Article
Materials Science, Multidisciplinary
Kun Wang, Qiang He, Deren Yang, Xiaodong Pi
Summary: This study synthesizes freestanding erbium-hyperdoped silicon quantum dots (Si QDs) with UV absorption and NIR emission via nonthermal plasma, and demonstrates their temperature-sensing capability and potential.
ADVANCED OPTICAL MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Jingyue Xu, Xue Qiu, Niko Hildebrandt
Summary: The combination of phenomena and materials of different nanoscales to exploit all their benefits at once remains a challenging endeavor. Six different approaches were investigated to overcome challenges when combining different nanoscales into a single biosensor, showing detection and multiplexing capability with FRET. The detailed view on various complex multi-nanodimensional assay systems highlighted the limited clinical translation of such sophisticated multicomponent nanobiosensors.
Article
Nanoscience & Nanotechnology
Haoyu Chen, Ying Tang, Jialing Gui, Peipei Li, Xiaohua Zhu, Cuiyan Wu, Peng Yin, Meiling Liu, Youyu Zhang, Shouzhuo Yao
Summary: In this study, near-infrared emitting Ag2S quantum dots were synthesized and used as sensitive fluorescent nanoprobes in sensing and bioimaging of glutathione (GSH) combined with CoOOH nanosheets. The fluorescence of Ag2S quantum dots was quenched when attached to the surface of CoOOH nanosheets through electrostatic interactions. However, the addition of GSH resulted in the recovery of the fluorescence due to the reduction of CoOOH by GSH. The nanoprobe composed of Ag2S quantum dots and CoOOH nanosheets showed promise in bioimaging and could distinguish normal and cancer cells and detect the content of GSH.
ACS APPLIED NANO MATERIALS
(2023)
Article
Chemistry, Physical
Songyang Guo, Hao Xu, Yiqiang Zheng, Linlin Li, Zhexin Li, Lei Zhang, Huibin Zhang, Xianbao Wang, Jinhua Li, Lili Wang, Liyuan Liu, Zheng Lou
Summary: We propose a stretchable photo-sensing logic gate based on the organic semiconductor DPP-DTT, which can achieve NOR logic gate function with the near infrared (NIR) light as input signal. Compared to conventional logic circuits, this system reduces transistor utilization and introduces NIR light to maximize and simplify the functionality of scalable photo-sensing logic circuits.
Article
Chemistry, Physical
Zhiyong Tang, Hongchao Yang, Ziqiang Sun, Yejun Zhang, Guangcun Chen, Qiangbin Wang
Summary: Cation exchange (CE) is a promising post-synthesis strategy for colloidal nanocrystals, and the choice of cation precursor significantly affects the CE process and the final nanocrystals. In this study, two Zn-B Lewis acid-base adduct complexes were used as Zn precursors for CE with Ag2S quantum dots. The results showed that the steric hindrance and complexing capabilities of the precursor greatly influenced the CE kinetics and led to the formation of Zn-doped Ag2S and Ag2S@ZnS core-shell quantum dots. Theoretical simulation provided insights into the formation mechanisms of these nanocrystals.
Article
Chemistry, Physical
Hae Mee Ju, Doheon Yoo, Min -Jae Choi
Summary: This study introduces a ligand-induced surface reconstruction strategy to significantly improve the photoluminescence quantum yield (PLQY) of silver sulfide quantum dots (Ag2S CQDs), enhancing their potential for bio-imaging applications.
APPLIED SURFACE SCIENCE
(2023)
Article
Engineering, Chemical
Minjie Gao, Haodong Zhao, Zhihua Wang, Yanbao Zhao, Xueyan Zou, Lei Sun
Summary: The study successfully prepared size-tunable Ag2S QDs with excellent photothermal effects and low cytotoxicity to cells. Furthermore, it was found that the size of Ag2S QDs significantly influences their fluorescence intensity and photothermal effect.
ADVANCED POWDER TECHNOLOGY
(2021)
Article
Chemistry, Physical
Hossein Roshan, Fereshte Ravanan, Mohammad Hossein Sheikhi, Ali Mirzaei
Summary: This study demonstrated a novel photoconductor based on Ag2S nanocrystals, showing high detectivity under different illuminations.
