Article
Clinical Neurology
Weiwei Wang, Hongyi Cheng, Yike Zhang, Chang Cui, Zhiqiao Lin, Yantao Xing, Xiaoyuan Zhong, Xichen Liang, Quan Cao, Yan Chen, Minglong Chen
Summary: This study investigated the prognostic value of heart rate variability (HRV) and skin sympathetic nerve activity (SKNA) in patients with intracerebral hemorrhage (ICH). The results suggest that reduced HRV and SKNA may be indicators of poor neurological outcomes in ICH patients.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Article
Pediatrics
Kartik K. Iyer, Unnah Leitner, Vito Giordano, James A. Roberts, Sampsa Vanhatalo, Katrin Klebermass-Schrehof, Nathan J. Stevenson
Summary: A tool was developed to track the functional autonomic age in preterm infants based on heart rate variability features. It provides a rapid assessment of autonomic maturation at the bedside and offers unique insights into cardiovascular health and maturational trajectories during neonatal intensive care unit monitoring.
PEDIATRIC RESEARCH
(2023)
Article
Psychiatry
Benedict Herhaus, Gesa Thesing, Rupert Conrad, Katja Petrowski
Summary: Based on the autonomic flexibility-neurovisceral integration model, panic disorder (PD) is associated with a generalized proinflammatory state and lower cardiac vagal tone. This study aimed to explore the heart rate variability, pro-inflammatory cytokines, and their associations in individuals with PD. The results showed that individuals with PD had significantly lower HRV in the time and frequency domain parameters during a short-term resting condition. A lower TNF-alpha concentration could be observed in individuals with PD compared to healthy controls, but no differences in IL-6. Furthermore, the HRV parameter absolute power in the LF band predicted TNF-alpha concentrations.
PSYCHIATRY RESEARCH
(2023)
Review
Clinical Neurology
Nicole Urbini, Libera Siciliano, Giusy Olivito, Maria Leggio
Summary: This systematic review confirms the presence of autonomic dysfunctions in different genetic subtypes of spinocerebellar ataxias (SCAs), highlighting the role of the cerebellum in the autonomic nervous system (ANS). It emphasizes the importance of investigating these functions in clinical practice.
JOURNAL OF NEUROLOGY
(2023)
Article
Pediatrics
Suma B. Hoffman, Rathinaswamy B. Govindan, Elena K. Johnston, Jordan Williams, Sarah D. Schlatterer, Adre J. du Plessis
Summary: This study explores the association between autonomic impairment and extubation readiness in premature infants. The results show that heart rate variability is associated with extubation success, with low sympathetic and elevated parasympathetic tone in those who fail. The predictive model developed based on these findings has a high sensitivity and specificity for extubation success.
PEDIATRIC RESEARCH
(2023)
Article
Multidisciplinary Sciences
Yoon Jung Kim, Hyun-Kyu Yoon, Yu Jin Kang, Seung-June Oh, Min Hur, Hee-Pyoung Park, Hyung-Chul Lee
Summary: Comparing autonomic responses during bladder hydrodistention in patients with IC/BPS under general and spinal anesthesia, our study found that spinal anesthesia has advantages over general anesthesia in preventing an abrupt increase in systolic blood pressure and postoperative pain in IC/BPS patients. The findings show significantly greater Delta SBP, significantly lower heart rate variability, and significantly higher postoperative pain scores in the general anesthesia group compared to the spinal anesthesia group.
SCIENTIFIC REPORTS
(2023)
Article
Clinical Neurology
Lara Rosler, Glenn van der Lande, Jeanne Leerssen, Austin G. Vandegriffe, Oti Lakbila-Kamal, Jessica C. Foster-Dingley, Anne C. W. Albers, Eus J. W. van Someren
Summary: This study evaluates the objective quantification of insomnia by assessing state-related changes in cardiac measures. The researchers found that incorporating these changes in cardiac features in the ambulatory monitoring of sleep could provide a more sensitive biomarker for diagnosing and assessing the severity of insomnia.
