Article
Neurosciences
Erika J. Wolf, Xiang Zhao, Sage E. Hawn, Filomene G. Morrison, Zhenwei Zhou, Dana Fein-Schaffer, Bertrand Huber, Mark W. Miller, Mark W. Logue
Summary: Psychiatric stress is associated with accelerated epigenetic aging and increased expression of inflammation genes in the brain, potentially linking accelerated cellular aging to premature disease onset and neurodegeneration. This suggests that anti-inflammatory interventions may be crucial in preventing or delaying cellular aging and increasing resilience to diseases of aging.
NEUROBIOLOGY OF STRESS
(2021)
Article
Clinical Neurology
Agaz H. Wani, Allison E. Aiello, Grace S. Kim, Fei Xue, Chantel L. Martin, Andrew Ratanatharathorn, Annie Qu, Karestan Koenen, Sandro Galea, Derek E. Wildman, Monica Uddin
Summary: This study identified a core set of factors including prior PTSD, social adversity, and DNA methylation using machine learning approaches, which together may predispose individuals to PTSD. Multiple factors play a role in predicting prospective risk of PTSD, with prior PTSD being the most important predictor.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychology, Clinical
Anthony S. Zannas, Sarah D. Linnstaedt, Xinming An, Jennifer S. Stevens, Nathaniel G. Harnett, Alyssa R. Roeckner, Katelyn I. Oliver, David R. Rubinow, Elisabeth B. Binder, Karestan C. Koenen, Kerry J. Ressler, Samuel A. McLean
Summary: Psychological trauma exposure and PTSD are associated with advanced epigenetic age. This study found that epigenetic age measured at the time of trauma may predict the subsequent development of PTSD. The neural substrates underlying posttraumatic outcomes associated with epigenetic aging are unclear.
PSYCHOLOGICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Michael C. Owens, Celia Zhang, Kathy Fange Liu
Summary: Enzyme-mediated chemical modifications of nucleic acids play critical roles in gene expression regulation, and recent technological advances have greatly improved our ability to accurately detect and map these modifications. Current research focuses on techniques that allow precise detection and mapping of nucleic acid modifications, with the goal of guiding the development of future technologies.
Article
Medicine, Research & Experimental
Mina Adampourezare, Gholamreza Dehghan, Mohammad Hasanzadeh, Mohammad-Ali Hosseinpoure Feizi
Summary: DNA methylation is a crucial epigenetic alteration that can suppress gene expression and contribute to diseases like cancer. To rapidly and simply detect DNA methylation, new methods like microfluidic platforms and lateral flow strip tests have been developed in recent years.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemical Research Methods
Christos Maniatis, Catalina Vallejos, Guido Sanguinetti
Summary: Single-cell multi-omics assays provide unprecedented opportunities to explore epigenetic regulation at the cellular level. However, high levels of technical noise and data sparsity often result in a lack of statistical power in correlative analyses. SCRaPL is a novel computational tool that addresses this issue by carefully modeling noise in the experimental systems.
PLOS COMPUTATIONAL BIOLOGY
(2022)
Review
Engineering, Marine
Licheng Qin, Xiaodong Bai, Hanbing Luo, Huailiang Li, Hongyan Ding
Summary: This paper presents a literature review on the research and technical challenges of floatover installations. Various floatover installation methods and concepts are reviewed, along with the exclusive mating units and related guidelines. The investigations in respect of measurements, modeling, and tests are discussed, as well as the gaps between practices and research. Finally, future developments and refinements in modeling techniques are envisioned.
