An allosteric MALT1 inhibitor is a molecular corrector rescuing function in an immunodeficient patient

N -aryl-piperidine-4-carboxamides as a novel class of potent inhibitors of MALT1 proteolytic activity

(2018) Achim Schlapbach et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The T-cell fingerprint of MALT1 paracaspase revealed by selective inhibition

(2017) Maureen Bardet et al.   IMMUNOLOGY AND CELL BIOLOGY

Deficiency in Mucosa-associated Lymphoid Tissue Lymphoma Translocation 1

(2017) Fabienne Charbit-Henrion et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Two Antagonistic MALT1 Auto-Cleavage Mechanisms Reveal a Role for TRAF6 to Unleash MALT1 Activation

(2017) Stefanie Ginster et al.   PLoS One

Successful clinical treatment and functional immunological normalization of human MALT1 deficiency following hematopoietic stem cell transplantation

(2016) Jacob Rozmus et al.   CLINICAL IMMUNOLOGY

The paracaspase MALT1 cleaves the LUBAC subunit HOIL1 during antigen receptor signaling

(2016) Tiphaine Douanne et al.   JOURNAL OF CELL SCIENCE

Quantitative proteomics and terminomics to elucidate the role of ubiquitination and proteolysis in adaptive immunity

(2016) Theo Klein et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES

Targeting MALT1 Proteolytic Activity in Immunity, Inflammation and Disease: Good or Bad?

(2016) Annelies Demeyer et al.   TRENDS IN MOLECULAR MEDICINE

MALT1 cleaves the E3 ubiquitin ligase HOIL-1 in activated T cells, generating a dominant negative inhibitor of LUBAC-induced NF-κB signaling

(2015) Lynn Elton et al.   FEBS Journal

Genetic errors of the human caspase recruitment domain–B-cell lymphoma 10–mucosa-associated lymphoid tissue lymphoma-translocation gene 1 (CBM) complex: Molecular, immunologic, and clinical heterogeneity

(2015) Rebeca Pérez de Diego et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Combined Immunodeficiency Due to MALT1 Mutations, Treated by Hematopoietic Cell Transplantation

(2015) Divya Punwani et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Deficiency of MALT1 Paracaspase Activity Results in Unbalanced Regulatory and Effector T and B Cell Responses Leading to Multiorgan Inflammation

(2015) Frédéric Bornancin et al.   JOURNAL OF IMMUNOLOGY

APR-246 overcomes resistance to cisplatin and doxorubicin in ovarian cancer cells

(2015) N Mohell et al.   Cell Death & Disease

The paracaspase MALT1 cleaves HOIL1 reducing linear ubiquitination by LUBAC to dampen lymphocyte NF-κB signalling

(2015) Theo Klein et al.   Nature Communications

MALT1 Protease Activity Is Required for Innate and Adaptive Immune Responses

(2015) Jong W. Yu et al.   PLoS One

Malt1 protease inactivation efficiently dampens immune responses but causes spontaneous autoimmunity

(2014) Maike Jaworski et al.   EMBO JOURNAL

The CARD11-BCL10-MALT1 (CBM) signalosome complex: Stepping into the limelight of human primary immunodeficiency

(2014) Stuart E. Turvey et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Uncoupling Malt1 Threshold Function from Paracaspase Activity Results in Destructive Autoimmune Inflammation

(2014) Andreas Gewies et al.   Cell Reports

Structural Analysis of Phenothiazine Derivatives as Allosteric Inhibitors of the MALT1 Paracaspase

(2013) Florian Schlauderer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Recent developments in targeting protein misfolding diseases

(2013) Rajiah Aldrin Denny et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Innate immune control of EBV-infected B cells by invariant natural killer T cells

(2013) B. K. Chung et al.   BLOOD

Protein Misfolding in Disease and Small Molecule Therapies

(2013) Claudio M. Gomes   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Pharmacological chaperones as a potential therapeutic option in methylmalonic aciduria cblB type

(2013) A. Jorge-Finnigan et al.   HUMAN MOLECULAR GENETICS

Combined immunodeficiency associated with homozygous MALT1 mutations

(2013) Margaret L. McKinnon et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Structural Architecture of the CARMA1/Bcl10/MALT1 Signalosome: Nucleation-Induced Filamentous Assembly

(2013) Qi Qiao et al.   MOLECULAR CELL

MALT1 Small Molecule Inhibitors Specifically Suppress ABC-DLBCL In Vitro and In Vivo

(2012) Lorena Fontan et al.   CANCER CELL

Pharmacologic Inhibition of MALT1 Protease by Phenothiazines as a Therapeutic Approach for the Treatment of Aggressive ABC-DLBCL

(2012) Daniel Nagel et al.   CANCER CELL

Structural Determinants of MALT1 Protease Activity

(2012) Christian Wiesmann et al.   JOURNAL OF MOLECULAR BIOLOGY

Data processing and analysis with theautoPROCtoolbox

(2011) Clemens Vonrhein et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

From MALT lymphoma to the CBM signalosome

(2011) Shaun Rosebeck et al.   CELL CYCLE

NF-κB in immunobiology

(2011) Matthew S Hayden et al.   CELL RESEARCH

T-cell receptor-induced JNK activation requires proteolytic inactivation of CYLD by MALT1

(2011) Jens Staal et al.   EMBO JOURNAL

Malt1-dependent RelB cleavage promotes canonical NF- B activation in lymphocytes and lymphoma cell lines

(2011) S. Hailfinger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of the mucosa-associated lymphoid tissue lymphoma translocation 1 (MALT1) paracaspase region

(2011) J. W. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma

(2010) R. Eric Davis et al.   NATURE

Isotopic labeling of terminal amines in complex samples identifies protein N-termini and protease cleavage products

(2010) Oded Kleifeld et al.   NATURE BIOTECHNOLOGY

Inhibition of MALT1 protease activity is selectively toxic for activated B cell–like diffuse large B cell lymphoma cells

(2009) Uta Ferch et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A20 Negatively Regulates T Cell Receptor Signaling to NF- B by Cleaving Malt1 Ubiquitin Chains

(2009) M. Duwel et al.   JOURNAL OF IMMUNOLOGY

The Potent Protein Kinase C-Selective Inhibitor AEB071 (Sotrastaurin) Represents a New Class of Immunosuppressive Agents Affecting Early T-Cell Activation

(2009) J.-P. Evenou et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Essential role of MALT1 protease activity in activated B cell-like diffuse large B-cell lymphoma

(2009) S. Hailfinger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T cell antigen receptor stimulation induces MALT1 paracaspase–mediated cleavage of the NF-κB inhibitor A20

(2008) Beatrice Coornaert et al.   NATURE IMMUNOLOGY

The proteolytic activity of the paracaspase MALT1 is key in T cell activation

(2008) Fabien Rebeaud et al.   NATURE IMMUNOLOGY