JOURNAL OF ALLOYS AND COMPOUNDS
(2021)
Article
Chemistry, Multidisciplinary
Wei Lian, Datao Tu, Xukeng Weng, Kaiyu Yang, Fushan Li, Decai Huang, Haomiao Zhu, Zhi Xie, Xueyuan Chen
Summary: In this study, highly efficient near-infrared nanophosphors based on copper indium selenide quantum dots (CISe QDs) were developed for portable micro and mini converted light-emitting diodes (pc-LEDs). By adjusting the stoichiometry and doping, the peak wavelength of the QDs' photoluminescence can be controlled within a wide range from 750 to 1150 nm. The use of a ZnSe shell significantly improves the photoluminescence quantum yield. The resulting NIR pc-LEDs exhibit remarkable photostability and the highest radiant flux among lead and cadmium-free NIR pc-LEDs. Additionally, the QDs-based nanophosphors show excellent luminescence conversion properties for micro-LEDs with resolutions exceeding current commercial inkjet display pixels.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Shu-Lan Li, Peng Jiang, Siyu Hua, Feng-Lei Jiang, Yi Liu
Summary: This study reported a simple one-step synthesis method for ultrasmall Zn-doped Cu2S QDs with high CDT activity and fluorescence imaging capability. The QDs were able to specifically inhibit cancer cell growth and induce apoptosis via a Fenton-like reaction, showing potential as multi-functional theranostic agents.
Article
Chemistry, Physical
Yunmo Sung, Wonseok Lee, Eunjae Lee, Young Ho Ko, Sungjee Kim
Summary: The surface atom stoichiometry of Ag2S NCs is controlled through ion-pair ligand-assisted surface reactions. Different combinations of cation and anion pairs are studied, leading to the synthesis of cation-rich-surfaced, anion-rich-surfaced, and perfectly stoichiometric Ag2S NCs. The ion-pair-assisted surface chemistry enables the enhancement of fluorescence intensity and epitaxial growth performance of Ag2S NCs.
CHEMISTRY OF MATERIALS
(2022)
Article
Spectroscopy
Xiufeng Wang, Yao Jin, Wenhui Ai, Siqi Wang, Zhiqing Zhang, Ting Zhou, Fang Wang, Guodong Zhang
Summary: This study successfully synthesized near infrared fluorescence Ag2S quantum dots (QDs) and developed a dual-mode sensor for sulfide anion using the excellent oxidase-like characteristics of manganese dioxide (MnO2) nanosheets. The sensor showed a wider detection range, higher sensitivity, and shorter reaction time, making it suitable for highly selective detection of sulfide in different concentration ranges.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2024)
Article
Chemistry, Physical
Jieyu Zhang, Jingjing Min, Binghan Li, Wenxing Yang, Zaiping Zeng, Dianyi Liu, Botao Ji
Summary: By using non-thiol ligands, colloidal cation-rich Ag2S nanocrystals were synthesized with high photoluminescence quantum yield up to 22%. These nanocrystals, decorated with heterovalent-metal cations, show potential applications in thin-film photovoltaics or biological taggants.
CHEMISTRY OF MATERIALS
(2023)
Article
Biophysics
Guojie Qin, Lixiang Zuo, Yanli Wei, Li Wang, Graham Bodwell
Summary: The paper introduces a highly sensitive sensing system for alkaline phosphatase using room temperature phosphorescence, with intense emission in the absence of alkaline phosphatase that gradually decreases upon addition of the enzyme. Factors affecting the performance of the sensing system were optimized, resulting in a linear range for alkaline phosphatase from 0.2-10 U/L with a LOD at 0.045 U/L and a recovery rate in human serum from 93.75%-103.03%. Additionally, an RTP-based INHIBIT logic gate utilizing doped ZnS quantum dots was presented.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Bin Sun, Amin Morteza Najarian, Laxmi Kishore Sagar, Margherita Biondi, Min-Jae Choi, Xiyan Li, Larissa Levina, Se-Woong Baek, Chao Zheng, Seungjin Lee, Ahmad R. Kirmani, Randy Sabatini, Jehad Abed, Mengxia Liu, Maral Vafaie, Peicheng Li, Lee J. Richter, Oleksandr Voznyy, Mahshid Chekini, Zheng-Hong Lu, F. Pelayo Garcia de Arquer, Edward H. Sargent
Summary: Colloidal quantum dots (CQDs) have tunable bandgap and solution processing, making them promising materials for infrared (IR) light detection. However, the time response of CQD IR photodiodes is currently inferior to that of Si and InGaAs. The high permittivity of II-VI CQDs leads to slow charge extraction, while III-Vs offer low permittivity and potential for high-speed operation. By managing the surface using amphoteric ligand coordination, the performance of InAs CQD solids is improved, achieving fast response time and high external quantum efficiency.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Analytical
Xiaoqiang Li, Zhenzhen Guo, Gangyin Luo, Peng Miao
Summary: A novel fluorescent sensing strategy for miRNA detection is proposed, which combines DSN-mediated amplification and dumbbell DNA structural switch. The sensor exhibits high sensitivity and selectivity, and performs well in biological samples.
