Article
Biochemistry & Molecular Biology
Kwang-Youn Kim, Un-Jung Yun, Seung-Hee Yeom, Sang-Chan Kim, Hu-Jang Lee, Soon-Cheol Ahn, Kwang-Il Park, Young-Woo Kim
Summary: This study found that HsA can induce apoptosis and autophagy in prostate cancer cells, with its effects mediated through ROS generation and protective autophagy signaling pathways. Additionally, the use of NAC and autophagy inhibitors can affect the cell death process induced by HsA. This research also demonstrated the anti-tumor effects of HsA in mice through the inhibition of xenografted tumor growth.
Article
Cell Biology
Chen Yang, Yanchun Li, Wanye Hu, Xu Wang, Jiayu Hu, Chen Yuan, Chaoting Zhou, Hairui Wang, Jing Du, Ying Wang, Xiangmin Tong
Summary: TEOA inhibits proliferation and migration of pancreatic cancer cells by inducing mitochondrial dysfunction and ROS-dependent autophagic cell death, suggesting its potential as a promising therapeutic agent for pancreatic cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Medicine, Research & Experimental
Alexey Ulasov, Andrey A. Rosenkranz, Georgii P. Georgiev, Alexander S. Sobolev
Summary: The Nrf2 transcription factor regulates the expression of genes involved in cell defense against oxidative stress, which is associated with various diseases. The interactions between Nrf2 and Keap1 protein play a crucial role in this regulation. The activation of the Nrf2 system is considered as a promising strategy to treat diseases related to oxidative stress, including COVID-19. Two approaches are being developed to inactivate the Keap1 guardian function and enhance Nrf2 activity.
Article
Chemistry, Medicinal
Ji Eon Park, Woo-Cheol Shin, Hyo-Jung Lee, Dahye Yoon, Deok Yong Sim, Chi-Hoon Ahn, Su-Yeon Park, Bum Sang Shim, So Jung Park, Kyung Seok Kim, Geum Duck Park, Sung-Hoon Kim, Dae Young Lee
Summary: In this study, the antiproliferative and apoptotic mechanism of SH-PRO, a mixture of Angelica gigas and Astragalus membranaceus, was evaluated in BPH-1 cells and rats with testosterone-induced BPH. Results showed that SH-PRO significantly inhibited cell viability and increased apoptosis in BPH-1 cells. It also downregulated the expression of certain genes and proteins related to BPH. SH-PRO generated reactive oxygen species (ROS) and its effects were mediated through ROS. Moreover, oral treatment with SH-PRO reduced prostate weight and improved plasma levels of certain markers in testosterone-treated rats. These findings indicate that SH-PRO has potential as an anti-BPH candidate.
PHYTOTHERAPY RESEARCH
(2023)
Article
Oncology
Tong Guo, Xitong Wang, Gensheng Zhang, Tian Xia, Runzhi Zhu, Jinfa Tou
Summary: This study found that dihydromyricetin (DHM) could inhibit the growth and increase cellular mortality of HuH-6 and HepG2 cells. DHM also decreased intracellular ROS level and increased the expression of SOD1. Regulating the SOD1/ROS pathway to induce apoptosis may be one of the potential mechanisms of DHM as a tumor suppressor in hepatoblastoma.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Liangwei Duan, Yucong Zhao, Jing Jia, Tianzhu Chao, Hao Wang, Yinming Liang, Yunwei Lou, Qianqian Zheng, Hui Wang
Summary: In atherosclerosis, macrophages play an important role in inflammation. CD68, a specific receptor in macrophages, regulates the occurrence and development of atherosclerosis. CD68 deficiency can reduce atherosclerosis, decrease inflammation and necrotic content, and increase smooth muscle cell content in atherosclerotic plaques.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Oncology
Xiao-Yu Wang, Hai-Wei Mao, Xiao-Hui Guan, Qi-Ming Huang, Zhen-Ping Yu, Jie Wu, Hui-Lan Tan, Feng Zhang, Xuan Huang, Ke-Yu Deng, Hong-Bo Xin
Summary: TRIM65 knockdown promotes cervical cancer cell death through enhancing autophagy and apoptosis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Takashi Shimizu, Akashi Taguchi, Yoshiki Higashijima, Yasuharu Kanki, Ryo Nakaki, Yoshihiro Urade, Youichiro Wada
Summary: Recent research has shown that the interaction between 23 K PRL and PERK signaling is cardioprotective during the peripartum period. The upregulation of 23 K PRL, compared to 16 K PRL, leads to activation of PERK signaling in neonatal rat cardiomyocytes. Additionally, CM-KO mice lacking PERK homogenous in cardiomyocytes exhibited PPCM phenotypes after consecutive deliveries, suggesting the importance of PERK signaling in protecting the heart during the perinatal period.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Xing Li, Lijiang Gu, Yuhang Chen, Xiaobing Wang, Yibo Mei, Jinlai Zhou, Minghai Ma, Jianbin Ma, Yue Chong, Xinyang Wang, Peng Guo, Dalin He, Jin Zeng
Summary: The study found that the novel 450-nm laser-mediated DVDMS-based photodynamic therapy (PDT) can inhibit and induce apoptosis in gastric cancer cells by producing excessive reactive oxygen species (ROS). Additionally, PDT also promoted apoptosis in gastric cancer cells through the autophagy pathway. Furthermore, the study identified the involvement of the ROS/PI3K/Akt/mTOR pathway in the regulation of PDT-induced autophagy.
