Article
Chemistry, Analytical
Tuhina Banerjee, Nilamben Panchal, Carissa Sutton, Rebekah Elliott, Truptiben Patel, Kajal Kajal, Eniola Arogunyo, Neelima Koti, Santimukul Santra
Summary: Frequent outbreaks of food-borne pathogens, particularly E. coli O157:H7, have significant effects on human health and the agricultural economy. Current detection methods for E. coli O157:H7 are sensitive but time-consuming and require extensive sample processing. To address these limitations, a novel magneto-plasmonic nanosensor (MPnS) was developed by integrating surface plasmon resonance (SPR) properties with spin-spin magnetic relaxation (T2 MR) technology. The MPnS exhibited rapid and ultrasensitive detection of E. coli O157:H7 using SPR, T2 MR, and colorimetric readout, with no cross-reactivity. It holds great potential for the detection of other foodborne pathogens, offering a simple and timely approach.
Article
Chemistry, Multidisciplinary
F. Mousseau, C. Feraudet Tarisse, S. Simon, T. Gacoin, A. Alexandrou, C. I. Bouzigues
Summary: The use of lanthanide-doped nanoparticles as luminescent LFA probes offers higher sensitivity and measurement accuracy for detecting various biomolecules, including enterotoxins. Compared to gold nanoparticle-based LFAs, this method shows at least an order of magnitude improvement in analytical sensitivity and enables simultaneous quantitative detection of multiple biological toxins.
Review
Biochemical Research Methods
Yeonjeong Ha, Ijung Kim
Summary: During the ongoing COVID-19 pandemic, there is an urgent need for point-of-care (POC) detection methods with high sensitivity and rapid detection time. Magnetic nanoparticles (MNPs) are attractive materials that can enhance the sensitivity and reduce the detection time of conventional immunoassays. This review discusses recent advances in different types of MNPs-based immunoassays and their advantages and strategies. Furthermore, the use of MNPs for COVID-19 diagnosis through color development is also introduced, demonstrating their potential as common tools for on-site diagnosis.
Article
Physics, Applied
Hongjia Liu, Yanhong Li, Guoqiang Liu
Summary: Magneto-thermal-acoustic imaging is a novel medical imaging modality that utilizes the thermoacoustic effect of magnetic nanoparticles (MNPs). A new dual-modality imaging strategy was proposed by combining thermoacoustic (TA) and echo signals. By fusing the imaging results of TA and echo signals, a boundary distribution map of breast cancer model was obtained, accurately locating the tumor tissue.
JOURNAL OF PHYSICS D-APPLIED PHYSICS
(2023)
Article
Engineering, Biomedical
Pengfei Zhao, Yan Han, Holly Nguyen, Eva Corey, Xiaohu Gao
Summary: A simple yet effective cancer treatment method involves repurposing clinically approved magnetic nanoparticles and utilizing static parallel magnetic fields for intracellular nanoparticle self-assembly, leading to targeted cell death while preserving other cells and organs intact. This approach opens up a new avenue for cancer treatment by utilizing nanosciences and nanoparticle design principles accumulated over the past decades.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Arkadiusz Jozefczak, Katarzyna Kaczmarek, Rafal Bielas, Jitka Prochazkova, Ivo Safarik
Summary: Magneto-responsive textiles have recently gained importance in various fields, including biomedical engineering. Most research has focused on single magnetic fibers and physical characterization of magnetic textiles. In this study, we engineered materials with magnetic properties from simple woven and non-woven textiles, which can potentially be used as a smart magnetic platform for heating treatments. Experiments showed that the temperature increase in tissue-mimicking phantoms depended on factors such as the type of textile material, concentration of magnetic nanoparticles, and number of layers covering the phantom. The achieved temperature elevation with magnetic textiles is sufficient for potential applications in magnetic hyperthermia therapies and heating patches or bandages.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Xueshan Jing, Huawei Chen, Liwen Zhang, Song Zhao, Yan Wang, Zelinlan Wang, Yu Zhou
Summary: A novel magnetic micropillars array (MMA) is developed for multi-dimensional droplet manipulation, allowing precise control of droplets on an open surface. The behavior of droplets and the driving force acting on them are derived from the deformation of the micropillars. Different modes of horizontal transport, propelling and rolling, can achieve accurate and rapid droplet transportation. This technology shows great potential for accurate 3D droplet manipulation.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Acoustics
Bohua Zhang, Huaiyu Wu, Leela Goel, Howuk Kim, Chang Peng, Jinwook Kim, Paul A. Dayton, Yu Gao, Xiaoning Jiang
Summary: This study introduces a novel technique using rotational magnetic field oscillation and low-intensity submegahertz ultrasound stimulation of magnetic microbubbles to promote the phase transition of nanodroplets, enhancing the permeation of nanodroplets into the blood clot fibrin network for improved sonothombolysis efficiency. By combining NDs with MMBs, there is a significant enhancement in the in vitro lysis of both unretracted and retracted clots, showcasing an unprecedented lysis rate.
Article
Engineering, Electrical & Electronic
Xinchao Cui, Chong Lu, Chunping Liu, Wenzhong Liu
Summary: In this paper, a new concept of using magnetic nanoparticles as magneto-optical markers is proposed and a magneto-optical gate effect is explored. A high-sensitivity detection method for magnetic nanoparticles is developed based on this principle.
