Article
Materials Science, Multidisciplinary
Dilong Liu, Rashed Aleisa, Zepeng Cai, Yue Li, Yadong Yin
Summary: Controllable assembly of molecular and nanoscale building blocks into uniform superstructures up to bulk dimensions is achieved through the self-assembly process using transient aqueous emulsion droplets. This method allows for the super-structuring of various types and shapes of nanoparticles, biomolecules, and inorganic compounds without the need for surfactants and chemical modifications, offering versatility, scalability, low-cost, and accurate positioning for advanced precision manufacturing in the future.
Article
Chemistry, Multidisciplinary
Yanfang Hu, Yonglong Li, Linfeng Yu, Yuying Zhang, Yuming Lai, Wei Zhang, Wei Xie
Summary: A universal assembly methodology for preparing hetero-superstructures is introduced in this study, enabling the assembly of building block materials without the need for molecular linkers and utilizing surface property modulation to achieve self-organization. The resulting superstructures exhibit superior photocatalytic activity and Raman scattering performance.
Article
Multidisciplinary Sciences
Zaiwang Zhao, Yujuan Zhao, Runfeng Lin, Yuzhu Ma, Lipeng Wang, Liangliang Liu, Kun Lan, Jie Zhang, Hanxing Chen, Mengli Liu, Fanxing Bu, Pengfei Zhang, Liang Peng, Xingmiao Zhang, Yupu Liu, Chin-Te Hung, Angang Dong, Wei Li, Dongyuan Zhao
Summary: We report on the fabrication of three-dimensional hierarchical core-satellite SiO2@monomicelle spherical superstructures through a previously unexplored monomicelle interfacial super-assembly route. The ultrathin single layer of monomicelle subunits with hexagon-like regular discontinuous distribution on solid spherical interfaces can be achieved, and the number of monomicelles on colloidal SiO2 interfaces can be quantitatively controlled. This strategy provides a controllable way for building multiscale hierarchical regular micro- and/or macroscale materials and devices.
Article
Chemistry, Multidisciplinary
Zaiwang Zhao, Linlin Duan, Yujuan Zhao, Lipeng Wang, Junye Zhang, Fanxing Bu, Zhihao Sun, Tengsheng Zhang, Mengli Liu, Hanxing Chen, Yi Yang, Kun Lan, Zirui Lv, Lianhai Zu, Pengfei Zhang, Renchao Che, Yun Tang, Dongliang Chao, Wei Li, Dongyuan Zhao
Summary: In this study, a method for fabricating three-dimensional mesoporous N-doped carbon superstructures with controllable morphology and adjustable pore structure was reported. The superstructures possess a large hollow, spherical mesopores, and interconnected porous structure, exhibiting high accessible surface area and good underwater aerophilicity.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Korath Shivan Sugi, Amritha P. P. Sandra, Nonappa, Debasmita Ghosh, Jyoti Sarita Mohanty, Murugesan Paulthangam Kannan, B. S. Sooraj, Pillalamarri Srikrishnarka, Jayoti Roy, Wakeel Ahmed Dar, Thalappil Pradeep
Summary: Orthogonal self-assembly is used to create complex superstructures from atomically precise silver nanoclusters, and the process is tunable by controlling the molar ratio of the ligand. The resulting nanostructures exhibit enhanced NIR emission due to restricted intramolecular motion.
Review
Oncology
Goknur Kara, Banu Arun, George A. Calin, Bulent Ozpolat
Summary: The discovery of microRNAs has revolutionized cancer treatment and their effective and safe delivery remains a challenge. New nanoparticle-based carriers have enabled successful tumor-targeted delivery of miRNA therapeutics, accelerating the transition of miRNAs from the lab to the bedside.
Article
Multidisciplinary Sciences
Zhiwei Li, Qingsong Fan, Zuyang Ye, Chaolumen Wu, Zhongxiang Wang, Yadong Yin
Summary: Colloidal assembly into chiral superstructures can be achieved rapidly and with materials of any chemical compositions and sizes using magnetic assembly techniques. The chiral superstructures are controlled by the strength of the magnetic field and the orientation of the magnets. Moreover, the chirality can be transferred to achiral molecules by incorporating guest molecules into the magnetic nanostructures.
