Review
Biochemistry & Molecular Biology
Kaja Michalczyk, Aneta Cymbaluk-Ploska
Summary: Matrix metalloproteinases (MMPs) play a crucial role in the development and progression of endometrial cancer, with significantly elevated levels in cancer patients compared to normal individuals. Understanding the role of MMPs may have implications for diagnosis and treatment of endometrial cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Deep Sankar Rudra, Uttam Pal, Nilkanta Chowdhury, Nakul Chandra Maiti, Angshuman Bagchi, Snehasikta Swarnakar
Summary: The repairing of damaged tissues in the gastric tract starts with extracellular matrix remodeling by matrix metalloproteinases (MMPs). The drug omeprazole, used to cure gastric ulcers, has been shown to restore MMP-2 activity and reduce apoptosis, preventing stress-induced gastric ulcers by modulating NF-kappa B and PPAR-gamma activity.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Caimei Wang, Yiyuan Wang, Congrong Liu, Xiaoyu Meng, Zhongxia Hang
Summary: This study reveals the important role of KNTC1 in the development of cervical cancer and identifies the mechanism by which KNTC1 promotes cervical cancer through MMP9 and MMP2-mediated reduction in tumor cell invasion and migration abilities.
Article
Agriculture, Dairy & Animal Science
Juanjuan Song, Ligang Yuan, Hua Wang, Guojuan Chen, Shaoyu Chen
Summary: This study investigated the distribution and expression of MMP-2 and TIMP-2 in yak testes. The results showed that MMP-2 and TIMP-2 were mainly located in different cell types at different ages. The expression levels of MMP-2 and TIMP-2 varied with age, with a decrease from newborn to adult and an increase in old yaks. This study revealed the possible roles of MMP-2 and TIMP-2 in testicular functionality of yaks at different ages.
REPRODUCTION IN DOMESTIC ANIMALS
(2023)
Article
Biochemistry & Molecular Biology
Sasha Coates-Park, Carolyn Lazaroff, Sadeechya Gurung, Josh Rich, Alexandra Colladay, Maura O'Neill, Georgina S. Butler, Christopher M. Overall, William G. Stetler-Stevenson, David Peeney
Summary: Extracellular proteolysis and turnover play crucial roles in tissue homeostasis. MMPs, as the main matrix-degrading enzymes, are regulated by TIMPs. The balance between MMP activity and TIMP levels is essential for healthy tissue homeostasis and can be disrupted in pathological conditions.
Article
Oncology
Yihe Zhang, Shiyu Liu, Bingjie Jiang, Sung Kay Chiu, Meng Huee Lee
Summary: Peritumoral fibroblasts can be therapeutically engineered with a specific metalloproteinase inhibitor to eliminate cancer cells, as shown in 3D co-culture models where the inhibitor promoted an attenuation in tumor development. This novel anti-tumor strategy could potentially enhance the efficacy of conventional chemo- and immunotherapies for cancer treatment.
INVESTIGATIONAL NEW DRUGS
(2022)
Article
Health Care Sciences & Services
Jung Hyun Park, Sun-Jung Cho, Chulman Jo, Moon Ho Park, Changsu Han, Eun-Joo Kim, Gi Yeong Huh, Young Ho Koh
Summary: Our study found that fluid levels of TIMP-3 were lower in AD patients, suggesting a possible association with cognitive decline.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Jacek Kudelski, Anna Tokarzewicz, Monika Gudowska-Sawczuk, Barbara Mroczko, Piotr Chlosta, Marta Bruczko-Goralewska, Przemyslaw Mitura, Grzegorz Mlynarczyk
Summary: This study aimed to evaluate the expression and activity of matrix metalloproteinase 2 and 9 (MMP-2 and MMP-9) in urinary bladder cancer at different stages. The results showed that the content and activity of MMP-9 were higher than MMP-2, especially in high-grade cancer tissue. MMP-9 may have higher clinical utility as a potential therapeutic option and a diagnostic biomarker for urinary bladder cancer.
