Article
Ophthalmology
Gun Tae Jung, Minha Kim, Jong Suk Song, Tae Im Kim, Tae Young Chung, Chul Young Choi, Hyun Seong Kim, Woo Ju An, Su Jin Jeong, Hye Sun Lee, Soyoung Jeon, Kwang Pyo Kim, Hyung Keun Lee
Summary: The study aimed to identify specific tear biomarkers for dry eye disease (DED) through tear proteomic analysis and clinical parameters. The results showed improvements in tear break-up time, corneal erosion, conjunctival erosion, and symptom assessment scores after treatment. However, no significant differences were found among the different drug groups, except for corneal erosion score. Useful tear protein biomarkers, clinically acceptable biomarker combinations, and adequate levels of specificity and sensitivity were not identified.
Article
Biochemistry & Molecular Biology
Yu-Ting Hsiao, Yu-Ting Huang, Hun-Ju Yu, Po-Chiung Fang, Ming-Tse Kuo
Summary: This study investigates the tear protein alterations in dry eye disease (DED) with primary Sjogren syndrome (pSS) and secondary Sjogren syndrome (sSS). The researchers identify ADAM10 and EGF as novel biomarkers for differentiating between primary and secondary SS patients with DED.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Ophthalmology
Rohit Shetty, Pooja Khamar, Sailie Shirodkar, Swaminathan Sethu, Archana P. Nair, Arkasubhra Ghosh
Summary: With changing lifestyles and increasing use of digital screens, dry eye disease has become more common. Despite various diagnostic and treatment options, patient satisfaction remains varied. Understanding the molecular basis of the disease may help customize treatment. We propose a stepwise protocol to incorporate biomarker assays in dry eye management.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Madhuri Amulya Koduri, Deeksha Prasad, Tejaswini Pingali, Vijay Kumar Singh, Swapna S. Shanbhag, Sayan Basu, Vivek Singh
Summary: This study compares different methods of extracting tear proteins from the Schirmer's strip and finds that the highest protein yield is obtained by incubating the strip in 100 mM ammonium bicarbonate (ABC) with 0.25% Nonidet P-40 (NP-40) at 4 degrees Celsius for an hour. Mass spectrometry analysis reveals unique protein signatures in tear samples from Stevens-Johnson syndrome (SJS) and dry eye disease (DED) patients. This study will contribute to the better design of tear protein-based experimental studies.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Biology
Hung-yin Lai, Alexander Chen, Po-chiung Fang, Hun-ju Yu, Ming-tse Kuo
Summary: This study compared tear film viscosity in Sjogren and non-Sjogren dry eye diseases. They found that Sjogren patients had lower tear film viscosity indices and higher symptom severity. The researchers concluded that tear film viscosity indices can be useful in early detection of Sjogren dry eye disease.
Review
Biochemistry & Molecular Biology
Janika Nattinen, Ulla Aapola, Praveena Nukareddy, Hannu Uusitalo
Summary: Tear proteomics has become an increasingly popular approach in studying ocular surface diseases, including glaucoma. With the implementation of modern technologies like LC-MS/MS, more in-depth analysis of glaucoma tear proteomics has emerged.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Deborah Lee, Seoyoon Song, Geonho Cho, Lucia C. Dalle Ore, Noah Malmstadt, Ahmed Fuwad, Sun Min Kim, Tae-Joon Jeon
Summary: This study reveals the important role of lysozyme in tear film lipid layer functionality, improving ocular health through increased tear evaporation and resistance to bacterial invasion.
Article
Medicine, General & Internal
Qiankun Chen, Zhengjiang Wei, Leying Wang, Xizhan Xu, Zhenyu Wei, Panpan Zheng, Kai Cao, Zijun Zhang, Kexin Chen, Qingfeng Liang
Summary: Patients with schizophrenia are more likely to experience asymptomatic dry eye disease, with mild symptoms and obvious signs. The inflammatory cytokines in the tears of schizophrenic patients differed greatly from that of non-schizophrenic patients.
FRONTIERS IN MEDICINE
(2022)
Article
Surgery
Yihong Kaufmann, Stephanie D. Byrum, Alison A. Acott, Eric R. Siegel, Charity L. Washam, V. Suzanne Klimberg, Anne T. Mancino
Summary: Protein profiling in tears can distinguish patients with and without colon lesions.
