Article
Medicine, General & Internal
Pietro Ripani, Matteo Mucci, Stefano Pantano, Maria Di Sabatino, Francesca Collini, Giulia Ferri, Mario Romano, Antonio Recchiuti
Summary: This article presents an improved LC-MS/MS method for measuring the concentration of elexacaftor/tezacaftor/ivacaftor (ETI) in the blood and breastmilk of women with cystic fibrosis (CF) during pregnancy and lactation. The study shows that ETI remains stable in breastmilk, is absorbed by the infant, and can be detected in child plasma.
FRONTIERS IN MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Xiangrong Guo, Leilei Zhou, Jian Xu, Zhiwei Liu, Junxia Liu, Chonghuai Yan
Summary: The study revealed a non-linear association between maternal selenium status and TSH levels, suggesting that low selenium status during pregnancy may be associated with low thyroid function and low birth weight.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Review
Immunology
Cristina Kalbermatter, Nerea Fernandez Trigo, Sandro Christensen, Stephanie C. Ganal-Vonarburg
Summary: The innate immune system is the oldest protection strategy conserved across all organisms, providing a fast defense mechanism against pathogens. The interaction between maternal immune cells, antibodies, dietary antigens, and microbial metabolites is crucial for preparing the newborn's immunity.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Ling Yang, Yao Meng, Yuxiang Shi, Hongxu Fang, Leying Zhang
Summary: This review focuses on the anatomical and immunological adaptations of the maternal liver during pregnancy, as well as the associated diseases. It also presents the factors that regulate hepatic immunology during pregnancy. These findings are important for the prevention of embryo loss, abortion, and pregnancy-associated liver diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Nutrition & Dietetics
Samantha Enstad, Sukhinder Cheema, Raymond Thomas, Raina N. Fichorova, Camilia R. Martin, Perrie O'Tierney-Ginn, Carol L. Wagner, Sarbattama Sen
Summary: The study found that higher maternal BMI was associated with higher levels of n-6:n-3 PUFA and leptin in breast milk, and infants exposed to high n-6:n-3 PUFA had higher BMI z-scores. In addition, higher levels of inflammatory cytokines in breast milk were associated with accelerated weight gain in infants.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2021)
Review
Multidisciplinary Sciences
Katherine Daiy, Victoria Harries, Kate Nyhan, Urszula M. Marcinkowska
Summary: This scoping review synthesizes the current literature on the microbial composition of human milk by maternal weight status. The review found that women with higher pre-pregnancy or postpartum BMI, or excessive gestational weight gain, had higher abundances of Staphylococcus genus, lower Bifidobacterium abundance, and lower alpha diversity in their breast milk.
Article
Pharmacology & Pharmacy
Yumiko Akamine, Nobuhiro Fujiyama, Hideaki Kagaya, Mitsuru Saito, Hiroshi Miura, Yukihiro Terada, Tsutomu Takahashi, Shigeru Satoh, Masatomo Miura
Summary: The study reveals that maternal tacrolimus concentrations directly affect the fetus and neonate, with minimal transfer through breast milk detected in the neonate 3 weeks after birth.
JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Ishani Jhamb, Alyssa Freeman, Michelle R. Lotfi, Matthew VanOrmer, Corrine Hanson, Ann Anderson-Berry, Melissa Thoene
Summary: This study aimed to evaluate the concentrations of alpha- and gamma-tocopherol in placental tissue and assess their relationships with maternal and umbilical cord plasma concentrations. The results demonstrated significant positive correlations of gamma-tocopherol concentrations among all sample types. Placental tissue had significantly lower alpha:gamma-tocopherol concentration ratio compared to maternal and umbilical cord plasma.
Article
Obstetrics & Gynecology
Mazen Khalifeh, Lorry G. Rubin, David Dayya, Jane Cerise, Karen Skinner, Mona Maloney, Charles Walworth, Christos J. Petropoulos, Terri Wrin, Kelly Chun, Barry Weinberger
Summary: This study quantified the levels of neutralizing SARS-CoV-2 antibodies in maternal serum, cord blood, and breast milk after vaccination and infection. The levels of neutralizing antibodies in cord blood and milk correlated with maternal levels and were higher in cord blood. Spike protein binding antibodies may serve as a feasible proxy for neutralizing antibodies.