Review
Oncology
Cui Wei
Summary: High expression of MMPs is associated with poor survival, advanced clinical stages, and cancer metastasis in lung cancer. MMPs play multiple roles in lung cancer, including involvement in drug resistance, induction of CSCLs, and participation in tumor immunity. Additionally, MMPs polymorphisms may elevate the risk of lung cancer.
FRONTIERS IN ONCOLOGY
(2023)
Article
Neurosciences
Griffin A. Greco, Mitchell Rock, Matthew Amontree, Maria Fe Lanfranco, Holly Korthas, Sung Hyeok Hong, R. Scott Turner, G. William Rebeck, Katherine Conant
Summary: The APOE4 allele increases the risk for Alzheimer's disease in a dose-dependent manner and is associated with cognitive decline. A study using mice with targeted gene replacement showed that APOE4 reduces neuronal dendritic complexity and impairs learning. APOE4 also reduces gamma oscillation power, important for learning and memory. The present study found that CCL5, an ECM effector, is increased in CSF samples from APOE4 individuals, and TIMPs, which inhibit ECM-degrading enzymes, are increased in APOE4 CSF and brain lysates. Knockout of CCR5, a receptor for CCL5, enhanced gamma power and improved learning and memory.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Veterinary Sciences
Florentina Daraban Bocaneti, Gennaro Altamura, Annunziata Corteggio, Oana Irina Tanase, Mihaela Anca Dascalu, Sorin Aurelian Pasca, Ozana Hritcu, Mihai Mares, Giuseppe Borzacchiello
Summary: This study conducted immunohistochemical and biochemical analysis on MMPs and TIMPs in BPV-2 positive bovine cutaneous fibropapillomas, revealing their significant role in tumor development and their unbalanced expression in tumor samples.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Emma Munoz-Saez, Natalia Moracho, Ana I. R. Learte, Alice Collignon, Alicia G. Arroyo, Agnes Noel, Nor Eddine Sounni, Cristina Sanchez-Camacho
Summary: MT4-MMP, a member of the MT-MMP family, is anchored to the cell surface by a GPI motif. Its expression in various cancers is well documented, but the molecular mechanisms behind its role in tumor development still need further investigation. In this review, we summarize the contribution of MT4-MMP in tumorigenesis, focusing on its involvement in tumor cell migration, invasiveness, proliferation, tumor vasculature and microenvironment, as well as metastasis. We also compare its role during embryonic development and highlight its potential as a biomarker for monitoring cancer progression and as a target for future drug development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Infectious Diseases
Bastian Lubis, Aznan Lelo, Putri Amelia, Agus Prima
Summary: This study was a randomized controlled trial examining the effects of vitamin C and thiamine in septic patients. The study found that thiamine alone provided better advantages than either vitamin C alone or their combination.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Oncology
Teodora Oltean, Lien Lippens, Kelly Lemeire, Caroline De Tender, Marnik Vuylsteke, Hannelore Denys, Katrien Vandecasteele, Peter Vandenabeele, Sandy Adjemian
Summary: Irradiation can trigger different cellular responses, including immunogenic cell death. This study aims to determine whether intra-tumoral immunogenic cell death markers can predict the outcomes of patients with cervical cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Endocrinology & Metabolism
Chenchen Yang, Can Shi
Summary: This meta-analysis aimed to study the correlation between four polymorphisms in the matrix metalloproteinase (MMP) gene and risk of cervical cancer. The results showed that MMP-7 rs11568818 G/A and MMP-3 rs3025058 5A/6A were significantly associated with cervical cancer susceptibility.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Endocrinology & Metabolism
Ilona Juchnicka, Mariusz Kuzmicki, Magdalena Niemira, Agnieszka Bielska, Iwona Sidorkiewicz, Monika Zbucka-Kretowska, Adam Jacek Kretowski, Jacek Szamatowicz
Summary: This study investigates the changes in miRNA profile in gestational diabetes mellitus (GDM) patients before the onset of hyperglycemia. Circulating miRNAs were measured using the NanoString quantitative assay platform and validated with real-time polymerase chain reaction (RT-PCR). The results demonstrate the significance of miRNAs in the pathophysiology of GDM and their potential as predictive factors for early diagnosis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Angelika Buczynska, Iwona Sidorkiewicz, Ahsan Hameed, Adam Jacek Kretowski, Monika Zbucka-Kretowska
Summary: This review provides novel insights into the pathogenesis of trisomy 13 and 18, with a particular focus on oxidative stress. Evaluating oxidative stress is important for understanding disrupted metabolic pathways, mitochondrial dysfunction, and epigenetics. Additionally, unifying research protocols related to trisomy could have potential medical targets.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Oncology
Angelika Buczynska, Iwona Sidorkiewicz, Adam Jacek Kretowski, Monika Zbucka-Kretowska, Agnieszka Adamska
Summary: Metformin treatment has pleiotropic actions, such as inhibiting inflammatory processes, enhancing antioxidant capacity, and improving glycemic and lipid metabolism, making it an attractive drug candidate for human trials. Promising results of metformin in various clinical trials are also summarized in this review.
