TRPV4-mediated calcium signaling in mesenchymal stem cells regulates aligned collagen matrix formation and vinculin tension

Vinculin Force-Sensitive Dynamics at Focal Adhesions Enable Effective Directed Cell Migration

(2018) Katheryn E. Rothenberg et al.   BIOPHYSICAL JOURNAL

Synchronized mechanical oscillations at the cell–matrix interface in the formation of tensile tissue

(2018) David F. Holmes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fell Muir Lecture: Collagen fibril formation in vitro and in vivo

(2017) Karl E. Kadler   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

TRPV4 mediates the Ca2+influx required for the interaction between flightless-1 and non-muscle myosin, and collagen remodeling

(2017) Pamma D. Arora et al.   JOURNAL OF CELL SCIENCE

New MSC: MSCs as pericytes are Sentinels and gatekeepers

(2017) Arnold I. Caplan   JOURNAL OF ORTHOPAEDIC RESEARCH

Experimental evaluation of multiscale tendon mechanics

(2017) Fei Fang et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Anisotropic forces from spatially constrained focal adhesions mediate contact guidance directed cell migration

(2017) Arja Ray et al.   Nature Communications

Novel Model of Tendon Regeneration Reveals Distinct Cell Mechanisms Underlying Regenerative and Fibrotic Tendon Healing

(2017) Kristen Howell et al.   Scientific Reports

Dissecting Collective Cell Behavior in Polarization and Alignment on Micropatterned Substrates

(2015) Shijie He et al.   BIOPHYSICAL JOURNAL

Controlling Cell Geometry Affects the Spatial Distribution of Load Across Vinculin

(2015) Katheryn E. Rothenberg et al.   Cellular and Molecular Bioengineering

Tendon development and musculoskeletal assembly: emerging roles for the extracellular matrix

(2015) A. Subramanian et al.   DEVELOPMENT

Engineering meniscus structure and function via multi-layered mesenchymal stem cell-seeded nanofibrous scaffolds

(2015) Matthew B. Fisher et al.   JOURNAL OF BIOMECHANICS

Uniaxial cyclic stretch stimulates TRPV4 to induce realignment of human embryonic stem cell-derived cardiomyocytes

(2015) Yan Qi et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

TRPV4 participates in the establishment of trailing adhesions and directional persistence of migrating cells

(2015) Sanela Mrkonjić et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Stress controls the mechanics of collagen networks

(2015) Albert James Licup et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanical forces regulate the interactions of fibronectin and collagen I in extracellular matrix

(2015) Kristopher E. Kubow et al.   Nature Communications

Distinct mechanisms regulating mechanical force-induced Ca2+ signals at the plasma membrane and the ER in human MSCs

(2015) Tae-Jin Kim et al.   eLife

Micro-scale and meso-scale architectural cues cooperate and compete to direct aligned tissue formation

(2014) Christopher L. Gilchrist et al.   BIOMATERIALS

TRPV4 mediates myofibroblast differentiation and pulmonary fibrosis in mice

(2014) Shaik O. Rahaman et al.   JOURNAL OF CLINICAL INVESTIGATION

Prolonged Mechanical Stretch Initiates Intracellular Calcium Oscillations in Human Mesenchymal Stem Cells

(2014) Tae-Jin Kim et al.   PLoS One

TRPV4-mediated mechanotransduction regulates the metabolic response of chondrocytes to dynamic loading

(2014) C. J. O'Conor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The puzzle of TRPV4 channelopathies

(2013) Bernd Nilius et al.   EMBO REPORTS

Human skeletal dysplasia caused by a constitutive activated transient receptor potential vanilloid 4 (TRPV4) cation channel mutation

(2013) Sang Sun Kang et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Embryonic mechanical and soluble cues regulate tendon progenitor cell gene expression as a function of developmental stage and anatomical origin

(2013) Jeffrey P Brown et al.   JOURNAL OF BIOMECHANICS

Vinculin–actin interaction couples actin retrograde flow to focal adhesions, but is dispensable for focal adhesion growth

(2013) Ingo Thievessen et al.   JOURNAL OF CELL BIOLOGY

Nonmuscle myosin II powered transport of newly formed collagen fibrils at the plasma membrane

(2013) N. S. Kalson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sacrificial nanofibrous composites provide instruction without impediment and enable functional tissue formation

(2012) B. M. Baker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutations in TRPV4 cause an inherited arthropathy of hands and feet

(2011) Shireen R Lamandé et al.   NATURE GENETICS

Ultra-rapid activation of TRPV4 ion channels by mechanical forces applied to cell surface β1 integrins

(2010) Benjamin D. Matthews et al.   Integrative Biology

A new lock-step mechanism of matrix remodelling based on subcellular contractile events

(2010) L. F. Castella et al.   JOURNAL OF CELL SCIENCE

Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics

(2010) Carsten Grashoff et al.   NATURE

Functional characterization of TRPV4 as an osmotically sensitive ion channel in porcine articular chondrocytes

(2009) Mimi N. Phan et al.   ARTHRITIS AND RHEUMATISM

One-dimensional topography underlies three-dimensional fibrillar cell migration

(2009) Andrew D. Doyle et al.   JOURNAL OF CELL BIOLOGY

Collagen fibrillogenesis: fibronectin, integrins, and minor collagens as organizers and nucleators

(2008) Karl E Kadler et al.   CURRENT OPINION IN CELL BIOLOGY

Substrate rigidity regulates Ca2+oscillation via RhoA pathway in stem cells

(2008) Tae-Jin Kim et al.   JOURNAL OF CELLULAR PHYSIOLOGY

In vitro Differentiation Potential of Mesenchymal Stem Cells

(2008) Jeffrey M. Gimble et al.   TRANSFUSION MEDICINE AND HEMOTHERAPY