Article
Pharmacology & Pharmacy
Lin Guo, Hui Gong, Ting-Li Tang, Bi-Kui Zhang, Lei-Yi Zhang, Miao Yan
Summary: The study investigated the mechanisms of crizotinib and sunitinib-induced hepatotoxicity and potential mitigation strategies through ROS and Nrf2 signaling. Both drugs activated oxidative stress and triggered hepatocyte mitochondrial apoptosis and necrosis in liver cells. ROS scavenger NAC and Nrf2 agonist tBHQ were found to alleviate cell damage and mitochondrial apoptosis during crizotinib- and sunitinib-induced hepatotoxicity.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ming Zhang, Jianmei Lai, Qianlong Wu, Jia Lai, Jingyao Su, Bing Zhu, Yinghua Li
Summary: Hepatocarcinoma is a common digestive system tumor worldwide with no effective treatment. Naringenin, isolated from citrus fruits, has shown anticancer effects. This study investigated the molecular mechanisms and oxidative stress implications of naringenin-induced cytotoxicity in HepG2 cells. Naringenin induced apoptosis in HepG2 cells through multiple pathways, enhanced cytotoxic effects, triggered reactive oxygen species, inhibited JAK-2/STAT-3 signaling pathways, and activated caspase-3. These findings suggest that naringenin could be a promising candidate for cancer therapy.
Article
Oncology
Hao Zhang, Huajun Sheng, Zhen Guo, Yu Xing, Qian Liu, Ziling Cai, Zihao Shen, Qingqian Xia, Shujuan Zhu
Summary: According to the study, AQP8 plays a significant role in the proliferation and growth of gliomas. Overexpression of AQP8 promotes cell proliferation, invasion, and migration, inhibits apoptosis, and affects the ROS/PTEN/AKT signaling pathway. Therefore, AQP8 may serve as a potential therapeutic target in gliomas.
Article
Pharmacology & Pharmacy
Guangjie Zhan, Tiantian Wei, Huichen Xie, Xiaoming Xie, Jun Hu, Hao Tang, Yating Cheng, Huaifeng Liu, Shujing Li, Guohua Yang
Summary: Apoptosis and autophagy can act cooperatively or antagonistically in self-elimination process. This study aims to investigate the function and molecular mechanism of trillin on autophagy in hepatocellular carcinoma (HCC) cells. The results demonstrated that trillin could inhibit autophagy in HCC cells and enhance apoptosis by activating the mTOR/STAT3 signaling pathway.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Plant Sciences
Yadi Geng, Ping Liu, Yanbo Xie, Yunxiao Liu, Xinge Zhang, Xingcun Hou, Lei Zhang
Summary: This study investigated the in vitro and in vivo effects of the Chinese herb Xanthatin on pancreatic cancer cells and its molecular mechanisms. It was found that Xanthatin can inhibit the proliferation and metastasis of pancreatic cancer cells and induce apoptosis. This effect may be mediated through the ROS/RBL1 signaling pathway.
