Article
Plant Sciences
Noga Sikron-Persi, Gila Granot, Albert Batushansky, David Toubiana, Gideon Grafi, Aaron Fait
Summary: A study on the petioles of perennial desert shrub Zygophyllum dumosum Boiss revealed a consistent seasonal pattern in petiole metabolism, involving organic acids, polyols, phenylpropanoids, sulfate conjugates, and piperazines. The metabolic changes were primarily related to the plant's development stage and its interaction with the environment, rather than specific environmental conditions.
Article
Agriculture, Multidisciplinary
Jing Sun, Haoan Zhao, Fanhua Wu, Min Zhu, Ying Zhang, Ni Cheng, Xiaofeng Xue, Liming Wu, Wei Cao
Summary: This study analyzed the different metabolites of honey samples at different stages using a metabolomics approach, revealing a distinct metabolic profile in mature honey compared to immature honey. Specific fatty acids, such as decenedioic acid, were identified as potential markers for discriminating between immature and mature honey. Additionally, mature honey showed higher concentrations of fatty acids, particularly three fatty acids that were significantly richer in mature honey compared to immature honey.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Chemistry, Applied
Zhihua Geng, Jun Wang, Lichun Zhu, Xianlong Yu, Qian Zhang, Mengqing Li, Bin Hu, Xuhai Yang
Summary: This study used ultra-performance liquid chromatography and metabolomics to analyze the effects of hot air drying and infrared drying on flavonoid compounds and antioxidant capacity in sea buckthorn berries. The results showed that isorhamnetin and quercetin contents increased in response to drying, while (-)-epigallocatechin and (-)-gallocatechin contents decreased. The metabolism of flavonoid compounds mainly occurred in flavonoid biosynthesis and secondary metabolite biosynthesis pathways. This study elucidated the effect of drying on nutritional components of sea buckthorn berries and may guide the improvement of quality during food processing.
Article
Plant Sciences
Sang Suk Kim, Hyun-Jin Kim, Kyung Jin Park, Seok Beom Kang, YoSup Park, Seong-Gab Han, Misun Kim, Yeong Hun Song, Dong-Shin Kim
Summary: This study analyzed the changes in chemical composition during the fruit development process of Citrus unshiu, revealing the trends in total phenolic content, total carotenoid content, antioxidant activity, and metabolite profiles at different stages, providing important information for understanding these changes.
Article
Plant Sciences
Omar M. Khattab, Dina M. El-Kersh, Shaden A. M. Khalifa, Nermeen Yosri, Hesham R. El-Seedi, Mohamed A. Farag
Summary: Urginea maritima L. (squill) species, consisting of two main varieties (white squill and red squill), have various health potentials. Squill contains cardiac glycosides, flavonoids, and anthocyanins as major secondary metabolite classes. Metabolomics approaches including MS, NMR, and chromatography were used for varieties classification and revealed different metabolite profiles between white squill and red squill.