JOURNAL OF PERINATOLOGY
(2023)
Article
Pediatrics
Ulrika K. Andersson-Hall, Aldina Pivodic, Hanna K. de Mare, J. Pernilla Svedin, E. Carina Mallard, Kerstin G. Albertsson-Wikland, Agneta B. Holmang
Summary: In normal-weight women, maternal leptin and sOB-R levels during pregnancy are associated with infant fat mass accumulation, while in women with obesity, maternal fat mass before pregnancy has a greater impact on infant fat mass. Understanding these relationships is important for addressing the intergenerational programming of obesity.
PEDIATRIC RESEARCH
(2021)
Article
Pediatrics
Kelsey A. Egan, Brian K. Lo, Sebastien Haneuse, Kirsten K. Davison, Susan Redline, Elsie M. Taveras
Summary: This study found that maternal consumption of 100% juice and sugar-sweetened beverages in the third trimester of pregnancy is associated with infant weight status at 6 and 12 months. Specifically, consumption of 100% juice is associated with an increase in weight-for-length z-scores at 6 months and rapid infant weight gain from birth to 6 and 12 months. However, consumption of sugar-sweetened beverages is not associated with any of these outcomes.
ACADEMIC PEDIATRICS
(2023)
Article
Nutrition & Dietetics
Jiajin Hu, Izzuddin M. Aris, Pi-I D. Lin, Ningyu Wan, Yilin Liu, Yinuo Wang, Deliang Wen
Summary: The study found that maternal adherence to a protein-rich dietary pattern during pregnancy was associated with lower infant body mass index z-scores and a lower risk of overweight and obesity, while adherence to a vegetable-fruit-rice dietary pattern was associated with increased infant BMI and obesity risk. The results suggest that different maternal dietary patterns may have varying effects on infant weight and obesity status.
Article
Nutrition & Dietetics
Qianqian Zhang, Chen Zhang, Yi Wang, Jiuru Zhao, Haiyuan Li, Qianwen Shen, Xiaoli Wang, Meng Ni, Fengxiu Ouyang, Angela Vinturache, Hao Chen, Zhiwei Liu
Summary: The study revealed that first trimester insufficient or deficient vitamin D levels and being overweight or obese significantly increased the risk of early fetal growth restriction. Furthermore, a combination of low Vitamin D concentrations and overweight or obesity had a significant effect on early fetal growth.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Article
Environmental Sciences
Wei Wu, Zhi-Li Ma, Fang Yang, Ping Wu, De-Xin Zhang, Rong Zeng, Dan-Ling Sun, Liu Cao
Summary: The study found positive associations between phthalate metabolites and factors such as lower education, living near roads, and consuming more puffed food in pregnant women. Additionally, certain phthalate esters were associated with altered thyroid hormone levels.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Nutrition & Dietetics
Shengchi Wu, Feng Zhao, Yannan He, Tingchao He, Sufang Duan, Gang Feng, Yujing Chen, Xin Wang, Ignatius Man-Yau Szeto, Lizi Lin, Li Cai
Summary: The study found that maternal erythrocyte PUFA levels during pregnancy were associated with offspring weight status within the first 2 years of age in the Chinese population. Specifically, erythrocyte levels of DPA and AA were significantly associated with offspring weight.
FRONTIERS IN NUTRITION
(2022)
Article
Peripheral Vascular Disease
Daniel A. Duprez, David R. Jacobs, Leah I. B. Andrews, Lyndia C. Brumback, Julie O. Denenberg, Robyn L. Mcclelland, Isac C. Thomas, Michael H. Criqui, Matthew A. Allison
Summary: This study investigated the difference, reproducibility, and incidence of cardiovascular disease (CVD) in inter-arm systolic blood pressure (sIAD). It found that high absolute sIAD values were not persistent over time, but were associated with increased risk for stroke and peripheral arterial disease (PAD). Measuring systolic blood pressure between arms can help identify individuals at higher risk for CVD.