AMERICAN JOURNAL OF SURGERY
(2022)
Article
Biochemistry & Molecular Biology
Kristina Krajcikova, Agnieszka Balicka, Maria Lapsanska, Alexandra Trbolova, Zuzana Gulasova, Daria Kondrakhova, Vladimir Komanicky, Adriana Rasiova, Vladimira Tomeckova
Summary: Dry eye disease is a chronic ophthalmological disease for which current therapy focuses on symptom suppression. Polyphenols have shown potential in improving dry eye disease therapy. This study aimed to target pathophysiological mechanisms by adding fisetin to the cyclosporine treatment protocol, but it was found that fisetin did not restore tear production but influenced molecular pathological events through MMP-9.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Ophthalmology
Maria L. Merino, Javier Belmonte, Jose Rosas, M. Carmen Acosta, Juana Gallar, Carlos Belmonte
Summary: This study aims to measure the tear flow changes evoked by controlled sensory stimulation of the eye surface using i-Onion (TM), a new stimulation device, in healthy subjects and dry eye disease (DED) patients. The results showed that CO2 stimulation significantly increased tear volume in 78% of control subjects, while DED patients had lower basal tear volume (BTV) and stimulated tear volume (STV) compared to healthy controls.
Review
Chemistry, Multidisciplinary
Joon Young Hyon, Sang Beom Han
Summary: Dry eye disease is a global public health problem that impairs quality of life and poses economic burden. Inflammation plays a key role in the worsening of the disease, and besides anti-inflammatory medications, vitamin supplementation may also be effective.
APPLIED SCIENCES-BASEL
(2022)
Article
Biochemistry & Molecular Biology
Tatsuma Kishimoto, Waka Ishida, Isana Nakajima, Ken Fukuda, Kenji Yamashiro
Summary: Dry eye disease (DED) and allergic conjunctivitis have interactions and can exacerbate each other in mice, leading to ocular surface epithelial damage and aggravated allergic signs and symptoms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Ophthalmology
Bhavya Gorimanipalli, Pooja Khamar, Swaminathan Sethu, Rohit Shetty
Summary: The endocrine system plays a role in influencing all tissues and cells in the human body, including the ocular surface. Dry eye disease is a multifactorial disorder, and endocrine anomalies are one of the contributing factors. This review examines the impact of various hormones, such as androgens, estrogens, progesterone, insulin, and thyroid hormones, on the ocular surface and the implications for dry eye disease. The potential use of hormonal therapies in the management of dry eye disease is also discussed.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2023)
Review
Pharmacology & Pharmacy
Atsushi Kawahara
Summary: Dry eye disease is a multifactorial disorder characterized by tear fluid imbalance. In Asia, the focus of treatment is on tear film stabilization. Traditional therapies like artificial tears and steroids have limitations, while new generation therapies have shown to be more effective in Asia.
Letter
Oncology
Lucas Caldi Gomes, Anna-Elisa Roser, Gaurav Jain, Tonatiuh Pena Centeno, Fabian Maass, Lukas Schilde, Caroline May, Anja Schneider, Mathias Baehr, Katrin Marcus, Andre Fischer, Paul Lingor
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Letter
Clinical Neurology
Fabian Maass, Bernhard Michalke, Desiree Willkommen, Sezgi Canaslan, Matthias Schmitz, Mathias Baehr, Inga Zerr, Paul Lingor
Summary: Longitudinal PD CSF samples were analyzed using ICP-MS to quantify the total amount of iron and other bioelements. In addition, ferritin and protein biomarkers of neurodegeneration were measured. Over time, mean iron levels significantly increased while ferritin levels decreased.
MOVEMENT DISORDERS
(2021)
Letter
Clinical Neurology
Matthias Schmitz, Sezgi Canaslan, Anna Villar-Pique, Karin Gmitterova, Daniela Varges, Paul Lingor, Franc Llorens, Peter Hermann, Fabian Maass, Inga Zerr
MOVEMENT DISORDERS
(2021)
Review
Clinical Neurology
Paul Theo Zebhauser, Isabell Cordts, Holger Hengel, Bernhard Haslinger, Paul Lingor, Hasan Orhan Akman, Tobias B. Haack, Marcus Deschauer
Summary: Adult polyglucosan body disease (APBD) is a rare neurodegenerative disorder caused by pathogenic variants in the GBE1 gene. It is characterized by neurogenic bladder dysfunction, spastic paraplegia, and axonal neuropathy, with possible cognitive symptoms and dementia.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Simon Witzel, Andre Maier, Robert Steinbach, Julian Grosskreutz, Jan C. Koch, Anastasia Sarikidi, Susanne Petri, Rene Guenther, Joachim Wolf, Andreas Hermann, Johannes Prudlo, Isabell Cordts, Paul Lingor, Wolfgang N. Loescher, Zacharias Kohl, Tim Hagenacker, Christian Ruckes, Birgit Koch, Susanne Spittel, Kornelia Guenther, Sebastian Michels, Johannes Dorst, Thomas Meyer, Albert C. Ludolph
Summary: This study found that long-term intravenous edaravone therapy for patients with ALS was feasible and well tolerated, but did not provide any disease-modifying benefit compared to standard therapy.
