期刊
NEUROBIOLOGY OF AGING
卷 75, 期 -, 页码 178-186出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2018.10.024
关键词
Neurodegeneration; Cognitive impairment; Cardiovascular risk factors
资金
- Intramural Research Program of the National Institutes of Health, National Institute on Aging
- NIH [N01-AG-3-2124, R01-AG14971, RF1-AG054409]
- NATIONAL INSTITUTE ON AGING [ZIAAG000191, ZIAAG000015, ZIAAG000185] Funding Source: NIH RePORTER
Effects of Alzheimer's disease (AD) risk factors on brain volume changes may partly explain what happens during the preclinical AD stage in people who develop subsequent cognitive impairment (SI). We investigated predictors of neurodegeneration, measured by MRI-based volume loss, in older adults before diagnosis of cognitive impairment. There were 623 cognitively normal and 65 SI Baltimore Longitudinal Study of Aging participants (age 55-92 years) enrolled in the neuroimaging substudy from 1994 to 2015. Mixed-effects regression was used to assess the associations of AD risk factors (age, APOE e4 carrier status, diabetes, hypertension, obesity, current smoking, and elevated cholesterol) with brain regional volume change among the overall sample and by diagnostic status. Older age, APOE e4 carrier status, hypertension, and HDL cholesterol were predictors of volumetric change. Among SI participants only, hypertension, obesity, and APOE e4 carrier status were associated with greater declines in selected brain regions. SI individuals in the preclinical AD stage are vulnerable to risk factors that have either a protective or null effect in cognitively normal individuals. (C) 2018 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据