Review
Psychiatry
Cao-Lei Lei, Daniel Saumier, Justine Fortin, Alain Brunet
Summary: Epigenetic research in PTSD examines the role of environmental stressors and fear in the disorder's development, providing insights into individual differences in prevalence and treatment response. The review discusses epigenetic markers associated with PTSD and treatment, as well as animal research on fear memory acquisition, update, and erasure. It also highlights the potential use of reconsolidation blockade as a treatment for PTSD and the challenges in studying epigenetics in humans.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Construction & Building Technology
Yaxin Tao, A. V. Rahul, Manu K. Mohan, Geert De Schutter, Kim Van Tittelboom
Summary: In this paper, the performance of CSA cement is comprehensively reviewed, including its hydration mechanism, mechanical performance, and long-term durability. The different types of CSA cement and their manufacturing process are introduced, followed by a detailed discussion on the hydration mechanisms and phase assemblage, mechanical performance, and long-term durability of CSA cement. Finally, the applications of CSA cement are discussed.
CEMENT & CONCRETE COMPOSITES
(2023)
Article
Psychology, Clinical
Sage E. Hawn, Zoe Neale, Erika J. Wolf, Xiang Zhao, Meghan Pierce, Dana Fein-Schaffer, William Milberg, Regina McGlinchey, Mark Logue, Mark W. Miller
Summary: This study found that methylation of the AIM2 gene mediates the association between symptoms of posttraumatic stress disorder (PTSD) and inflammatory and neuropathology markers. The results suggest that AIM2 methylation may have clinical utility for assessing the risk of adverse health outcomes associated with these peripheral indices of inflammation and neuropathology.
DEPRESSION AND ANXIETY
(2022)
Review
Biochemistry & Molecular Biology
Ghazi I. Al Jowf, Clara Snijders, Bart P. F. Rutten, Laurence de Nijs, Lars M. T. Eijssen
Summary: Exposure to trauma is a major risk factor for mental and physical health, with individuals showing varying susceptibility to developing mental illness after exposure. Epigenetic changes are suggested to play a role in the relationship between traumatic stress exposure and vulnerability to developing PTSD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Evi Lianidou
Summary: Liquid biopsy combined with DNA methylation is a powerful method to identify early cancer biomarkers. Blood-based epigenetic biomarkers have high potential for early cancer detection.
MOLECULAR ONCOLOGY
(2021)
Review
Pharmacology & Pharmacy
Zhixiong Zhang, Guan Wang, Yuyan Li, Dongsheng Lei, Jin Xiang, Liang Ouyang, Yanyan Wang, Jinliang Yang
Summary: DNA methylation is an important epigenetic process that regulates gene expression and has become a promising target for cancer treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Psychiatry
Khethelo R. Xulu, Jacqueline S. Womersley, Jessica Sommer, Martina Hinsberger, Thomas Elbert, Roland Weierstall, Debbie Kaminer, Stefanie Malan-Muller, Soraya Seedat, Sian M. J. Hemmings
Summary: The study found that psychotherapeutic interventions can reduce PTSD and AA symptoms in South African men with chronic trauma exposure. The FORNET group showed a significant reduction in PTSD and AA symptom severity at 8 and 16 months compared to baseline. Increased methylation of genes related to dopaminergic neurotransmission (NR4A2) and synaptic plasticity (AUTS2) was associated with reduced PTSD symptoms in participants receiving FORNET therapy.
PSYCHIATRY RESEARCH
(2021)
Article
Clinical Neurology
Hudson P. Santos, Harry Adynski, Rebeca Harris, Arjun Bhattacharya, Angela C. Incollingo Rodriguez, Ryan Cali, Alessandra Torres Yabar, Benjamin C. Nephew, Christopher Murgatroyd
Summary: This study explores the complex relationships among psychological distress symptoms, psychosocial factors, and biological factors in Latina women during pregnancy and postpartum period. Everyday discrimination has the strongest and most consistent association with psychological distress. DNA methylation of NR3C1 impacts the associations between psychological and psychosocial distress.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Neurosciences
Mark W. Miller
NEUROSCIENCE LETTERS
(2020)
Article
Biochemistry & Molecular Biology
Gang Li, Laura Raffield, Mark Logue, Mark W. Miller, Hudson P. Santos, T. Michael O'Shea, Rebecca C. Fry, Yun Li
Summary: DNA methylation at CpG dinucleotides is a well-studied epigenetic mark, and the CpG impUtation Ensemble (CUE) is a valuable tool for imputing CpG methylation from the Illumina HumanMethylation450 (HM450) BeadChip to the Illumina HumanMethylationEPIC (HM850) BeadChip, achieving high accuracy in predicting methylation levels.