SENSORS AND ACTUATORS A-PHYSICAL
(2023)
Article
Engineering, Environmental
Fangbin Xiao, Weiqiang Li, Zhixing Wang, Qian Xu, Yang Song, Jin Huang, Xuekun Bai, Hengyi Xu
Summary: In this study, a novel magnetic platform with high enrichment efficiency for L. monocytogenes was developed. The platform was designed using branched polyglutamic acid-mediated indirect coupling of cefepime on magnetic nanoparticles. Low-abundance L. monocytogenes in real samples were specifically enriched using an external magnet, with a capture efficiency over 90%. A controllable and highly active platinum-palladium nanozyme was synthesized and introduced in the magnetic platform for the construction of an enzymatic colorimetric biosensor. The total detection time for L. monocytogenes was less than 100 min, with a limit of detection (LOD) of 3.1 x 101 CFU/mL and high reliability and accuracy (with a recovery rate ranging from 96.5% to 116.4%) in real sample tests. The concept of this method can be applied to various biosensing fields that rely on magnetic separation platforms.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Review
Biochemistry & Molecular Biology
Aleksey A. Nikitin, Anna Ivanova, Alevtina S. Semkina, Polina A. Lazareva, Maxim A. Abakumov
Summary: The magneto-mechanical approach is a powerful technique used in various biomedical applications. However, predicting its effects and translating research results to other experiments is challenging. This review provides a theoretical explanation, discusses the nature of mechanical forces, and showcases major applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Esther Cazares-Cortes, Claire Wilhelm, Jose Efrain Perez, Ana Espinosa, Sandra Casale, Aude Michel, Ali Abou-Hassan, Christine Menager
Summary: A novel synthesis method was introduced to enhance the load of magnetic nanoparticles and gold nanorods in nanogels. Two different structures, simple cores and core-shell, were synthesized and their heating properties under alternating magnetic field or laser exposure were compared. The core-shell structure exhibited a higher heating capacity in both modalities.
CHEMICAL COMMUNICATIONS
(2021)
Review
Chemistry, Analytical
Donato Calabria, Maria Maddalena Calabretta, Martina Zangheri, Elisa Marchegiani, Ilaria Trozzi, Massimo Guardigli, Elisa Michelini, Fabio Di Nardo, Laura Anfossi, Claudio Baggiani, Mara Mirasoli
Summary: Paper-based lateral-flow immunoassays have achieved commercial success and are continuously growing in the field of diagnostics. These assays, which provide qualitative information about the target analyte, have the potential to be adapted for ultrasensitive quantitative analysis.
Article
Engineering, Biomedical
Chenyang Yao, Fang Yang, Jiaji Zhang, Junlie Yao, Yi Cao, Hao Peng, Stefan G. Stanciu, Costas A. Charitidis, Aiguo Wu
Summary: Recent advancements in magneto-mechanical therapies have shown promising potential in enhancing or replacing conventional therapeutic strategies. This study focuses on deciphering the dependence between cell death pathways and the geometry of magnetic nanocomposites under a rotating magnetic field. The findings demonstrate that different geometries of magnetic nanocomposites result in distinct magneto-mechanical effects and cell death mechanisms, with magnetic nanospheres inducing apoptosis and magnetic nanochains leading to necrosis. This study enhances the current understanding of the relationship between magneto-mechanical therapeutic effects and cell death pathways, paving the way for improved biomedical tools and treatment approaches.
ACTA BIOMATERIALIA
(2023)
Review
Medicine, Research & Experimental
Kelsey P. Kubelick, Mohammad Mehrmohammadi
Summary: Superparamagnetic nanoparticles have become an important tool in biomedicine due to their controllable small size, biocompatibility, and magnetic properties. The magnetically-induced motion of these nanoparticles has been investigated as a new source of imaging contrast. Multiple imaging modalities can utilize magneto-motive contrast to monitor smaller scale biological events with enhanced contrast and sensitivity.
Article
Nanoscience & Nanotechnology
Daniela Rubanova, Svitlana Skoroplyas, Alena Libanska, Eva Randarova, Josef Bryja, Michaela Chorvatova, Tomas Etrych, Lukas Kubala
Summary: This study explored the use of nanocarriers to deliver dexamethasone for treating rheumatoid arthritis. The results showed that this method increased the accumulation of dexamethasone in the arthritic area, had a dose-dependent healing effect, and reduced the accumulation of the RA mediator RANKL. This study provides a feasible strategy for improving rheumatoid arthritis therapy.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2024)
Article
Nanoscience & Nanotechnology
Thanpisit Lomphithak, Apiwit Sae-Fung, Simone Sprio, Anna Tampieri, Siriporn Jitkaew, Bengt Fadeel
Summary: In this study, iron-doped hydroxyapatite (FeHA) was evaluated as a potential nanomedicine approach for treating PDAC. The results showed that FeHA, in combination with a sublethal dose of the GPX4 inhibitor RSL3, could trigger ferroptosis in KRAS mutant PANC-1 cells while sparing normal human cells. The induction of ferroptosis by FeHA plus RSL3 was found to be dependent on the metalloreductase STEAP3 in PDAC cells.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2024)
Review
Nanoscience & Nanotechnology
Marco Felipe Salas-Orozco, Ana Cecilia Lorenzo-Leal, Idania de Alba Montero, Nuria Patino Marin, Miguel Angel Casillas Santana, Horacio Bach
Summary: The emergence of antibiotic-resistant bacteria in severe infections is a growing concern, particularly in hospital environments. Metal-based nanomaterials have shown potential as an alternative to combat these bacteria, but there is a risk of bacterial resistance and environmental accumulation.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2024)