Article
Plant Sciences
Jianhua Chen, Shan Ning, Xuan Lu, Wei Xiang, Xiao Zhou, Yuanyuan Bu, Liangbo Li, Rongshao Huang
Summary: Pyrrosia petiolosa has both medicinal and health benefits in China, and its potential antioxidant activities have attracted attention. This study used a metabolomics approach to determine flavonoid concentrations and evaluate antioxidant activities of P. petiolosa from different geographic origins. 97 flavonoid components were identified, and their concentrations varied significantly among different locations. The antioxidant capacities were positively correlated with some flavonoid markers, and they were influenced by factors like altitude and longitude. P. petiolosa is a promising source of natural antioxidants.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Food Science & Technology
Lei He, Qian Hu, Jiukai Zhang, Ranran Xing, Yongsheng Zhao, Ning Yu, Ying Chen
Summary: This study comprehensively investigated the metabolite variability of black soybeans from different geographical origins in China. The results showed that black soybeans from Gansu had higher amounts of procyanidins, epicatechin, malonylated isoflavones, and beta-pinene. Guangxi black soybeans had higher amounts of linoleic acid and its oxidation products, while Xinjiang and Yunnan black soybeans contained higher levels of delphinidin-derived anthocyanins, gamma-glutamyl peptides, and aromatic hydrocarbons. The study also identified characteristic metabolites in black soybeans from other geographical origins.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Agriculture, Multidisciplinary
Yuqi Fan, Xiunan Cao, Mengmeng Zhang, Shujie Wei, Yameng Zhu, Huizi Ouyang, Jun He
Summary: This study comprehensively investigates the chemical constituents of Perilla frutescens and identifies potential markers for discriminating between different medicinal parts, varieties, and harvest periods. The results provide a theoretical basis and guidance for the quality evaluation and optimization of the harvest period of this plant.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Food Science & Technology
Rajender Kumar, Dinesh Kumar
Summary: Allium is widely consumed as a spice around the world. This study compared the metabolome and antioxidant activity of different tissues of Allium cepa, A. sativum, and A. semenovii. The results showed that A. cepa and A. semenovii had higher antioxidant activity and polyphenol content compared to A. sativum. Additionally, various metabolites including polyphenols and sulfur containing compounds were identified. This study highlights the potential of A. semenovii for utilization in food and nutraceuticals.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Pharmacology & Pharmacy
Qiong Chen, Ting Zhou, Jun-jie Yuan, Xiao-yi Xiong, Xue-hui Liu, Zong-ming Qiu, Lin-lin Hu, Hui Lu, Qian He, Chang Liu, Qing-wu Yang
Summary: This study investigated the metabolic alterations during ischemia-reperfusion injury using metabolomic analysis. A total of 82 differentially expressed metabolites were identified, with some significantly elevated in the reperfusion group. Metabolomics pathway analysis revealed the importance of glycerophospholipid metabolism, linoleic acid metabolism, pyrimidine metabolism, and galactose metabolism in the response to cerebral ischemia-reperfusion. This study provides important insights into the metabolic changes induced by cerebral ischemia-reperfusion.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Yiyuan Zhang, Yang Feng, Fang Chen, Jiang Yu, Xiehong Liu, Yanjuan Liu, Jielin Ouyang, Mingyu Liang, Yiming Zhu, Lianhong Zou
Summary: Cardiac arrest is a severe global health problem, and therapeutic hypothermia is widely used to mitigate the cardiac injury. The study investigated the serum metabolic characteristics after cardiac arrest using advanced metabolomics techniques. The results showed that therapeutic hypothermia improved survival and neurological outcomes in rabbits, with significant changes in metabolic profiles compared to the control group.
Article
Chemistry, Applied
Fitra Tunnisa, Didah Nur Faridah, Ani Afriyanti, Dian Rosalina, Mohamad Ana Syabana, Noviyan Darmawan, Nancy Dewi Yuliana
Summary: This study aimed to identify compounds in minor Zingiberaceae spices grown in Indonesia that are linked with antioxidant and alpha-glucosidase inhibitor activities. The results showed that Zingiber aromaticum Val., Alpinia malaccensis (Burm.f.) Roscoe, Amomum compactum Sol. ex Maton, and Zingiber purpureum Roscoe exhibited the highest antioxidant and alpha-glucosidase inhibitor activities. Furthermore, the total phenolic content positively influenced the antioxidant activities.
Article
Environmental Sciences
Zhehan Yang, Bohan Xue, Guilong Song, Shengqing Shi
Summary: Exogenous citric acid application enhances cadmium (Cd) tolerance of Dahurian wildrye grass by increasing antioxidant capacity, reducing reactive oxygen, and promoting root Cd accumulation. CA also alters metabolic pathways, increasing the content of resistant substances and promoting amino acid metabolism. These changes contribute to the enhancement of Cd resistance in Dahurian wildrye grass.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Chemistry, Applied
Ajay Anand, Anusha Komati, Kumar Katragunta, Hussain Shaik, Narendra Kumar Nagendla, Madhusudana Kuncha, Mohana Krishna Reddy Mudiam, Katragadda Suresh Babu, Ashok Kumar Tiwari
Summary: Boiled rhizome of Nymphaea nouchali shows significant antihyperglycemic and antioxidative stress potentials, making it a promising food material for managing hyperglycemia and oxidative stress.
