期刊
BIOLOGICAL PSYCHIATRY
卷 78, 期 3, 页码 167-177出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.biopsych.2014.12.003
关键词
Amygdala; Anxiety; Bed nucleus of the stria terminalis; Fear; Pain; Parabrachial nucleus
资金
- National Alliance for Research on Schizophrenia and Depression
- University of Vermont College of Arts and Sciences
- Center of Biomedical Research Excellence in Neuroscience at the University of Vermont (National Institutes of Health National Center for Research Resources) [P20RR16435]
- [MH-97988]
- [MH-072088]
- [MH-096764]
- NATIONAL CENTER FOR RESEARCH RESOURCES [P20RR016435] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [P30GM103498] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF MENTAL HEALTH [F32MH072088, R01MH097988, R01MH096764, R21MH080935] Funding Source: NIH RePORTER
The maladaptive expression and function of several stress-associated hormones have been implicated in pathological stress and anxiety-related disorders. Among these, recent evidence has suggested that pituitary adenylate cyclase activating polypeptide ( PACAP) has critical roles in central neurocircuits mediating stress-related emotional behaviors. We describe the PACAPergic systems, the data implicating PACAP in stress biology, and how altered PACAP expression and signaling may result in psychopathologies. We include our work implicating PACAP signaling within the bed nucleus of the stria terminalis in mediating the consequences of stressor exposure and relatedly, describe more recent studies suggesting that PACAP in the central nucleus of the amygdala may impact the emotional aspects of chronic pain states. In aggregate, these results are consistent with data suggesting that PACAP dysregulation is associated with posttraumatic stress disorder in humans.
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