Article
Nutrition & Dietetics
Marta Suarez-Gonzalez, Flor Angel Ordonez-Alvarez, Helena Gil-Pena, Sara Carnicero-Ramos, Lucia Hernandez-Pelaez, Sonia Garcia-Fernandez, Fernando Santos-Rodriguez
Summary: This study aimed to assess the effect of a registered dietitian intervention on the eating habits of pediatric patients with chronic kidney disease (CKD). The results showed that after nutritional education and dietary intervention, the diet quality of CKD children improved, but not significantly. The children decreased protein intake, increased dietary fiber intake, and reduced the consumption of meat, dairy, and processed foods.
Review
Nutrition & Dietetics
Paulina Mertowska, Sebastian Mertowski, Julia Wojnicka, Izabela Korona-Glowniak, Ewelina Grywalska, Anna Blazewicz, Wojciech Zaluska
Summary: Chronic kidney disease is a progressive and irreversible condition that can lead to alterations in the gut microbiota and activation of the immune system, with dietary factors playing a significant role in immune cell activation and microbiota balance. Understanding the relationship between intestinal microbiota and kidney dysfunction is crucial in the progression of kidney diseases.
Article
Nutrition & Dietetics
Sofia Cecchi, Silvio Di Stante, Sara Belcastro, Veronica Bertuzzi, Assunta Cardillo, Laura Diotallevi, Xhensila Grabocka, Hrissa Kulurianu, Mauro Martello, Valentina Nastasi, Osmy Paci Della Costanza, Francesca Pizzolante, Marina Di Luca
Summary: Supplemented very low-protein diet (sVLPD) has been effective in delaying the start of dialysis treatment for stage 5 chronic renal failure patients, but it may increase the risk of malnutrition and is difficult to implement. By prescribing sVLPD supplemented with essential amino acids instead of keto-analogues, the progression of chronic kidney disease was slowed down and the start of dialysis treatment was delayed without evidence of malnutrition.
Review
Pediatrics
Erin Melhuish, Rachel Lindeback, Kelly Lambert
Summary: This study analyzed and summarized the evidence regarding the dietary intake of children with chronic kidney disease and identified subgroups where nutrient intake is suboptimal or not well described. Future studies should be conducted to further describe the intake in these groups.
PEDIATRIC NEPHROLOGY
(2022)
Article
Peripheral Vascular Disease
Chloe Douglas, Jennifer T. Roem, Joseph L. Flynn, Susan A. Furth, Bradley M. Warady, Susan Halbach
Summary: Using data from the CKiD Study, this study found that younger children with chronic kidney disease are more likely to have unrecognized and untreated hypertensive blood pressure, highlighting the need for efforts to improve blood pressure control in this population.
Article
Nutrition & Dietetics
Almudena Perez-Torres, M. Elena Gonzalez Garcia, Marta Ossorio-Gonzalez, Laura Alvarez Garcia, M. Auxiliadora Bajo, Gloria del Peso, Ana Castillo Plaza, Rafael Selgas
Summary: Individualized nutrition education for patients with end-stage kidney disease has long-term positive effects on nutritional status, reducing hospitalizations, and increasing survival rates. Patients who did not receive nutritional interventions had higher mortality odds ratio.
Review
Nutrition & Dietetics
Maria Elena Capra, Giacomo Biasucci, Giuseppe Banderali, Cristina Pederiva
Summary: Hypertriglyceridemia is a lipid disorder that can range in prevalence, being very common when considering slightly elevated triglyceride plasma values and extremely rare when only severely elevated levels are considered. The severe forms are often caused by genetic mutations, while secondary forms are usually less severe and can be linked to various diseases or drugs. Nutritional intervention plays a crucial role in treating hypertriglyceridemia, with different approaches for different forms.