Article
Agriculture, Dairy & Animal Science
Laura B. Hunter, Marie J. Haskell, Fritha M. Langford, Cheryl O'Connor, James R. Webster, Kevin J. Stafford
Summary: Research suggests that heart rate and heart rate variability in cows change with sleep stages, indicating they could be a promising alternative method to assess sleep in dairy cows. These measures could provide valuable insights into the effects of stress or environmental changes on cow welfare.
Article
Psychology, Biological
Keri J. Heilman, Danielle M. Zageris, Danielle Keir, Stephanie A. Aylward, Tiffany Burkhardt, Linda Gilkerson, Zack Boukydis, Larry Gray, Stephen W. Porges
Summary: This study examined autonomic regulation and social-behavioral development in six-month old infants with a history of excessive crying. It found that these infants exhibited atypical autonomic responses during feeding, with dampened reductions in respiratory sinus arrhythmia and decreases in heart period. The atypical autonomic regulation was only observed in bottle-fed infants, while breastfed infants showed similar autonomic regulation patterns to those without a history of excessive crying. Behavioral data suggested that breastfeeding may mitigate the behavioral effects of excessive crying on sociability at 24 months.
INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY
(2022)
Article
Endocrinology & Metabolism
Sara Bachmann, Anne Auderset, Marie-Anne Burckhardt, Gabor Szinnai, Melanie Hess, Urs Zumsteg, Kris Denhaerynck, Birgit Donner
Summary: The study found that nocturnal hypoglycemia can lead to QTc prolongation in children with T1D, and significant changes in heart rate variability were observed, which may be helpful for predicting hypoglycemia.
PEDIATRIC DIABETES
(2021)
Article
Medicine, General & Internal
Sung-Min You, Baek-Hwan Cho, Hyo-Eun Bae, Young-Kyun Kim, Jae-Rim Kim, Soo-Ryun Park, Young-Min Shon, Dae-Won Seo, In-Young Kim
Summary: The impact of epilepsy on cardiovascular function and autonomic regulation, particularly heart-rate variability (HRV), is complex and may contribute to sudden unexpected death in epilepsy (SUDEP). A retrospective study analyzed data from 75 patients with temporal lobe epilepsy to investigate the influence of various factors on HRV indices during different seizure intervals. Significant differences in HRV indices were observed based on hemispheric laterality, language dominancy, hippocampal atrophy, amygdala enlargement, sustained theta activity, and seizure frequency. This study suggests a potential relationship between HRV and the risk of SUDEP.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pediatrics
Robert L. Myette, Janusz Feber, Henrietta Blinder, Glenda N. Bendiak, Bethany J. Foster, Joanna E. MacLean, Evelyn Constantin, Sherri L. Katz
Summary: This study analyzed the improvement of blood pressure variability in obese youth with sleep-disordered breathing after positive airway pressure treatment, showing significant decreases in nighttime blood pressure. The findings suggest that positive airway pressure treatment can lead to a clinically significant improvement in sympathetic nerve activity in youth with obesity and sleep-disordered breathing.
PEDIATRIC RESEARCH
(2022)
Article
Computer Science, Information Systems
Cristhyne Leon, Sandie Cabon, Hugues Patural, Geraldine Gascoin, Cyril Flamant, Jean-Michel Roue, Geraldine Favrais, Alain Beuchee, Patrick Pladys, Guy Carrault
Summary: This study utilized machine learning model to analyze heart rate variability (HRV) data from preterm and full-term infants, and found that it could be used to estimate their functional maturational age (FMA). The FMA, predicted based on HRV data, showed small deviation from the actual postmenstrual age (PMA), indicating potential value in monitoring the maturation progress of infants.
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
(2022)
Article
Multidisciplinary Sciences
Rene D. Rotzer, Verena F. Brox, Konstantin Hennis, Stefan B. Thalhammer, Martin Biel, Christian Wahl-Schott, Stefanie Fenske
Summary: Blood pressure and heart rate are controlled by the autonomic nervous system and are closely intertwined through reflex mechanisms, with baroreflex sensitivity playing a key role in maintaining physiological balance. Cardiovascular diseases often involve impaired baroreflex function, with studies reporting reduced sensitivity in conditions like heart failure. Surgical procedures involve inserting pressure sensors, subcutaneous transmitters, and ECG electrodes, followed by postoperative care and long-term monitoring.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2021)
Article
Medicine, General & Internal
Luca Vismara, Andrea Gianmaria Tarantino, Andrea Bergna, Giuliana Bianchi, Cristina Bragalini, Elisa Billo, Fulvio Dal Farra, Francesca Buffone, Massimo Agosti
Summary: This study evaluated the inter-rater reliability, clinical characteristics, and functional correlation of the somatic dysfunctions (SD) Grade score with the heart rate variability (HRV) and salivary cortisol (sCor) in preterm infants. The results suggest a linear relationship between the cardiac vagal tone and SD Grade, which can improve decision making and management in the NICU.
