Article
Obstetrics & Gynecology
Erika P. New, Samantha Kodama, Kate Devine, Samad Jahandideh, Anthony N. Imudia, Shayne M. Plosker
Summary: This retrospective cohort study aimed to determine the association between serum estradiol (E2) level at the time of hCG trigger or LH surge and the live birth rate (LBR) during ovulation induction (OI) or controlled ovarian hyperstimulation with letrozole followed by intrauterine insemination (IUI). The results showed that patients with higher E2 levels had higher LBR and clinical pregnancy rates in letrozole OI cycles followed by IUI. Therefore, it is recommended to delay hCG trigger until the E2 level reaches the physiological periovulatory level to improve pregnancy rates with letrozole followed by IUI.
FERTILITY AND STERILITY
(2023)
Article
Behavioral Sciences
Melise Edwards, Sam Lam, Ravi Ranjan, Mariana Pereira, Courtney Babbitt, Agnes Lacreuse
Summary: Aromatase inhibitors (AIs) are commonly used drugs for treating estrogen receptor (ER)-dependent breast cancers, but they can cause adverse effects. Previous studies in marmosets have shown that AIs can replicate these negative effects and increase estradiol levels in the hippocampus. RNA-sequencing analysis revealed that AIs may differentially affect males and females, potentially through processes mediated by the CYP450 superfamily.
HORMONES AND BEHAVIOR
(2023)
Review
Obstetrics & Gynecology
Zhuo Liu, Yuli Geng, Yanjing Huang, Runan Hu, Fan Li, Yufan Song, Mingmin Zhang
Summary: The study aimed to evaluate the effect of letrozole and clomiphene citrate on women with infertility and polycystic ovarian syndrome (PCOS). A total of 29 randomized controlled trials (RCTs) were included, involving 3,952 women and 7,633 ovulation induction cycles. The pooled analysis showed that letrozole had superior outcomes in terms of ovulation rate, clinical pregnancy rate, and live-birth rate compared to clomiphene citrate. Therefore, letrozole is recommended as an ovulation induction drug in women with infertility and PCOS.
OBSTETRICS AND GYNECOLOGY
(2023)
Article
Endocrinology & Metabolism
Xin Yuan, Ruimin Chen, Ying Zhang, Xiaohong Yang, Xiangquan Lin
Summary: This study describes the clinical characteristics and long-term treatment with letrozole in a boy diagnosed with familial male-limited precocious puberty (FMPP). The boy's height approached his adult height after long-term treatment with letrozole, triptorelin, and spironolactone.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Obstetrics & Gynecology
Caitlin E. Martin, Christopher Lewis, Kenan Omurtag
Summary: In this case report, successful ovarian hyperstimulation and oocyte cryopreservation were achieved in a 15-year-old transgender male adolescent by using a gonadotropin-releasing hormone (GnRH) agonist and the aromatase inhibitor letrozole to maintain low serum estradiol levels. The patient's peak estradiol concentration was 510 pg/mL and 22 mature oocytes were cryopreserved, with minimal changes in breast budding observed. The use of letrozole to maintain low estradiol levels for transgender male adolescents during ovarian stimulation may help minimize pubertal development and prevent gender dysphoria symptoms, making oocyte cryopreservation a more desirable option.
FERTILITY AND STERILITY
(2021)
Article
Obstetrics & Gynecology
Nathalie Soderhamn Bulow, Sven Olaf Skouby, Agnieszka Katarzyna Warzecha, Hanne Udengaard, Claus Yding Andersen, Marianne Dreyer Holt, Marie Louise Grondahl, Anders Nyboe Andersen, Negjyp Sopa, Anne Lis Englund Mikkelsen, Anja Pinborg, Nicholas Stephen Macklon
Summary: The use of letrozole during ovarian stimulation for IVF did not significantly decrease the proportion of women with premature progesterone levels above 1.5 ng/ml at the time of triggering final oocyte maturation. However, letrozole did significantly increase the proportion of women with mid-luteal progesterone levels above 30 ng/ml.
HUMAN REPRODUCTION
(2022)
Article
Obstetrics & Gynecology
Liv C. Poulsen, Agnieszka K. Warzecha, Nathalie S. Bulow, Leif Bungum, Nicholas S. Macklon, Claus Yding Andersen, Sven O. Skouby
Summary: The study demonstrates that letrozole cotreatment has significant effects on follicle diameter and corpus luteum function during ovarian stimulation, without impacting the recruitment of secondary follicles.
