Article
Genetics & Heredity
Kakeru Hisakane, Masahiro Seike, Teppei Sugano, Kuniko Matsuda, Takeru Kashiwada, Shinji Nakamichi, Masaru Matsumoto, Akihiko Miyanaga, Rintaro Noro, Kaoru Kubota, Akihiko Gemma
Summary: The study found that serum-derived exosomal miR-125a-3p can predict the efficacy of anti-PD-1/PD-L1 monoclonal antibody treatment in NSCLC patients. High expression of miR-125a-3p is associated with reduced progression-free and overall survival. Cell experiments also demonstrated that this miRNA regulates PD-L1 expression by suppressing neuregulin 1 (NRG1).
Article
Genetics & Heredity
Jingwei Ma, Meng Zhu, Xiaofeng Ye, Bo Wu, Tao Wang, Muyuan Ma, Tao Li, Ning Zhang
Summary: This study analyzed PSAT1-targeted miRNAs as a prognostic predictor for gastric cancer. The study found that PSAT1 expression was related to the clinical manifestations and prognosis of gastric cancer. Six microRNAs associated with gastric cancer were identified, and a model for predicting bone metastasis in gastric cancer was constructed.
FRONTIERS IN GENETICS
(2022)
Article
Multidisciplinary Sciences
Scott Ferguson, Katherine S. Yang, Piotr Zelga, Andrew S. Liss, Jonathan C. T. Carlson, Carlos Fernandez del Castillo, Ralph Weissleder
Summary: This study shows that tumor cell-derived extracellular vesicles (EVs) have potential as circulating biomarkers for early cancer detection. Single-EV analysis (sEVA) technique improves diagnostic accuracy for pancreatic cancer (PDAC), even when the levels of KRAS(mut) and P53(mut) proteins are low.
Review
Biochemistry & Molecular Biology
Israel Martinez-Espinosa, Jose Antonio Serrato, Blanca Ortiz-Quintero
Summary: The high mortality from lung cancer is mainly due to metastasis at the time of diagnosis. Recent research suggests that tumor cell exosomes play a significant role in tumor progression and metastasis. They release biologically active components to distant organs, directing tumor metastasis.
Article
Biochemistry & Molecular Biology
Anelis Maria Marin, Sibelle Botogosque Mattar, Rafaela Ferreira Amatuzzi, Roger Chammas, Miyuki Uno, Dalila Luciola Zanette, Mateus Nobrega Aoki
Summary: Pancreatic cancer is a leading cause of cancer-related death worldwide, and early diagnosis is crucial. Plasma microRNAs have emerged as potential non-invasive biomarkers for diagnosis and prognosis. This study identified specific microRNAs that were overexpressed in the plasma exosomes of pancreatic cancer patients, suggesting their potential as diagnostic and prognostic markers.
Article
Oncology
Lin Shi, Weiliang Zhu, Yuanyuan Huang, Lin Zhuo, Siyun Wang, Shaobing Chen, Bei Zhang, Bin Ke
Summary: This study found that exosomes released by cancer-associated fibroblasts (CAFs) can promote the progression and chemoresistance of non-small-cell lung cancer (NSCLC). Mechanistically, the exosomes transmit miR-20a to tumor cells, enhancing chemoresistance and proliferation by targeting PTEN.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Sofia V. Krylova, Daorong Feng
Summary: Exosomes are small membrane-contained vesicles secreted by cells, which play important roles in maintaining cellular homeostasis, facilitating intercellular communication, and removing cellular debris. They are being extensively studied as potential diagnostic markers and therapeutic targets in various diseases. However, the underlying mechanisms of exosome biogenesis, release and uptake are still largely unknown. This review aims to provide updated molecular details of these processes to facilitate the design of future impactful exosome experiments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Songjie Shen, Yu Song, Bin Zhao, Yali Xu, Xinyu Ren, Yidong Zhou, Qiang Sun
Summary: The study identified miR-7641 as a key miRNA in cancer-derived exosomes promoting tumor progression and metastasis via intercellular communication. Exosomal miR-7641 may serve as a non-invasive diagnostic biomarker and potential therapeutic target in breast cancer treatment.