Article
Clinical Neurology
Camilla Binz, Alma Osmanovic, Nele H. Thomas, Benjamin Stolte, Maren Freigang, Isabell Cordts, Ramona Griep, Zeljko Uzelac, Claudia D. Wurster, Christoph Kamm, Hannah A. Siegler, Gary Wieselmann, Andreas Hermann, Paul Lingor, Marcus Deschauer, Albert C. Ludolph, Thomas Meyer, Rene Guenther, Tim Hagenacker, Susanne Petri, Olivia Schreiber-Katz
Summary: This study investigates the validity and reliability of the German Multidimensional Fatigue Inventory in spinal muscular atrophy and evaluates the presence of clinically relevant fatigue. The results show that the questionnaire has good internal consistency and convergent validity, and can effectively assess different dimensions of fatigue. Fatigue is a significant problem in spinal muscular atrophy and should be incorporated into standard care.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2022)
Article
Oncology
Lucas Caldi Gomes, Ana Galhoz, Gaurav Jain, Anna-Elisa Roser, Fabian Maass, Eleonora Carboni, Elisabeth Barski, Christof Lenz, Katja Lohmann, Christine Klein, Mathias Baehr, Andre Fischer, Michael P. Menden, Paul Lingor
Summary: This study investigated the molecular landscape of Parkinson's disease (PD) in human post-mortem midbrains and identified multiple molecular targets and networks that are relevant to the disease mechanism. The findings suggest that neuroinflammation, immune response activation, mitochondrial dysfunction, and defects in synaptic function could be potential therapeutic targets for advanced PD.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Clinical Neurology
Antonia F. Demleitner, Andreas W. Wolff, Johanna Erber, Friedemann Gebhardt, Erica Westenberg, Andrea S. Winkler, Susanne Kolbe-Busch, Iris F. Chaberny, Paul Lingor
Summary: Parkinson's disease (PD) is a common neurodegenerative disease with a rising prevalence. Infection with SARS-CoV-2 can lead to a complicated disease course for PD patients. Currently, there is a lack of guidelines for managing outpatient PD patients during times of increased infection risk. However, measures such as mask-wearing, hand hygiene, social distancing, and appropriate testing strategies can minimize exposure risk. Telemedicine consultations can be used for low urgency visits, while in-person presentation is required for moderate and high urgency visits. Vaccination against SARS-CoV-2 is safe and effective for PD patients, playing a key role in reducing infection risk.
JOURNAL OF NEURAL TRANSMISSION
(2022)
Article
Neurosciences
Pretty Garg, Fabian Maass, Sivaraj M. Sundaram, Brit Mollenhauer, Sameehan Mahajani, Christoph van Riesen, Sebastian Kuegler, Mathias Baehr
Summary: Several studies have explored the differences in serum levels of alpha-synuclein autoantibodies (alpha-syn AAb) in Parkinson's disease (PD) patients and healthy subjects, but the results have been inconclusive. In this study, with the largest sample size examined so far, the researchers aimed to validate the use of serum alpha-syn AAb levels as a biomarker for PD and investigate the presence of other synuclein antibodies. The results showed that while the levels of alpha- and beta-syn AAb were significantly reduced in PD patients and other neurodegenerative disorder patients compared to controls, there was high variability in the AAb levels. Furthermore, the alpha-syn AAb levels did not correlate with clinical parameters such as age, disease duration, disease severity, and gender. In conclusion, serum synuclein AAb levels may distinguish PD from healthy subjects but not from other neurodegenerative disorders, indicating that they cannot be regarded as a reliable biomarker for PD.
