Discovery and characterization of potent IL-21 neutralizing antibodies via a novel alternating antigen immunization and humanization strategy

Sequential Immunization Elicits Broadly Neutralizing Anti-HIV-1 Antibodies in Ig Knockin Mice

(2016) Amelia Escolano et al.   CELL

N-glycosylation heterogeneity and the influence on structure, function and pharmacokinetics of monoclonal antibodies and Fc fusion proteins

(2016) Fabian Higel et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Phage display-derived human antibodies in clinical development and therapy

(2016) André Frenzel et al.   mAbs

Antibody Glycosylation and Its Impact on the Pharmacokinetics and Pharmacodynamics of Monoclonal Antibodies and Fc-Fusion Proteins

(2015) Liming Liu   JOURNAL OF PHARMACEUTICAL SCIENCES

pSTAT3: a target biomarker to study the pharmacology of the anti-IL-21R antibody ATR-107 in human whole blood

(2013) Ming Zhu et al.   Journal of Translational Medicine

Serum IL-21 levels decrease with glucocorticoid treatment in myasthenia gravis

(2013) Y. Li et al.   NEUROLOGICAL SCIENCES

Follicular Helper T Cells (Tfh) and IL-21 Involvement in the Pathogenesis of Bullous Pemphigoid

(2013) Qiuju Li et al.   PLoS One

Charge Heterogeneity of Monoclonal Antibodies by Multiplexed Imaged Capillary Isoelectric Focusing Immunoassay with Chemiluminescence Detection

(2012) David A. Michels et al.   ANALYTICAL CHEMISTRY

Crystal Structure of Interleukin-21 Receptor (IL-21R) Bound to IL-21 Reveals That Sugar Chain Interacting with WSXWS Motif Is Integral Part of IL-21R

(2012) Ole J. Hamming et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Generation and characterization of human anti-human IL-21 neutralizing monoclonal antibodies

(2012) Mark F. Maurer et al.   mAbs

A regulatory effect of IL-21 on T follicular helper-like cell and B cell in rheumatoid arthritis

(2012) Rui Liu et al.   ARTHRITIS RESEARCH & THERAPY

Phage display—A powerful technique for immunotherapy

(2012) Justyna Bazan et al.   Human Vaccines & Immunotherapeutics

Interleukin-21 modulates Th1 and Th17 responses in giant cell arteritis

(2011) Benjamin Terrier et al.   ARTHRITIS AND RHEUMATISM

A Subset of Interleukin-21+ Chemokine Receptor CCR9+ T Helper Cells Target Accessory Organs of the Digestive System in Autoimmunity

(2011) Helen M. McGuire et al.   IMMUNITY

Alum adjuvant: some of the tricks of the oldest adjuvant

(2011) M. Kool et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Engineering the variable region of therapeutic IgG antibodies

(2011) Tomoyuki Igawa et al.   mAbs

Impact of interleukin-21 in the pathogenesis of primary Sjogren's syndrome: increased serum levels of interleukin-21 and its expression in the labial salivary glands

(2011) Kwi Kang et al.   ARTHRITIS RESEARCH & THERAPY

Increase in IL-21 producing T-cells in patients with systemic lupus erythematosus

(2011) Sebastian Dolff et al.   ARTHRITIS RESEARCH & THERAPY

IL-21 in the pathogenesis and treatment of skin diseases

(2010) Antonio Costanzo et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

In vitro potency, pharmacokinetic profiles and pharmacological activity of optimized anti-IL-21R antibodies in a mouse model of lupus

(2010) Yulia Vugmeyster et al.   mAbs

Exploring blocking assays using Octet, ProteOn, and Biacore biosensors

(2008) Yasmina N. Abdiche et al.   ANALYTICAL BIOCHEMISTRY

The Yin and Yang of interleukin-21 in allergy, autoimmunity and cancer

(2008) Rosanne Spolski et al.   CURRENT OPINION IN IMMUNOLOGY

The role of IL-21 in regulating B-cell function in health and disease

(2008) Rachel Ettinger et al.   IMMUNOLOGICAL REVIEWS

Interleukin-21: Basic Biology and Implications for Cancer and Autoimmunity

(2007) Rosanne Spolski et al.   Annual Review of Immunology