标题
Review of Biomarkers in Ocular Matrices: Challenges and Opportunities
作者
关键词
aqueous humor, biomarkers, conjunctiva, ocular diseases, tears, vitreous
出版物
PHARMACEUTICAL RESEARCH
Volume 36, Issue 3, Pages -
出版商
Springer Nature
发表日期
2019-02-22
DOI
10.1007/s11095-019-2569-8
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Efficacy and safety of 0.1% ciclosporin A cationic emulsion in dry eye disease: a pooled analysis of two double-masked, randomised, vehicle-controlled phase III clinical studies
- (2018) Andrea Leonardi et al. BRITISH JOURNAL OF OPHTHALMOLOGY
- Variability of Tear Osmolarity Measurements With a Point-of-Care System in Healthy Subjects—Systematic Review
- (2018) Philipp B. Baenninger et al. CORNEA
- The analysis of human conjunctival epithelium proteome in ocular surface diseases using impression cytology and 2D-DIGE
- (2018) Javier Soria et al. EXPERIMENTAL EYE RESEARCH
- A novel and less invasive technique to assess cytokine profile of vitreous in patients of diabetic macular oedema
- (2018) G Srividya et al. EYE
- Proinflammatory Markers, Chemokines, and Enkephalin in Patients Suffering from Dry Eye Disease
- (2018) Pierre Nicolle et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Proteomic Analysis of Aqueous Humor from Primary Open Angle Glaucoma Patients on Drug Treatment Revealed Altered Complement Activation Cascade
- (2018) Sunil S. Adav et al. JOURNAL OF PROTEOME RESEARCH
- Metabolomics Analysis of Human Vitreous in Diabetic Retinopathy and Rhegmatogenous Retinal Detachment
- (2018) Nathan R. Haines et al. JOURNAL OF PROTEOME RESEARCH
- Severity, therapeutic, and activity tear biomarkers in dry eye disease: An analysis from a phase III clinical trial
- (2018) José Pinto-Fraga et al. Ocular Surface
- Quantitative proteomics analysis of vitreous body from type 2 diabetic patients with proliferative diabetic retinopathy
- (2018) Jianqing Li et al. BMC Ophthalmology
- Increased Cathepsin S activity associated with decreased protease inhibitory capacity contributes to altered tear proteins in Sjögren’s Syndrome patients
- (2018) Maria C. Edman et al. Scientific Reports
- Differential profiling of lacrimal cytokines in patients suffering from thyroid-associated orbitopathy
- (2018) Edina Kishazi et al. Scientific Reports
- Aqueous humor protein dysregulation in primary angle-closure glaucoma
- (2018) Sunil S. Adav et al. INTERNATIONAL OPHTHALMOLOGY
- Unconventional aqueous humor outflow: A review
- (2017) Mark Johnson et al. EXPERIMENTAL EYE RESEARCH
- Circulating biomarkers in glaucoma, age-related macular degeneration, and diabetic retinopathy
- (2017) Thirumurthy Velpandian et al. INDIAN JOURNAL OF OPHTHALMOLOGY
- Goblet Cells Contribute to Ocular Surface Immune Tolerance—Implications for Dry Eye Disease
- (2017) Flavia Barbosa et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Concentration of acute phase factors in vitreous fluid in diabetic macular edema
- (2017) Kazuhiro Kimura et al. JAPANESE JOURNAL OF OPHTHALMOLOGY
- Human tear proteomics and peptidomics in ophthalmology: Toward the translation of proteomic biomarkers into clinical practice
- (2017) Mikel Azkargorta et al. Journal of Proteomics
- Lacrimal gland–derived IL-22 regulates IL-17-mediated ocular mucosal inflammation
- (2017) Y W Ji et al. Mucosal Immunology
- The Intriguing Role of Neuropeptides at the Ocular Surface
- (2017) Francesco Sabatino et al. Ocular Surface
- TFOS DEWS II Tear Film Report
- (2017) Mark D.P. Willcox et al. Ocular Surface
- Corneal Nerve Morphology, Sensitivity, and Tear Neuropeptides in Contact Lens Wear
- (2017) Blanka Golebiowski et al. OPTOMETRY AND VISION SCIENCE
- Link between neurodegeneration and trabecular meshwork injury in glaucomatous patients
