Article
Biophysics
Xinli Wang, Jiahe Chen, Hui Xu, Yufei Fan, Xue Wang, Meng Zhang, Yue Liu, Binxiao Li, Jing Liu, Hong Zhou
Summary: In this work, an electrochemiluminescent dual-mode sensor platform based on molecularly imprinted polymer modified closed bipolar electrodes was developed for high sensitivity detection of L-phenylalanine and D-phenylalanine. The sensor achieved dual-mode detection of the target molecules with high stability and specificity, and successfully detected actual samples.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Chemistry, Analytical
Qing Zhang, Shangshang Ma, Xin Zhuo, Cong Wang, Hongyan Wang, Yuying Xing, Qingyuan Xue, Keying Zhang
Summary: A simple and green method was reported to anchor silver nanoparticles onto three-dimensional reduced graphene oxide, and a reliable electrochemical sensing platform was designed for the ultrasensitive detection of rifampicin. The modified electrode exhibited effective electrical activity for the analysis of RIF. The sensor showed excellent electrochemical performance for RIF detection under experimental conditions and demonstrated great potential in practical applications.
Article
Chemistry, Analytical
Wenyuan Zhao, Ying Ma, Jianshan Ye
Summary: In this study, a new ECL sensing strategy was proposed by combining molecular imprinting technology (MIT) and bipolar electrode (BPE) for rapid dopamine (DA) analysis. The MIP modified electrode showed improved sensitivity, selectivity, and stability for DA detection, demonstrating great sensing performance in the established platform.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Xiao-Yan Yang, Yi-Yan Bai, Yue-Yue Huangfu, Wen-Jing Guo, Yan-Ju Yang, Dai-Wen Pang, Zhi-Ling Zhang
Summary: An ultrasensitive electrochemiluminescence biosensor based on a closed bipolar electrode was proposed for the detection of alkaline phosphatase. The sensitivity of the system was greatly enhanced by utilizing enzyme catalysis for signal amplification and electrodeposition of Au nanoparticles on the cathode surface. This biosensor showed high sensitivity and specificity, with a detection limit as low as 3.7 aM, and successfully realized ALP detection in single cells.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Kai Niu, Juan Gao, Lingxia Wu, Xianbo Lu, Jiping Chen
Summary: Enzymatic biosensors based on nitrogen-doped graphdiyne exhibit high sensitivity, excellent reproducibility, and stability, showing great potential for rapid detection of environmental pollutants. The nitrogen doping enhances electrical conductivity and substance adsorption, contributing to significantly improved biosensing performance.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Lin Zhu, Xue Lv, Haihan Yu, Xiaoran Tan, Yumeng Rong, Weihao Feng, Lina Zhang, Jinghua Yu, Yan Zhang
Summary: In this study, a hand-drawing paper-based bipolar electrode electrochemiluminescence platform was developed for the detection of M.SssI methyltransferase. The platform utilized high electrocatalytic Pt@CeO2 as an ECL co-reaction accelerator and pencil-drawing graphite electric circuits as wires and electrodes. The platform provides a convenient, low-cost and easy-to-operate solution for early disease diagnosis and pathogenesis research.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Xin-Ying Wang, Xue-Xue Yan, Ya-Pan Wu, Xue-Qian Wu, Ya-Meng Yin, Shuang Li, Qichun Zhang, Bin Liu, Dong-Sheng Li
Summary: Two-dimensional metal-organic framework (MOF) crystalline materials with tunable structures and abundant metal active sites were synthesized and used to fabricate nonenzymatic glucose sensors. The optimized sensor demonstrated high sensitivity, a wide linear range, and good stability, making it a promising candidate for preliminary screening for diabetes.
INORGANIC CHEMISTRY
(2023)
Article
Biophysics
Tingting Zhan, Yan Su, Wei Lai, Zhenyu Chen, Chunsun Zhang
Summary: A dry chemistry-based, ultrasensitive closed bipolar electrode-ECL immunosensor has been designed for rapid detection of Cardiac Troponin I (cTnI). The immunosensor showed a wide linear range, high sensitivity, and good specificity, reproducibility, and stability. Moreover, the analysis process was simple and fast, making it a promising tool for early diagnosis of acute myocardial infarction and other diseases.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Chemistry, Applied
Lintao Zeng, Yingjun Ke, Xiaorui Yang, Minhuan Lan, Shaojing Zhao, Beitong Zhu
Summary: In this study, a practical sensing platform based on BDP-OPD was designed for rapid and accurate quantification of nitrite in food. The platform exhibited high sensitivity, rapid response, and good selectivity. A portable smartphone-based fluorescence device was fabricated for nitrite determination, offering advantages such as rapid response, low cost, ease of operation, portability, and satisfactory recoveries.