Article
Neurosciences
Erika J. Wolf, Ci-Di Chen, Xiang Zhao, Zhenwei Zhou, Filomene G. Morrison, Nikolaos P. Daskalakis, Annjanette Stone, Steven Schichman, Jaclyn Garza Grenier, Dana Fein-Schaffer, Bertrand R. Huber, Carmela R. Abraham, Mark W. Miller, Mark W. Logue
Summary: This study found that a specific polymorphism of the longevity gene klotho (KL), rs9315202, interacted with posttraumatic stress disorder (PTSD) to predict advanced epigenetic age in the motor cortex. Additionally, alcohol abuse was associated with advanced epigenetic age in the motor cortex. The results suggest that alterations in the KL gene may operate through long noncoding RNA to affect KL gene expression.
NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Neurosciences
Jasmeet P. Hayes, Meghan E. Pierce, Kate E. Valerio, Mark W. Miller, Bertrand Russell Huber, Catherine B. Fortier, Jennifer R. Fonda, William Milberg, Regina McGlinchey
Summary: This study found positive correlations between traumatic stress, affective, somatic, and metabolic latent variables and systemic inflammation levels, with the most significant relationship between war-zone blast exposures and metabolic dysregulation. Blast exposure was associated with metabolic dysregulation in a dose-response manner, with closer blast proximity linked to the greatest metabolic dysregulation.
NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Neurosciences
Mark W. Logue, Zhenwei Zhou, Filomene G. Morrison, Erika J. Wolf, Nikolaos P. Daskalakis, Christos Chatzinakos, Foivos Georgiadis, Adam T. Labadorf, Matthew J. Girgenti, Keith A. Young, Douglas E. Williamson, Xiang Zhao, Jaclyn Garza Grenier, Bertrand Russell Huber, Mark W. Miller
Summary: This study identified several novel PTSD-associated genes and brain region-specific PTSD-associated immune-related networks. Replication of dlPFC associations in an independent cohort from a recent study showed a strong correlation between the dlPFC PTSD effect sizes for significant genes in the two studies.
NEUROBIOLOGY OF STRESS
(2021)
Article
Psychology, Clinical
Sage E. Hawn, Zoe Neale, Erika J. Wolf, Xiang Zhao, Meghan Pierce, Dana Fein-Schaffer, William Milberg, Regina McGlinchey, Mark Logue, Mark W. Miller
Summary: This study found that methylation of the AIM2 gene mediates the association between symptoms of posttraumatic stress disorder (PTSD) and inflammatory and neuropathology markers. The results suggest that AIM2 methylation may have clinical utility for assessing the risk of adverse health outcomes associated with these peripheral indices of inflammation and neuropathology.
DEPRESSION AND ANXIETY
(2022)
Article
Psychiatry
Sage E. Hawn, Xiang Zhao, Danielle R. Sullivan, Mark Logue, Dana Fein-Schaffer, William Milberg, Regina McGlinchey, Mark W. Miller, Erika J. Wolf
Summary: The study found that psychopathology is associated with accelerated biological aging and early mortality risk. Externalizing psychopathology significantly predicted GrimAge residuals in both cohorts, while PTSD predicted GrimAge residuals in the younger cohort.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Genetics & Heredity
Jasmeet Pannu Hayes, Meghan E. Pierce, Emma Brown, David Salat, Mark W. Logue, Julie Constantinescu, Kate Valerio, Mark W. Miller, Richard Sherva, Bertrand Russell Huber, William Milberg, Regina McGlinchey
Summary: The aim of this study was to investigate cortical thinning associated with genetic risk for Alzheimer's disease (AD) in middle-aged military veterans. The findings suggest that higher genetic risk for AD is associated with accelerated cortical thinning, particularly in the right hemisphere inferior parietal cortex. Additionally, plasma tau levels are related to cortical thinning, while mild traumatic brain injury and posttraumatic stress disorder are not.
