: The optosensor designed for detecting ultra-trace levels of cefoperazone utilized synthesized magnetic composite sensing probes with porous graphene, quantum dots, magnetite nanoparticles, and a highly specific polymer. The sensor showed good linearity towards cefoperazone, high specificity, and successful detection in milk with promising recoveries and consistency.
MICROCHEMICAL JOURNAL
(2021)
Article
Chemistry, Analytical
Nutnicha Chansud, Opas Bunkoed
Summary: The optosensor utilizing nanocomposite probes demonstrated high sensitivity and excellent selectivity for the detection of trace cefazolin by integrating titanium dioxide, graphene quantum dots, and molecularly imprinted polymer. The fabricated nanoprobe exhibited good linearity, high imprinting factor, and unaffected selectivity towards cefazolin analogues. Detection of cefazolin in milk using this nano-optosensor probe showed promising results compared to HPLC analysis, indicating the potential application of the fabrication strategy for measuring other toxic compounds.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2021)
Article
Chemistry, Analytical
Maria Teresa Giardi, Daniele Zappi, Mehmet Turemis, Gabriele Varani, Fabrizio Lo Celso, Giampaolo Barone, Pietro Calandra, Amina Antonacci, Viviana Scognamiglio
Summary: This passage describes a method to design and synthesize novel artificial peptides that mimic the plastoquinone binding niche of the D1 protein from Chlamydomonas reinhardtii, with the ability to bind herbicides. These peptides were then functionalized with quantum dots for the development of a hybrid optosensor for the detection of atrazine, meeting E.U. legislation requirements with detection limits in the mu g/L concentration range.
Article
Chemistry, Applied
Pratik Kolhe, Akanksha Roberts, Sonu Gandhi
Summary: The unregulated usage of Cephalexin (CFX) in animal source food products has led to antimicrobial resistance (AMR) in humans. Graphene quantum dots (GQD) were utilized to enhance the electrochemical response of the sensor for the sensitive detection of CFX. The developed biofunctionalized electrode may have potential applications for on-site detection of other antibiotics in food samples.
Article
Chemistry, Analytical
Surisa Sa-nguanprang, Anukorn Phuruangrat, Opas Bunkoed
Summary: A nanocomposite fluorescent probe was developed for the simultaneous determination of florfenicol and sparfloxacin through fluorescence quenching. The probe consisted of nitrogen-doped graphene quantum dots, cadmium telluride quantum dots, and zinc oxide nanoparticles integrated into a molecularly imprinted polymer. The probe showed high sensitivity and specificity, with good linear relationships and low limits of detection for both analytes. It was successfully applied to determine these antibiotics in food samples with good accuracy, precision, and recovery rates.
Article
Chemistry, Analytical
Nutnicha Chansud, Noppanut Longnapa, Opas Bunkoed
Summary: A nanohybrid magnetic fluorescent sensing probe was developed for ultrasensitive and selective determination of levofloxacin, showing excellent performance and specificity. It could enrich the target substance quickly in complex samples and provide detection results comparable to HPLC.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2021)
Article
Chemistry, Multidisciplinary
Ting Meng, Zifei Wang, Ting Yuan, Xiaohong Li, Yunchao Li, Yang Zhang, Louzhen Fan
Summary: This study presents a gram-scale synthesis of red/green/blue solid-state fluorescent carbon quantum rings with high quantum yields, offering a potential alternative to REE-free phosphor-converted white LEDs. These R/G/B-SBF-CQRs-based LEDs emit warm white light with low CCT, high CRI, and high luminous efficiency, comparable to REE-phosphor-based LEDs.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Niall M. C. Mulkerns, William H. Hoffmann, Javier Ramos-Soriano, Noelia de la Cruz, Teodoro Garcia-Millan, Robert L. Harniman, Ian D. Lindsay, Annela M. Seddon, M. Carmen Galan, Henkjan Gersen
Summary: A practical method based on measuring the refractive index of nanoparticles in suspension is proposed for determining the ratio of functionalisation layer volume to particle volume. The method is successfully applied to different nanoparticles and shows the ability to detect differences in surface functionalisation or composition of nanosized particles. This non-destructive and rapid method is well-suited for industrial particle characterisation and biological applications.
Article
Chemistry, Analytical
Qiang Zhang, Lingxiao Wang, Pengchen Su, Long Yu, Ranhao Yin, Yiming Bu, Xiangyang Hao, Mingtai Sun, Suhua Wang
Summary: A method based on ratiometric fluorescence and colorimetric method using nitrogen-rich carbon dots as fluorophore was developed for selective and sensitive determination of ceftriaxone sodium (CTR) trace residues. The functional surfaces of indole-derived carbon dots (I-CDs) can selectively bind to CTR via electrostatic forces, resulting in a distinct variety in fluorescence and absorption wavelength and intensity. The detection limits (LODs) were estimated to be 19.7 nM and 78.0 nM for the ratiometric fluorescence method and colorimetric method, respectively. The nanosensor combined with a smartphone's color recognizer allowed for in situ visual quantitative determination of CTR.