JOURNAL OF HUMAN HYPERTENSION
(2023)
Article
Public, Environmental & Occupational Health
Patrick Brady, Lisa Harnack, Rachel Widome, Kaitlyn M. Berry, Sruthi Valluri
Summary: The emergency food system (EFS) is an essential part of the US social safety net, however, the utilization of EFS among food insecure, low-income households varies over time. While overall EFS use increased in 2020, there was no significant increase for older adults and non-metropolitan households compared to previous years. Targeted outreach efforts are necessary to extend the reach of EFS to underserved and marginalized populations.
JOURNAL OF HUNGER & ENVIRONMENTAL NUTRITION
(2023)
Article
Behavioral Sciences
Katie A. Loth, Derek Hersch, Amanda Trofholz, Lisa Harnack, Kristin Norderud
Summary: This study investigates the impact of early pandemic disruptions on home food environment and parent feeding practices in families with young children. Findings suggest that food security status plays a role in families' coping strategies and feeding practices.
Article
Nutrition & Dietetics
Carles Lerin, Maria Carmen Collado, Elvira Isganaitis, Erland Arning, Brandi Wasek, Ellen W. Demerath, David A. Fields, Teodoro Bottiglieri
Summary: The concentration of S-adenosylmethionine (SAM) is higher in breast milk compared to other biofluids and is absent in infant milk formulas. This may suggest a strong demand for this metabolic nutrient during infant early growth.
Article
Cardiac & Cardiovascular Systems
Yuni Choi, David R. R. Jacobs Jr, Michael Patrick Bancks, Cora E. E. Lewis, EunSeok Cha, Fengxia Yan, Mercedes R. R. Carnethon, Pamela J. J. Schreiner, Daniel A. A. Duprez
Summary: The study found that the American Heart Association's cardiovascular health (CVH) score is closely associated with early-onset diabetes, later-onset diabetes, and subsequent complications of diabetes. Higher CVH score is associated with lower risk of both early- and later-onset diabetes, as well as diabetic complications. This study highlights the importance of maintaining good cardiovascular health in preventing diabetes and its complications.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Medicine, General & Internal
Kelley Pettee Gabriel, Byron C. Jaeger, Cora E. Lewis, Stephen Sidney, Erin E. Dooley, Mercedes R. Carnethon, David R. Jacobs, Bjoern Hornikel, Jared P. Reis, Pamela J. Schreiner, JamesM. Shikany, Kara M. Whitaker, Alexander Arynchyn, Barbara Sternfeld
Summary: This study found that higher early-adulthood cardiorespiratory fitness and greater retention of early-adulthood cardiorespiratory fitness throughout midlife were associated with a lower risk of premature death and CVD events.
Article
Cardiac & Cardiovascular Systems
Alessandro Menotti, Paolo Emilio Puddu, Anthony G. Kafatos, Hanna Tolonen, Hisashi Adachi, David R. Jacobs
Summary: This study aimed to investigate mortality rates from three major cardiovascular diseases (coronary heart disease, cerebrovascular diseases, and other heart diseases of uncertain etiology) in a pooled cohort over a 60-year follow-up period. The results showed that countries with high serum cholesterol levels had higher death rates from coronary heart disease, while countries with low cholesterol levels had higher death rates from stroke and other heart diseases. Differences in lifelong cardiovascular disease mortalities across different countries were smaller than expected.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Article
Respiratory System
Gabrielle Y. Liu, Laura A. Colangelo, Samuel Y. Ash, Raul San Jose Estepar, David R. Jacobs, Bharat Thyagarajan, J. Michael Wells, Rachel K. Putman, Bina Choi, Christopher S. Stevenson, Mercedes Carnethon, George R. Washko, Ravi Kalhan
Summary: This epidemiological study found that CT lung injury is associated with future interstitial features and restrictive spirometry abnormality. Among 2213 participants, a 10% higher amount of CT lung injury at mean age 40 years was associated with a 4.37% higher amount of lung tissue characterised as interstitial features at mean age 50 years. Compared to those with the lowest quartile of CT lung injury at mean age 40 years, there were higher odds of incident restrictive spirometry at mean age 55 years in quartile 2, quartile 3, and quartile 4.