NEUROLOGY-GENETICS
(2023)
Correction
Psychiatry
Sage E. Hawn, Xiang Zhao, Danielle R. Sullivan, Mark Logue, Dana Fein-Schaffer, William Milberg, Regina McGlinchey, Mark W. Miller, Erika J. Wolf
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Psychology, Clinical
Erika J. Wolf, Diana M. Higgins, Xiang Zhao, Sage E. Hawn, Victoria Sanborn, Catherine A. Todd, Dana Fein-Schaffer, Antoun Houranieh, Mark W. Miller
Summary: This study investigated the relationship between chronic pain, PTSD, and psychological factors in military Veterans. The findings indicated that Veterans with chronic pain and probable PTSD had elevated symptom scores, and that all symptom scales were more strongly correlated with pain interference than severity. Moreover, there was a significant association between self-rated pain interference and physical performance.
JOURNAL OF CLINICAL PSYCHOLOGY IN MEDICAL SETTINGS
(2023)
Article
Psychology, Clinical
Erika J. Wolf, Sage E. Hawn, Danielle R. Sullivan, Mark W. Miller, Victoria Sanborn, Emma Brown, Zoe Neale, Dana Fein-Schaffer, Xiang Zhao, Mark W. Logue, Catherine B. Fortier, Regina E. McGlinchey, William P. Milberg
Summary: This study investigated the psychometric evidence for the dissociative subtype of PTSD in a sample of young, primarily male post-9/11-era Veterans and evaluated its biological correlates with respect to resting state functional connectivity, brain morphology, neurocognitive functioning, and genetic variation. The results suggested a class structure for dissociation symptoms to be superior, and a small percentage of the sample (7.5%) belonged to the dissociative class, which showed stability over time. The study also found specific biological structures and systems associated with the dissociative subtype of PTSD.
JOURNAL OF PSYCHOPATHOLOGY AND CLINICAL SCIENCE
(2023)
Article
Immunology
Erika J. Wolf, Mark W. Miller, Sage E. Hawn, Xiang Zhao, Sara E. Wallander, Beth McCormick, Christine Govan, Ann Rasmusson, Annjanette Stone, Steven A. Schichman, Mark W. Logue
Summary: Traumatic stress is associated with accelerated epigenetic age and increased risk for dementia. The advanced epigenetic age might be linked to dementia-associated biomarkers. Externalizing comorbidity is associated with accelerated epigenetic age, which in turn is associated with subsequent increases in neuropathology and inflammatory markers. Advanced epigenetic age and neuropathology biomarkers are associated with worse cognitive function.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Psychology, Clinical
Stephanie Ellickson-Larew, Shaline Escarfulleri, Erika J. Wolf
PSYCHOLOGICAL INJURY & LAW
(2020)
Article
Clinical Neurology
Nadia Deflorin, Ulrike Ehlert, Rita T. Amiel Castro
Summary: Changes in the gut microbiome of infants have been associated with maternal psychological symptoms during pregnancy. This study found that maternal prenatal depressive symptoms are associated with lower diversity of the infant's microbiome, while maternal saliva cortisol levels are linked to increased diversity and changes in specific bacterial groups. Further research is needed to understand the implications of these microbiota alterations for child health.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Zheng Ma, Hui-Xia Zhou, Da-Chun Chen, Dong-Mei Wang, Xiang-Yang Zhang
Summary: The impaired glucose metabolism in drug-na & iuml;ve schizophrenia patients is strongly associated with suicidal behavior, suggesting that glucose metabolism abnormalities may be potential biomarkers of suicide in schizophrenia patients. Regular monitoring of glucose metabolism variables is essential for suicide prevention.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Katie M. Lavigne, Jiaxuan Deng, Delphine Raucher-Chene, Adele Hotte-Meunier, Chloe Voyer, Lisa Sarraf, Martin Lepage, Genevieve Sauve
Summary: Psychiatric disorders are characterized by cognitive deficits and cognitive biases, which are associated with specific symptoms. While cognitive biases are present across diagnoses, their severity varies.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Yong-Yu Yin, Jiao-Zhao Yan, Shi-Xin Lai, Qian-Qian Wei, Si-Rui Sun, Li-Ming Zhang, Yun-Feng Li