HUMAN REPRODUCTION
(2022)
Article
Fisheries
H. Alijani, M. Amini Chermahini, D. Zargham, M. Mohiseni
Summary: This study investigated the efficiency of conjugating chitosan nanoparticles to letrozole on the masculinization of rainbow trout larvae. The results showed that letrozole-chitosan nanoparticles significantly increased the amount of testosterone compared to letrozole alone, indicating the positive effect of chitosan in enhancing the effectiveness of letrozole.
IRANIAN JOURNAL OF FISHERIES SCIENCES
(2022)
Article
Oncology
Brian M. Slomovitz, Virginia L. Filiaci, Joan L. Walker, Michael C. Taub, Karen A. Finkelstein, John W. Moroney, Aimee C. Fleury, Carolyn Y. Muller, Laura L. Holman, Larry J. Copeland, David S. Miller, Robert L. Coleman
Summary: This study evaluated the efficacy and tolerability of everolimus/letrozole and medroxyprogesterone acetate/tamoxifen in the treatment of metastatic endometrial carcinoma. The results showed that both treatment regimens demonstrated clinically meaningful efficacy in patients, especially in chemotherapy-naive patients.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Oncology
Rashidra R. Walker, Karen M. Gallegos, Melyssa R. Bratton, Kitani P. Lemieux, Kun Zhang, Guangdi Wang, A. Michael Davidson, Syreeta L. Tilghman
Summary: The study revealed that activation of the p38/MAPK pathway leads to ER+ AI resistance, and inhibiting p38 can reduce cell proliferation and induce apoptosis.
ANTICANCER RESEARCH
(2021)
Article
Oncology
Manuela Rabaglio, Zhuoxin Sun, Rudolf Maibach, Anita Giobbie-Hurder, Bent Ejlertsen, Vernon J. Harvey, Patrick Neven, Istvan Lang, Herve Bonnefoi, Andrew Wardley, Barbara Ruepp, Monica Castiglione, Alan S. Coates, Richard D. Gelber, Aron Goldhirsch, Marco Colleoni, Beat Thurlimann, Meredith M. Regan
Summary: This study investigates cardiovascular events in breast cancer patients during treatment with different drugs and found that monotherapy with letrozole is associated with a higher risk of ischemic heart disease, while the use of tamoxifen increases the risk of thromboembolic events.
BREAST CANCER RESEARCH AND TREATMENT
(2021)
Article
Reproductive Biology
Hamideh Adeldust, Amjad Farzinpour, Abbas Farshad, Jalal Rostamzadeh, Manel Lopez Bejar
Summary: The study evaluated the effects of orally administered Letrozole on the reproductive performance of aged roosters, finding significant improvements in sperm quality and in vitro fertility rates at a dosage of 0.03 mg/kg body weight/day. Letrozole treatment also had a significant impact on testosterone, estradiol, and FSH levels in plasma and testicular tissues.
Article
Biochemistry & Molecular Biology
Borja Diaz de Grenu, Diego M. Fernandez-Aroca, Juan A. Organero, Gema Dura, Felix Angel Jalon, Ricardo Sanchez-Prieto, M. Jose Ruiz-Hidalgo, Ana Maria Rodriguez, Lucia Santos, Jose L. Albasanz, Blanca R. Manzano
Summary: Compound 6, a new derivative of aromatase inhibitors, exhibits higher inhibitory activity and potent cytostatic behavior compared to established inhibitors, making it a promising candidate for hormone-dependent cancer treatment.
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
(2023)
Article
Endocrinology & Metabolism
Yi Zhao, Xiaofei Luan, Yuya Wang
Summary: The study found that the combination of letrozole and oral contraceptives for treating endometriosis-related pain significantly reduced pain intensity in patients, with noticeable improvements in pain symptoms at 1-month and 6-month follow-ups.
GYNECOLOGICAL ENDOCRINOLOGY
(2021)
Article
Oncology
Maria Faltinova, Leena Vehmanen, Heli Lyytinen, Mikko Haanpaa, Esa Hamalainen, Aila Tiitinen, Carl Blomqvist, Johanna Mattson
Summary: This study utilized LC-MS/MS to monitor serum estradiol levels in breast cancer patients switching from tamoxifen to letrozole, revealing a relatively high risk of inadequate estrogen suppression during AI treatment. However, baseline variables were not significantly associated with the risk of AI failure.
