Article
Biotechnology & Applied Microbiology
Seungman Park, Anna L. Chien, Isabelle D. Brown, Jingchun Chen
Summary: The mechanical properties of melanoma tissue, including increased elasticity and decreased viscosity, were found to be significantly different from normal tissue. The thickness of the tissue was also found to have a significant impact on the viscoelastic properties. These findings provide important insights into the role of melanoma cell mechanics in the disease state and progression.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Polymer Science
Barbara Adrover-Monserrat, Silvia Garcia-Vilana, David Sanchez-Molina, Jordi Lluma, Ramon Jerez-Mesa, J. Antonio Travieso-Rodriguez
Summary: This study aims to characterize the viscoelastic behavior of PEBA and provide reference values for constitutive model parameters for mechanical behavior simulation. The results show that a Quasi-Linear Visco-Elastic (QLVE) model accurately predicts the relaxation test results and fits well with the measurements of fast cyclic loading tests.
Article
Materials Science, Multidisciplinary
A. R. Dusane, P. Lenarda, M. Paggi
Summary: This study experimentally characterizes and computationally models the viscoelastic response of commercially available backsheet materials, proposing small-strain viscoelastic models based on Prony-series and Fractional Calculus. The models are validated with experimental data and show good predictability, aiding in the design and simulation of a more comprehensive digital-twin model of PV modules.
MECHANICS OF MATERIALS
(2023)
Article
Materials Science, Textiles
M. Arulmurugan, K. Prabu, G. Rajamurugan, A. S. Selvakumar
Summary: This paper investigates the mechanical properties of aloe/hemp/flax natural fiber sandwich laminate composites with the addition of barium sulfate filler. It was found that the addition of barium sulfate improved the flexural strength but reduced the tensile strength of the composites. Additionally, the dynamic mechanical analysis showed changes in storage modulus and loss modulus with the addition of barium sulfate filler.
JOURNAL OF INDUSTRIAL TEXTILES
(2021)
Article
Chemistry, Multidisciplinary
Kalipada Koner, Susobhan Das, Shibani Mohata, Nghia Tuan Duong, Yusuke Nishiyama, Sharath Kandambeth, Suvendu Karak, C. Malla Reddy, Rahul Banerjee
Summary: Covalent organic nanotubes (CONTs) are one-dimensional porous frameworks constructed via dynamic covalent chemistry. Flexible and robust self-standing fabric has been successfully constructed using selected building blocks. The fabric has been characterized and its formation mechanism has been established. The synthesized fabric exhibits high mechanical strength and time-dependent elastic recovery.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Amirhossein Emamian, Farzaneh Aghajani, Farzaneh Safshekan, Mohammad Tafazzoli-Shadpour
Summary: This study aimed to describe the viscoelastic behavior of human dentin and determine the best-fitting viscoelastic model. Despite a nearly linear trend at small strains, there was some degree of nonlinearity in dentine viscoelasticity. The modified superposition formulation was found to best capture the viscoelastic behavior of human dentin.
Article
Engineering, Multidisciplinary
Md Niamul Islam, Konstantinos P. Baxevanakis, Vadim V. Silberschmidt
Summary: This study investigates the viscoelastic performance of additively manufactured (AM) nylon and nylon-matrix composites reinforced with different fibre orientations. The results showed that the addition of fibres increased the storage modulus of most composites, but also led to increased porosity and poor fibre-matrix bonding. The fibre orientation and other factors affected the loss modulus of the composite structures. The quantified parameters can be used in numerical simulations to support the design and optimization of AM components.
COMPOSITES PART B-ENGINEERING
(2023)
Article
Pharmacology & Pharmacy
Shubhajit Paul, Chenguang Wang, Changquan Calvin Sun
Summary: This study demonstrates a method for determining the hardness of powders that cannot form intact tablets. By using a mixing rule and a power law based on weight fraction, the hardness at zero porosity of a given powder can be predicted. This method is suitable for various binary mixtures and can capture changes in hardness caused by particle size differences.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Construction & Building Technology
Xavier Centelles, Fernandez Pelayo, Maria Jesus Lamela-Rey, A. Ines Fernandez, Rebeca Salgado-Pizarro, J. Ramon Castro, Luisa F. Cabeza
Summary: This study evaluated seven different commercial interlayer materials through relaxation tests to determine their viscoelastic behavior, and provided the Prony coefficients and components of the complex modulus needed for creating numerical models.
