Review
Biochemistry & Molecular Biology
Cecilia Gonzalez Corona, Ronald J. J. Parchem
Summary: This article reviews the impact of diabetes on pregnant women and their infants, covering current knowledge and unanswered questions.
Article
Social Issues
Margrit Shildrick
Summary: This article discusses the implications of microchimerism in sociocultural and ethico-legal contexts, particularly in relation to the destabilization of genetic origins. Despite its increasing prevalence in the human population, conventional biomedicine and related law have been reluctant to acknowledge the existence of microchimerism. The exception is maternal-fetal microchimerism, which has been recognized but with little consideration of its nonmedical implications. The ongoing biomedical debate focuses on the benefits, harms, or neutrality of microchimerism in terms of immunological responses, but the author emphasizes that biological concerns cannot be separated from sociocultural and ethico-legal effects. The diversity of DNA coding within an individual's body has implications for kinship relations, legal parenthood, and surrogacy laws.
SCIENCE TECHNOLOGY & HUMAN VALUES
(2022)
Article
Immunology
Caroline Charlier, Julia Dina, Francois Freymuth, Astrid Vabret, Olivier Lortholary, Denise Antona, Marc Lecuit
Summary: Research shows that measles virus can be detected in the saliva and blood of pregnant women, leading to transmission to the fetus during pregnancy, resulting in asymptomatic infection at birth. Despite severe peripartum congenital measles, asymptomatic vertical transmission of the measles virus can occur in early pregnancy.
CLINICAL INFECTIOUS DISEASES
(2021)
Review
Obstetrics & Gynecology
Perrine Ginod, Michael H. Dahan
Summary: Polygenic embryo screening and Embryo Health Score have the potential to select embryos with reduced disease risk and improved long-term health outcomes. However, the potential impacts of trophectoderm biopsy on offspring health are unclear. Studies suggest a possible increased risk of preterm delivery, birth defects, and pre-eclampsia after trophectoderm biopsy. Further research is needed to determine the risks of PES for prenatal and postnatal health.
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)
Article
Neurosciences
Megan G. McGill, Irina Pokhvisneva, Andrew S. Clappison, Lisa M. McEwen, Roseriet Beijers, Marieke S. Tollenaar, Hung Pham, Michelle Z. L. Kee, Elika Garg, Euclides J. de Mendonca Filho, Neerja Karnani, Patricia P. Silveira, Michael S. Kobor, Carolina de Weerth, Michael J. Meaney, Kieran J. O'Donnell
Summary: Prenatal maternal anxiety predicts child PedBE epigenetic age acceleration, predominantly in males. PedBE age acceleration predicts increased externalizing symptoms in males in the BIBO cohort.
BIOLOGICAL PSYCHIATRY
(2022)
Article
Immunology
Delphine M. Depierreux, Jens Kieckbusch, Norman Shreeve, Delia A. Hawkes, Bryan Marsh, Robert Blelloch, Andrew Sharkey, Francesco Colucci
Summary: Reproductive immunology focuses on understanding how the maternal immune system supports fetal growth. Maternal uterine natural killer (uNK) cells, in partnership with fetal trophoblast cells, regulate physiological vascular changes in the uterus to build the placenta and sustain fetal growth. The education of uNK cells by maternal MHC-I is crucial for optimal fetal growth.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Baimei Zhuang, Jin Shang, Yuanqing Yao
Summary: HLA-G plays a crucial role in maternal-fetal immune tolerance, maintaining immune homeostasis and considered a key factor for successful pregnancies. Understanding the characteristics of HLA-G is important for treating pathological pregnancies and other immune-related diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Editorial Material
Medicine, General & Internal
Louis J. Muglia, Katrien Benhalima, Stephen Tong, Susan Ozanne
Summary: This article explores the importance of improving pregnancy health for the lifelong well-being of the mother and offspring. It highlights the immediate and long-term impacts of maternal environmental factors on fetal development and maternal cardiometabolic health. Using 'omics technologies across different platforms, research on preterm birth, metabolic influences, maternal disorders, and their effects on pregnancy outcomes and child health is expected to provide new insights and preventative strategies.
Review
Microbiology
Christina J. Megli, Carolyn B. Coyne
Summary: Infections during pregnancy pose a significant threat to maternal and fetal health, with the placenta having robust mechanisms to defend against microbial transmission. However, pathogens causing congenital disease may have evolved diverse mechanisms to bypass these defences. This review discusses how TORCH pathogens breach the maternal-fetal interface and cause disease.