Article
Urology & Nephrology
Mona Khurana, Gunter F. Egger, Lynne Yao, Aliza Thompson, Chrissi Pallidis, Stuart L. Goldstein, Benjamin L. Laskin, Shamir Tuchman, Meaghan A. Malley, Katrin Uhlig
Summary: Children with CKD need safe and effective medicines, but conducting trials for pediatric drug development remains a challenge. There are difficulties in recruitment and completion, as well as a significant time lag between adult approval and pediatric labeling. This article provides an overview of regulatory frameworks, current landscape, challenges, and progress in drug development for children with CKD.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Review
Pediatrics
Kyra Newmaster, Zahra Zhu, Elizabeth Bolt, Ryan J. Chang, Christopher Day, Asmaa Mhanna, Sita Paudel, Osman Farooq, Arun Swaminathan, Prakrati Acharya, Wisit Cheungpasitporn, Siddharth Gupta, Debopam Samanta, Naeem Mahfooz, Gayatra Mainali, Paul R. Carney, Sunil Naik
Summary: Ketogenic diets are effective for treating epilepsy but can have various complications. Common side effects can be managed with careful monitoring. Rare and serious complications may require advanced investigations and discontinuation of the diet.
Article
Peripheral Vascular Disease
Monica L. Guzman-Limon, Shuai Jiang, Derek Ng, Joseph T. Flynn, Bradley Warady, Susan L. Furth, Joshua A. Samuels
Summary: This study investigated the effects of nocturnal hypertension on the progression of chronic kidney disease (CKD) in children. The study found that children with both daytime and nocturnal hypertension had the highest risk of kidney replacement therapy. The study confirmed the utility of ambulatory blood pressure monitoring in children with CKD. Identifying and controlling both daytime and nocturnal hypertension using ambulatory blood pressure monitoring may improve outcomes and delay CKD progression in this population.
Article
Nutrition & Dietetics
Rupesh Raina, Sidharth Kumar Sethi, Anvitha Soundararajan, Ann-Marie Brown, Kirsten Kusumi, Jonathan VanGeest, Timothy Bunchman
Summary: We conducted a survey to examine the knowledge and practices of pediatric nephrologists in the nutritional management of critically ill children during CRRT. The survey revealed a lack of knowledge and variability in nutritional management practices. The heterogeneity of the survey results highlights the need for clinical practice guidelines and consensus in this area.
Article
Nutrition & Dietetics
Ban-Hock Khor, Dina A. Tallman, Tilakavati Karupaiah, Pramod Khosla, Maria Chan, Joel D. Kopple
Summary: This study evaluated the nutrient composition of plant-based low protein diets and moderately high protein diets for chronic kidney disease patients in the Asia Pacific region. The study found that plant-based diets were deficient in essential amino acids at lower protein prescriptions, but met the Recommended Dietary Allowances at higher protein intakes. Plant-based and vegetarian diets contained higher potassium, phosphorus, and calcium content but lower long-chain n-3 polyunsaturated fatty acids and vitamin B-12 compared to conventional diets. Planning of all low protein diets, especially plant-based and vegetarian diets, should ensure the adequacy of all nutrients, particularly essential amino acids, and consider supplementing with multivitamins and trace elements.
Review
Urology & Nephrology
Luigi Cirillo, Letizia De Chiara, Samantha Innocenti, Carmela Errichiello, Paola Romagnani, Francesca Becherucci
Summary: Chronic kidney disease (CKD) is a significant global healthcare issue, but the prevalence of pediatric CKD has not been systematically assessed and consistent information is lacking. The current definition of CKD based on glomerular filtration rate (GFR) and albuminuria is challenging in the pediatric population, resulting in underdiagnosis and delays in treatment. Advances in sequencing technology have revealed that CKD is more common in children and adolescents than previously realized, leading to identification of new therapeutic targets. This review focuses on recent innovations in pediatric CKD and aims to provide a new perspective on the disease.
