Biological and clinical insights from genetics of insomnia symptoms

Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways

(2018) David M. Howard et al.   Nature Communications

The MR-Base platform supports systematic causal inference across the human phenome

(2018) Gibran Hemani et al.   eLife

Genome-wide association studies of brain imaging phenotypes in UK Biobank

(2018) Lloyd T. Elliott et al.   NATURE

The UK Biobank resource with deep phenotyping and genomic data

(2018) Clare Bycroft et al.   NATURE

Clinical Practice Guideline for the Pharmacologic Treatment of Chronic Insomnia in Adults: An American Academy of Sleep Medicine Clinical Practice Guideline

(2017) Michael J. Sateia et al.   Journal of Clinical Sleep Medicine

European guideline for the diagnosis and treatment of insomnia

(2017) Dieter Riemann et al.   JOURNAL OF SLEEP RESEARCH

Identification of novel risk loci for restless legs syndrome in genome-wide association studies in individuals of European ancestry: a meta-analysis

(2017) Barbara Schormair et al.   LANCET NEUROLOGY

Identification of preoptic sleep neurons using retrograde labelling and gene profiling

(2017) Shinjae Chung et al.   NATURE

Genome-wide association analysis of insomnia complaints identifies risk genes and genetic overlap with psychiatric and metabolic traits

(2017) Anke R Hammerschlag et al.   NATURE GENETICS

Insomnia heterogeneity: Characteristics to consider for data-driven multivariate subtyping

(2017) Jeroen S. Benjamins et al.   SLEEP MEDICINE REVIEWS

Molecular Mechanisms of Sleep Homeostasis in Flies and Mammals

(2017) Ravi Allada et al.   Cold Spring Harbor Perspectives in Biology

Functional mapping and annotation of genetic associations with FUMA

(2017) Kyoko Watanabe et al.   Nature Communications

LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis

(2016) Jie Zheng et al.   BIOINFORMATICS

Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator

(2016) Jack Bowden et al.   GENETIC EPIDEMIOLOGY

Operation of a homeostatic sleep switch

(2016) Diogo Pimentel et al.   NATURE

Forward-genetics analysis of sleep in randomly mutagenized mice

(2016) Hiromasa Funato et al.   NATURE

A method to decipher pleiotropy by detecting underlying heterogeneity driven by hidden subgroups applied to autoimmune and neuropsychiatric diseases

(2016) Buhm Han et al.   NATURE GENETICS

Haplotype estimation for biobank-scale data sets

(2016) Jared O'Connell et al.   NATURE GENETICS

Genome-wide association analyses of sleep disturbance traits identify new loci and highlight shared genetics with neuropsychiatric and metabolic traits

(2016) Jacqueline M Lane et al.   NATURE GENETICS

Integrative approaches for large-scale transcriptome-wide association studies

(2016) Alexander Gusev et al.   NATURE GENETICS

Enrichr: a comprehensive gene set enrichment analysis web server 2016 update

(2016) Maxim V. Kuleshov et al.   NUCLEIC ACIDS RESEARCH

Fast and Rigorous Computation of Gene and Pathway Scores from SNP-Based Summary Statistics

(2016) David Lamparter et al.   PLoS Computational Biology

Non-coding genetic variants in human disease: Figure 1.

(2015) Feng Zhang et al.   HUMAN MOLECULAR GENETICS

Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression

(2015) J. Bowden et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Partitioning heritability by functional annotation using genome-wide association summary statistics

(2015) Hilary K Finucane et al.   NATURE GENETICS

An atlas of genetic correlations across human diseases and traits

(2015) Brendan Bulik-Sullivan et al.   NATURE GENETICS

LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

(2015) Brendan K Bulik-Sullivan et al.   NATURE GENETICS

Efficient Bayesian mixed-model analysis increases association power in large cohorts

(2015) Po-Ru Loh et al.   NATURE GENETICS

UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age

(2015) Cathie Sudlow et al.   PLOS MEDICINE

Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank

(2015) Louise V Wain et al.   Lancet Respiratory Medicine

Insomnia disorder

(2015) Charles M. Morin et al.   Nature Reviews Disease Primers

Improved Sleep in Military Personnel is Associated with Changes in the Expression of Inflammatory Genes and Improvement in Depression Symptoms

(2015) Whitney S. Livingston et al.   Frontiers in Psychiatry

Misuse of benzodiazepines and Z-drugs in the UK

(2014) V. Kapil et al.   BRITISH JOURNAL OF PSYCHIATRY

Genetic and epigenetic fine mapping of causal autoimmune disease variants

(2014) Kyle Kai-How Farh et al.   NATURE

Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool

(2013) Edward Y Chen et al.   BMC BIOINFORMATICS

Sleep is not just for the brain: transcriptional responses to sleep in peripheral tissues

(2013) Ron C Anafi et al.   BMC GENOMICS

An emerging role for Cullin-3 mediated ubiquitination in sleep and circadian rhythm

(2013) Amanda A.H. Freeman et al.   FLY

Mendelian Randomization Analysis With Multiple Genetic Variants Using Summarized Data

(2013) Stephen Burgess et al.   GENETIC EPIDEMIOLOGY

Prevalence and Characteristics of Probable Major Depression and Bipolar Disorder within UK Biobank: Cross-Sectional Study of 172,751 Participants

(2013) Daniel J. Smith et al.   PLoS One

Increased Rostral Anterior Cingulate Cortex Volume in Chronic Primary Insomnia

(2013) John W. Winkelman et al.   SLEEP

Diagnostic and statistical manual of mental disorders 5: A quick glance

(2013) VihangN Vahia   Indian Journal of Psychiatry

Cohort Profile: The HUNT Study, Norway

(2012) S. Krokstad et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Chronic insomnia

(2012) Charles M Morin et al.   LANCET

Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits

(2012) Jian Yang et al.   NATURE GENETICS

insomniac and Cullin-3 Regulate Sleep and Wakefulness in Drosophila

(2011) Nicholas Stavropoulos et al.   NEURON

Sleep Duration and Sleep Quality in Relation to 12-Year Cardiovascular Disease Incidence: The MORGEN Study

(2011) Marieke P. Hoevenaar-Blom et al.   SLEEP

METAL: fast and efficient meta-analysis of genomewide association scans

(2010) C. J. Willer et al.   BIOINFORMATICS

Role of Basal Ganglia in Sleep–Wake Regulation: Neural Circuitry and Clinical Significance

(2010) Ramalingam Vetrivelan et al.   Frontiers in Neuroanatomy

The genetic and molecular regulation of sleep: from fruit flies to humans

(2009) Chiara Cirelli   NATURE REVIEWS NEUROSCIENCE