Article
Spectroscopy
Xiaoping Chen, Jianwei Lin, Yafeng Zhuang, Siqi Huang, Jinghua Chen, Zhizhong Han
Summary: A new ratiometric fluorescence sensor is developed for the selective detection of chlorotetracycline (CTC) using dual-mode fluorescence method, demonstrating good selectivity and sensitivity.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Chemistry, Analytical
Zihui Liang, Junyi Zhao, Peilin Wang, Yixin Nie, Shuping Xu, Qiang Ma
Summary: In this study, a polarization-resolved ECL sensor based on the surface plasmon coupling effect was constructed for sensitive detection of miRNA-155, which is related to triple-negative breast cancer. The sensing system utilized a gold nanorod vertical array as a surface-enhanced structure, improving the detection sensitivity of the ECL signal.
ANALYTICAL CHEMISTRY
(2022)
Review
Engineering, Environmental
Jixi Zhang, Jiahui Jin, Jianqin Wan, Shaohua Jiang, Yongzhong Wu, Wufeng Wang, Xiao Gong, Hangxiang Wang
Summary: Research on QDs/hydrogel composites is progressing rapidly with wide applications in health, energy, and environment. Synthetic strategies are classified based on preparative sequence, and the latest applications in sensing, particularly fluorescence sensing, are summarized.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Chemistry, Inorganic & Nuclear
Chuqiao Wu, Wenjie Sun, Qianming Wang
Summary: In this study, various sulfur-derived nanomaterials were prepared using different sulfur sources, with poly(ethylene glycol) playing an important role in the assembly process and the definition of sulfur dots being inaccurate. The photophysical properties of different sulfur-derived nanomaterials vary, with NSO-QDs demonstrating high selectivity and sensitivity in the detection of Ni2+.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Applied
Na Wei, Meng-Xia Wei, Bo-Hui Huang, Xiao-Feng Guo, Hong Wang
Summary: Fluorescent silicon quantum dots (SiQDs) with excellent properties have attracted attention for nitrite detection. The green-emitting SiQDs exhibit selectivity, good water dispersibility, and stability for potential routine analysis in food samples. The sensor displays a significant linear relation between fluorescence quenching efficiency and the concentration of NO2-.
Article
Chemistry, Analytical
Nutnicha Chansud, Opas Bunkoed
Summary: The optosensor utilizing nanocomposite probes demonstrated high sensitivity and excellent selectivity for the detection of trace cefazolin by integrating titanium dioxide, graphene quantum dots, and molecularly imprinted polymer. The fabricated nanoprobe exhibited good linearity, high imprinting factor, and unaffected selectivity towards cefazolin analogues. Detection of cefazolin in milk using this nano-optosensor probe showed promising results compared to HPLC analysis, indicating the potential application of the fabrication strategy for measuring other toxic compounds.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2021)
Article
Biochemical Research Methods
Sirintorn Jullakan, Opas Bunkoed
Summary: A composite adsorbent was developed for extracting and quantifying sulfonamides in milk samples with good extraction efficiency and recovery rates.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2021)
Article
Chemistry, Analytical
Pattamaporn Klongklaew, Opas Bunkoed
Summary: A polydopamine-coated microporous composite of metal-organic frameworks and magnetite nanoparticles embedded in carrageenan hydrogel beads was successfully utilized for magnetic solid-phase extraction of parabens with high efficiency and broad linear range. The composite adsorbent showed good accuracy, stability, and reusability when extracting parabens in real samples.
MICROCHEMICAL JOURNAL
(2021)
Article
Chemistry, Physical
Kanokrat Suanchan, Nutnicha Chansud, Surisa Sa-nguanprang, Opas Bunkoed
Summary: The hierarchical nanocomposite optosensing probe designed for detecting ofloxacin showed high sensitivity and selectivity, with a linear range from 0.10 to 25 µg L-1 and a limit of detection of 0.066 µg L-1. The probe was accurate in detecting ofloxacin in milks with recoveries of 92-99% and could be a cost-effective alternative method for detecting trace compounds in various samples.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2021)
Article
Biochemical Research Methods
Piyaluk Nurerk, Opas Bunkoed, Sirintorn Jullakan, Sarawut Khongkla, Maria Llompart, Sujittra Poorahong
Summary: A dumbbell shaped stir bar adsorbent of MIL 101 entrapped in PVA cryogel coated with poly(3,4-ethylenedioxythiophene) was fabricated to extract synthetic phenolic antioxidants in foodstuffs. The optimized extraction efficiency was achieved by evaluating various factors such as adsorbent compositions, extraction time, stirring speed, and sample pH. High performance liquid chromatography was used for the analysis of extracted synthetic phenolic antioxidants.
