Review
Biochemistry & Molecular Biology
Michal Rakowski, Szymon Porebski, Agnieszka Grzelak
Summary: This review focuses on the modulation of autophagy by selected vitamins and nutraceuticals, and their potential value in the treatment of neurodegenerative diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Xiaoyan Zeng, Hedi An, Fei Yu, Kai Wang, Lanlan Zheng, Wei Zhou, Yiwen Bao, Jie Yang, Nan Shen, Dongya Huang
Summary: This study demonstrates that iron overload can lead to neuronal death potentially through apoptosis and ferroptosis pathways. The iron chelator DFO has been shown to inhibit ferroptosis and protect neurons in vitro.
NEUROCHEMICAL RESEARCH
(2021)
Article
Clinical Neurology
Mario H. Flores-Torres, Chadwick W. Christine, Kjetil Bjornevik, Samantha A. Molsberry, Albert Y. Hung, Brian C. Healy, Deborah Blacker, Michael A. Schwarzschild, Alberto Ascherio
Summary: This study examined the association between long-term intake of folate, vitamin B6, and vitamin B12 and the incidence of Parkinson's disease. The results showed that there was no association between folate and B6 intake and PD risk, but a higher baseline intake of vitamin B12 may have a protective effect.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Mario H. Flores-Torres, Chadwick W. Christine, Kjetil Bjornevik, Samantha A. Molsberry, Albert Y. Hung, Brian C. Healy, Deborah Blacker, Michael A. Schwarzschild, Alberto Ascherio
Summary: This study examined the association between long-term intake of folate, vitamin B6, and vitamin B12 and the incidence of Parkinson's disease (PD). The results showed that there was no association between total folate, B6, and B12 intake and the risk of PD. However, a lower risk of PD was observed among individuals with higher baseline total intake of B12, indicating a possible protective effect of vitamin B12 on PD development.
MOVEMENT DISORDERS
(2023)
Review
Pharmacology & Pharmacy
Tapan Behl, Piyush Madaan, Aayush Sehgal, Hafiz A. Makeen, Mohammed Albratty, Hassan A. Alhazmi, Abdulkarim M. Meraya, Md. Khalid Anwer, Raman Verma
Summary: Parkinson's disease (PD) is a complex neurodegenerative disorder characterized by a significant decrease in dopaminergic neurons in the midbrain region. The main symptoms of the disease are slow movement, muscle tension, shaking, and disrupted balance, but the underlying pathology is still unclear. Modern medicinal treatment focuses on reducing symptoms rather than preventing the destruction of dopaminergic neurons. Therefore, the development and use of novel neuroprotective candidates are crucial in addressing PD.
CURRENT PHARMACEUTICAL DESIGN
(2023)
Article
Multidisciplinary Sciences
Corinne Jola, Moa Sundstrom, Julia McLeod
Summary: Dance classes designed for people with Parkinson's have benefits in improving motor control abilities and mood. However, the quantitative evidence of these benefits is inconsistent. A mixed method approach was used to explore the effects of music in dance classes. The study found that music had a significant effect on improving gait before class, but not after class. The importance of music was further emphasized in qualitative data. Understanding how music and dance affect Parkinson's symptoms will help in the design of future interventions.
Review
Clinical Neurology
Sama Rahnemayan, Sasan Ghazanfar Ahari, Reza Rikhtegar, Sevda Riyahifar, Sarvin Sanaie
Summary: This umbrella review systematically reviewed the literature on the association between dietary intake or serum levels of different vitamins and the risk of PD. It found that PD patients had significantly lower levels of serum vitamin D and B12, and higher levels of homocysteine. Higher vitamin E intake was associated with significantly lower risk of PD development. However, there was no significant difference in the risk of PD and higher intake or serum levels of vitamin A, C, B6, or folate.
ACTA NEUROLOGICA BELGICA
(2023)
Review
Biochemistry & Molecular Biology
Giuseppina Malcangi, Assunta Patano, Anna Maria Ciocia, Anna Netti, Fabio Viapiano, Irene Palumbo, Irma Trilli, Mariafrancesca Guglielmo, Alessio Danilo Inchingolo, Gianna Dipalma, Francesco Inchingolo, Elio Minetti, Angelo Michele Inchingolo
Summary: In recent years, there has been increased focus on the relationship between oxidation-reduction mechanisms and human health. Free radicals produced through cellular processes are the main drivers of oxidation and can cause cellular damage due to their instability. The body counters the harmful effects of free radicals by producing endogenous antioxidants and nutraceuticals have been found to have antioxidant capacity. Research is being conducted to understand the interaction between reactive oxygen species, exogenous antioxidants, and the microbiota to enhance protection against oxidative stress. This scoping review aims to map the scientific literature on oxidative stress and oral microbiota, and assess the available studies while identifying potential research gaps.
