Article
Chemistry, Analytical
Dan Li, Tingting Zhao, Jing Chen, Jiaheng Shi, Junhao Wang, Yue Yin, Shuwei Chen, Shenghao Xu, Xiliang Luo
Summary: This study presents a DNA computation-mediated DNAzyme platform for spatiotemporally controlled ultrasensitive AND-gated molecular imaging of c-MYC. The platform incorporates a photo-cleavable linker to enable AND-gated imaging, and employs strand displacement amplification and gold nanopyramids to enhance fluorescence. The designed AND-gate sensing mechanism has been validated in cell and inhibitor-treated cell experiments, showing improved fluorescence intensity and detection limit. The study demonstrates the promising potential of the designed platform for precise molecular imaging.
ANALYTICAL CHEMISTRY
(2022)
Article
Nanoscience & Nanotechnology
Ge Mu, Tianyu Rao, Shuo Zhang, Chong Wen, Menglu Chen, Qun Hao, Xin Tang
Summary: This study reports colloidal quantum-dot upconverters with unprecedented performance, achieving a wider range of operation spectral and higher efficiency through optimization of device structure.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Analytical
Marketa Prochazkova, Eliska Kuchovska, Michael Killinger, Karel Kleparnik
Summary: In this study, a molecular probe based on Fo center dot rster resonance energy transfer (FRET) was designed and synthesized for investigating biological phenomena at a single-cell level. The probe utilizes a highly luminescent quantum dot (QD) as a donor and a specific peptide as a linker to a fluorophore or fluorescence quencher as an acceptor. The synthesized probe showed high reaction yield and specificity, and provided longer imaging times of caspases compared to commercial products.
ANALYTICA CHIMICA ACTA
(2023)
Article
Chemistry, Physical
Lijun Liang, Xin Shen, Mengdi Zhou, Yijian Chen, Xudong Lu, Li Zhang, Wei Wang, Jia-Wei Shen
Summary: In this study, molecular dynamics simulation was used to investigate the adsorption behavior and structural changes of single-stranded and double-stranded DNA on the surfaces of graphene quantum dots with different sizes and oxidation levels. The results showed that single-stranded DNA can strongly adsorb and lay flat on the surface, while double-stranded DNA prefers to orient vertically.
Article
Chemistry, Multidisciplinary
Ilhwan Ryu, Jee-Yeon Ryu, Geunpyo Choe, Hyemin Kwon, Hyeji Park, Young-Seok Cho, Rose Du, Sanggyu Yim
Summary: A real-time in vivo cancer detection method using attenuation-based plain X-ray imaging is proposed, successfully detecting 5 mm-sized Panc-1 cell tumors in mice. Quantum dot scintillators of CPB are used as markers, showing significant X-ray attenuation effects for clear signal observation under 2 cm-thick tissue.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Spectroscopy
Mengyu Chen, Jingdan Zhang, Jianyu Chang, Huiya Li, Yongqing Zhai, Zhenguang Wang
Summary: A highly sensitive fluorescence assay for BChE activity was developed based on the self-polymerization modulated fluorescence of sulfur quantum dots. The assay demonstrated low detection limit, linear relationship, and excellent selectivity, allowing direct detection of BChE activity in human serum.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Biophysics
Renpeng Xia, Hua Chai, Jin Jiao, Peng Miao
Summary: Early screening of biomarkers is important for the therapy and prognosis of cancers. MiRNAs encapsulated in tumor-derived exosomes have emerged as biomarkers for early cancer diagnosis. However, traditional methods have limitations that restrict their wide applications. In this study, a convenient electrochemical approach based on DNA triangular pyramid frustum (TPF) and strand displacement amplification was developed for quantification of exosomal miRNA. The biosensor showed excellent analytical performances and successfully analyzed exosomal miRNAs from cells and clinical serum samples.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Chemistry, Analytical
Yu-Yi Zhou, Guan-Feng Li, Rong-Xian Ma, Yu Lin, Jia-Wen Wu, Ye-Yu Wu, Jun Yan, Shao-Gang Liu, Xue-Cai Tan, Ke-Jing Huang
Summary: One highly attractive research direction in the ECL field is the regulation and improvement of ECL efficiency, which is achievable with the use of quantum dots (QDs) as ECL materials. The study presents the synthesis of MoS2 NSs@QDs, an ECL emitter, and investigates its ECL mechanism. It also develops an innovative ECL sensor for the precise and ultrasensitive detection of target miRNA-199a.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Hong Jiang, Li-Bin Wang, Ya-Ting Zhang, Min Dong, Jian Li, Ji-Dong Wang
Summary: In this study, a simple fluorescent signal amplification biosensor based on an entropy-driven three-dimensional DNA walker was developed for highly sensitive detection of cancer cells. The biosensor showed excellent selectivity and sensitivity, and has great potential for early diagnosis and clinical treatment of cancer.
