Hydrogen exchange reveals Hsp104 architecture, structural dynamics, and energetics in physiological solution

Reference Parameters for Protein Hydrogen Exchange Rates

(2018) David Nguyen et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Folding of maltose binding protein outside of and in GroEL

(2018) Xiang Ye et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of Calcarisporiella thermophila Hsp104 Disaggregase that Antagonizes Diverse Proteotoxic Misfolding Events

(2018) Karolina Michalska et al.   STRUCTURE

Ratchet-like polypeptide translocation mechanism of the AAA+ disaggregase Hsp104

(2017) Stephanie N. Gates et al.   SCIENCE

Mechanistic and Structural Insights into the Prion-Disaggregase Activity of Hsp104

(2016) Elizabeth A. Sweeny et al.   JOURNAL OF MOLECULAR BIOLOGY

Spiral architecture of the Hsp104 disaggregase reveals the basis for polypeptide translocation

(2016) Adam L Yokom et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Spiral architecture of the Hsp104 disaggregase reveals the basis for polypeptide translocation

(2016) Adam L Yokom et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Disparate Mutations Confer Therapeutic Gain of Hsp104 Function

(2015) Meredith E. Jackrel et al.   ACS Chemical Biology

The Hsp104 N-Terminal Domain Enables Disaggregase Plasticity and Potentiation

(2015) Elizabeth A. Sweeny et al.   MOLECULAR CELL

ClpB N-terminal domain plays a regulatory role in protein disaggregation

(2015) Rina Rosenzweig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spring-loaded unraveling of a single SNARE complex by NSF in one round of ATP turnover

(2015) J.-K. Ryu et al.   SCIENCE

Potentiated Hsp104 Variants Antagonize Diverse Proteotoxic Misfolding Events

(2014) Meredith E. Jackrel et al.   CELL

Conserved Distal Loop Residues in the Hsp104 and ClpB Middle Domain Contact Nucleotide-binding Domain 2 and Enable Hsp70-dependent Protein Disaggregation

(2013) Morgan E. DeSantis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein hydrogen exchange at residue resolution by proteolytic fragmentation mass spectrometry analysis

(2013) Z.-Y. Kan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stepwise protein folding at near amino acid resolution by hydrogen exchange and mass spectrometry

(2013) W. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Operational Plasticity Enables Hsp104 to Disaggregate Diverse Amyloid and Nonamyloid Clients

(2012) Morgan E. DeSantis et al.   CELL

Minimizing Back Exchange in the Hydrogen Exchange-Mass Spectrometry Experiment

(2012) Benjamin T. Walters et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

The elusive middle domain of Hsp104 and ClpB: Location and function

(2011) Morgan E. DeSantis et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

ExMS: Data Analysis for HX-MS Experiments

(2011) Zhong-Yuan Kan et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Many Overlapping Peptides for Protein Hydrogen Exchange Experiments by the Fragment Separation-Mass Spectrometry Method

(2011) Leland Mayne et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

CryoEM structure of Hsp104 and its mechanistic implication for protein disaggregation

(2010) S. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Motor Mechanism for Protein Threading through Hsp104

(2009) Petra Wendler et al.   MOLECULAR CELL

The C-terminal Extension ofSaccharomyces cerevisiaeHsp104 Plays a Role in Oligomer Assembly†

(2008) Ryder G. Mackay et al.   BIOCHEMISTRY

Peptide and Protein Binding in the Axial Channel of Hsp104

(2008) Ronnie Lum et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Substrate threading through the central pore of the Hsp104 chaperone as a common mechanism for protein disaggregation and prion propagation

(2008) Peter Tessarz et al.   MOLECULAR MICROBIOLOGY

Hsp104 and ClpB: protein disaggregating machines

(2008) Shannon M. Doyle et al.   TRENDS IN BIOCHEMICAL SCIENCES