- (2017) Yong Zhang et al. BMC Ophthalmology
- Histamine H 1 and H 4 receptor expression on the ocular surface of patients with chronic allergic conjunctival diseases
- (2017) Noriko Inada et al. ALLERGOLOGY INTERNATIONAL
- An Overview of the Fovista and Rinucumab Trials and the Fate of Anti-PDGF Medications
- (2017) Evan N. Dunn et al. Ophthalmic Surgery Lasers & Imaging Retina
- Evaluation of vitreous levels of advanced glycation end products and angiogenic factors as biomarkers for severity of diabetic retinopathy
- (2017) Makiko Katagiri et al. INTERNATIONAL OPHTHALMOLOGY
- Analysis of Th17-associated cytokines and clinical correlations in patients with dry eye disease
- (2017) Rongjun Liu et al. PLoS One
- Tissue resident memory T cells in the human conjunctiva and immune signatures in human dry eye disease
- (2017) Tanima Bose et al. Scientific Reports
- Tear proteome analysis in ocular surface diseases using label-free LC-MS/MS and multiplexed-microarray biomarker validation
- (2017) Javier Soria et al. Scientific Reports
- Interferon-γ–Induced Unfolded Protein Response in Conjunctival Goblet Cells as a Cause of Mucin Deficiency in Sjögren Syndrome
- (2016) Terry G. Coursey et al. AMERICAN JOURNAL OF PATHOLOGY
- Differential Profiling of T-Cell Cytokines as Measured by Protein Microarray Across Dry Eye Subgroups
- (2016) Jillian F. Meadows et al. CORNEA
- Expression of Lipid Peroxidation Markers in the Tear Film and Ocular Surface of Patients with Non-Sjogren Syndrome: Potential Biomarkers for Dry Eye Disease
- (2016) Won Choi et al. CURRENT EYE RESEARCH
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- (2016) Kristine Baumane et al. CURRENT EYE RESEARCH
- Emerging therapeutics for ocular surface disease
- (2016) Brett P. Bielory et al. Current Opinion in Allergy and Clinical Immunology
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- (2016) Ilene K. Gipson et al. EXPERIMENTAL EYE RESEARCH
- Proteomics of vitreous in neovascular age-related macular degeneration
- (2016) Matthias Nobl et al. EXPERIMENTAL EYE RESEARCH
- Vitreous levels of placental growth factor correlate with activity of proliferative diabetic retinopathy and are not influenced by bevacizumab treatment
- (2016) E Al Kahtani et al. EYE
- Introduction to metabolomics and its applications in ophthalmology
- (2016) S Z Tan et al. EYE
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- (2016) Wen Zhou et al. Genetic Testing and Molecular Biomarkers
- Immunological impression cytology of the conjunctival epithelium in patients with thyroid orbitopathy-related dry eye
- (2016) S.L. Hsu et al. GENETICS AND MOLECULAR RESEARCH
- The Role of Cathepsin D in the Pathogenesis of Human Neurodegenerative Disorders
- (2016) Chiara Vidoni et al. MEDICINAL RESEARCH REVIEWS
- Effects of Punctal Occlusion on Clinical Signs and Symptoms and on Tear Cytokine Levels in Patients with Dry Eye
- (2016) Louis Tong et al. Ocular Surface
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- (2016) Yukihiko Suzuki et al. OPHTHALMOLOGICA
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- (2016) Tulio B. Abud et al. OPHTHALMOLOGY
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- (2016) Elisabeth M. Messmer et al. OPHTHALMOLOGY
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- (2016) Michael Reich et al. PLoS One
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- (2016) Ilene K. Gipson PROGRESS IN RETINAL AND EYE RESEARCH
- MicroRNA signatures in vitreous humour and plasma of patients with exudative AMD
- (2016) Catherine Ménard et al. Oncotarget
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- (2016) Chen Zhang et al. BMJ Open
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- (2016) Suzanne Hagan et al. EPMA Journal