Article
Chemistry, Analytical
Harleen Kaur, Prasanthi Chittineedi, Ravi Shankar Bellala, Venkata Madhavi Bellala, Sandeep Singh, Rohini Kumari, Pranjal Chandra, Santhi Latha Pandrangi, Surinder P. Singh
Summary: An immunosensor based on graphene oxide nanosheets was fabricated to indirectly detect transferrin levels in cancer patients, showing excellent detection capability in a wide linear range and a lower limit of detection compared to the enzyme-linked immunosorbent assay. The immunosensor demonstrated clinical potential with a high degree of accuracy and correlation with other detection techniques.
Article
Biophysics
Hongkun Li, Qianqian Cai, Jianru Wang, Guifen Jie
Summary: This study presents a unique FeMoOv nanozyme-bipolar electrode (NM-BPE) electrochemiluminescence (ECL) biosensing and imaging platform for sensitive detection of hydrogen peroxide (H2O2) and prostate specific antigen (PSA). The anode of the BPE is equipped with ECL reagent bipyridine ruthenium (Ru(bpy)32+), while the cathode is equipped with Fe-doped molybdenum oxide/Au nanoparticles (FeMoOv/AuNPs) with excellent peroxidase (POD) and catalase (CAT)-like activity. By utilizing the efficient enzyme catalysis effect of FeMoOv/AuNPs, the electron transfer rate in the NM-BPE system is accelerated, enhancing the ECL signal of Ru(bpy)32+. Based on this principle, the study achieved sensitive detection of H2O2 and designed a sandwich immunosensor for highly sensitive detection of PSA using FeMoOv/AuNPs as recognition probe. A unique mobile phone ECL imaging system was also developed for PSA assay, providing a portable imaging sensing device for bioassays. This study not only broadened the applications of nanozymes, but also pioneered the new joint ECL research technique of bipolar electrode and ECL imaging in bioassays, showing great application prospect for multiple detection of proteins, nucleic acids, and cancer cells.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Chemistry, Analytical
Rongrong Yuan, Zhuojun Yan, Alateng Shaga, Hongming He
Summary: A novel porous organic polymer (POP) with high surface area and stability was successfully prepared and used to fabricate an ultrasensitive electrochemical aptasensor for detecting trace ampicillin. The biosensor exhibited a low detection limit and accurate monitoring ability for detecting amp in multiple real samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Analytical
Yue Hu, Jiangwei Li, Jiang Liu, Xinge Yu, Jiao Yang, Yingchun Li
Summary: The article discusses the emergence of health monitoring devices for personalized health monitoring. The integration of physical sensing and biochemical sensing into one device is a significant trend in health monitoring. The researchers developed a multifunctional platform consisting of a strain sensing unit and a sweat detection unit, using hydrogels functionalized with reduced graphene oxide (rGO) and luminol (Lum). The platform demonstrated rapid response to motion behaviors and accurate analysis of physiological indicators in sweat, and it overcame the issues associated with sweat complexity through a closed bipolar electrode design. The work is expected to provide useful guidance and insights for expanding daily health care.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Engineering, Environmental
Yindian Wang, Zhijuan Niu, Chengcheng Xu, Minghui Zhan, Kwangnak Koh, Junfeng Niu, Hongxia Chen
Summary: A real-time and label-free surface plasmon resonance (SPR) sensor was developed using a two-dimensional metal-organic framework as an SPR sensitizer to accurately monitor sulfamethazine (SMZ) in the environment. The sensor utilizes host-guest recognition to specifically capture SMZ from other similar antibiotics.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Chemistry, Analytical
Yixia Yang, Jingzhao Yang, Feng Gong, Pengfei Zuo, Zhiyou Tan, Juanjuan Li, Conghua Xie, Xinghu Ji, Wenhua Li, Zhike He
Summary: This study presents a sensing platform based on CRISPR/Cas12a and isothermal exponential amplification reaction (EXPAR) for ultrasensitive analysis of miRNA. The platform provides a wide detection range and low limit of detection, and has the capability to detect other microRNA biomarkers. Additionally, the platform can assess miR-27a levels in breast cancer cell and serum samples, showing promising potential for clinical application in molecular diagnostics.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Mathematics, Applied
Jing Zhao, Zhenhai Liu, Yongjian Liu
Summary: This paper aims to address the approximate controllability of control systems described by non-autonomous second-order evolution hemivariational inequalities with nonlocal conditions in Hilbert spaces. A concept of mild solution is first defined based on the existence of an evolution operator for the corresponding linear equation and the property of Clarke subdifferential. Then, the solvability and approximate controllability are investigated using a fixed-point strategy. Finally, two examples are provided to illustrate the main results.