NATURE REVIEWS MICROBIOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Davell Carter, Marina Better, Saed Abbasi, Fareeha Zulfiqar, Rachel Shapiro, Laura M. Ensign
Summary: Conception, pregnancy, and childbirth are complex processes that have significant impact on both the mother and fetus. However, there is a lack of safe and effective treatment options in women's health and pregnancy. The physiological changes during menstrual cycle and pregnancy make drug administration and delivery more complicated, and overcoming physiological barriers is also challenging. Nanomedicine offers a unique opportunity to improve safety and minimize side effects by targeting drug delivery to the reproductive tract and other relevant organs in the mother and fetus, and has the potential to improve the management and treatment of infertility, obstetric complications, and fetal conditions.
Article
Nutrition & Dietetics
Hamam Hadi, Siti Nurunniyah, Joel Gittelsohn, Ratih Devi Alfiana, Themistoklis I. Fatimatasari, Emma C. Lewis, Detty Nurdiati
Summary: This study found that implementing a maternal mentoring program in Indonesia can improve fetal growth and birth weight. The program includes preconception health education, health monitoring, and text message reminders for women, which contribute to better maternal and fetal health outcomes.
Review
Biochemistry & Molecular Biology
Lu Zhao, Qing Chang, Zhangzhao Cong, Yalin Zhang, Zhuxi Liu, Yuhong Zhao
Summary: The incidences of maternal and fetal adverse outcomes caused by maternal diabetes are increasing. Polyphenols have been shown to have anti-diabetic properties and can alleviate gestational diabetes mellitus and diabetic embryopathy. However, further research is needed to fully understand the complex interactions between polyphenols and maternal diabetes.
Review
Biochemistry & Molecular Biology
Lu Zhao, Qing Chang, Zhangzhao Cong, Yalin Zhang, Zhuxi Liu, Yuhong Zhao
Summary: The incidences of adverse maternal and fetal outcomes caused by maternal diabetes are increasing. Many researchers have investigated natural treatment methods due to the problems associated with hypoglycemic drugs. Polyphenols have anti-diabetic properties and can alleviate gestational diabetes mellitus and diabetic embryopathy through various mechanisms. Diets rich in polyphenols are beneficial to pregnant women with diabetes. However, further research is needed to better understand the complex interactions between polyphenols and maternal diabetes.
Review
Biochemistry & Molecular Biology
Monika Baczkowska, Magdalena Zgliczynska, Jan Faryna, Ewa Przytula, Blazej Nowakowski, Michal Ciebiera
Summary: Placental abruption, a rare perinatal complication, involves the separation of the placenta from the uterus lining before childbirth, posing serious consequences and a high risk of maternal and fetal mortality. Disruption of immunological processes on the maternal-fetal interface plays a crucial role in the pathophysiology of this condition, requiring further research to fully understand this complex process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Liseanne J. van't Hof, Naomi Schotvanger, Geert W. Haasnoot, Carin van der Keur, Dave L. Roelen, Lisa E. E. L. O. Lashley, Frans H. J. Claas, Michael Eikmans, Marie-Louise P. van der Hoorn
Summary: In uncomplicated pregnancies, maternal-fetal HLA matching was not different than expected by chance, while in preeclamptic pregnancies, there was a higher degree of HLA-C matching than expected by chance. Preeclamptic pregnancies showed an overall tendency towards higher maternal-fetal HLA compatibility, suggesting a potential role of HLA mismatches in immune regulation leading to preeclampsia.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Jill M. Pulley, Jillian P. Rhoads, Rebecca N. Jerome, Anup P. Challa, Kevin B. Erreger, Meghan M. Joly, Robert R. Lavieri, Kelly E. Perry, Nicole M. Zaleski, Jana K. Shirey-Rice, David M. Aronoff
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 60
(2020)
Article
Multidisciplinary Sciences
Rebecca A. Flaherty, Elena C. Borges, Jessica A. Sutton, David M. Aronoff, Jennifer A. Gaddy, Margaret G. Petroff, Shannon D. Manning
Article
Developmental Biology
Lisa M. Rogers, Carlos H. Serezani, Alison J. Eastman, Alyssa H. Hasty, Linda Englund-Ogge, Bo Jacobsson, Kasey C. Vickers, David M. Aronoff
Article
Obstetrics & Gynecology
Lauren Richardson, Juan Gnecco, Tianbing Ding, Kevin Osteen, Lisa M. Rogers, David M. Aronoff, Ramkumar Menon