Article
Environmental Sciences
Natsumi Fujiwara, Shohei Yamashita, Motoki Okamoto, Marion A. Cooley, Kazumi Ozaki, Eric T. Everett, Maiko Suzuki
Summary: In this study, it was found that perfluorooctanoic acid (PFOA) negatively affects tooth enamel development through cell death mechanisms involving necrosis/necroptosis and apoptosis, mediated by the ROS-MAPK/ERK signaling pathway. PFOA also suppressed cell proliferation and viability. This research provides initial evidence that PFOA could potentially contribute to cryptogenic enamel malformation.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Chemistry, Multidisciplinary
Wenqian Liu, Yulin Xu, Xue Li, Yan Meng, Huiling Wang, Chunrong Liu, Changlin Liu, Li Wang
Summary: This study reveals the crucial role of nucleic acids with G4 elements in regulating the morphology and toxicity of SOD1 aggregates. It also demonstrates that fibrillar or fibril-like SOD1 species with G4 elements are less toxic, shedding light on the formation of protein aggregates and membraneless organelles involved in intracellular phase transitions.
CHINESE CHEMICAL LETTERS
(2021)
Article
Agriculture, Multidisciplinary
Xiaoyan Zeng, Weijie Chen, Chunrong Liu, Jun Yin, Guang-Fu Yang
Summary: This article summarizes the recent progress of organic small-molecule fluorescent probes for monitoring RSS in plants, including research on small-molecule biological thiols, hydrogen sulfide, and sulfane sulfurs, as well as their imaging applications in plants within the field of agricultural chemistry.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Xiang Li, Yuhui Wang, Man Li, Huipeng Wang, Xiongwei Dong
Summary: Reactive oxygen species (ROS) play crucial roles in biological functions and cancer progression. Intervention in the ROS homeostasis of cancer cells through chelating agents or metal complexes is an important anti-cancer strategy, as it can inhibit the activity of antioxidant enzymes or directly regulate ROS levels. This review comprehensively analyzes metal complexes or chelators with ROS regulation capacity, aiming to develop novel inorganic anti-cancer drugs based on ROS regulation.
Article
Chemistry, Analytical
Man Li, Bing Wang, Mengzhao Li, Xiang Li, Li Wang, Na Li, Li Rao, Cuihong Wan, Changlin Liu, Chunrong Liu
Summary: This study introduced a novel reaction of sulfenic acid towards arylhydrazine and developed a multifunctional probe for the detection, labeling, and profiling of protein S-sulfenylation within cells. The probe was successfully applied in imaging and signaling research in prostate cancer cells, providing a convenient and robust tool for understanding the physiological and pathological roles of protein S-sulfenylation.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Multidisciplinary
Hao-Dong Qian, Zhi-Heng Li, Shuang Deng, Chaochao Yao, Hua-Ming Xiang, Guang Xu, Zi-Qi Geng, Zihao Wang, Linfeng Chen, Chunrong Liu, Cuiju Zhu, Xiaotian Qi, Hao Xu
Summary: Distinct regio- and enantioselectivity control has been achieved in copper-catalyzed vinylogous and bisvinylogous propargylic substitution using a novel chiral N,N,P ligand. The developed method provides an efficient and selective approach to the synthesis of enantioenriched alkynyl unsaturated carbonyl compounds, with excellent functional group tolerance and broad substrate scope. The synthetic utility of the developed method is demonstrated by gram-scale synthesis and application to the enantioselective synthesis of challenging compounds.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Applied
Xiongwei Dong, Huipeng Wang, Hui Zhang, Man Li, Zheng Huang, Qian Wang, Xiang Li
Summary: Personal protective equipment (PPE) is crucial in combating bacterial crises. This study developed biodegradable and antibacterial fibers by grafting highly effective antibacterial complexes onto cellulose fibers. The conjugated fibers maintained mechanical properties and thermal stability, and exhibited excellent growth inhibition against various bacteria.
CARBOHYDRATE POLYMERS
(2022)
Article
Biochemistry & Molecular Biology
Huiling Wang, Mingfang Wang, Zefeng Nie, Shuang Qiu, Xiaoping Huang, Xiang Li, Yanfang Cui, Chunrong Liu, Changlin Liu
Summary: Cu/Zn superoxide dismutase (SOD1) plays a key role as an antioxidant enzyme in maintaining cellular reactive oxygen species (ROS) homeostasis and regulating gene expression. We found that SOD1 is involved in gene expression regulation in response to changes in cellular ROS levels through its binding to DNA and the binding is redox-dependent.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Analytical
Man Li, Zhiyi Cai, Mengzhao Li, Linfeng Chen, Weili Zeng, Hong Yuan, Chunrong Liu
Summary: To reveal the inter-relationship between protein sulfenic acid (RSOH) and formaldehyde (FA) in different physiological processes, a dual-detection sensor NA-SF was developed. NA-SF successfully detected RSOH and FA at physiological concentrations in various cell lines and Arabidopsis thaliana roots, indicating their important roles in promoting plant growth. The probe NA-SF shows potential application in biological and pathological research of RSOH and FA in plant physiology.
