Review
Allergy
Andrew W. Liu, Jacob E. Gillis, Tina L. Sumpter, Daniel H. Kaplan
Summary: The skin is populated by various immune cells and sensory neurons, and the interaction between the nervous and immune systems plays a crucial role in inflammatory skin diseases. Neurotransmitters secreted by nerve terminals mediate immune cell function, while immune factors derived from immune cells interact with neurons to induce itching. This review explores the effector functions of neurons on skin immune cells in mouse models of atopic and contact dermatitis, and discusses the contribution of specific neuronal subsets and immune factors to itch induction and inflammation. The findings also shed light on treatment strategies and the relationship between scratching and dermatitis.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Lai-San Wong, Yu-Ta Yen, Chih-Hung Lee
Summary: Atopic dermatitis is a prototypic inflammatory disease characterized by intense itching, with multifactorial pathophysiology involving environmental factors, genetic susceptibility, skin barrier function, and immune responses. Recent research has shown that pruritogens not only trigger itch but also interact with immune cells and act as inflammatory mediators, worsening the severity of atopic dermatitis. Targeted therapies for atopic dermatitis focus on the interaction between pruritogens and inflammatory molecules.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Franz J. Legat
Summary: Atopic dermatitis is a common inflammatory skin disease affecting up to 20% of children and 10% of adults in higher income countries, with chronic pruritus as a major symptom causing significant impact on quality of life. New systemic and topical treatments targeting specific cytokines and receptors have ushered in a new era in atopic dermatitis and pruritus therapy.
FRONTIERS IN MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Yoshie Umehara, Chanisa Kiatsurayanon, Juan Valentin Trujillo-Paez, Panjit Chieosilapatham, Ge Peng, Hainan Yue, Hai Le Thanh Nguyen, Pu Song, Ko Okumura, Hideoki Ogawa, Francois Niyonsaba
Summary: Itch or pruritus is a hallmark of atopic dermatitis and is believed to be a signal of danger from various environmental factors or physiological abnormalities. While histamine is a well-known substance inducing itch, H-1-antihistamines may not be fully effective against intractable itch in patients with atopic dermatitis. Treatment of the underlying conditions that cause itch is necessary to improve the quality of life of patients with atopic dermatitis.
Review
Biochemistry & Molecular Biology
Wei-Yu Chen, Shao-Chuan Chen, Shou-Yi Hsu, Yu-An Lin, Chun-Ming Shih, Chun-Yao Huang, Kuo-Hsien Wang, Ai-Wei Lee
Summary: Skin diseases have a significant impact on individuals and society, and there is a need for high attention and effective treatment methods in the medical field.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Kjell Lussmann, Kerry Montgomery, Andrew Thompson, Uwe Gieler, Christoph Zick, Joerg Kupfer, Christina Schut
Summary: Itch intensity is positively correlated with itch catastrophizing, while mindfulness is negatively correlated with itch catastrophizing. Increasing acting with awareness may buffer itch catastrophizing and lead to lower itch intensity in patients with AD.
FRONTIERS IN MEDICINE
(2021)
Review
Allergy
Raj Chovatiya, Amy S. Paller
Summary: Atopic dermatitis (AD) is a chronic inflammatory skin disorder with limited treatment options. Recent studies have shown that both topical and systemic Janus kinase (JAK) inhibitors hold promise in treating AD, with further research needed to fully understand their efficacy and safety.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Niuniu Yang, Haifeng Shao, Jialin Deng, Yan Yang, Zongxiang Tang, Guanyi Wu, Yanqing Liu
Summary: Chronic itch is a prominent feature of atopic dermatitis (AD), and antihistamine treatment is often ineffective. This study focused on the MrgprA3-TRPA1 itch pathway and explored the potential of dictamnine, a component of Cortex Dictamni, in treating AD-induced chronic itch. The results showed that dictamnine effectively reduced itch, inflammation, and expression of MrgprA3 and TRPA1 in a mouse model of AD. It also inhibited the excitability of itch-sensing neurons. These findings suggest that dictamnine may have therapeutic potential for AD treatment.