Article
Oncology
Mariusz Rogucki, Iwona Sidorkiewicz, Magdalena Niemira, Janusz Bogdan Dzieciol, Angelika Buczynska, Agnieszka Adamska, Katarzyna Siewko, Maria Kosciuszko, Katarzyna Maliszewska, Anna Wojcicka, Jakub Supronik, Malgorzata Szelachowska, Joanna Reszec, Adam Jacek Kretowski, Anna Poplawska-Kita
Summary: In this study, the microRNA profile of papillary thyroid cancer (PTC) tissue was investigated to identify important pathways and propose a diagnostic biomarker. Four microRNAs (miR-152-3p, miR-221-3p, miR-551b-3p, and miR-7-5p) were identified as potential diagnostic tools for PTC. This study highlights the potential of microRNAs as diagnostic biomarkers for PTC.
Review
Oncology
Aleksandra Kicman, Marek Niczyporuk, Monika Kulesza, Joanna Motyka, Slawomir Lawicki
Summary: Ovarian cancer is a common gynecologic malignancy with a high mortality rate mainly due to its asymptomatic course. New diagnostic methods are being explored to enable earlier detection and better monitoring. Among these methods, extracellular matrix metalloproteinases (MMPs) are of particular interest. This article compiles the existing knowledge of MMPs in ovarian cancer patients and explores their potential diagnostic utility. Preliminary results indicate that MMPs may differ in tissue expression and blood and body fluid levels between ovarian cancer patients and healthy women. Moreover, the expression and concentration of individual MMPs have been shown to be correlated with cancer stage and disease severity.
CANCER MANAGEMENT AND RESEARCH
(2022)
Article
Medicine, General & Internal
Joanna Motyka, Ewa Gacuta, Aleksandra Kicman, Monika Kulesza, Pawel Lawicki, Slawomir Lawicki
Summary: This study aims to evaluate the plasma concentrations of CXCL1, CXCL8, and CA 15-3 in breast cancer patients and investigate their diagnostic value. The results suggest that CXCL8 can be used as an additional diagnostic marker for breast cancer, especially in the luminal B subtype.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Klaudia Katarzyna Brogowska, Monika Zajkowska, Barbara Mroczko
Summary: Breast cancer is the most common and lethal malignancy in women. Its development is influenced by factors such as age, genetic mutations, and body weight. Currently, there is a lack of sensitive and specific screening tests, but researchers are exploring new diagnostic biomarkers. The VEGF family of proteins and their receptors play a significant role in the pathogenesis of breast cancer and could potentially be used as diagnostic biomarkers and therapeutic targets.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Pawel Lawicki, Pawel Malinowski, Joanna Motyka, Michal Lawicki, Aleksandra Kicman, Monika Kulesza, Ewa Gacuta, Tomasz Guszczyn, Marcin Januszkiewicz, Monika Zbucka-Kretowska, Slawomir Lawicki
Summary: The aim of this study was to assess the plasma concentrations and diagnostic utility of MMP-3 and MMP-7 in early-stage breast cancer patients. The results showed that plasma levels of MMP-7 were significantly higher in Luminal A and Luminal B HER2-negative subtype breast cancer patients compared to the healthy group. MMP-7 demonstrated comparable or higher values of diagnostic sensitivity, specificity, positive and negative predictive values, and AUC compared to CA 15-3 or MMP-3. Therefore, combining MMP-7 with CA 15-3 may improve the diagnostic accuracy of breast cancer, particularly in Luminal B HER2-negative subtype patients, and MMP-7 could be a potential new tumor marker.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Monika Zajkowska, Barbara Mroczko
