期刊
ORGANIC LETTERS
卷 21, 期 5, 页码 1292-1296出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.8b04051
关键词
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资金
- NSFC [21672184, 21861042]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT13095]
- Shenzhen STIC [JCYJ20170412150343516]
- Program for Innovative Research Team (in Science and Technology) in University of Yunnan Province
The first metal/organo cooperatively catalyzed asymmetric reaction of C-alkynyl N-Boc-protected N,O-acetals with in situ generated oxonium ylides has been developed. This new type of propargylation allows for the efficient synthesis of structurally diverse unreported chiral propargylamines bearing oxa-quaternary stereo centers. The reaction features unprecedented substrate scope and high diastereo- and enantioselectivity. Theoretical studies suggest a novel cooperative catalysis model and the unique transfer of (ROH)-O-2.
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