ANALYTICA CHIMICA ACTA
(2022)
Article
Chemistry, Multidisciplinary
Julie Descamps, Camille Colin, Gilles Tessier, Stephane Arbault, Neso Sojic
Summary: Here, a label-free electrochemiluminescence (ECL) microscopy using significantly low concentrations of the [Ru(bpy)(3)](2+) luminophore is reported. This study addresses the minimal concentration requirement of the ECL luminophore for imaging single entities. The authors demonstrate the ability to capture ECL images of cells and mitochondria at concentrations as low as nM and pM, which is seven orders of magnitude lower than conventional concentrations. The obtained ECL images exhibit sharp negative optical contrast and the method is concluded to be a simple, fast, and highly sensitive approach for ultrasensitive ECL imaging and reactivity at the single molecule level.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Chemistry, Inorganic & Nuclear
Qian Zhang, Xinyi Zhang, Fei Ma, Chun-yang Zhang
Summary: DNA-modifying enzymes play crucial roles in genetic functions and their malfunction can lead to various human diseases. Detection of DNA-modifying enzymes is essential for fundamental research, drug discovery, and clinical diagnosis.
COORDINATION CHEMISTRY REVIEWS
(2022)
Article
Chemistry, Multidisciplinary
Hua Chai, Peng Miao
Summary: A novel electrochemical strategy combining strand displacement amplification and DNA nanostructures was developed for ultrasensitive detection of ctDNA, achieving a limit of detection as low as 48 amol/L. This proposed electrochemical biosensor shows great potential for clinical applications.
CHINESE CHEMICAL LETTERS
(2021)
Article
Chemistry, Analytical
Xiaofei Li, Yawen Zhang, Lulu Hao, Yanju Liu, Xia Wang, Huaixia Yang, Jinming Kong
Summary: The study introduced a sensitive tumor marker detection method utilizing PCL in an electrochemical impedance system, showing high sensitivity and a low detection limit for CYFRA 21-1 DNA quantification.
Article
Neurosciences
Ian D. Tomlinson, Oleg Kovtun, Ruben Torres, Laurel G. Bellocchio, Travis Josephs, Sandra J. Rosenthal
Summary: The study focused on developing a novel ligand, IDT785, that effectively studied the cellular trafficking and membrane dynamics of SERT, providing valuable insights into SERT localization and function. The ligand demonstrated biological activity by inhibiting SERT-mediated reuptake of serotonin and enabling membrane labeling of SERT for further research.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Chemistry, Analytical
Guosheng Zhang, Sheng Zhou, Guoqing Yan, Tongtong Jiang, Zhexiang Wang, Zhaoyuan Guan, Kui Chen, Zhigang Cao, Benli Yu
Summary: This study introduced quantum dots-crosslinked light-guiding hydrogels for detecting folate receptor-overexpressed cancer cells. The prepared hydrogels showed outstanding fluorescence stability and specific detection ability. Detection and measurement of cancer cell concentrations were achieved, with potential for real-time in vivo applications.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Physical
Jidong Chu, Zhijin Ge, Jiahui Peng, Hui Hu, Shujuan Guo, Xiaohui Chen
Summary: The study proposes a novel method, refluxing and implanting titanium, for synthesizing high catalytic performance MWW zeolite. By conducting titanium implantation under mild conditions, the preparation time is reduced. This method also explains the formation mechanism of the zeolite structure through density functional theory and achieves larger pore structure and improved catalytic performance through modified treatment.