Summary: Colorectal cancer is a global problem and scientists are trying to expand their knowledge on its early detection and treatment. Chemokines, as protein factors involved in cancer development, are potential biomarkers for colorectal cancer detection.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Angelika Buczynska, Iwona Sidorkiewicz, Maria Kosciuszko, Agnieszka Adamska, Katarzyna Siewko, Janusz Dzieciol, Piotr Szumowski, Janusz Mysliwiec, Anna Poplawska-Kita, Adam Jacek Kretowski
Summary: Markers of oxidative status, including total oxidative status (TOS), total antioxidant capacity (TAC), tumor protein 53 (p53), nuclear factor kappa B (NF-?B), forkhead box protein O1 (FOXO), and sirtuin 1 (SIRT1), play important roles in oxidative homeostasis and the progression of papillary thyroid cancer (PTC). Analyzing these markers can help determine eligibility for radioiodine (RAI) treatment. This study evaluated the relationship between oxidative status markers and qualification for RAI treatment in PTC patients.
Review
Oncology
Joanna Motyka, Aleksandra Kicman, Monika Kulesza, Slawomir Lawicki
Summary: Currently, there is a constant search for tumor markers that can improve breast cancer diagnostics, especially in the early stages. Among the potential markers, chemokines have been found to be closely implicated in tumorigenesis and scientists have evaluated their usefulness in breast cancer diagnosis. This study summarizes the reports on the expression and peripheral blood concentration of ELR-positive CXC chemokines as potential markers and prognostic factors for breast cancer.
Article
Multidisciplinary Sciences
Angelika Buczynska, Iwona Sidorkiewicz, Maria Kosciuszko, Agnieszka Adamska, Katarzyna Siewko, Janusz Dzieciol, Piotr Szumowski, Janusz Mysliwiec, Malgorzata Szelachowska, Anna Poplawska-Kita, Adam Kretowski
Summary: Angioinvasion remains an important prognostic factor in papillary thyroid cancer (PTC) patients. This study evaluated the utility of selected parameters in screening for angioinvasion and metastasis in PTC patients. The results showed that levels of serum antioxidant capacity (TAC) and sirtuin 3 (SIRT3) were decreased, while levels of DNA/RNA oxidative stress damage products (DNA/RNA OSDP) and malondialdehyde (MDA) were increased in PTC patients with angioinvasion and metastasis. The highest screening accuracy for detecting angioinvasion and metastasis in PTC patients was achieved using DNA/RNA OSDP, SIRT3, and TAC.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Iwona Sidorkiewicz, Maciej Jozwik, Angelika Buczynska, Anna Erol, Marcin Jozwik, Marcin Moniuszko, Katarzyna Jarzabek, Magdalena Niemira, Adam Kretowski
Summary: Aberrant metabolism has been identified as a main driver of cancer. In this study, transcriptomic profiles of metabolism-related pathways in endometrial cancer (EC) were established using NanoString nCounter Technology. 11 deregulated genes associated with 'central carbon metabolism in cancer' were identified, and drug repurposing validated several drug candidates. These findings have significant implications for personalized therapeutic strategies in EC.
SCIENTIFIC REPORTS
(2023)
Meeting Abstract
Medical Laboratory Technology
M. Kulesza, J. Motyka, A. Kicman, E. G. Bedkowska, S. Lawicki, T. Guszczyn, P. Lawicki
CLINICA CHIMICA ACTA
(2022)
Meeting Abstract
Medical Laboratory Technology
S. Lawicki, A. Grytczuk, E. Gruszewska, A. Panasiuk, B. Cylwik, L. Chrostek
CLINICA CHIMICA ACTA
(2022)