Article
Chemistry, Multidisciplinary
Tong Bian, Andrea Gardin, Julius Gemen, Lothar Houben, Claudio Perego, Byeongdu Lee, Nadav Elad, Zonglin Chu, Giovanni M. Pavan, Rafal Klajn
Summary: The use of small molecules with electric charges can effectively induce attractive interactions between oppositely charged nanoparticles in water, guiding their assembly into colloidal crystals. This approach offers a facile way to fabricate, manipulate, and investigate nanostructured materials in aqueous environments.
Article
Chemistry, Multidisciplinary
Jun Zhang, Renaud A. L. Vallee, Zdravko Kochovski, Wei Zhang, Chen Shen, Florian Bertram, Nicola Pinna
Summary: In this study, chiral CuO superstructures are used as a model system to investigate the formation process of hierarchical chiral structures. The research reveals the chiral transfer mechanism between inorganic compounds and chiral organic additives. The morphology evolution of the chiral superstructure involves hierarchical assembly at different growth stages. Moreover, the study successfully reproduced the structural chirality through electro-dynamical simulations and predicted its modulation.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Multidisciplinary Sciences
Dengping Lyu, Wei Xu, Nansen Zhou, Wendi Duan, Zhisheng Wang, Yijiang Mu, Renjie Zhou, Yufeng Wang
Summary: Soft-and-hard hybrid structures have been challenging to realize at microscale due to material integration and actuation difficulties. In this research, microscale superstructures consisting of soft and hard materials were created through simple colloidal assembly. The resulting structures, referred to as MicroSpine, demonstrated thermoresponsive shape-transforming properties and served as microactuators. By solidifying the liquid parts within the chains with prescribed patterns, various chain morphologies were designed to achieve controlled actuating behaviors. The chains were further used to construct colloidal capsules for temperature-programmed encapsulation and release of guests.
Article
Chemistry, Physical
Rebeca Fortes Martin, Claudia Prietzel, Joachim Koetz
Summary: In this study, bimetallic magnetite-gold nanostructures were synthesized using microemulsions, with different types of nanoparticles modulating the morphology and surfactant film properties. Phase separation into Winsor phases allowed the formation of micrometer-scale bimetallic heterostructures upon solvent evaporation.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Andreas Frank, Christian Hils, Melina Weber, Klaus Kreger, Holger Schmalz, Hansooo-Werner Schmidt
Summary: By matching the functional groups of the surface patches on polymer fibers with the corresponding substituents of BTAs, specific superstructures can be induced.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Nanoscience & Nanotechnology
Huimin Zhou, Yao Jiang, Wenjing Zhao, Shusheng Zhang
Summary: In this study, a light-activated nanodevice based on DNA nanotechnology was constructed for high precision detection of low-abundance miRNA. The nanodevice enabled on-demand imaging of miRNA in living cells with high spatial and temporal control.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Shan She, Weimin Xuan, Nicola L. Bell, Robert Pow, Eduard Garrido Ribo, Zoe Sinclair, De-Liang Long, Leroy Cronin
Summary: This research utilizes oligopeptides as structure-directing ligands to modulate the self-assembly of POM superstructures via metal-coordination and hydrogen bonded interactions. It is found that changing the N-terminal amino acid on the peptide chain can readily switch the helicity of the nanowheel. Additionally, a delicate balance between Mo-coordination and hydrogen bonds within the internal cavity of the inorganic nanowheels leads to the sequence mediated formation of two unprecedented asymmetrical nanowheel frameworks: {Mo122Ce5} and {Mo126Ce4}.
Article
Chemistry, Multidisciplinary
Bishnu P. Khanal, Eugene R. Zubarev
Summary: This study describes a universal method for the spontaneous self-assembly of nanostructures into ring-like superstructures. The method is applicable to nanostructures of different shapes, sizes, and surface materials. By changing the solvent and surface ligands, the formation of self-assembled structures can be controlled.
