期刊
PROGRESS IN NEUROBIOLOGY
卷 178, 期 -, 页码 6-30出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pneurobio.2019.03.003
关键词
ICH; Secondary injury; Inflammatory reaction; Cytokines
资金
- Key Research Project Program of Shandong Province of China [2016GSF201056]
- Shandong Provincial Natural Science Foundation of China [ZR2010HM041]
- National Institutes of Health [R01NS078026, R01AT007317, R01NS102583, R01NS105894]
- Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University
Intracerebral hemorrhage (ICH) is a common and severe cerebrovascular disease that has high mortality. Few survivors achieve self-care. Currently, patients receive only symptomatic treatment for ICH and benefit poorly from this regimen. Inflammatory cytokines are important participants in secondary injury after ICH. Increases in proinflammatory cytokines may aggravate the tissue injury, whereas increases in anti-inflammatory cytokines might be protective in the ICH brain. Inflammatory cytokines have been studied as therapeutic targets in a variety of acute and chronic brain diseases; however, studies on ICH are limited. This review summarizes the roles and functions of various pro- and anti-inflammatory cytokines in secondary brain injury after ICH and discusses pathogenic mechanisms and emerging therapeutic strategies and directions for treatment of ICH.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据