BIOCHEMICAL PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Agnieszka Kaczmarska, Dominika Kwiatkowska, Katarzyna Konstancja Skrzypek, Zbigniew Tadeusz Kowalewski, Kamila Jaworecka, Adam Reich
Summary: Pruritus, an unpleasant sensation that elicits a desire to scratch, is widely observed in various inflammatory skin diseases. The pathogenesis of pruritus in conditions like atopic dermatitis and psoriasis involves complex interactions between biochemical mediators, enzymes, and pathways. Although the exact mechanisms remain elusive, considerable progress has been made in recent years.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Szergej Capec, Martin Petrek, Gabriella Capec, Roman Yaremkevych, Yuriy Andrashko
Summary: Chronic itch is a complex psychophysiological sensation that significantly affects the quality of life in patients with atopic dermatitis and psoriasis. Patients with chronic itch often experience sleep disorders, irritability, and nervous system depletion, leading to disruptions in social relationships and mental health. Psychological interventions can positively impact the mechanisms of itch and scratching and improve social functioning. Among these interventions, family constellation seminars have been found to be effective in reducing itch intensity, improving sleep, and performance.
FRONTIERS IN MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Ya-Chu Tsai, Tsen-Fang Tsai
Summary: Psoriasis and atopic dermatitis are now considered to be a spectrum of disease, with overlapping genetic loci and immunopathogenesis. The clinical presentations also have similarities.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Letter
Engineering, Environmental
Jordan Zeldin, Tan T. Tran, Manoj Yadav, Prem Prashant Chaudhary, Brandon N. D'Souza, Grace Ratley, Sundar Ganesan, Ian A. Myles
Summary: Compared to rhinitis and asthma, environmental exposure research for atopic dermatitis (AD) is not well established. An analysis of U.S. EPA databases revealed that isocyanates are strongly associated with AD. Further research identified antimony compounds as another top associated pollutant in regions with low levels of diisocyanate pollution. These findings suggest a causal relationship between compounds associated with AD, inhibition of commensal lipid production, and activation of TRPA1.
ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS
(2023)
Article
Food Science & Technology
Pamela Gallegos-Alcala, Mariela Jimenez, Daniel Cervantes-Garcia, Laura Elena Cordova-Davalos, Irma Gonzalez-Curiel, Eva Salinas
Summary: In this study, it was found that glycomacropeptide (GMP) has anti-inflammatory and antioxidative properties on HaCaT keratinocytes in an in vitro model of atopic dermatitis. Furthermore, GMP stimulated cell proliferation and migration, suggesting its potential therapeutic use in wound healing.
Review
Medicine, General & Internal
Catharina Sagita Moniaga, Mitsutoshi Tominaga, Kenji Takamori
Summary: Recent evidence on type 2 inflammation-associated itch in atopic dermatitis has been reported, highlighting the importance of neuroimmune interactions in research. Understanding bidirectional neuroimmune interactions is crucial in gaining insights into the pathogenesis of itch and its treatment. Improved management and treatment options for itch in atopic dermatitis are being explored through novel and targeted biologic agents in advanced clinical trials.
Review
Cell Biology
Robert Ramer, Burkhard Hinz
Summary: The endocannabinoid system plays a role in various skin functions and has potential therapeutic applications in the treatment of skin diseases, including inflammatory, fibrotic, and pruritic conditions.