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- (2016) Cédric Benoist d’Azy et al. PLoS One
- Proteomics analysis of human tears from aqueous-deficient and evaporative dry eye patients
- (2016) Natarajan Perumal et al. Scientific Reports
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- (2015) Quianta L. Moore et al. AMERICAN JOURNAL OF OPHTHALMOLOGY
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- (2015) Yuichi Uchino et al. AMERICAN JOURNAL OF OPHTHALMOLOGY
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- (2015) Anthony P. Corfield BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- Evaluation of point-of-care test for elevated tear matrix metalloproteinase 9 in post-LASIK dry eyes
- (2015) Tommy C Y Chan et al. BRITISH JOURNAL OF OPHTHALMOLOGY
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- (2015) Marc Schargus et al. CORNEA
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- (2015) Andrea Cacciamani et al. CURRENT EYE RESEARCH
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- (2015) AlexanderN Trunov et al. INDIAN JOURNAL OF OPHTHALMOLOGY
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- (2015) Laura Soriano-Romaní et al. JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS
- Interaction of IFN-γ with cholinergic agonists to modulate rat and human goblet cell function
- (2015) L García-Posadas et al. Mucosal Immunology
- Proteomics of Human Aqueous Humor
- (2015) Krishna R. Murthy et al. OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY
- Altered Mucin and Glycoprotein Expression in Dry Eye Disease
- (2015) Denise N. Stephens et al. OPTOMETRY AND VISION SCIENCE
- Unraveling the molecular repertoire of tears as a source of biomarkers: Beyond ocular diseases
- (2015) Damiana Pieragostino et al. Proteomics Clinical Applications
- Variability of Tear Osmolarity in Patients With Dry Eye
- (2015) Vatinee Y. Bunya et al. JAMA Ophthalmology
- Effects of Azithromycin on Gene Expression Profiles of Proinflammatory and Anti-inflammatory Mediators in the Eyelid Margin and Conjunctiva of Patients With Meibomian Gland Disease
- (2015) Lili Zhang et al. JAMA Ophthalmology
- Dry Eye Exacerbation in Patients Exposed to Desiccating Stress under Controlled Environmental Conditions
- (2014) Alberto López-Miguel et al. AMERICAN JOURNAL OF OPHTHALMOLOGY
- Biomarkers and surrogate endpoints in glaucoma clinical trials
- (2014) Felipe A Medeiros BRITISH JOURNAL OF OPHTHALMOLOGY
- Prospective, Multicenter, Clinical Evaluation of Point-of-Care Matrix Metalloproteinase-9 Test for Confirming Dry Eye Disease
- (2014) Robert Sambursky et al. CORNEA
- Evaluation of Oxidative Stress Markers in Aqueous Humor of Primary Open Angle Glaucoma and Primary Angle Closure Glaucoma Patients
- (2014) Amita Goyal et al. CURRENT EYE RESEARCH
- Intra- and inter-day variation of cytokines and chemokines in tears of healthy subjects
- (2014) María Jesús Benito et al. EXPERIMENTAL EYE RESEARCH
- Analysis of Th17-associated cytokines in tears of patients with dry eye syndrome
- (2014) X Tan et al. EYE
- Autoimmunity in Dry Eye Is Due to Resistance of Th17 to Treg Suppression
- (2014) S. K. Chauhan et al. JOURNAL OF IMMUNOLOGY
- Vascular Endothelial Growth Factor and Its Soluble Receptors-1 and -2 in Iris Neovascularization and Neovascular Glaucoma
- (2014) Hidetaka Noma et al. OPHTHALMOLOGICA
- Vitreous and Plasma VEGF Levels as Predictive Factors in the Progression of Proliferative Diabetic Retinopathy after Vitrectomy
- (2014) Jiaxing Wang et al. PLoS One
- Profiles of Extracellular miRNAs in the Aqueous Humor of Glaucoma Patients Assessed with a Microarray System
- (2014) Yuji Tanaka et al. Scientific Reports