ANALYTICA CHIMICA ACTA
(2023)
Article
Biochemistry & Molecular Biology
Ying Yang, Shuyu Liang, Hongen Geng, Mengmeng Xiong, Man Li, Qian Su, Fang Jia, Yimei Zhao, Kai Wang, Jun Jiang, Si Qin, Xiang Li
Summary: This study reveals the interaction between copper stress and cuproptosis, and explores the potential of copper ionophore curcumin as an anticancer agent. Copper stress not only correlates with cuproptosis, but also leads to reactive oxygen species stress, oxidative damage, and cell cycle arrest. Copper withdrawal can block the cuproptosis process and protect cancer cells from apoptosis, protein degradation, and oxidative damage. Additionally, curcumin, a copper ionophore, can regulate positive cuproptosis mediators and control the metabolism of colorectal cancer cells.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Jiayuan Shi, Huiling Wang, Yuhui Wang, Yujie Peng, Xiaoping Huang, Yunfeng Zhang, Hongen Geng, Yi Wang, Xiang Li, Chunrong Liu, Changlin Liu
Summary: Defects in mitochondrial proteostasis contribute to various diseases, and a strategy of restoring damaged mitochondrial proteostasis is through the targeted delivery of exogenous functional proteins. In this study, we designed and characterized photocage groups that can be activated by light to release proteins for cellular delivery. These photocage-modified proteins can penetrate cell membranes and be released in mitochondria and cytoplasm upon illumination, enabling accumulation of exogenous proteins in these compartments.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Fang Jia, Xiang Li, Kai Wang, Xin Dong, Tao Liao, Cao Li, Gang Chen, Jun Jiang
Summary: This study presents a H2S depletion aided photodynamic therapy (PDT) platform that can effectively kill cancer cells through in situ irradiation. The platform also exhibits prominent anticancer effects in tumor-bearing mice without notable toxic side effects.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Li Chen, Xiang Li, Mengmeng Xiong, Yimei Zhao, Suyi Liu, Cao Li, Kai Wang
Summary: A new organic CP compound (Ppordpp) with efficient absorption in the NIR-II region was synthesized and self-assembled into NPs, showing high photothermal conversion efficiency and effective cancer treatment through photothermal therapy.
MATERIALS & DESIGN
(2023)
Article
Biotechnology & Applied Microbiology
Xilong Li, Cong Lei, Qitao Song, Lin Bai, Bo Cheng, Ke Qin, Xiang Li, Boyuan Ma, Bing Wang, Wen Zhou, Xing Chen, Jiayang Li
Summary: This study identified O-GlcNAcylation sites and proteins in rice through a large-scale analysis. The O-GlcNAcylated proteins were found to be involved in multiple biological processes such as transcription, translation, and plant hormone signaling. Additionally, two O-GlcNAc transferases were discovered in rice. This research provides a valuable resource for studying O-GlcNAc biology in rice and the MGL method can facilitate the identification of O-GlcNAcylated proteins in various plants.
PLANT BIOTECHNOLOGY JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Yi Hao, Xiang Li, Ke Qin, Yujie Shi, Yanwen He, Che Zhang, Bo Cheng, Xiwen Zhang, Guangyu Hu, Shuyu Liang, Qi Tang, Xing Chen
Summary: The O-GlcNAc modification is found to affect the self-renewal and differentiation of embryonic stem cells (ESCs), and the core pluripotency transcription factor NANOG is regulated by this modification. During neuronal lineage differentiation, the O-GlcNAc modification decreases, and suppressing O-GlcNAcylation can upregulate neuron-related genes, thus influencing the fate determination of ESCs.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Optics
Fang Zhao, Gang Chen, Xiao Lin, Jun Jiang, Yue Xia, Xiang Li, Kai Wang
Summary: As an important signaling molecule, hydrogen sulfide (H2S) plays crucial roles in physiological and pathological processes. Real-time monitoring of H2S levels in the body is critical due to its association with various diseases. In this study, a novel H2S fluorescent probe, named F3, was designed and synthesized. F3 showed high selectivity and sensitivity to H2S, making it suitable for biological monitoring. Furthermore, F3 demonstrated promising photodynamic therapy effects in cervical cancer cells.
JOURNAL OF LUMINESCENCE
(2023)