Letter
Dermatology
Imre L. Szabo, Erika Lisztes, Gabriella Beke, Kinga Fanni Toth, Ralf Paus, Attila Olah, Tamas Biro
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2020)
Article
Dermatology
Arnold Markovics, Agnes Angyal, Kinga Fanni Toth, Dorottya Adam, Zsofia Penzes, Jozsef Magi, Agnes Por, Ilona Kovacs, Daniel Torocsik, Christos C. Zouboulis, Tamas Biro, Attila Olah
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2020)
Article
Pharmacology & Pharmacy
Balazs Kelemen, Erika Lisztes, Anita Vladar, Martin Hanyicska, Janos Almassy, Attila Olah, Attila Gabor Szollosi, Zsofia Penzes, Janos Posta, Thomas Voets, Tamas Biro, Balazs Istvan Toth
BIOCHEMICAL PHARMACOLOGY
(2020)
Article
Dermatology
Attila Olah, Majid Alam, Jeremy Cheret, Nikolett Greta Kis, Zoltan Hegyi, Attila Gabor Szollosi, Silvia Vidali, Tamas Biro, Ralf Paus
EXPERIMENTAL DERMATOLOGY
(2020)
Article
Pharmacology & Pharmacy
Balazs Kelemen, Silvia Pinto, Nawoo Kim, Erika Lisztes, Martin Hanyicska, Anita Vladar, Attila Olah, Zsofia Penzes, Brian Shu, Joris Vriens, Tamas Biro, Tibor Rohacs, Thomas Voets, Balazs Istvan Toth
Summary: TRPM3 selectively mediates pain sensation but not itch sensation, making it a promising candidate for selectively targeting pain sensation.
BIOCHEMICAL PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Dora Kovacs, Fruzsina Fazekas, Attila Olah, Daniel Torocsik
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Agnes Angyal, Zsofia Penzes, Shahrzad Alimohammadi, Dorottya Horvath, Lili Takacs, Gyorgy Vereb, Barbara Zsebik, Tamas Biro, Kinga Fanni Toth, Erika Lisztes, Balazs Istvan Toth, Attila Olah, Attila Gabor Szollosi
Summary: The study found that human corneal epithelial cells express members of the endocannabinoid system, playing a role in inflammatory responses. Despite previous reports on the anti-inflammatory potential of endocannabinoids, their effects on the immune phenotype of human corneal epithelium may be more complex and context dependent.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Dorottya Adam, Jozsef Arany, Kinga Fanni Toth, Balazs Istvan Toth, Attila Gabor Szollosi, Attila Olah
Summary: Atopic dermatitis is a common skin disease, especially prevalent among children. Although there have been advancements in understanding its pathogenesis, curative treatments are still lacking. Therefore, it is important to further investigate the mechanisms and explore new therapeutic approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Attila Gabor Szollosi, Attila Olah, Erika Lisztes, Zoltan Griger, Balazs Istvan Toth
Summary: Pruritus, or itch, is a common symptom associated with various skin and immune disorders. Despite significant progress in understanding the molecular mechanisms behind acute and chronic itch, there are still gaps in our knowledge, making the clinical management of pruritic conditions challenging. Recent research has highlighted the interactions between pruriceptive sensory neurons and different cutaneous cell types, particularly in inflammatory conditions, where these cells release mediators that excite the itch-sensing fibers. There is also bidirectional communication, with sensory neurons releasing mediators that maintain an inflamed and itchy tissue environment.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Dermatology
Shahrzad Alimohammadi, Zsofia Penzes, Dorottya Horvath, Agnes Gyetvai, Attila Bacsi, Nikoletta Greta Kis, Akos Nemeth, Jozsef Arany, Attila Olah, Erika Lisztes, Balazs Istvan Toth, Tamas Biro, Attila Gabor Szollosi
Summary: This study compared the transcriptome of monocyte-derived Langerhans cells (moLCs) with that of immature dendritic cells using RNA sequencing. The results showed that moLCs express genes characteristic of LC2 cells and TRPV4. Activation of TRPV4 increased the expression of Langerin and intracellular calcium concentration in moLCs. Furthermore, TRPV4 activation mitigated the inflammatory responses of moLCs by decreasing cytokine production and T-cell activating capability.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)