Article
Health Care Sciences & Services
Meredith Bock, Maya Katz, Stefan Sillau, Kwame Adjepong, Kristine Yaffe, Roman Ayele, Zachary A. Macchi, Steven Pantilat, Janis M. Miyasaki, Benzi Kluger
Summary: This study found that palliative care has specific benefits for individuals with Parkinson's disease and related disorders, including improvement in patients' holistic self-impressions, care partners' self-efficacy, and non-motor symptoms.
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
(2022)
Review
Food Science & Technology
Venkata Sita Rama Raju Allam, Dinesh Kumar Chellappan, Niraj Kumar Jha, Madhur D. Shastri, Gaurav Gupta, Shakti D. Shukla, Sachin K. Singh, Krishna Sunkara, Nitin Chitranshi, Vivek Gupta, Peter R. Wich, Ronan MacLoughlin, Brian Gregory George Oliver, Sara Wernersson, Gunnar Pejler, Kamal Dua
Summary: Respiratory diseases have a significant impact on global health, with current treatment strategies revolving around anti-inflammatory agents and bronchodilators; researchers are exploring novel therapeutic strategies, with nutraceuticals being considered a safe and effective alternative that may have a positive impact on respiratory diseases.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Biotechnology & Applied Microbiology
Amanda Li, Joel Tyson, Shivni Patel, Meer Patel, Sruthi Katakam, Xiaobo Mao, Weiwei He
Summary: With the aging population, the prevalence of neurodegenerative diseases such as PD and AD is expected to rise. These diseases are classified as proteinopathies with misfolded proteins like alpha-synuclein, amyloid-beta, and tau. Nanomaterials offer advantages over traditional therapies in targeting specific mechanisms, such as reducing oxidative stress or disaggregating fibrils.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Neurosciences
Carmen Costas, Lilian R. F. Faro
Summary: Parkinson's disease is a common neurodegenerative disease characterized by a decrease in dopamine levels. Multiple mechanisms contribute to its pathogenesis. There is currently no effective treatment to slow down or stop disease progression. However, natural antioxidants in the diet have shown promising results in experimental models of Parkinson's disease by improving physiological and behavioral mechanisms. These exogenous antioxidants could be potential therapeutic candidates for prevention and treatment.
CURRENT NEUROPHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Sachchida Nand Rai, Payal Singh, Harry W. M. Steinbusch, Emanuel Vamanu, Ghulam Ashraf, Mohan Prasad Singh
Summary: It is essential to maintain the recommended daily allowance of vitamins to prevent neurodegenerative diseases and ensure neuronal health. Different types of vitamins have varying effects on neurodegeneration, with some showing therapeutic activity while others may exhibit toxic effects.
Review
Biochemistry & Molecular Biology
Arian Kola, Federico Nencioni, Daniela Valensin
Summary: Metal ions and vitamins are essential for the regular physiological activity of the human body. However, their full potential interaction has not been fully explored, necessitating further research. This review provides an overview of the scientific literature on the implications of vitamins and selected metal ions in neurodegenerative diseases such as Alzheimer's and Parkinson's disease. Additionally, the bioinorganic chemistry of vitamin-metal ion interactions is discussed to stimulate interest in this fascinating field.
Article
Biochemistry & Molecular Biology
Ana Gabrielle Bispo, Caio S. Silva, Camille Sena-dos-Santos, Dafne Dalledone Moura, Brenda Hanae Bentes Koshimoto, Bruno Lopes Santos-Lobato, Andrea Ribeiro-dos-Santos, Giovanna C. Cavalcante
Summary: Mitophagy dysfunction caused by gene mutations is associated with the development of Parkinson's Disease (PD). However, the association between the variants of mitophagy-related genes and the treatment with levodopa (LD) in PD patients has not been well explored. This study investigated the association of 14 variants of the PRKN gene with LD treatment in PD patients. The results suggest that while age at onset of symptoms, duration of PD, and LD treatment and dosage can influence the occurrence of dyskinesia, the investigated PRKN variants did not show a significant association.