Article
Cell Biology
Daji Guo, Xiaoman Yang, Ming Gao, Xiaoqing Chen, Yanping Tang, Lingling Shen, Keshen Li, Lei Shi
Summary: This study found that ASD-like behaviors persist into late-middle age in Dock4 KO mice, with specific alterations in spatial memory and hippocampal anatomy by age.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2023)
Article
Oncology
Shuwen Zhang, Jingjing Chen, Rui Zhang, Liqin Xu, Yan Wang, Zaixin Yuan, Xiaohui Hou, Jian Feng
Summary: PNETs are a group of highly heterogeneous tumors with different clinical manifestations, pathological features, and prognoses. Knowing clinicopathological characteristics and immunophenotypes of PNETs is significant for diagnosis.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Review
Metallurgy & Metallurgical Engineering
Changyong Chen, Lu Wang, Meng Sun, Xiaoqing Chen, Yang Li, Zhouhua Jiang
Summary: This paper reviews the technical progress in the control of inclusions and central segregation in tyre cord steel wires and saw wire steel in the last 20 years and formulates the unresolved issues that should be studied in the next 10 years.
IRONMAKING & STEELMAKING
(2023)
Article
Cell Biology
Li Wang, Zhiwen Song, Hongjun Zou, Haining Chen, Yong Hu, Xiangnan Li, Jinbo Liu
Summary: The present study investigates the role of circRNA3616 in neuronal inflammation and apoptosis in spinal cord injury (SCI). The findings suggest that silencing of circRNA3616 can attenuate inflammation and apoptosis in SCI by inhibiting TLR4/NF-kappa B activity via sponging miR-137.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Tao Yang, Shuren Zhang, Hao Yuan, Ying Wang, Linxiang Cai, Hanhua Chen, Xiaoyu Wang, Dongfan Song, Xiaohui Wang, Zijian Guo, Xiaoyong Wang
Summary: Triggering receptor expressed on myeloid cells-2 (TREM2) is a marker of tumor-infiltrating macrophages with immunosuppressive activity in the tumor microenvironment. The platinum(IV) complex OPA derived from oxaliplatin and artesunate has direct cytotoxicity against human colon cancer cells and inhibits TREM2 on macrophages in vitro and vivo. Furthermore, OPA reduces immunosuppressive macrophages and promotes the expansion and infiltration of immune-stimulating cells.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Computer Science, Artificial Intelligence
Xiang Jia, Liang Wang, Ying-Ming Wang, Hui-Hui Song
Summary: This paper proposes a two-sided matching decision-making (TSMDM) approach with probabilistic linguistic evaluations. By normalizing and aggregating the evaluations, satisfaction degrees are calculated and a multi-objective TSMDM model is built aiming to maximize the comprehensive satisfaction degree. Results from an illustrative example show that the proposed approach can avoid information loss and effectively integrate probabilistic linguistic term sets with correlative criteria.
INTERNATIONAL JOURNAL OF INFORMATION TECHNOLOGY & DECISION MAKING
(2023)
Article
Plant Sciences
Yongliang Hu, Yuqin Chen, Xiaoxia Su, Jiawei Huang, Hongxing Yin, Jie Zhang, Zhongkai Zhang, Yong Ding, Kuanyu Zheng
Summary: The present study characterized two potyviruses, wild tomato mosaic virus Dehong isolate (WTMV-Dh) and chilli veinal mottle virus Dehong isolate (ChiVMV-Dh), and assessed their mix-infection on chilli pepper. The complete genome sequences of both viruses were obtained using transcriptome next-generation sequencing technology and RT-PCR. Phylogenetic analysis revealed the relationship between these Dehong isolates and previously reported isolates of the same viruses. Mix-inoculation of these two viruses resulted in more severe symptoms compared to single-infection.