Article
Green & Sustainable Science & Technology
Nurul Atiqah Izzati Md Ishak, Siti Kartom Kamarudin, Sharifah Najiha Timmiati, Suhaila Mohd Sauid, Nabila A. Karim, Sahriah Basri
Summary: A novel and eco-friendly method was used to synthesize biogenic platinum nanoparticles (Pt NPs) using sugar cane bagasse extract as the reducing agent. The Pt NPs were characterized using various techniques and the metabolites involved in the biosynthesis process were identified. The biogenic Pt NPs showed high antioxidant properties and superior electrocatalytic activity.
JOURNAL OF CLEANER PRODUCTION
(2023)
Article
Biochemical Research Methods
Mona M. Okba, Rania A. El Gedaily, Rehab M. Ashour
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2017)
Article
Biochemical Research Methods
Rehab M. S. Ashour, Mona M. Okba, Esther T. Menze, Rania A. El Gedaily
JOURNAL OF CHROMATOGRAPHIC SCIENCE
(2019)
Article
Biochemistry & Molecular Biology
Seham S. El-Hawary, Rana Ahmed El-Fitiany, Ola Mohamed Mousa, Abeer A. A. Salama, Rania A. El Gedaily
Summary: This study found that Malpighia glabra Linn. leaves are rich in secondary metabolites and exhibit significant hepatoprotective potential, especially at higher doses. This suggests that the leaves may have the same importance as the fruits and could be used in pharmaceuticals and foods.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Manal M. Sabry, Ahlam M. El-Fishawy, Ahmed A. El-Rashedy, Rania A. El Gedaily
Summary: The stem bark of Cordia africana Lam. showed antibacterial activity against MRSA and H. pylori. The compound methyl rosmarinate showed the best antibacterial activity and has the potential to target both MRSA and H. pylori enzymes, providing a pathway for antibacterial treatment.
Article
Plant Sciences
Haidy A. Abbas, Ahmed M. Salama, Sayed A. El-Toumy, Abeer A. A. Salama, Soad H. Tadros, Rania A. El Gedaily
Summary: This study explored the metabolome of Bunchosia armeniaca leaves and investigated their neuroprotective effect in an Alzheimer's disease model. The extracts from the leaves showed improved behavioral activity, reduced inflammation and oxidative stress, and protected against neuronal damage. Additionally, the leaves exhibited strong antioxidant and acetylcholinesterase inhibitory activity in vitro.
Article
Multidisciplinary Sciences
Dalia E. Ali, Rania A. El Gedaily, Shahira M. Ezzat, Maged A. El Sawy, Meselhy R. Meselhy, Essam Abdel-Sattar
Summary: Plant resins from Eucalyptus trees contain bioactive compounds with high medicinal values. This study investigated the chemistry and anti-inflammatory activity of these resins and found that 1,6-dicinnamoyl-O-alpha-D-glucopyranoside (C5) showed significant inhibition against COX-2, TNF-alpha, NF-kappa B, and NO.
SCIENTIFIC REPORTS
(2023)
Review
Chemistry, Multidisciplinary
Haidy A. Abbas, Soad H. Tadros, Sayed A. El-Toumy, Ahmed M. Salama, Rania A. El Gedaily
Summary: Herbal medicine is gaining popularity, leading to efforts to document valuable phyto-constituents and pharmacological knowledge. Malpighiaceae, a plant family rich in secondary metabolites, has potential therapeutic effects. This review provides an overview of the chemistry and biological impact of Malpighiaceae plants in recent years.
EGYPTIAN JOURNAL OF CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Seham S. El-Hawary, Ola Mohamed Mousa, Rana Ahmed El-Fitiany, Rania A. El Gedaily
JOURNAL OF REPORTS IN PHARMACEUTICAL SCIENCES
(2020)
Article
Pharmacology & Pharmacy
Seham S. El-Hawary, Rehab M. S. Ashour, Sabah H. El-Gayed, Haidy A. Gad, Gehad A. Abdel Jaleel, Rania A. El Gedaily
PHARMACOGNOSY RESEARCH
(2020)