REPRODUCTIVE SCIENCES
(2020)
Review
Chemistry, Medicinal
Jacky Lu, Jamisha Francis, Ryan S. Doster, Kathryn P. Haley, Kelly M. Craft, Rebecca E. Moore, Schuyler A. Chambers, David M. Aronoff, Kevin Osteen, Steven M. Damo, Shannon Manning, Steven D. Townsend, Jennifer A. Gaddy
ACS INFECTIOUS DISEASES
(2020)
Article
Reproductive Biology
Anup P. Challa, Andrew L. Beam, Min Shen, Tyler Peryea, Robert R. Lavieri, Ethan S. Lippmann, David M. Aronoff
REPRODUCTIVE TOXICOLOGY
(2020)
Article
Immunology
Alison J. Eastman, Erin N. Vrana, Maria T. Grimaldo, Amanda D. Jones, Lisa M. Rogers, Donald J. Alcendor, David M. Aronoff
Summary: The study found that chorion-derived trophoblasts (CTBs) can suppress inflammation in macrophages (M phi) through an as-yet unknown cell-to-cell contact-mediated mechanism, and this immunosuppression is also influenced by physical contact.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2021)
Article
Immunology
Jennifer L. Thompson, Lynsa M. Nguyen, Kristen N. Noble, David M. Aronoff
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2020)
Article
Pharmacology & Pharmacy
Alison J. Eastman, Rebecca E. Moore, Steven D. Townsend, Jennifer A. Gaddy, David M. Aronoff
Summary: This review examines how maternal obesity and associated fatty acids influence placental inflammation. Findings suggest that palmitate, commonly used in in vitro studies, induces negative effects on placental cells, while obesity as a whole may have more complex regulation mechanisms due to the presence of unsaturated fatty acids.
CLINICAL THERAPEUTICS
(2021)
Review
Pharmacology & Pharmacy
Camille S. Westlake, David M. Aronoff
Summary: A scoping review was conducted to evaluate the safety of systemic ivermectin exposure during pregnancy in both human and vertebrate animal studies. High doses were associated with adverse pregnancy outcomes in mice, rats, and rabbits, but therapeutic doses did not show significant associations with adverse birth outcomes in humans. Further research is needed to address safety concerns regarding the use of ivermectin in pregnant women.
CURRENT DRUG SAFETY
(2021)
Article
Public, Environmental & Occupational Health
Bin Ni, Erin Gettler, Rebecca Stern, Heather M. Munro, Mark Steinwandel, Melinda C. Aldrich, Debra L. Friedman, Maureen Sanderson, David Schlundt, David M. Aronoff, Deepak K. Gupta, Martha J. Shrubsole, Loren Lipworth
Summary: Disruptions to healthcare during the COVID-19 pandemic were primarily driven by health system-initiated deferrals and individual perceptions of COVID-19 risk, disproportionately affecting different population groups.
JOURNAL OF PUBLIC HEALTH RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Felicia Kuperwaser, Gal Avital, Michelle J. Vaz, Kristen N. Noble, Allison N. Dammann, Tara M. Randis, David M. Aronoff, Adam J. Ratner, Itai Yanai
Summary: Group B Streptococcus (GBS) is a pathobiont that ascends to the placenta and causes adverse pregnancy outcomes by producing the toxin beta-hemolysin/cytolysin (beta-h/c). This study shows that GBS modulates the state of innate immune cells by subverting host inflammation through beta-h/c, leading to worse outcomes.
MOLECULAR SYSTEMS BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Joshua Soto Ocana, Nile U. Bayard, Jessica L. Hart, Audrey K. Thomas, Emma E. Furth, D. Borden Lacy, David M. Aronoff, Joseph P. Zackular
Summary: Clostridioides difficile damages the colonic mucosa through potent exotoxins. The factors contributing to C. difficile pathogenesis are not fully understood, but likely involve ecological, immune, and environmental factors. Recent studies have shown that nonsteroidal anti-inflammatory drugs exacerbate C. difficile infection, although the mechanism behind this is unclear.
Article
Medicine, Research & Experimental
P. Challa Anup, Xinnan Niu, Etoi A. Garrison, Sara L. Van Driest, Lisa M. Bastarache, Ethan S. Lippmann, Robert R. Lavieri, Jeffery A. Goldstein, David M. Aronoff
Summary: Pregnant people have been systematically excluded from clinical trials, resulting in a lack of safety data for common drugs. This study used electronic health records to investigate the effects of maternal exposure to different drugs on neurodevelopmental defects in their children, and proposed an agile framework for improving medication regulations.
COMMUNICATIONS MEDICINE
(2022)
Review
Immunology
Laura E. Dellalana, Kelly C. Byrge, Jocelyn S. Gandelman, Tara Lines, David M. Aronoff, Anna K. Person
INFECTIOUS DISEASES IN CLINICAL PRACTICE
(2019)