- Alteration of Tear Mucin 5AC in Office Workers Using Visual Display Terminals
- (2014) Yuichi Uchino et al. JAMA Ophthalmology
- Tear Cathepsin S as a Candidate Biomarker for Sjögren's Syndrome
- (2014) Sarah F. Hamm-Alvarez et al. Arthritis & Rheumatology
- Analysis of the Correlations of Mucins, Inflammatory Markers, and Clinical Tests in Dry Eye
- (2013) Jianan Zhang et al. CORNEA
- Adaptation of Impression Cytology to Enable Conjunctival Surface Cell Transcriptome Analysis
- (2013) John L. Bradley et al. CURRENT EYE RESEARCH
- In VivoConfocal Microscopy of the Ocular Surface: From Bench to Bedside
- (2013) Edoardo Villani et al. CURRENT EYE RESEARCH
- HLA-DR expression as a biomarker of inflammation for multicenter clinical trials of ocular surface disease
- (2013) Seth P. Epstein et al. EXPERIMENTAL EYE RESEARCH
- Allergy and allergic mediators in tears
- (2013) Andrea Leonardi EXPERIMENTAL EYE RESEARCH
- Tears as a source of biomarkers for ocular and systemic diseases
- (2013) Nadine von Thun und Hohenstein-Blaul et al. EXPERIMENTAL EYE RESEARCH
- Vitreous biomarkers in diabetic retinopathy: A systematic review and meta-analysis
- (2013) Annie K. McAuley et al. JOURNAL OF DIABETES AND ITS COMPLICATIONS
- Tear Fluid Biomarker Profiling: A Review of Multiplex Bead Analysis
- (2013) Suzanne Hagan et al. Ocular Surface
- The Human Eye Proteome Project: Perspectives on an emerging proteome
- (2013) Richard D. Semba et al. PROTEOMICS
- A Brief History of Anti-VEGF for the Treatment of Ocular Angiogenesis
- (2012) Leo A. Kim et al. AMERICAN JOURNAL OF PATHOLOGY
- Evaluation of Tear Osmolarity in Non-Sjögren and Sjögren Syndrome Dry Eye Patients With the TearLab System
- (2012) Eszter Szalai et al. CORNEA
- Expression of CCR5 and Its Ligands CCL3, -4, and -5 in the Tear Film and Ocular Surface of Patients with Dry Eye Disease
- (2012) Won Choi et al. CURRENT EYE RESEARCH
- Molecular and cellular biomarkers in dry eye disease and ocular allergy
- (2012) Amalia Enríquez-de-Salamanca et al. Current Opinion in Allergy and Clinical Immunology
- Limitations of an ocular surface inflammatory biomarker in impression cytology specimens
- (2012) Rolla Yafawi et al. Cutaneous and Ocular Toxicology
- Tear proteome and protein network analyses reveal a novel pentamarker panel for tear film characterization in dry eye and meibomian gland dysfunction
- (2012) J. Soria et al. Journal of Proteomics
- Impression Cytology: Recent Advances and Applications in Dry Eye Disease
- (2012) Eli Lopin et al. Ocular Surface
- Vitreous Levels of Proteins Implicated in Angiogenesis Are Modulated in Patients with Retinal or Choroidal Neovascularization
- (2012) Matthias Huber et al. OPHTHALMOLOGICA
- Immunomodulatory Effect of the Topical Ophthalmic Janus Kinase Inhibitor Tofacitinib (CP-690,550) in Patients with Dry Eye Disease
- (2012) Jing-Feng Huang et al. OPHTHALMOLOGY
- Autotaxin-Lysophosphatidic Acid Axis Is a Novel Molecular Target for Lowering Intraocular Pressure
- (2012) Padma Iyer et al. PLoS One
- Lacrimal Proline Rich 4 (LPRR4) Protein in the Tear Fluid Is a Potential Biomarker of Dry Eye Syndrome
- (2012) Saijyothi Venkata Aluru et al. PLoS One
- Tear analysis in ocular surface diseases
- (2012) Lei Zhou et al. PROGRESS IN RETINAL AND EYE RESEARCH
- Histamine H4 receptors in normal conjunctiva and in vernal keratoconjunctivitis
- (2011) A. Leonardi et al. ALLERGY
- Tear Osmolarity in the Diagnosis and Management of Dry Eye Disease
- (2011) Michael A. Lemp et al. AMERICAN JOURNAL OF OPHTHALMOLOGY
- Alterations of Tear Neuromediators in Dry Eye Disease
- (2011) Alessandro Lambiase ARCHIVES OF OPHTHALMOLOGY
- The role of TGF-β in the pathogenesis of primary open-angle glaucoma
- (2011) Rudolf Fuchshofer et al. CELL AND TISSUE RESEARCH