Article
Public, Environmental & Occupational Health
Caitlin E. Caspi, Maria Fernanda Gombi-Vaca, Julian Wolfson, Lisa J. Harnack, Molly De Marco, Rebekah Pratt, Thomas Durfee, Samuel L. Myers Jr
Summary: There was no evidence of a beneficial or adverse effect of the Minimum Wage Ordinance on health-related variables during a period of economic and social change. The trends in hourly wage, BMI, food insecurity, employment, hours worked, SNAP participation, and dietary outcomes were similar in both cities, suggesting that other contextual factors may have contributed to the observed trends.
PUBLIC HEALTH NUTRITION
(2023)
Article
Genetics & Heredity
Lisa de las Fuentes, Karen L. M. Schwander, Michael R. Brown, Amy R. Bentley, Thomas W. Winkler, Yun Ju Sung, Patricia B. Munroe, Clint L. Miller, Hugo Aschard, Stella Aslibekyan, Traci M. Bartz, Lawrence F. Bielak, Jin Fang Chai, Ching-Yu Cheng, Rajkumar Dorajoo, Mary F. Feitosa, Xiuqing Guo, Fernando P. Hartwig, Andrea Horimoto, Ivana Kolcic, Elise Lim, Yongmei Liu, Alisa K. Manning, Jonathan Marten, Solomon K. Musani, Raymond Noordam, Sandosh Padmanabhan, Tuomo Rankinen, Melissa A. Richard, Paul M. Ridker, Albert V. Smith, Dina Vojinovic, Alan B. Zonderman, Maris Alver, Mathilde Boissel, Kaare Christensen, Barry I. Freedman, Chuan Gao, Franco Giulianini, Sarah E. Harris, Meian He, Fang-Chi Hsu, Brigitte Kuehnel, Federica Laguzzi, Xiaoyin Li, Leo-Pekka Lyytikainen, Ilja M. Nolte, Alaitz Poveda, Rainer Rauramaa, Muhammad Riaz, Antonietta Robino, Tamar Sofer, Fumihiko Takeuchi, Bamidele O. Tayo, Peter J. van der Most, Niek Verweij, Erin B. Ware, Stefan Weiss, Wanqing Wen, Lisa R. Yanek, Yiqiang Zhan, Najaf Amin, Dan E. Arking, Christie Ballantyne, Eric Boerwinkle, Jennifer A. Brody, Ulrich Broeckel, Archie Campbell, Mickael Canouil, Xiaoran Chai, Yii-Der Ida Chen, Xu Chen, Kumaraswamy Naidu Chitrala, Maria Pina Concas, Ulf de Faire, Renee de Mutsert, H. Janaka de Silva, Paul S. de Vries, Ahn Do, Jessica D. Faul, Virginia Fisher, James S. Floyd, Terrence Forrester, Yechiel Friedlander, Giorgia Girotto, C. Charles Gu, Goeran Hallmans, Sami Heikkinen, Chew-Kiat Heng, Georg Homuth, Steven Hunt, M. Arfan Ikram, David R. Jacobs, Maryam Kavousi, Chiea Chuen Khor, Tuomas O. Kilpelainen, Woon-Puay Koh, Pirjo Komulainen, Carl D. Langefeld, Jingjing Liang, Kiang Liu, Jianjun Liu, Kurt Lohman, Reedik Magi, Ani W. Manichaikul, Colin A. McKenzie, Thomas Meitinger, Yuri Milaneschi, Matthias Nauck, Christopher P. Nelson, Jeffrey R. O'Connell, Nicholette D. Palmer, Alexandre C. Pereira, Thomas Perls, Annette Peters, Ozren Polasek, Olli T. Raitakari, Kenneth Rice, Treva K. Rice, Stephen S. Rich, Charumathi Sabanayagam, Pamela J. Schreiner, Xiao-Ou Shu, Stephen Sidney, Mario Sims, Jennifer A. Smith, John M. Starr, Konstantin Strauch, E. Shyong Tai, Kent D. Taylor, Michael Y. Tsai, Andre G. Uitterlinden, Diana van Heemst, Melanie Waldenberger, Ya-Xing Wang, Wen-Bin Wei, Gregory Wilson, Deng Xuan, Jie Yao, Caizheng Yu, Jian-Min Yuan, Wei Zhao, Diane M. Becker, Amelie Bonnefond, Donald W. Bowden, Richard S. Cooper, Ian J. Deary, Jasmin Divers, Tonu Esko, Paul W. Franks, Philippe Froguel, Christian Gieger, Jost B. Jonas, Norihiro Kato, Timo A. Lakka, Karin Leander, Terho Lehtimaki, Patrik K. E. Magnusson, Kari E. North, Ioanna Ntalla, Brenda Penninx, Nilesh J. Samani, Harold Snieder, Beatrice Spedicati, Pim van der Harst, Henry Voelzke, Lynne E. Wagenknecht, David R. Weir, Mary K. Wojczynski, Tangchun Wu, Wei Zheng, Xiaofeng Zhu, Claude Bouchard, Daniel Chasman, Michele Evans, Ervin R. Fox, Vilmundur Gudnason, Caroline Hayward, Bernardo L. Horta, Sharon L. R. Kardia, Jose Eduardo Krieger, Dennis O. Mook-Kanamori, Patricia A. Peyser, Michael M. Province, Bruce M. Psaty, Igor Rudan, Xueling Sim, Blair H. Smith, Rob M. van Dam, Cornelia M. van Duijn, Tien Yin Wong, Donna K. Arnett, Dabeeru C. Rao, James Gauderman, Ching-Ti Liu, Alanna C. Morrison, Jerome I. Rotter, Myriam Fornage