CONSTRUCTION AND BUILDING MATERIALS
(2021)
Article
Biotechnology & Applied Microbiology
Manuel P. Kainz, Alexander Greiner, Jan Hinrichsen, Dagmar Kolb, Ester Comellas, Paul Steinmann, Silvia Budday, Michele Terzano, Gerhard A. Holzapfel
Summary: A novel nonlinear poro-viscoelastic computational model based on the Theory of Porous Media was proposed to describe the mechanical response of brain tissue. Indentation experiments were conducted on a tailor-made hydrogel mimicking brain tissue, and an inverse parameter identification scheme was used to extract the optimal constitutive model parameters. The model was validated through finite element simulations.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Huixin Wei, Xuliang Liu, Linan Li, Chuanwei Li, Wenjian Chen, Shibin Wang, Zhiyong Wang, Jianxiong Ma
Summary: This study developed a hybrid experimental-numerical method to characterize the mechanical properties of human skin, including the dermis and subcutaneous tissue. Through an indentation experiment and finite element analysis, the three-dimensional mechanical properties of in vivo skin were successfully determined, demonstrating the effectiveness of this method.
MECHANICS OF MATERIALS
(2021)
Article
Engineering, Electrical & Electronic
B. Alekya, V. S. N. Sitaramgupta V., B. S. Arjun, Hardik J. Pandya
Summary: This article discusses the fabrication and characterization of a small silicon diaphragm-based force sensor used for measuring tissue stiffness. The sensor has been validated for mechanical characterization of soft tissues and used to measure the stiffness of cartilage and smooth muscle tissues in different anatomical regions.
IEEE SENSORS JOURNAL
(2022)
Article
Geochemistry & Geophysics
Jianfeng Wang, Yuke Liu, Chao Yang, Wenmin Jiang, Yun Li, Yongqiang Xiong
Summary: The viscoelastic behavior of quartz and clay minerals in shale was studied using nanoindentation and optical microscope techniques. The results showed that residual imprints on clay minerals were larger and had higher initial creep rates and depths compared to quartz. However, the creep rates displayed similar trends for both minerals, independent of peak load. Three viscoelastic models were used to fit the experimental data, with Burger's model performing the best in obtaining regression parameters. The regression results indicated that the viscoelastic parameters are associated with peak load, and clay minerals had lower viscoelastic parameters compared to quartz and the bulk shale.
Article
Engineering, Civil
Jianlong Zhang, Chunguo Zhang, Shengyong Mu, Shuai Wang, Hongchang Li
Summary: In this study, a method combining continuous indentation test and numerical simulation was established to accurately acquire the mechanical properties of nickel-based alloy 600 before and after creep. The high stress creep constitutive equation of alloy 600 in autoclave environment was obtained, and the influencing factors of mechanical properties were analyzed. The results showed that the mechanical properties of nickel-based alloy 600 increased with the increase of creep time, and the indentation test model verified by numerical simulation provided a nondestructive way to obtain the mechanical property parameters.
Article
Materials Science, Textiles
Ruihua Yang, Aiting Hu, Xin Zhang, Shuai Liu, Jiaqi Gao, Zelin Lv, Hua Zhang
Summary: A viscoelastic model was developed to predict the tensile stress-strain relationship of a core/wrapped composite yarn with double filaments. The tensile properties of the yarn were tested and analyzed. A five-element nonlinear viscoelastic model was established based on the tensile fracture characteristics. The model was used to simulate and calculate the tensile properties of the composite yarns with high accuracy.
TEXTILE RESEARCH JOURNAL
(2023)
Review
Geriatrics & Gerontology
Seungman Park
Summary: Skin, as the largest organ of the human body, undergoes significant changes in its biochemical, structural, and physical properties during the aging process. This review provides an overview of these changes and explores the relationship among these properties. Furthermore, potential mechanisms are discussed based on previous findings.
Article
Chemistry, Multidisciplinary
Gayatri J. Pahapale, Jiaxiang Tao, Milos Nikolic, Sammy Gao, Giuliano Scarcelli, Sean X. Sun, Lewis H. Romer, David H. Gracias
Summary: Precise spatial organization of multicellular structures plays a vital role in biological processes. This study uncovers a new mode of self-organization of endothelial cells guided by the combined effects of stiffness and geometry, independent of protein or chemical patterning.