- Effects of Topical Cyclosporine A Plus Artificial Tears Versus Artificial Tears Treatment on Conjunctival Goblet Cell Density in Dysfunctional Tear Syndrome
- (2011) Elvan Demiryay et al. Eye & Contact Lens-Science and Clinical Practice
- Inflammatory cytokine profiles in the tears of thyroid-associated ophthalmopathy
- (2011) Danping Huang et al. GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
- Association of preoperative vitreous IL-8 and VEGF levels with visual acuity after vitrectomy in proliferative diabetic retinopathy
- (2010) Mojca Globočnik Petrovič et al. ACTA OPHTHALMOLOGICA
- Cytokine and chemokine levels in tears from healthy subjects
- (2010) Ester Carreño et al. ACTA OPHTHALMOLOGICA
- Association of tear proteins with Meibomian gland disease and dry eye symptoms
- (2010) L. Tong et al. BRITISH JOURNAL OF OPHTHALMOLOGY
- Performance of Tear Osmolarity Compared to Previous Diagnostic Tests for Dry Eye Diseases
- (2010) P. Versura et al. CURRENT EYE RESEARCH
- Immune response in the conjunctival epithelium of patients with dry eye
- (2010) Stefano Barabino et al. EXPERIMENTAL EYE RESEARCH
- Myocilin Levels in Primary Open-angle Glaucoma and Pseudoexfoliation Glaucoma Human Aqueous Humor
- (2010) Kyle G. Howell et al. JOURNAL OF GLAUCOMA
- Proteome Alterations in Primary Open Angle Glaucoma Aqueous Humor
- (2010) A. Izzotti et al. JOURNAL OF PROTEOME RESEARCH
- Vitreous and serum levels of vascular endothelial growth factor and platelet-derived growth factor and their correlation in patients with non-proliferative diabetic retinopathy and clinically significant macula oedema
- (2009) Anna Praidou et al. ACTA OPHTHALMOLOGICA
- Baseline profiles of ocular surface and tear dynamics after allogeneic hematopoietic stem cell transplantation in patients with or without chronic GVHD-related dry eye
- (2009) Y Wang et al. BONE MARROW TRANSPLANTATION
- Biomarkers in Clinical Drug Development
- (2009) JVS Gobburu CLINICAL PHARMACOLOGY & THERAPEUTICS
- Effects of Sequential Artificial Tear and Cyclosporine Emulsion Therapy on Conjunctival Goblet Cell Density and Transforming Growth Factor-β2 Production
- (2009) Stephen C Pflugfelder et al. CORNEA
- Analysis of Inflammatory Cytokines in the Tears of Dry Eye Patients
- (2009) Morgan L Massingale et al. CORNEA
- Mass Spectrometry-Based Proteomic Analyses in Contact Lens-Related Dry Eye
- (2009) Jason J Nichols et al. CORNEA
- Multiple Cytokine Analysis in Human Tears: An Optimized Procedure for Cytometric Bead-Based Assay
- (2009) Martin W. LaFrance et al. CURRENT EYE RESEARCH
- Identification of Tear Fluid Biomarkers in Dry Eye Syndrome Using iTRAQ Quantitative Proteomics
- (2009) Lei Zhou et al. JOURNAL OF PROTEOME RESEARCH
- Conjunctival Mucin mRNA Expression in Contact Lens Wear
- (2009) Rosa M. Corrales et al. OPTOMETRY AND VISION SCIENCE
- A PROSPECTIVE STUDY OF IN-OFFICE DIAGNOSTIC VITREOUS SAMPLING IN PATIENTS WITH VITREORETINAL PATHOLOGY
- (2009) SCOTT M. PFAHLER et al. RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
- Alterations of the ocular surface epithelial MUC16 and goblet cell MUC5AC in patients with atopic keratoconjunctivitis
- (2008) M. Dogru et al. ALLERGY
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- (2008) Helene Lam et al. AMERICAN JOURNAL OF OPHTHALMOLOGY
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- (2008) Ursula Schlötzer-Schrehardt EXPERIMENTAL EYE RESEARCH
- Inflammatory Markers in the Tears of Patients with Ocular Surface Disease
- (2008) Arantxa Acera et al. OPHTHALMIC RESEARCH
- Aqueous humor myocilin protein levels in normal, genetic carriers, and glaucoma Beagles
- (2008) E. O. MacKay et al. VETERINARY OPHTHALMOLOGY
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