Article
Chemistry, Analytical
Jinwen Zhu, Zhenzhen Guo, Jinjiang Cui, Peng Miao
Summary: We have developed a simple electrochemical approach for the detection of miRNA. This method involves the design of a programmable DNA tetrahedron that undergoes target-initiated collapse, leading to the integration of recognition, electrode immobilization, signal recruitment, and amplification. The use of duplex-specific nuclease-assisted amplification further enhances the sensitivity of this biosensor. The highly sensitive detection of miRNA is achieved by measuring the sharp silver stripping peak, which also performs well with challenging biological samples. This method offers simplicity, high sensitivity, and practical application potential in clinical diagnosis.
Article
Nanoscience & Nanotechnology
Jinwen Zhu, Nan Ouyang, Rongchuan Zhao, Zhenzhen Guo, Jiao Yang, Minxuan Sun, Peng Miao
Summary: In this study, a novel nanocomposite composed of black phosphorus nanosheets, gold nanorods, carbon nanodots, and doxorubicin was prepared. The nanoagents exhibited high antitumor activity due to their broad light absorption, excellent catalytic ability, and significant photothermal and photodynamic effects. The components of the nanocomposite were able to diagnose and guide tumor treatment, induce cell apoptosis, increase the levels of ROS, and enhance the efficacy of photothermal and photodynamic therapies, leading to satisfactory antitumor results.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Analytical
Jiarong Guo, Mingyue Li, Shipeng Long, Jin Zhu, Peng Miao, Tianxiang Wei, Tao Gao
Summary: Inspired by the structure of a specific protein, a biomimetic catalytic center is constructed for efficient and sensitive detection of nitric oxide (NO) through electrocatalytic oxidation. The electrochemical microsensor exhibits a low detection limit and wide detection range, and has been successfully used for real-time monitoring of NO release by live cells.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Hua Chai, Xifeng Chen, Ruiju Shi, Peng Miao
Summary: In this study, a three-dimensional DNA nanostructure based electrochemical platform was developed for duplicate detection of miRNA amplified by nicking endonuclease. Target miRNA levels can be determined by evaluating the electrochemical response. In addition, the triplexes can be disassociated by simply changing pH conditions, and the iTPDNA biointerface can be regenerated for duplicate analyses.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Peng Miao
Summary: miRNAs in circulating blood are regarded as potential biomarkers for diagnosing various diseases. This study introduces a novel electrochemical sensing strategy that combines DNA walker strands on membrane-coated nanomaterials, target-mediated recycling activation, and electrochemical signal enrichment for the detection of miRNAs. The DNA walking nanomachine demonstrates enhanced signal amplification efficiency and easy magnetic separation, allowing for rapid analysis of miRNAs in human circulating blood samples. With its high sensitivity, simple operation, and excellent specificity, this magnetic multipedal DNA walker holds promise for determining miRNA levels in biomedical applications.