APPLICABLE ANALYSIS
(2023)
Article
Cell Biology
Xiaojie Wang, Liang Wang, Mingyi Luo, Qian Bu, Chunqi Liu, Linhong Jiang, Rui Xu, Shaomin Wang, Haoluo Zhang, Jiamei Zhang, Xuemei Wan, Hongchun Li, Yonghai Wang, Bin Liu, Ying Zhao, Yuanyuan Chen, Yanping Dai, Min Li, Hongbo Wang, Jingwei Tian, Yinglan Zhao, Xiaobo Cen
Summary: Clarithromycin (CLA) treatment causes anxiety-like behaviors, possibly through altered glycerophospholipid metabolism.
CELL BIOLOGY AND TOXICOLOGY
(2023)
Article
Neurosciences
Yonghai Wang, Hongchun Li, Ying Zhao, Feng Qin, Liang Wang, Linhong Jiang, Xiaojie Wang, Rong Chen, Yuman He, Qinfan Wei, Shu Li, Yuanyuan Chen, Yuzhou Xiao, Yanping Dai, Qian Bu, Yinglan Zhao, Jingwei Tian, Hongbo Wang, Xiaobo Cen
Summary: Sevoflurane exposure in the neonatal period causes cognitive impairment and social behavior deficits in adolescent rats. Lipidomics and proteomics analysis revealed the remodeling of lipid metabolism and downregulation of LPCAT1 expression in the hippocampus, suggesting their involvement in neurobehavioral dysfunction.
Article
Chemistry, Multidisciplinary
Yan-ni Wang, Zhi-hao Zhang, Hong-jiao Liu, Zhi-yuan Guo, Liang Zou, Ya-mei Zhang, Ying-yong Zhao
Summary: Dysregulation in lipid metabolism is closely related to the pathogenesis of chronic kidney disease (CKD). This study identified differential plasma lipid species in CKD rats and revealed that dysregulation of PC metabolism was involved in CKD pathology. Moreover, administration of Rheum officinale improved kidney function and aberrant PC metabolism in CKD rats.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Engineering, Chemical
Mengxiang Ye, Chao Zhang, Zhenzhen Liu, Huaimeng Li, Zhen Fu, Haimin Zhang, Guozhong Wang, Yunxia Zhang
Summary: The conversion of e-waste into high-performance catalysts offers an economical solution for the degradation of bisphenol A (BPA). In this study, CuAu bimetallic catalysts were electro-codeposited on carbon cloth (CC) with waste central processing unit (CPU) leachate as the electrolyte. The resulting CuAu/CC composites were efficient electro-catalysts for the decontamination of BPA via the electro-Fenton process. The optimized CuAu/CC electrodes achieved 99.5% BPA removal and 64.2% total organic carbon (TOC) removal within 120 minutes.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Oncology
Shuchen Chen, Wanyi Huang, Zhenzhen Liu, Meizi Jin, Jielin Li, Lihui Meng, Ting Li, Yuzhu Diao, Hong Gao, Chengyu Hong, Jian Zheng, Fei Li, Yue Zhang, Dan Bi, Lin Teng, Xiaoling Li
Summary: This study identifies nine mutant genes and smoking history associated with organ tropism metastases of NSCLC and provides three models for predicting metastatic organs.
Article
Chemistry, Physical
Qin Liu, Shibo Xi, Xinnan Peng, Lei Feng, Guangyuan Xu, Zhendong Liu, Yuan Kong, Xiaoxu Zhao, Huan Yan
Summary: This study proposes a new strategy for investigating the coordination environment of catalytic centers and its effect on reactivity. By altering the surrounding atoms instead of the catalytic metal center, a clear relationship between coordination environment and catalytic activity was observed. DFT calculations provided a comprehensive map of the relationship between coordination environments and catalytic performances. This coordination environment engineering method can be widely applied to screen new catalysts and offers a novel way to investigate the fundamental chemistry of active sites in catalysis.
Article
Environmental Sciences
Chunhong Teng, Ying Li, Tao Cang, Hao Xu, Zhenzhen Liu, Peipei Qi, Zhiwei Wang, Huiyu Zhao, Shanshan Di, Xinquan Wang
Summary: This study investigated the enantioselective bioaccumulation and dissipation of uniconazole enantiomers in an earthworm-soil microcosm. A fast enantioseparation method was established using supercritical fluid chromatography-tandem mass spectrometry. The results showed that the bioaccumulation of uniconazole enantiomers in earthworms increased with time and reached a maximum on the 7th day, while the dissipation in soil was slow. No enantioselectivity was observed in the earthworm-soil microcosm.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Review
Immunology
Siwei Wang, Yanhua Zhou, Jiangrong Huang, Huilin Li, Huidan Pang, Dandan Niu, Guangyao Li, Fei Wang, Zushan Zhou, Zhenzhen Liu
Summary: This review provides an overview of the establishment, pathological features, potential mechanisms, advantages, and limitations of currently available rheumatoid arthritis (RA) models. It highlights the importance of translating laboratory research into clinical practice.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Environmental Sciences
Zhendong Liu, Wenhu Qv, Haolin Cai, Hongliang Guan, Shuaizhe Zhang
Summary: In this paper, an efficient and robust hybrid SfM method is proposed to address the challenges of loose spatial distribution of images within subclusters and unbalanced connectivity between subclusters. The method employs a multifactor joint scene partition measure and a preassignment balanced image expansion algorithm to improve the degree of connection among subclusters. Experimental results demonstrate that the proposed method outperforms state-of-the-art methods in terms of accuracy and robustness.