BREAST CANCER RESEARCH AND TREATMENT
(2021)
Article
Biochemistry & Molecular Biology
Sajjad Esmaeili, Sarwar Azizian, Bahareh Shahmoradi, Sajad Moradi, Mohsen Shahlaei, Reza Khodarahmi
BIOORGANIC CHEMISTRY
(2019)
Article
Chemistry, Multidisciplinary
Hosna Ehzari, Meysam Safari, Mohsen Shahlaei
JOURNAL OF THE IRANIAN CHEMICAL SOCIETY
(2019)
Article
Chemistry, Analytical
Shabnam Mirzaei, Sajad Moradi, Hosna Ehzari, Negin Farhadian, Mohsen Shahlaei
MICROCHEMICAL JOURNAL
(2019)
Article
Spectroscopy
Sajad Moradi, Negin Farhadian, Fatemeh Balaei, Mohabbat Ansari, Mohsen Shahlaei
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2020)
Article
Chemistry, Applied
Marjan Motiei, Vladimir Sedlarik, Lucian A. Lucia, Haojie Fei, Lukas Munster
CARBOHYDRATE POLYMERS
(2020)
Article
Biochemistry & Molecular Biology
Somayeh Rezaei, Soheila Kashanian, Yadollah Bahrami, Luis J. Cruz, Marjan Motiei
Article
Engineering, Electrical & Electronic
Maryam Haghighi, Mohsen Shahlaei, Mohsen Irandoust, Alireza Hassanpour
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
(2020)
Article
Chemistry, Analytical
Giti Paimard, Mohsen Shahlaei, Pouran Moradipour, Hamzeh Akbari, Mahsa Jafari, Elham Arkan
SENSORS AND ACTUATORS B-CHEMICAL
(2020)
Article
Spectroscopy
Mahtab Amoorahim, Mohammad Reza Ashrafi-Kooshk, Sajjad Esmaeili, Mohsen Shahlaei, Sajad Moradi, Reza Khodarahmi
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2020)
Article
Chemistry, Multidisciplinary
Amir Kiani, Mohsen Shahlaei, Mahdi Rahpeyma, Hadi Adibi
Summary: Angiogenesis plays a crucial role in cancer progression and other non-neoplastic diseases. Isatin-based compounds have shown potential as anticancer agents, with some exhibiting antiangiogenic effects. Specifically, (Z)-3-((5-(benzylthio)-4H-1,2,4-triazol-3-yl)imino)-5-haloindolin-2-one macromolecules showed the highest cytotoxicity and ability to reduce MMP-2 and MMP-9 levels in cancer cell lines. Further investigation is needed to understand the molecular mechanisms of these compounds.
JOURNAL OF THE IRANIAN CHEMICAL SOCIETY
(2021)
Article
Medicine, General & Internal
Marjan Motiei, Katerina Vaculikova, Andrea Cela, Katerina Tvrdonova, Reza Khalili, David Rumpik, Tatana Rumpikova, Zdenek Glatz, Tomas Saha
JOURNAL OF CLINICAL MEDICINE
(2020)
Article
Engineering, Electrical & Electronic
Maryam Haghighi, Mohsen Shahlaei, Kiumars Bahrami, Homa Targhan
Summary: A new electrochemical sensor using RGO/Ti-MOF-modified GCE was introduced for the electro-catalytic oxidation and determination of Propranolol, showing high sensitivity and low detection limit. The synthesized composite exhibited excellent performance in phosphate buffer solution, significantly reducing the oxidation over-potential of Propranolol.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
(2021)
Article
Biology
Kosar Sadat Ebrahimi, Mohabbat Ansari, Mahdieh S. Hosseyni Moghaddam, Zohre Ebrahimi, Zohre Salehi, Mohsen Shahlaei, Sajad Moradi
Summary: This study investigated the inhibitory potential of secondary metabolites from endophytic fungi against the new coronavirus RNA-dependent RNA polymerase using computational methods. Two fungal metabolites, 18-methoxy cytochalasin J and pyrrocidine A, were identified as promising candidates for inhibiting COVID-19 based on their high binding energy, protein instability, strong complex formation, and pharmacokinetic properties. Further laboratory evaluation of these compounds is recommended.
COMPUTERS IN BIOLOGY AND MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Maryam Haghighi, Mehdi Rezaei, Payam Sariaslani, Sajad Moradi, Mohsen Shahlaei
Summary: A modified carbon paste electrode based on nanomagnetic core-shell and reduced graphene oxide was developed for sensitive determination of lamotrigine, with a detection limit of 0.7 nM. The electrochemical sensor was successfully applied for quantification of lamotrigine in tablet and plasma samples under optimized conditions.
MONATSHEFTE FUR CHEMIE
(2021)
Article
Chemistry, Multidisciplinary
Meghdad Pirsaheb, Sajad Moradi, Mohsen Shahlaei, Negin Farhadian
NEW JOURNAL OF CHEMISTRY
(2020)