ANALYTICAL CHEMISTRY
(2023)
Article
Biophysics
Gang Wang, Tao Cheng, Hongxiu Yuan, Fangbo Zou, Peng Miao, Jin Jiao
Summary: In this study, multiple DNA probes were loaded onto 2D Cu-MOF nanosheets to monitor and locate the interaction between circRNA and miRNA in living cells. The nanosheets acted as powerful fluorescence quenchers and nanocarriers of DNA probes for further assembly. This platform showed high sensitivity and co-localization analysis, making it a promising tool for studying the biological functions of circRNA-miRNAs in cancer pathogenesis and for therapeutic applications.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Electrochemistry
Yulin Zhu, Jinwen Zhu, Yan Gao, Jiayue Shi, Peng Miao
Summary: We developed a novel electrochemical approach for detecting the level of FEN1 based on CRISPR and Cas proteins trans-cleavage. This method exhibits high sensitivity and good specificity, enabling direct monitoring of FEN1 in various biological samples and assisting in screening FEN1 inhibitors for potential use in anti-cancer drug discovery.
Article
Engineering, Biomedical
Xiaoyi Ma, Wuping Zhou, Haiwen Li, Bo Zhang, Peng Miao
Summary: In this study, the protection of hetero-nanostructure of MnO2 and AuNPs from salt-induced aggregation was systematically investigated using DNA as a medium. By analyzing the optical responses of these nanostructures, highly sensitive analysis of miRNA can be achieved. The excellent analytical performances are attributed to the unique features of MnO2@Au nanostructures and signal amplification designs, making them promising for the construction of novel biosensors in clinical applications.
MATERIALS TODAY BIO
(2023)
Article
Chemistry, Analytical
Qing Qian, Yuguo Tang, Peng Miao
Summary: In this study, a mass-encoded biosensing approach with duplex-specific nuclease (DSN) mediated signal amplification is developed to address the challenges of low abundance and multiplexing. The proposed method successfully detects multiple targets (such as five miRNAs) with high selectivity and sensitivity. Therefore, it can be utilized as an important and valuable tool for quantifying multiplex miRNAs in disease screening and biomedical investigations.
ANALYTICAL CHEMISTRY
(2023)
Article
Biophysics
Renpeng Xia, Hua Chai, Jin Jiao, Peng Miao
Summary: Early screening of biomarkers is important for the therapy and prognosis of cancers. MiRNAs encapsulated in tumor-derived exosomes have emerged as biomarkers for early cancer diagnosis. However, traditional methods have limitations that restrict their wide applications. In this study, a convenient electrochemical approach based on DNA triangular pyramid frustum (TPF) and strand displacement amplification was developed for quantification of exosomal miRNA. The biosensor showed excellent analytical performances and successfully analyzed exosomal miRNAs from cells and clinical serum samples.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Engineering, Environmental
Ruiju Shi, Siyuan Fu, Yuanyuan Xu, Peng Miao
Summary: In this study, a novel electrochemical biosensor for HIV DNA detection was developed, which utilized target induced recycling amplification to enhance sensitivity. Magnetic nanoparticles were used for facile separation and immobilization of target DNA. The proposed method showed excellent sensing performances and was successfully applied in clinical samples.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Physical
Zhenzhen Guo, Jinwen Zhu, Jian Yin, Peng Miao
Summary: A novel fluorescent biosensor based on Zeolitic Imidazolate Framework-8 (ZIF-8) nanocomposites is developed for the detection of H2O2 and glucose. The AgNP-CD-ZIF-8 nanocomposites serve as a highly sensitive platform for the analysis of H2O2. This turn-on biosensor can be used for facile and convenient quantification of H2O2 and further extended to detect glucose in real samples.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Nanoscience & Nanotechnology
Zhenzhen Guo, Yulin Zhu, Yuanyuan Xu, Peng Miao
Summary: Green-emissive carbon nanodots (CDs) with high quantum yield are prepared, which can selectively interact with Cu2+ due to the abundant functional groups on their surfaces. The formed cupric amine complexes lead to significant fluorescence quenching, which can be switched back to the "on" mode by the introduction of glutathione (GSH) that hinders the interactions between CDs and Cu2+. The fantastic optical behavior of CDs enables highly sensitive detection of Cu2+ and GSH, as well as intracellular imaging of these targets.
ACS APPLIED BIO MATERIALS
(2023)
Article
Chemistry, Analytical
Ruizhi Liu, Yuge Wang, Hua Chai, Peng Miao
Summary: An electrochemical sensing approach for ultrasensitive MTase activity assay is proposed based on cascade strand displacement polymerization after specific cleavage reaction in the methylated state. This method offers conveniences, high sensitivity, and reliability, making it useful for related biological studies and clinical applications.
