期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 116, 期 7, 页码 2488-2493出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1818134116
关键词
PM2.5; lung; air pollution; particle deposition; extrapulmonary organs
资金
- Beijing Natural Science Foundation [3172018]
- National Natural Science Foundation of China [51420105006, 51322501]
The deposition of PM2.5 (fine particulate matter in air with diameter smaller than 2.5 mu m) in lungs is harmful to human health. However, real-time observation on the deposition of particles in the acinar area of the lung is still a challenge in experiments. Here, a fluorescent imaging method is developed to visualize the deposition process with a high temporal and spatial resolution. The observations reveal that the deposition pattern is nonuniform, and the maximum deposition rate in the acinar area differs significantly from the prediction of the widely used average deposition model. The method is also used to find single particles in the kidney and liver, though such particles are commonly believed to be too large to enter the extrapulmonary organs.
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