CLINICAL KIDNEY JOURNAL
(2023)
Review
Nutrition & Dietetics
Tania Naber, Sharad Purohit
Summary: Chronic kidney disease affects millions of adults in the US, interfering with the body's physiological mechanisms. Monitoring protein and other nutrients can slow disease progression, while plant-based diets show potential benefits and medical nutrition therapy is crucial in CKD intervention.
Review
Nutrition & Dietetics
Valeria Calcaterra, Elvira Verduci, Michele Ghezzi, Hellas Cena, Martina Chiara Pascuzzi, Corrado Regalbuto, Rossella Lamberti, Virginia Rossi, Matteo Manuelli, Alessandra Bosetti, Gian Vincenzo Zuccotti
Summary: There is a connection between asthma and obesity, with diet playing a significant role in asthma development. Early nutritional intervention may play a critical role in preventing and managing asthma associated with obesity.
Article
Urology & Nephrology
Oleh Akchurin, Zhongfang Du, Nadira Ramkellawan, Vidhi Dalal, Seung Hyeok Han, James Pullman, Anne Musch, Katalin Susztak, Kimberly J. Reidy
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2016)
Article
Urology & Nephrology
Oleh M. Akchurin, Amy J. Kogon, Juhi Kumar, Christine B. Sethna, Hoda T. Hammad, Paul J. Christos, John D. Mahan, Larry A. Greenbaum, Robert Woroniecki
Article
Urology & Nephrology
Edwin Patino, Stephen B. Doty, Divya Bhatia, Kelly Meza, Yuan-Shan Zhu, Stefano Rivella, Mary E. Choi, Oleh Akchurin
KIDNEY INTERNATIONAL
(2020)
Letter
Urology & Nephrology
John R. Lee, Jeffrey Silberzweig, Oleh Akchurin, Mary E. Choi, Vesh Srivatana, Jonathan Lin, Frank Liu, Line Malha, Michelle Lubetzky, Darshana M. Dadhania, Divya Shankaranarayanan, Daniil Shimonov, Sanjay Neupane, Thalia Salinas, Aarti Bhasin, Elly Varma, Lorenz Leuprecht, Supriya Gerardine, Perola Lamba, Parag Goyal, Eric Caliendo, Victoria Tiase, Rahul Sharma, Joel C. Park, Peter A. D. Steel, Manikkam Suthanthiran, Yiye Zhang
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Pediatrics
Kelly Meza, Sharmi Biswas, Yuan-Shan Zhu, Anuradha Gajjar, Eduardo Perelstein, Juhi Kumar, Oleh Akchurin
Summary: The study found that TNF-alpha in pediatric CKD is positively associated with biomarkers of CKD-MBD and negatively associated with height Z-score, indicating that inflammation may contribute to the development of CKD-MBD and growth impairment in this population.
PEDIATRIC NEPHROLOGY
(2021)
Review
Pediatrics
Edwin Patino, Oleh Akchurin
Summary: Chronic kidney disease causes alterations in iron metabolism, leading to anemia and the need for iron supplementation. Therapeutic iron supplementation has pleiotropic effects on various organ systems in CKD patients, beyond traditional hematologic effects. The effects of iron supplementation depend on the administration route and the specific iron preparation used.
PEDIATRIC NEPHROLOGY
(2022)
Article
Physiology
Brent A. Momb, Edwin Patino, Oleh M. Akchurin, Mark S. Miller
Summary: Children with chronic kidney disease (CKD) often experience delayed physical development and reduced physical performance, possibly due to skeletal muscle dysfunction. However, the cellular and molecular mechanisms underlying skeletal muscle impairment in juvenile CKD are still poorly understood.
PHYSIOLOGICAL REPORTS
(2023)
Article
Pediatrics
Kelly Meza, Sharmi Biswas, Chantal Talmor, Kanza Baqai, Dmitry Samsonov, Sonia Solomon, Oleh Akchurin
Summary: Around 30% of children with chronic kidney disease do not respond to oral iron therapy for anemia. The severity of anemia at baseline is correlated with treatment response, suggesting the need for further studies to improve iron therapy outcomes and identify predictors of treatment response in children with anemia of CKD.