Summary: This study found that gamma oscillations are closely associated with depression and may serve as predictive biomarkers of depression. Chronic restraint stress and lipopolysaccharide induced significant depression-like behaviors in mice and reduced gamma oscillations in the medial prefrontal cortex. Administration of ketamine, scopolamine, or fluoxetine increased gamma oscillations and exhibited rapid-acting antidepressant effects.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Veronica Begni, Moira Marizzoni, Kerstin Camile Creutzberg, Diana Morena Silipo, Mariusz Papp, Annamaria Cattaneo, Marco Andrea Riva
Summary: Exposure to stressful experiences is a significant risk factor for mental disorders, and pharmacological interventions targeting stress-induced alterations can help restore brain function. Lurasidone, an antipsychotic drug, has been shown to normalize the impairments caused by stress exposure and could be a valuable treatment for stress-induced mental illnesses. However, the mechanisms underlying the therapeutic effects of lurasidone are not well understood. This study found that chronic lurasidone treatment counteracted some of the transcriptional changes induced by chronic mild stress exposure, providing new insights into the potential therapeutic effects of lurasidone.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Esther E. Palacios-Barrios, Kunal Patel, Jamie L. Hanson
Summary: This review examines the association between early life interpersonal stress (ELIS) and depression, as well as the underlying mechanisms. The research shows that ELIS affects how youth respond to social rewards, and similar impairments in social reward processing are observed in youth with depression. The authors propose a preliminary model that suggests neurobehavioral disruptions in social reward processing as a mediating factor in the connection between ELIS and depression.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Rui Li, Jiaming Tang, Yizhuo Wang, Ying Wang, Hua Yang, Hongen Wei
Summary: Restricted and repetitive behaviors (RRBs) are characteristic features of neuropsychiatric disorders. This study focused on repetitive self-grooming behavior and investigated the involvement of the Pax2 gene in its control. Through the use of Pax2 neuron-specific deletion mice, the study found that the deletion of Pax2 gene affects the expression of the Arc gene in the prefrontal cortex, leading to impaired synaptic plasticity and excitatory/inhibitory imbalance, thereby contributing to the occurrence of repetitive self-grooming behavior.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Sara Derosa, Paulina Misztak, Jessica Mingardi, Giulia Mazzini, Heidi Kaastrup Muller, Laura Musazzi
Summary: This study investigated the involvement of neurotrophic signaling pathways in stress vulnerability/resilience and fast antidepressant response/non-response to ketamine in a rat model of depression. The findings showed that stress and ketamine induced specific changes in these pathways in different brain areas and subcellular fractions.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Review
Clinical Neurology
Georgia F. Caruana, Sean P. Carruthers, Michael Berk, Susan L. Rossell, Tamsyn E. Van Rheenen
Summary: Cognitive impairment is related to both white matter macrostructure and microstructure in bipolar disorder patients. However, there is inconsistency in the results of the studies examining this relationship. Some studies have found an association between higher fractional anisotropy in white matter and better complex attention skills and executive functioning in bipolar disorder patients, while others have found no associations. Further research with increased statistical power and standardized methods is needed.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Review
Clinical Neurology
Alberto Galimberti, Martin Tik, Giovanni Pellegrino, Anna-Lisa Schuler