CELL COMMUNICATION AND SIGNALING
(2021)
Article
Medicine, General & Internal
Jonas Dohmen, Alexander Semaan, Makbule Kobilay, Martin Zaleski, Vittorio Branchi, Anja Schlierf, Karina Hettwer, Steffen Uhlig, Gunther Hartmann, Jorg C. Kalff, Hanno Matthaei, Philipp Lingohr, Stefan Holdenrieder
Summary: The study compared the use of exosomal and free circulating microRNAs in colorectal adenocarcinoma, showing higher levels of microRNAs in the exosomal compartment with significant differences from the healthy control group. Combining multiple exosomal miRNAs can further enhance diagnostic sensitivity and specificity.
Article
Biochemistry & Molecular Biology
Dandan Zheng, Meng Cao, Siyu Zuo, Xin Xia, Chunchun Zhi, Yanbing Lin, Sitong Deng, Xiaoqin Yuan
Summary: High expression of RANBP1 in CRC is associated with poor prognosis, promoting cell proliferation and invasion, and influencing the expression of YAP by regulating miRNAs and the Hippo pathway, forming a positive feedback loop to enhance CRC progression.
Review
Oncology
Mohsen Karami Fath, Jalil Azami, Alireza Masoudi, Reza Mosaddeghi Heris, Elnaz Rahmani, Fatemeh Alavi, Armina Alagheband Bahrami, Zahra Payandeh, Bahman Khalesi, Masoomeh Dadkhah, Navid Pourzardosht, Vahideh Tarhriz
Summary: This review focuses on the role of exosomes in glioblastoma, highlighting their involvement in creating an immunosuppressive tumor microenvironment and their potential as therapeutic and diagnostic tools.
CANCER CELL INTERNATIONAL
(2022)
Article
Gastroenterology & Hepatology
Lei Sun, Arabella Wan, Zhuolong Zhou, Dongshi Chen, Heng Liang, Chuwei Liu, Shijia Yan, Yi Niu, Ziyou Lin, Siyue Zhan, Shanfeng Wang, Xianzhang Bu, Weiling He, Xiongbin Lu, Anlong Xu, Guohui Wan
Summary: The study identified an RNA-binding protein RALY as a critical regulator in colorectal cancer metabolism, promoting the post-transcriptional processing of miRNAs that downregulate metabolism-associated genes and reprogram mitochondrial metabolism in cancer cells. Increased levels of RALY were associated with poor prognosis in CRC patients expressing low levels of mitochondrion-associated genes, and this effect was facilitated by N6-methyladenosine switch under reactive oxygen species stress. Inhibition of m6A methylation abolished RALY recognition of pri-miRNAs, leading to inhibition of colorectal tumor growth and progression both in vivo and in organoid models.
Review
Biochemistry & Molecular Biology
Kwang-Min Lee, Eun-Chan Seo, Jeong-Hyung Lee, Hyo-Jin Kim, Cheol Hwangbo
Summary: Syntenin serves as an important adaptor and scaffold protein, participating in multiple signaling pathways and modulating cellular physiology. It plays a significant role in regulating exosome trafficking and communication between cells. Targeting the regulation mechanism of exosomes by syntenin-1 and microRNAs may provide a novel treatment strategy for cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Cell Biology
Seung Cho Lee, Robert A. Martienssen
Summary: Nuclear dicing bodies in plants are now understood as liquid-liquid phase-separated condensates driven by intrinsically disordered regions of the Dicing component SERRATE, which play a role in both phase separation and miRNA processing.
NATURE CELL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Mohsen Fathi, Melisa Martinez-Paniagua, Ken Chen, Ali Rezvan, Melisa J. Montalvo, Vakul Mohanty, Sendurai A. Mani, Navin Varadarajan
Summary: Excitatory cells play an important role in the neuronal circuits underlying feeding behavior in Drosophila. We show here that the activity of a subset of excitatory neurons expressing either neuropeptide F (NPF) or short neuropeptide F (sNPF) in the adult Drosophila brain is necessary for sleep homeostasis. These neurons promote sleep primarily through output signals downstream of the mushroom body output neurons.