PEDIATRIC NEPHROLOGY
(2023)
Article
Urology & Nephrology
Brent A. Momb, Edwin Patino, Oleh M. Akchurin, Mark S. Miller
Summary: Patients with chronic kidney disease (CKD) often have compromised physical performance. In this study, it was found that untreated CKD led to a significant reduction in skeletal muscle force production, which was not solely due to muscle mass loss. Iron supplementation may help improve CKD-induced myopathy.
Article
Urology & Nephrology
Oleh Akchurin, Kelly Meza, Sharmi Biswas, Michaela Greenbaum, Alexandra P. Licona-Freudenstein, Parag Goyal, Justin J. Choi, Mary E. Choi
Summary: Patients with CKD are at higher risk of in-hospital mortality due to COVID-19, especially in elderly populations. Acute-on-chronic kidney injury increases the likelihood of in-hospital death in patients with CKD hospitalized with COVID-19.
Article
Medicine, Research & Experimental
Divya Bhatia, Kuei-Pin Chung, Kiichi Nakahira, Edwin Patino, Michelle C. Rice, Lisa K. Torres, Thangamani Muthukumar, Augustine M. K. Choi, Oleh M. Akchurin, Mary E. Choi
Article
Urology & Nephrology
Oleh Akchurin, Edwin Patino, Vidhi Dalal, Kelly Meza, Divya Bhatia, Simon Brovender, Yuan-Shan Zhu, Susanna Cunningham-Rundles, Eduardo Perelstein, Juhi Kumar, Stefano Rivella, Mary E. Choi
KIDNEY INTERNATIONAL REPORTS
(2019)
Article
Medicine, Research & Experimental
Angara Sureshbabu, Edwin Patino, Kevin C. Ma, Kristian Laursen, Eli J. Finkelsztein, Oleh Akchurin, Thangamani Muthukumar, Stefan W. Ryter, Lorraine Gudas, Augustine M. K. Choi, Mary E. Choi
Article
Physiology
Oleh Akchurin, Angara Sureshbabu, Steve B. Doty, Yuan-Shan Zhu, Edwin Patino, Susanna Cunningham-Rundles, Mary E. Choi, Adele Boskey, Stefano Rivella
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2016)
Article
Pediatrics
Rebecca R. Seltzer, Simone Thompson
PEDIATRIC CLINICS OF NORTH AMERICA
(2024)
Article
Pediatrics
Kimberly E. Sawyer, Douglas J. Opel
PEDIATRIC CLINICS OF NORTH AMERICA
(2024)
Article
Pediatrics
Micah Hester, Skye A. Miner
Summary: The process of soliciting a minor's assent has moral importance, even if it is not always required by regulations. It allows the child's opinion to be heard and respects their development and involvement in research. The extent of the child's involvement depends on their age, experience, and maturity.
PEDIATRIC CLINICS OF NORTH AMERICA
(2024)
Article
Pediatrics
Nicholas A. Jabre, Margaret R. Moon
PEDIATRIC CLINICS OF NORTH AMERICA
(2024)
Article
Pediatrics
Carrie M. Henderson, Renee D. Boss
Summary: An increasing number of children with serious/complex illness are living with long-term prognostic uncertainty, intensive interactions with medical systems, functional limitations, and the use of chronic medical technologies that affect their quality of life. These families often face multiple medical decision points and rely on intentional and iterative discussions to guide their care goals.
PEDIATRIC CLINICS OF NORTH AMERICA
(2024)
Article
Pediatrics
Margaret R. Moon
PEDIATRIC CLINICS OF NORTH AMERICA
(2024)
Article
Pediatrics
Mark T. Hughes
PEDIATRIC CLINICS OF NORTH AMERICA
(2024)