MOLECULAR AND CELLULAR NEUROSCIENCE
(2022)
Letter
Clinical Neurology
Jonas Deppe, Natalie Deininger, Paul Lingor, Tobias B. Haack, Bernhard Haslinger, Marcus Deschauer
MOVEMENT DISORDERS
(2022)
Article
Immunology
Sina Bohnacker, Franziska Hartung, Fiona Henkel, Alessandro Quaranta, Johan Kolmert, Alina Priller, Minhaz Ud-Dean, Johanna Giglberger, Luisa M. Kugler, Lisa Pechtold, Sarah Yazici, Antonie Lechner, Johanna Erber, Ulrike Protzer, Paul Lingor, Percy Knolle, Adam M. Chaker, Carsten B. Schmidt-Weber, Craig E. Wheelock, Julia Esser-von Bieren
Summary: SARS-CoV-2 infection leaves an inflammatory imprint in MDM, resulting in aberrant macrophage function and eicosanoid metabolism, leading to long-term immune aberrations in patients recovering from mild COVID-19.
MUCOSAL IMMUNOLOGY
(2022)
Article
Neurosciences
Andreas Wolfgang Wolff, Bernhard Haller, Antonia Franziska Demleitner, Erica Westenberg, Paul Lingor
Summary: The COVID-19 pandemic has had a significant impact on the medical care of patients with Parkinson's disease, leading to worsening symptoms, appointment cancellations, and difficulties in organizing treatments. Physicians offered alternative consultation options, with telephone consultations being the most accepted by patients.
Letter
Clinical Neurology
Fabian Maass, Ala Jamous, Saskia Biskup, Hanna Eisenberg, Zara D'Hedouville, Mathias Baehr, Christoph van Riesen
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Article
Immunology
Johanna Erber, Verena Kappler, Bernhard Haller, Hrvoje Mijocevic, Ana Galhoz, Clarissa Prazeres da Costa, Friedemann Gebhardt, Natalia Graf, Dieter Hoffmann, Markus Thaler, Elke Lorenz, Hedwig Roggendorf, Florian Kohlmayer, Andreas Henkel, Michael P. Menden, Jurgen Ruland, Christoph D. Spinner, Ulrike Protzer, Percy Knolle, Paul Lingor
Summary: This study investigated the prevalence of SARS-CoV-2 infection in hospital staff in Munich, Germany and found that staff engaged in direct patient care had a similar probability of being seropositive as non-patient-facing staff. Increased risk of infection was observed in staff who had interactions with infected coworkers or private contacts, as well as those who had exposure to COVID-19 patients without appropriate personal protective equipment. The study also identified that the infection hotspots for SARS-CoV-2-positive staff and patients only partially overlapped.
EMERGING INFECTIOUS DISEASES
(2022)
Article
Clinical Neurology
Jun-Pyo Hong, Hanim Kwon, Euyhyun Park, Sun-Uk Lee, Chan-Nyoung Lee, Byung-Jo Kim, Ji-Soo Kim, Kun-Woo Park
Summary: In patients with mild-to-moderate PD, vestibular function assessed by video head-impulse tests appears relatively preserved and has minimal impact on the risk of falls. Risk of postural instability is associated with the severity of clinical symptoms in PD.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Clinical Neurology
Yaqin Xiang, XiuRong Huang, Qian Xu, Zhenhua Liu, Yase Chen, Qiying Sun, Junling Wang, Hong Jiang, Lu Shen, Xinxiang Yan, Beisha Tang, Jifeng Guo
Summary: Using the novel data-driven method DEBM, this study determined the sequence of several common biomarker changes in Parkinson's disease (PD). The left putamen was found to be the earliest biomarker to become abnormal, followed by the right putamen, CSF alpha-synuclein, right caudate, left caudate, and serum NfL. The estimated disease stages showed significant differences between PD and healthy controls, and achieved a high accuracy for distinguishing PD from HC.
PARKINSONISM & RELATED DISORDERS
(2024)
Article
Clinical Neurology
Yan Li, David J. McLernon, Carl E. Counsell, Angus D. Macleod
Summary: This study aimed to investigate the incidence and risk factors for institutionalisation in Parkinson's disease (PD) and atypical parkinsonism (AP). The study found that institutionalisation was more frequent in AP compared to PD and controls. Age, poorer cognition, and more-severe parkinsonian impairment were independent predictors of institutionalisation.
PARKINSONISM & RELATED DISORDERS
(2024)