Article
Peripheral Vascular Disease
Hugo S. Diaz, David C. Andrade, Camilo Toledo, Karla G. Schwarz, Katherin Pereyra, Esteban Diaz-Jara, Noah J. Marcus, Rodrigo Del Rio
Summary: Recent evidence suggests that chronic activation of catecholaminergic neurons in the rostral ventrolateral medulla plays a crucial role in promoting autonomic imbalance and cardiorespiratory dysfunction in high output heart failure. In this study, researchers assessed the presence of brainstem endoplasmic reticulum stress (ERS) and its potential impact on cardiorespiratory dysfunction in a high output heart failure model induced by volume overload. The results demonstrate that treatment with TUDCA, an inhibitor of ERS, can improve cardiac function, reduce arrhythmia incidence, and improve abnormal respiratory patterns in this model.
Article
Peripheral Vascular Disease
David C. Andrade, Camilo Toledo, Hugo S. Diaz, Katherin Pereyra, Karla G. Schwarz, Esteban Diaz-Jara, Claudia Melipillan, Angelica P. Rios-Gallardo, Atenea Uribe-Ojeda, Julio Alcayaga, Rodrigo A. Quintanilla, Rodrigo Iturriaga, Jean-Paul Richalet, Nicolas Voituron, Rodrigo Del Rio
Summary: The study demonstrated that cEpo treatment significantly reduced the carotid body chemoreflex and hypertension induced by CIH, and normalized breathing patterns. This suggests a potential therapeutic application of cEpo in treating cardiorespiratory disorders associated with CIH.
JOURNAL OF HYPERTENSION
(2021)
Article
Multidisciplinary Sciences
Manuel Vasquez-Munoz, Alexis Arce-Alvarez, Magdalena von Igel, Carlos Veliz, Gonzalo Ruiz-Esquide, Rodrigo Ramirez-Campillo, Cristian Alvarez, Robinson Ramirez-Velez, Fernando A. Crespo, Mikel Izquierdo, Rodrigo Del Rio, David C. Andrade
Summary: The study found that glycemic variability in diabetic patients displays a specific oscillation pattern, mainly with circadian characteristics, and episodes of hypoglycemia and hyperglycemia during the daytime.
SCIENTIFIC REPORTS
(2021)
Article
Physiology
Alexis Arce-Alvarez, Carlos Veliz, Manuel Vazquez-Munoz, Magdalena von Igel, Cristian Alvares, Rodrigo Ramirez-Campillo, Mikel Izquierdo, Gregoire P. Millet, Rodrigo Del Rio, David C. Andrade
Summary: The study found that swimmers had a reduced HVR response and longer maximum voluntary apnea duration, possibly due to decreased HVR.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Esteban Diaz-Jara, Hugo S. Diaz, Angelica Rios-Gallardo, Domiziana Ortolani, David C. Andrade, Camilo Toledo, Katherin V. Pereyra, Karla Schwarz, Gigliola Ramirez, Fernando C. Ortiz, Marcelo E. Andia, Rodrigo Del Rio
Summary: Enhanced central chemoreflex drive and irregular breathing are characteristic features of heart failure (HF). This study found that HF rats have high levels of ROS in the RTN, which are closely related to the enhanced central chemoreflex and breathing disorders. Exercise training increases antioxidant defense in the RTN, reduces ROS formation, and restores normal central chemoreflex drive and breathing regularity in HF rats.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Physiology
Alexis Arce-Alvarez, Camila Salazar-Ardiles, Carlos Cornejo, Valeria Paez, Manuel Vasquez-Munoz, Katherine Stillner-Vilches, Catherine R. Jara, Rodrigo Ramirez-Campillo, Mikel Izquierdo, David C. Andrade
Summary: This article summarizes the available evidence related to chemoreflex control in immersion water sports and proposes a possible physiological mechanistic model that could contribute to providing new avenues for understanding the respiratory physiology of water sports.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Camila Salazar-Ardiles, Leyla Asserella-Rebollo, David C. Andrade
Summary: This review summarizes the role of free-living amoebas (FLAs) in different environments, discusses their adaptive capacity, and explores the mechanisms behind their ability to survive in extreme environments.