Article
Chemistry, Analytical
Xiaofang Li, Liqiang Liu, Lingling Guo, Liguang Xu, Hua Kuang, Chuanlai Xu
Summary: Researchers developed a fast and sensitive method for detecting nicotine in e-cigarette oils using anti-NCT monoclonal antibodies and a colloidal gold immunochromatographic strip. The method showed high reliability and rapidity for on-site screening.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Review
Chemistry, Multidisciplinary
Junyoung Kwon, Ki Hyun Park, Won Jin Choi, Nicholas A. Kotov, Jihyeon Yeom
Summary: Chirality is found in various scales in the universe and living creatures. This article discusses the state of the art spectroscopic methods for analyzing chiral nanomaterials at different photon wavelengths, with a focus on self-organized hierarchical chirality and single-particle spectroscopy.
ACCOUNTS OF CHEMICAL RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Anastasia Visheratina, Alexander Visheratin, Prashant Kumar, Michael Veksler, Nicholas A. Kotov
Summary: Nanoscale chirality is a rapidly advancing research field that studies the properties and activities of chiral nanostructures. Computational identification of chirality from electron microscopy images is challenging due to ambiguity in differentiating left-handed and right-handed particles and the two-dimensional projection of the three-dimensional structure. In this study, deep learning algorithms were shown to accurately identify and classify twisted bowtie-shaped microparticles as left-handed or right-handed. The algorithm, trained on a small set of electron microscopy images, demonstrated the ability to recognize other chiral shapes with high accuracy, indicating its true learning abilities.
Article
Chemistry, Multidisciplinary
E. Sumeyra Turali-Emre, Ahmet E. Emre, Drew A. Vecchio, Usha Kadiyala, J. Scott VanEpps, Nicholas A. Kotov
Summary: Self-assembled multicompartment supraparticles (mSPs) are formed from FeS2 nanoparticles (NPs) stabilized by l-cysteine. These mSPs contain approximately 340 interconnected compartments with an average size of approximately 5 nm, encapsulating biological cargo such as DNA. The temperature stability of the DNA cargo is enhanced compared to traditional delivery vehicles, making biomimetic compartmentalized particles a promising tool for various bioapplications.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Medicinal
Prashant Kumar, Alexander Simon, Nicholas A. Kotov
Summary: Circularly polarized light interacts with biomolecules to generate spectral fingerprints reflecting their structure. Coupling biomolecules with noble metal plasmonic assemblies transfers the spectral features to visible and near-infrared regions. Nanoscale gold tetrahelices can detect chiral objects 40 times smaller in size using plane-polarized light. Chiral hotspots between tetrahelices differentiate between weakly scattering S- and R-molecules. Simulations show enantiomeric discrimination with selectivity up to 0.54.
Article
Multidisciplinary Sciences
Inho Song, Jaeyong Ahn, Hyungju Ahn, Sang Hyuk Lee, Jianguo Mei, Nicholas A. Kotov, Joon Hak Oh
Summary: In this study, a simple and powerful method was used to fabricate chiroptical flexible layers through supramolecular helical ordering of conjugated polymer chains. The multiscale chirality and optical activity of these layers can be varied across a broad spectral range by chiral templating. After template removal, chromophores remain in one-dimensional helical nanofibrils, producing a homogeneous chiroptical layer with drastically enhanced polarization-dependent absorbance, enabling well-resolved detection and visualization of the spin angular momentum (SAM) of photons. This study provides a scalable path towards on-chip detection of the spin degree of freedom of photons necessary for encoded quantum information processing and high-resolution polarization imaging.
