FDPS cooperates with PTEN loss to promote prostate cancer progression through modulation of small GTPases/AKT axis

Cancer statistics, 2019

(2019) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

An aberrant SREBP-dependent lipogenic program promotes metastatic prostate cancer

(2018) Ming Chen et al.   NATURE GENETICS

Current Status of 3-D Organoids as Pre-Clinical Models

(2018) Garima Kaushik et al.   STEM CELLS

Genomic hallmarks of localized, non-indolent prostate cancer

(2017) Michael Fraser et al.   NATURE

Deregulated expression and activity of Farnesyl Diphosphate Synthase (FDPS) in Glioblastoma

(2017) Mario Abate et al.   Scientific Reports

Targeting protein geranylgeranylation slows tumor development in a murine model of prostate cancer metastasis

(2016) Jacqueline E. Reilly et al.   CANCER BIOLOGY & THERAPY

PR55α Subunit of Protein Phosphatase 2A Supports the Tumorigenic and Metastatic Potential of Pancreatic Cancer Cells by Sustaining Hyperactive Oncogenic Signaling

(2016) Ashley L. Hein et al.   CANCER RESEARCH

MUC5AC interactions with integrin β4 enhances the migration of lung cancer cells through FAK signaling

(2016) I Lakshmanan et al.   ONCOGENE

Probing the molecular and structural elements of ligands binding to the active site versus an allosteric pocket of the human farnesyl pyrophosphate synthase

(2015) Dimitrios Gritzalis et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

ErbB-2 signaling plays a critical role in regulating androgen-sensitive and castration-resistant androgen receptor-positive prostate cancer cells

(2015) Sakthivel Muniyan et al.   CELLULAR SIGNALLING

PTEN Protein Loss and Clinical Outcome from Castration-resistant Prostate Cancer Treated with Abiraterone Acetate

(2015) Roberta Ferraldeschi et al.   EUROPEAN UROLOGY

Loss of signal transducer and activator of transcription 1 is associated with prostate cancer recurrence

(2015) Sophia Hatziieremia et al.   MOLECULAR CARCINOGENESIS

Dysregulated metabolism contributes to oncogenesis

(2015) Matthew D. Hirschey et al.   SEMINARS IN CANCER BIOLOGY

Inhibition of insulin-like growth factor receptor/AKT/mammalian target of rapamycin axis targets colorectal cancer stem cells by attenuating mevalonate-isoprenoid pathway in vitro and in vivo

(2015) Chetna Sharon et al.   Oncotarget

Unbiased analysis of pancreatic cancer radiation resistance reveals cholesterol biosynthesis as a novel target for radiosensitisation

(2014) J J Souchek et al.   BRITISH JOURNAL OF CANCER

Serum Lipid Profile and Risk of Prostate Cancer Recurrence: Results from the SEARCH Database

(2014) E. H. Allott et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Global Transcriptome Analysis of Formalin-Fixed Prostate Cancer Specimens Identifies Biomarkers of Disease Recurrence

(2014) Q. Long et al.   CANCER RESEARCH

Organoid Cultures Derived from Patients with Advanced Prostate Cancer

(2014) Dong Gao et al.   CELL

Cholesteryl Ester Accumulation Induced by PTEN Loss and PI3K/AKT Activation Underlies Human Prostate Cancer Aggressiveness

(2014) Shuhua Yue et al.   Cell Metabolism

Conditional Deletion of the Pten Gene in the Mouse Prostate Induces Prostatic Intraepithelial Neoplasms at Early Ages but a Slow Progression to Prostate Tumors

(2013) Mi Kyung Kwak et al.   PLoS One

Zoledronic Acid Sensitizes Renal Cell Carcinoma Cells to Radiation by Downregulating STAT1

(2013) Toshiki Kijima et al.   PLoS One

High-Risk Prostate Cancer: From Definition to Contemporary Management

(2012) Patrick J. Bastian et al.   EUROPEAN UROLOGY

The mutational landscape of lethal castration-resistant prostate cancer

(2012) Catherine S. Grasso et al.   NATURE

Farnesyl pyrophosphate synthase: a key enzyme in isoprenoid biosynthetic pathway and potential molecular target for drug development

(2012) Manoj K. Dhar et al.   New Biotechnology

Altered expression of farnesyl pyrophosphate synthase in prostate cancer: evidence for a role of the mevalonate pathway in disease progression?

(2012) Tilman Todenhöfer et al.   WORLD JOURNAL OF UROLOGY

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

Sterol-regulatory-element-binding protein 2 and nuclear factor Y control human farnesyl diphosphate synthase expression and affect cell proliferation in hepatoblastoma cells

(2010) Kenji Ishimoto et al.   BIOCHEMICAL JOURNAL

Combined effects of the bisphosphonate, zoledronic acid and the aromatase inhibitor letrozole on breast cancer cells in vitro: evidence of synergistic interaction

(2010) H L Neville-Webbe et al.   BRITISH JOURNAL OF CANCER

Integrative Genomic Profiling of Human Prostate Cancer

(2010) Barry S. Taylor et al.   CANCER CELL

Biology and pathology of Rho GTPase, PI-3 kinase-Akt, and MAP kinase signaling pathways in chondrocytes

(2010) Frank Beier et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Mouse Prostate Cancer Cell Lines Established from Primary and Postcastration Recurrent Tumors

(2010) Chun-Peng Liao et al.   Hormones & Cancer

Chronic inhibition of farnesyl pyrophosphate synthase attenuates cardiac hypertrophy and fibrosis in spontaneously hypertensive rats

(2009) Liang Li et al.   BIOCHEMICAL PHARMACOLOGY

Review of major adverse effects of androgen-deprivation therapy in men with prostate cancer

(2009) Lockwood G. Taylor et al.   CANCER

Docetaxel/zoledronic acid combination triggers apoptosis synergistically through downregulating antiapoptotic Bcl-2 protein level in hormone-refractory prostate cancer cells

(2008) B KARABULUT et al.   CELL BIOLOGY INTERNATIONAL

Protein Interaction Data Set Highlighted with Human Ras-MAPK/PI3K Signaling Pathways

(2008) Jian Wang et al.   JOURNAL OF PROTEOME RESEARCH

Antitumor Effects of Doxorubicin Followed by Zoledronic Acid in a Mouse Model of Breast Cancer

(2008) P. D. Ottewell et al.   JNCI-Journal of the National Cancer Institute