BIOMED RESEARCH INTERNATIONAL
(2022)
Article
Physiology
Francisco Fernandez, Manuel Vazquez-Munoz, Andrea Canals, Alexis Arce-Alvarez, Camila Salazar-Ardiles, Cristian Alvarez, Rodrigo Ramirez-Campillo, Gregoire P. Millet, Mikel Izquierdo, David C. Andrade
Summary: Exercise training has been found to improve the survival rate of hypertensive patients with COVID-19 during their hospitalization period, providing strong evidence for its therapeutic efficacy in improving outcomes for these patients.
JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Article
Physiology
Alexis Oyarzo-Aravena, Alexis Arce-Alvarez, Camila Salazar-Ardiles, Rodrigo Ramirez-Campillo, Cristian Alvarez, Camilo Toledo, Mikel Izquierdo, David C. Andrade
Summary: This study aimed to determine the cardiorespiratory optimal point (COP) in highly trained athletes and its influence on maximum and sub-maximum variables during CPET through principal component analysis (PCA). The data revealed that COP values were different between males and females, but both groups had COP located before VT1. The PCA analysis suggested that COP variance was mainly explained by expired CO2 at VO2max and VE at VT2, which may influence cardiorespiratory efficiency at VO2max and VT2. Therefore, COP could be used as a submaximal index to assess endurance athletes' cardiorespiratory system efficiency.
FRONTIERS IN PHYSIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Camila Salazar-Ardiles, Leyla Asserella-Rebollo, Carlos Cornejo, Dayana Arias, Manuel Vasquez-Munoz, Camilo Toledo, David C. Andrade
Summary: This article introduces the diagnostic methods and advancements for COVID-19 caused by the novel coronavirus SARS-CoV-2. Real-time quantitative reverse transcription PCR is the main diagnostic method, while antigen and serological tests have also been widely used. There have been significant advancements in sample collection methods, including the introduction of saliva-based tests. Genomic surveillance is important due to the ongoing mutations in the virus. However, each diagnostic method has limitations.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Biology
Manuel Vasquez-Munoz, Alexis Arce-Alvarez, Cristian Alvarez, Rodrigo Ramirez-Campillo, Fernando A. Crespo, Dayana Arias, Camila Salazar-Ardiles, Mikel Izquierdo, David C. Andrade
Summary: This study aims to determine the characteristics of glycemic oscillations in Type 2 Diabetes (T2D) and develop a reliable predictive model. The results demonstrate that T2D patients exhibit specific oscillatory patterns of glycemic control, which can accurately predict hyper- and hypoglycemia events. These findings have the potential to improve the treatment of DM by considering the individual oscillatory patterns of patients.
BIOLOGICAL RESEARCH
(2022)
Article
Biology
Karla G. Schwarz, Katherin Pereyra, Camilo Toledo, David C. Andrade, Hugo S. Diaz, Esteban Diaz-Jara, Domiziana Ortolani, Angelica Rios-Gallardo, Paulina Arias, Alexandra Las Heras, Ignacio Vera, Fernando C. Ortiz, Nibaldo C. Inestrosa, Carlos P. Vio, Rodrigo Del Rio
Summary: The study showed that dietary potassium supplementation can improve cardiorespiratory function in non-ischemic chronic heart failure (CHF) rats. Potassium supplemented diet significantly reduced arrhythmia incidence, decreased cardiac sympathetic tone, restored baroreflex function, and attenuated irregular breathing patterns in CHF rats.
BIOLOGICAL RESEARCH
(2021)