Summary: This study provides a systematic review and meta-analysis on the effectiveness of repetitive transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) for post-traumatic brain injury (TBI) symptoms. The results show that non-invasive brain stimulation techniques have a small overall effect on TBI sequelae, with significant effects observed for anxiety and headache. However, larger randomized controlled trials with longer follow-ups, optimized stimulation parameters, and standardized methodology are needed to establish the efficacy of these techniques in addressing TBI sequelae.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Amanda J. Sales, Pedro H. Gobira, Joa F. C. Pedrazzi, Joao R. Silveia, Elaine Del Bel, Felipe V. Gomes, Francisco S. Guimaraes
Summary: The study found that doxycycline can inhibit metalloproteinase in the brain and attenuate the rewarding effects and locomotor sensitization of drug abuse. This suggests that doxycycline could be repurposed for the treatment of substance use disorders.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Alejandro Borrego-Ruiz, Juan J. Borrego
Summary: There is substantial evidence that the development of the nervous system is related to the composition and functions of the gut microbiome. The communication between the central nervous system (CNS) and the gut microbiota is bidirectional, with various routes such as immune, endocrine, and neural circuits. Dysbiosis of the gut microbiota has been associated with neuropsychiatric diseases and psychological disorders. Fecal microbiota transplantation (FMT) therapy has shown a causal-effect relationship between the gut microbiota and behavioral features. Interventions based on prebiotics, probiotics, or synbiotics have demonstrated their influence on neurological disorders through the synthesis of neuroactive compounds and regulation of inflammatory and endocrine processes. Further research is needed to explore the impact of gut microbiota dysbiosis on psychiatric and psychological disorders and the potential therapeutic role of microbiota-based interventions.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Zhinan Li, Zhuang Kang, Xiaowei Xia, Leijun Li, Junyan Wu, Jiamin Dai, Tong Liu, Cai Chen, Yong Qiu, Ming Chen, Yanxi Liu, Ziyi Zhang, Zili Han, Zhengjia Dai, Qinling Wei
Summary: This study found that patients with schizophrenia showed lower levels of resilience and cognitive functions compared to healthy controls, as well as abnormal global properties and nodal metrics in brain networks. Furthermore, characteristic path length might moderate the relationship between resilience and working memory in these patients.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
David H. Adamowicz, Tsung-Chin Wu, Rebecca Daly, Michael R. Irwin, Dilip Jeste, Xin M. Tu, Lisa T. Eyler, Ellen E. Lee
Summary: This study aimed to explore the relationship between executive functioning and inflammatory biomarkers in people with schizophrenia. The results showed that systemic inflammation did not predict long-term declines in executive functioning. This suggests the need for further research to better understand the relationship and mechanisms between inflammation and cognition in schizophrenia.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Nina Walter, Julian Wenzel, Shalaila S. Haas, Letizia Squarcina, Carolina Bonivento, Anne Ruef, Dominic Dwyer, Theresa Lichtenstein, Oeznur Bastruek, Alexandra Stainton, Linda A. Antonucci, Paolo Brambilla, Stephen J. Wood, Rachel Upthegrove, Stefan Borgwardt, Rebekka Lencer, Eva Meisenzahl, Raimo K. R. Salokangas, Christos Pantelis, Alessandro Bertolino, Nikolaos Koutsouleris, Joseph Kambeitz, Lana Kambeitz-Ilankovic
Summary: Clinical and neuroimaging data can be used to predict the potential of cognitive training to improve social functioning in recent onset psychosis patients. The use of multivariate pattern analysis and support vector machine classifier allows for the prediction of social functioning improvement based on baseline cognitive data. The findings suggest that cognitive data can provide a robust individual estimate of future social functioning for patients with recent onset psychosis.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