Article
Engineering, Biomedical
Seungman Park, Byunggik Kim
Summary: This study reveals that aging results in significant changes in the mechanical quantities and transport properties of the extracellular matrix (ECM). The hydraulic conductivity tends to decrease while the pressure loss and drag force increase in aging ECM-mimetic fibrous networks. These findings can serve as important biological cues for evaluating the aging process and potentially offer insights into treating age-related diseases.
MEDICAL ENGINEERING & PHYSICS
(2022)
Article
Physics, Multidisciplinary
Matthew Pittman, Ernest Iu, Keva Li, Mingjiu Wang, Junjie Chen, Nilay Taneja, Myung Hyun Jo, Seungman Park, Wei-Hung Jung, Le Liang, Ishan Barman, Taekjip Ha, Stavros Gaitanaros, Jian Liu, Dylan Burnette, Sergey Plotnikov, Yun Chen
Summary: Cell behaviour is influenced by the physical forces and mechanical properties of both cells and their microenvironment. This study explores the effect of viscosity, an important component of the cellular microenvironment, on cell behaviour. The results show that cells respond in a similar manner to elevated viscosity, with increased spread area, focal adhesion formation and turnover, traction forces, and migration speed. Cells utilize membrane ruffling to sense changes in extracellular fluid viscosity and trigger adaptive responses.
Article
Chemistry, Multidisciplinary
Alexandros Afthinos, Kaustav Bera, Junjie Chen, Altug Ozcelikkale, Alice Amitrano, Mohammad Ikbal Choudhury, Randy Huang, Pavlos Pachidis, Panagiotis Mistriotis, Yun Chen, Konstantinos Konstantopoulos
Summary: In this study, we developed polyacrylamide-based microchannels with physiological stiffness and prescribed dimensions for high-throughput analysis of cell migration. We found a biphasic dependence of cell speed on confinement and stiffness. By utilizing novel four-walled microchannels, we revealed the distinct contributions of apicolateral and basal microchannel wall stiffness to confined and unconfined migration. We also innovated three-dimensional traction force measurements around spatially confining cells at subcellular resolution by tracking nanobeads embedded within the channel walls.
Article
Oncology
Peng Huang, Peter B. Illei, Wilbur Franklin, Pei-Hsun Wu, Patrick M. Forde, Saeed Ashrafinia, Chen Hu, Hamza Khan, Harshna V. Vadvala, Ie-Ming Shih, Richard J. Battafarano, Michael A. Jacobs, Xiangrong Kong, Justine Lewis, Rongkai Yan, Yun Chen, Franck Housseau, Arman Rahmim, Elliot K. Fishman, David S. Ettinger, Kenneth J. Pienta, Denis Wirtz, Malcolm Brock, Stephen Lam, Edward Gabrielson
Summary: There have been few significant advances in predicting lung cancer progression risk after surgical removal of tumor in stage IA non-small-cell lung cancers (NSCLCs). This study developed an integrated deep learning evaluation (IDLE) score that combines preoperative lung CT image findings and postoperative pathologic assessment, which was found to better predict cancer progression risk compared to traditional TNM staging and tumor grade. The improved predictive value of the IDLE score was due to the use of tumor measurements in CT images and microscopic tissue characteristics. integrating measurements from different aspects of tumor morphology can increase prediction accuracy.
Review
Cell Biology
Jennifer Flournoy, Shahad Ashkanani, Yun Chen
Summary: Biophysical and biochemical cues cooperate to regulate angiogenesis, guiding its process during development, wound healing, and tumor progression. The mechanical microenvironment, including stiffness, ligand availability, and topography, plays a crucial role in modulating angiogenesis-related signaling pathways. Additionally, mechanical perturbations such as stretching and fluid shearing can acutely alter angiogenesis-related signal transduction, leading to gene expression changes. Tissue engineering-based approaches are also discussed for studying angiogenesis, along with proposed future directions.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Matthew Pittman, Abdulla M. Ali, Yun Chen
Summary: In this study, we review the progress made in imaging probes for three important physical parameters: viscosity, membrane tension, and temperature. These parameters play crucial roles in various cellular processes, and understanding their dynamics is crucial. We discuss the techniques used to measure these parameters at subcellular resolution and explore the future applications of recently developed techniques.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Seungman Park, Anna L. Chien, Beiyu Lin, Keva Li
Summary: In this study, a new method called FACES was developed to identify and classify rosacea more efficiently using artificial intelligence. The results showed that the performance of FACES was superior to individual CNN models and the majority rule method in terms of accuracy, sensitivity, specificity, and precision.