JOURNAL OF PHYTOPATHOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Xiaoqing Chen, Yu Zhang, Ruijuan Tian, Xianghu Wu, Zhengdong Luo, Yan Liu, Xinran Wang, Jianlin Zhao, Xuetao Gan
Summary: A quadratically nonlinear photodetector (QNPD) composed of a van der Waals (vdW) stacked GaSe/InSe heterostructure is reported in this study. The QNPD exhibits unique electronic and optical attributes and extends the photodetection wavelength range from 900 to 1750 nm due to the extra second-harmonic generation (SHG) process in GaSe/InSe. It is highly sensitive to the variation of optical intensity and can be used as an autocorrelator for measuring ultrafast pulse widths and an optoelectronic mixer for signal processing.
Article
Management
Liang Wang, Zi-Xin Zhang, Alessio Ishizaka, Ying-Ming Wang, Luis Martinez
Summary: Many MCDS methods have been developed and applied to solve real-world problems. However, existing studies have neglected the psychological behavior of decision makers during the sorting process. This research proposes a new sorting method that considers psychological behavior and verifies its importance through country risk classification.
OMEGA-INTERNATIONAL JOURNAL OF MANAGEMENT SCIENCE
(2023)
Article
Engineering, Chemical
Shengyu Zhang, Shen Yan, Kangwei Lu, Shixuan Qiu, Xiao Dong Chen, Winston Duo Wu
Summary: Based on drug repositioning strategy, niclosamide has shown potential for treating COVID-19. However, developing effective NCL delivery formulations remains challenging. In this study, NCL-embedded dry powder for inhalation was fabricated using a novel spray freeze drying technology. By adjusting the composition and temperature, the size, morphology, crystal properties, flowability, and aerosol performance of the SFD microparticles were systematically investigated.
Article
Chemistry, Physical
Xiaoyan Chen, Rachel M. Johnson, Bo Li
Summary: Amide N-methylation is crucial for the activity and permeability of bioactive compounds. This study identifies the amide N-methyltransferase DtpM, which converts holomycin to thiolutin, expanding the examples of amide N-methyltransferases and potentially enabling the synthesis of diverse dithiolopyrrolone compounds for therapeutics.
Article
Chemistry, Multidisciplinary
Yingming Wang, Hui Huang, Jie Wu, Hongyuan Yang, Zhenhui Kang, Yang Liu, Zhaowu Wang, Prashanth W. W. Menezes, Ziliang Chen
Summary: Se-vacancy with charge polarization is created in the NiSe2 structure, which enhances the stability, decreases the electron transfer kinetics, and optimizes the free adsorption energy of reaction intermediate. The prepared NiSe2-V-Se exhibits high selectivity in alkaline media and excellent stability over a wide potential range.
Article
Computer Science, Artificial Intelligence
Liuqing Yang, Shoudong Wang, Xiaohong Chen, Wei Chen, Omar M. Saad, Xu Zhou, Nam Pham, Zhicheng Geng, Sergey Fomel, Yangkang Chen
Summary: This article proposes a deep learning model combining convolutional and recurrent networks for predicting reservoir permeability and porosity. By training a combination of nonlinear and linear modules, the mapping between logging data and reservoir parameters is established. Optimization algorithms and a self-attention mechanism are used to improve prediction accuracy. Testing on blind wells from different regions demonstrates the accuracy and robustness of the proposed method.
IEEE TRANSACTIONS ON NEURAL NETWORKS AND LEARNING SYSTEMS
(2023)
Article
Chemistry, Multidisciplinary
Tianyu Yang, Ziliang Chen, Yingming Wang, Hui Huang, Kui Yin, Fan Liao, Yang Liu, Zhenhui Kang
Summary: An oriented coupling strategy is developed for the acidic hydrogen evolution reaction by in situ inserting hollow porous Co/NC nanocage by Si nanowires, which delivers remarkable activity and stability. The presence of Si nanowire toward Co/NC polyhedra not only facilitates the charge transfer during catalysis, but also optimizes the hydrogen adsorption and desorption.