Summary: This study conducted a genome-wide meta-analysis to investigate the interaction between educational attainment and lipid levels. They identified novel lipid loci that were not previously detected by analyses limited to main genetic effects. The study also highlighted the potential importance of brain-adipose-liver communication in lipid metabolism and identified gene targets that interact with drugs approved by the FDA.
FRONTIERS IN GENETICS
(2023)
Article
Medicine, General & Internal
Daniel J. Mcdonough, Mahesh Mathew, Zachary C. Pope, Pamela J. Schreiner, David R. Jacobs Jr, Lisa B. Vanwagner, John Jeffrey Carr, James G. Terry, Kelley Pettee Gabriel, Jared P. Reis, Mark A. Pereira
Summary: This study examined the association between lifestyle factors and NAFLD and found that regular moderate-vigorous aerobic and muscle-strengthening activities, along with reduced television viewing time, significantly reduce the risk of NAFLD.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Junia N. de Brito, Daniel J. McDonough, Mahesh Mathew, Lisa B. VanWagner, Pamela J. Schreiner, Kelley Pettee Gabriel, David R. Jacobs Jr, James G. Terry, John Jeffrey Carr, Mark A. Pereira
Summary: This study found that higher levels of vigorous-intensity physical activity (VPA) throughout young to middle adulthood were associated with a reduced risk of nonalcoholic fatty liver disease (NAFLD) in middle age.
Article
Nutrition & Dietetics
Patrick J. Brady, Lisa Harnack, Rachel Widome, Kaitlyn M. Berry, Sruthi Valluri
Summary: Surveillance data suggests that during the COVID-19 pandemic, there was an increase in food security rates among participants of the Supplemental Nutrition Assistance Program (SNAP) compared to the pre-pandemic period. Demographic differences between households participating in SNAP in different years were examined to determine if they contributed to the increased prevalence of food secure households. The study found that the increased prevalence of food secure households during the pandemic was not solely due to socio-demographic differences.
JOURNAL OF NUTRITIONAL SCIENCE
(2023)
Article
Peripheral Vascular Disease
Gabor Szalo, Margareta I. Hellgren, Matthew Allison, Ying Li, Lennart Rastam, Karin Radholm, Entela Bollano, Daniel A. Duprez, David R. Jacobs, Ulf Lindblad, Bledar Daka
Summary: The association between arterial elasticity obtained by radial artery pulse wave analysis and risk for cardiovascular diseases (CVD) was investigated. The study found a significant increase in the risk for incident CVD with each quartile decrease in arterial elasticity.
JOURNAL OF HUMAN HYPERTENSION
(2023)
Article
Geriatrics & Gerontology
Paolo Emilio Puddu, Alessandro Menotti, David R. Jacobs, Hisashi Adachi, Antony Kafatos, Hanna Tolonen
Summary: This study examined the age at death and its determinants in cohorts of middle-aged men. The results showed that cardiovascular disease risk factors were strongly associated with age at death. Other factors such as age, physical activity, and smoking status were also related to age at death.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2023)