Article
Chemistry, Multidisciplinary
Aihua Qu, Qiwen Chen, Maozhong Sun, Liguang Xu, Changlong Hao, Chuanlai Xu, Hua Kuang
Summary: Excessive accumulation of ROS can cause oxidative stress and damage, leading to aging and age-related diseases. This study introduces MnO2 nanoparticles that can monitor and eliminate ROS in real-time, providing a new strategy for the diagnosis and treatment of age-related diseases.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Sung-Won Hwang, Chung-Man Lim, Cong Truc Huynh, Hossein Moghimianavval, Nicholas A. Kotov, Eben Alsberg, Allen P. Liu
Summary: This study presents a strategy to confer mechano-responsive behavior on hydrogels by embedding hybrid vesicles. Under mechanical stress, these vesicles release encapsulated compounds that control the hydrogel network, offering promise for diverse biomedical applications.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Dan Meng, Chen Li, Changlong Hao, Wenxiong Shi, Jun Xu, Maozhong Sun, Hua Kuang, Chuanlai Xu, Liguang Xu
Summary: In this study, chiral selenium nanoparticles were synthesized using cysteine and the interfacial assembly strategy, leading to the generation of self-assembled nanomembranes with controllable morphology and handedness on a large scale. The nanomembranes demonstrated ultrasensitive recognition of enantioselective kynurenine (Kyn) and could accurately distinguish L-Kyn in serum and cerebrospinal fluid samples from Alzheimer's disease patients and healthy subjects.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Jiarong Cai, An-An Liu, Xue-Hui Shi, Haohao Fu, Wei Zhao, Liguang Xu, Hua Kuang, Chuanlai Xu, Dai-Wen Pang
Summary: In this study, a novel methodology for synthesizing chiral CdSe@ZnS quantum dots (QDs) with enhanced circularly polarized luminescence (CPL) was developed. The resulting chiral QDs exhibit exceptional photoluminescence quantum yield and chiroptical activities. Investigations of the synthetic pathway reveal the importance of the interface as a binary synthetic environment in facilitating ligand exchange and shell growth, leading to maximum fluorescent brightness and chiral effects.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Review
Nanoscience & Nanotechnology
Guangbo Yu, Aihua Qu, Zhimeng Wu, Liguang Xu, Chuanlai Xu, Hua Kuang
Summary: This article introduces the progress in the application of chiral nanomaterials in the field of bioscience, including the strategies for constructing different types of ROS-related chiral nanomaterials and the biological effects achieved by regulating ROS using chiral nanomaterials. The key issues and future prospects of chiral nanomaterials in the regulation of ROS are also discussed.
Review
Chemistry, Multidisciplinary
Changlong Hao, Chuanlai Xu, Hua Kuang
Summary: This article provides an overview of recent advances in chiral nanomaterials for biosensing applications, including individual chiral nanoparticles, chiral assemblies, and chiral 2D film-based sensors.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Physical
Xinxin Xu, Aihong Wu, Lingling Guo, Hua Kuang, Liguang Xu, Chuanlai Xu, Liqiang Liu
Summary: In this study, a gold nanoparticle-based immunochromatographic assay was developed for the rapid detection of IMZ in grapes and tomatoes, demonstrating excellent practicality.
NANOSCALE HORIZONS
(2023)
Article
Food Science & Technology
Yang Liu, Liqiang Liu, Maozhong Sun, Xinxin Xu, Hua Kuang, Chuanlai Xu, Liguang Xu
Summary: In this study, a novel hapten scheme was designed to prepare a monoclonal antibody for the simultaneous detection of common gibberellins (GAs) with high sensitivity and homogeneity. Then, a colloidal gold immunochromatographic assay (GICA) was established using synthetic gold nanoparticles, which simplifies the sample pre-treatment step. The method showed rapid, sensitive, and efficient on-site detection of GAs in food.
Article
Chemistry, Applied
Qianqian Lu, Hongliu Ding, Liqiang Liu, Liguang Xu, Hua Kuang, Chuanlai Xu, Lingling Guo
Summary: An immunochromatographic assay was developed for the rapid and efficient screening of FPF residues in grapes, blueberries, and tomatoes. The assay showed high sensitivity and specificity, with detection limits of 0.009 mg/kg, 0.033 mg/kg, and 0.040 mg/kg for grapes, blueberries, and tomatoes, respectively. The results obtained from the assay were consistent with those obtained from LC-MS/MS analysis.