APPLIED SCIENCES-BASEL
(2023)
Article
Biophysics
Junjie Chen, Daniel Yan, Yun Chen
Summary: Cell migration is a complex process, with different cells and even the same cell capable of changing their migration mode. The mystery of cell migration plasticity, particularly the relationship between force generation and migration mode transition, is still actively investigated. This article explores the future directions in measurement platforms and imaging-based techniques to elucidate this relationship. By reviewing the evolution of past platforms and techniques, the article proposes desirable features for achieving accurate measurements and improved temporal and spatial resolution in order to unveil the mystery of cell migration plasticity.
BIOPHYSICAL JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Le Liang, Peng Zheng, Sisi Jia, Krishanu Ray, Yun Chen, Ishan Barman
Summary: Researchers have successfully developed a novel hybrid free-standing plasmonic nanodiamond using DNA self-assembly, which demonstrates significantly enhanced brightness and emission rate. The nanodiamonds hold great potential as stable solid-state single-photon sources and versatile platforms for studying nontrivial quantum effects in biological systems.
Article
Biochemistry & Molecular Biology
Frederick R. Adler, Alexander R. A. Anderson, Abhinav Bhushan, Paul Bogdan, Jose Javier Bravo-Cordero, Amy Brock, Yun Chen, Edna Cukierman, Kathleen E. DelGiorno, Gerald V. Denis, Meghan C. Ferrall-Fairbanks, Zev Jordan Gartner, Ronald N. Germain, Deborah M. Gordon, Ginger Hunter, Mohit Kumar Jolly, Loukia Georgiou Karacosta, Karthikeyan Mythreye, Parag Katira, Rajan P. Kulkarni, Matthew L. Kutys, Arthur D. Lander, Ashley M. Laughney, Herbert Levine, Emil Lou, Pedro R. Lowenstein, Kristyn S. Masters, Dana Pe'er, Shelly R. Peyton, Manu O. Platt, Jeremy E. Purvis, Gerald Quon, Jennifer K. Richer, Nicole C. Riddle, Analiz Rodriguez, Joshua C. Snyder, Gregory Lee Szeto, Claire J. Tomlin, Itai Yanai, Ioannis K. Zervantonakis, Hannah Dueck
Summary: Collective cell behavior plays a crucial role in all stages of cancer progression. Exploring how this behavior emerges through cell-cell interactions and decision-making is essential for advancing our knowledge of cancer biology and developing new therapeutic approaches. This article summarizes an interdisciplinary discussion on multicellular behavior in cancer, highlights insights from other scientific disciplines, and identifies future research directions.
Article
Biotechnology & Applied Microbiology
Seungman Park, Anna L. Chien, Isabelle D. Brown, Jingchun Chen
Summary: The mechanical properties of melanoma tissue, including increased elasticity and decreased viscosity, were found to be significantly different from normal tissue. The thickness of the tissue was also found to have a significant impact on the viscoelastic properties. These findings provide important insights into the role of melanoma cell mechanics in the disease state and progression.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Kurmanbek Kaiyrbekov, Kirsten Endresen, Kyle Sullivan, Zhaofei Zheng, Yun Chen, Francesca Serra, Brian A. Camley
Summary: Collective movement and organization of cell monolayers are crucial for wound healing and tissue development. Recent experiments have emphasized the significance of liquid crystal order in these layers, suggesting that +1 topological defects play a role in organizing tissue morphogenesis. In our study, we investigate fibroblast organization, motion, and proliferation on a substrate with micron-sized ridges that induce +1 and -1 topological defects using simulation and experiment. Our findings indicate that density variation near defects cannot be explained by collective migration, instead suggesting that fibroblasts have different division rates depending on their area and aspect ratio. This work provides insights into tissue patterning using topological defects without relying on cell migration.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