Article
Green & Sustainable Science & Technology
Bin Luo, Zhenhai Liu, Sichao Mai
Summary: Since the 1960s, scholars have conducted empirical research on environmental federalism theory, mainly focusing on whether a country's environmental regulation should be centralized or decentralized. Countries have been actively exploring and implementing their own environmental governance systems, especially in the face of resource constraints, environmental challenges, and the need for sustainable development. Encouraging enterprises' technological innovation to build an appropriate environmental governance system and promote green development is an urgent practical problem to be solved.
Article
Chemistry, Multidisciplinary
Juntao Zhou, Xianhui Cheng, Zhanchen Guo, Muhammad Mujahid Ali, Guiyuan Zhang, W. Andy Tao, Lianghai Hu, Zhen Liu
Summary: Phospholipids are key components of cell membranes with important functions in molecule transportation and cell recognition. However, methods for specific recognition of lipids are limited compared to proteins and glycans due to their structural diversity and amphipathic nature. In this study, a molecular imprinting strategy was developed for controllable imprinting of the polar head of phospholipid on the surface of cellular membranes. Phosphatidylserine, a unique lipid on the outer membrane leaflet of exosomes and a hallmark for cell apoptosis, was successfully imprinted using this method. The resulting phosphatidylserine imprinted materials exhibited high efficiency and specific targeting capability for apoptotic cell imaging and exosome isolation. These molecularly imprinted materials have great potential for selective plasma membrane recognition in targeted drug delivery and biomarker discovery.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Infectious Diseases
Yanchun Zhong, Yuxi Huang, Di Zhang, Zhaoyuan Chen, Zhenxing Liu, Yongjun Ye
Summary: This article reports a rare case of isolated sacral cryptococcal osteomyelitis in an immunocompetent patient. Furthermore, it identified and reviewed 18 published cases of spine cryptococcal osteomyelitis. Clinical manifestation and imaging are insufficient to diagnose cryptococcal osteomyelitis of the spine, and invasive examinations, such as puncture biopsy and fungal examinations, are needed. Antifungal therapy yields satisfactory results for the treatment of cryptococcal osteomyelitis of the spine, however, if the infective lesion is large, especially when it compresses the spinal cord and nerves, a regimen combining aggressive surgery with antifungal therapy is indispensable.
BMC INFECTIOUS DISEASES
(2023)
Review
Chemistry, Analytical
Qian-Nan He, Zheng-Yuan Ma, Yu-Xin Yang, Cong-Hui Xu, Wei Zhao
Summary: In recent years, there has been an increasing demand for advanced analytical techniques in order to track life processes with high sensitivity. Electrochemiluminescence (ECL) analysis has emerged as a promising approach for various purposes, such as biomolecule detection, cellular activity monitoring, subcellular imaging, and cell viability evaluation. ECL analysis and imaging provide high sensitivity, low background noise, and spatiotemporal resolution for single-cell analysis. This review explores the evolution of ECL technology in cell analysis and emphasizes single-cell assays, including the detection of cellular molecules and biomarkers, analysis of intracellular components, imaging of cell membranes, and cell adhesion. The latest advances in ECL-driven photodynamic therapy and super-resolution ECL microscopy are also discussed, along with the current obstacles and prospects for ECL single-cell analysis.
Article
Energy & Fuels
Zhenhai Liu, Wei Zeng, Feipeng Qi, Yi Zhou, Quan Li, Ping Chen, Chunyu Yin, Yong Liu, Wenbo Zhao, Haoyu Wang, Yongzhong Huang
Summary: Coupling fuel performance and neutronics can enhance the accuracy of predicting fuel rod behavior, which is crucial for fuel design and performance evaluation. A fuel rod multiphysics coupled system was developed using COMSOL and RMC, enabling the simulation of fuel behavior in 2D-RZ or 3D mode. By wrapping RMC as a component of COMSOL, two-way coupling was achieved through data transfer and communication. Model validation of a fuel rod pin lattice demonstrated reasonable power and temperature distributions. The flexibility of the coupled system makes it applicable for evaluating the performance of new fuel designs.
FRONTIERS IN ENERGY RESEARCH
(2023)