JOURNAL OF CHROMATOGRAPHY A
(2021)
Article
Chemistry, Analytical
Nutnicha Chansud, Noppanut Longnapa, Opas Bunkoed
Summary: A nanohybrid magnetic fluorescent sensing probe was developed for ultrasensitive and selective determination of levofloxacin, showing excellent performance and specificity. It could enrich the target substance quickly in complex samples and provide detection results comparable to HPLC.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2021)
Article
Chemistry, Analytical
Sarawut Khongkla, Apichai Phonchai, Piyaluk Nurerk, Opas Bunkoed
Summary: In this study, a hierarchical composite ZnO@Carbon foam/PVA cryogel was developed for the extraction and enrichment of parabens and synthetic phenolic antioxidants from fruit juice samples. The method showed good linear responses, with high recoveries, low relative standard deviations, and low limits of detection and quantification. The fabricated porous composite sorbent demonstrated ease of use and reusability, making it a promising tool for sample preparation in analytical chemistry.
MICROCHEMICAL JOURNAL
(2022)
Article
Chemistry, Analytical
Nuntanut Chaitong, Nutnicha Chansud, Naphatsakorn Orachorn, Warakorn Limbut, Opas Bunkoed
Summary: The optosensor designed for detecting ultra-trace levels of cefoperazone utilized synthesized magnetic composite sensing probes with porous graphene, quantum dots, magnetite nanoparticles, and a highly specific polymer. The sensor showed good linearity towards cefoperazone, high specificity, and successful detection in milk with promising recoveries and consistency.
MICROCHEMICAL JOURNAL
(2021)
Article
Chemistry, Analytical
Naphatsakorn Orachorn, Pattamaporn Klongklaew, Opas Bunkoed
Summary: A composite alginate hydrogel magnetic fiber adsorbent was developed for the extraction and enrichment of phthalate esters, showing high sensitivity and good reproducibility in quantitative analysis. The adsorbent is easy to use, with high recovery rates, and can be reused multiple times.
MICROCHEMICAL JOURNAL
(2021)
Article
Spectroscopy
Surisa Sa-nguanprang, Anukorn Phuruangrat, Opas Bunkoed
Summary: A hybrid fluorescent sensing probe was developed for the quantitative analysis of thiamphenicol, showing high sensitivity and selectivity. The accuracy of the optosensor was evaluated by analyzing spiked milk samples, which agreed well with HPLC analysis results, with recoveries in the range of 93.5 to 100.1% and good precision.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Chemistry, Physical
Angkana Pongprom, Nutnicha Chansud, Opas Bunkoed
Summary: A hierarchical composite nanoprobe was developed for the detection of sulfadimethoxine, showing both specificity and sensitivity in quantitative analysis. The probe effectively recognized and measured the presence of sulfadimethoxine, with high recovery rates and low variability. This nano-optosensor demonstrated improved sensitivity compared to traditional methods, offering a cost-effective and convenient solution for detection purposes.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2022)
Article
Chemistry, Analytical
Natnaree Rattanakunsong, Sirintorn Jullakan, Justyna Plotka-Waylka, Opas Bunkoed
Summary: A hierarchical porous composite magnetic sorbent was prepared and applied for solid-phase extraction of polycyclic aromatic hydrocarbons. The sorbent exhibited a hierarchical porous structure, which enhanced the extraction efficiency through pi-pi and hydrophobic interactions. The developed sorbent showed good reproducibility and could be reused for multiple cycles.
JOURNAL OF SEPARATION SCIENCE
(2022)
Article
Chemistry, Analytical
Suppawan Sillapawisut, Opas Bunkoed, Maria Llompart, Piyaluk Nurerk
Summary: In this study, cellulose acetate fibers were modified and a composite adsorbent was developed for the adsorption of polycyclic aromatic hydrocarbons in water samples. The adsorbent exhibited good stability and could be used for up to 21 cycles of efficient extraction and desorption.
Article
Chemistry, Applied
Sirintorn Jullakan, Sakchaibordee Pinsrithong, Opas Bunkoed
Summary: A hierarchically porous composite was fabricated and utilized for dispersive liquid-solid phase extraction of polycyclic aromatic hydrocarbons (PAHs), achieving high extraction efficiency and stability with the ability for repeated use.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2022)
Article
Chemistry, Analytical
Ananya Kliangsuwan, Apichai Phonchai, Opas Bunkoed
Summary: A hierarchical composite adsorbent was used to extract, preconcentrate and determine sulfonamides. The zinc oxide carbon foam nanocomposite improved the adsorption, while the magnetic molecularly imprinted polymer provided specific recognition cavities and enabled easy separation. The developed strategy showed good linearity, low LOD and LOQ, and high extraction recoveries with low RSDs.
MICROCHEMICAL JOURNAL
(2022)
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)