Upregulation of Proteolytic Pathways and Altered Protein Biosynthesis Underlie Retinal Pathology in a Mouse Model of Alzheimer’s Disease

Targeted brain proteomics uncover multiple pathways to Alzheimer's dementia

(2018) Lei Yu et al.   ANNALS OF NEUROLOGY

The retina as a window to early dysfunctions of Alzheimer's disease following studies with a 5xFAD mouse model

(2018) Chiara Criscuolo et al.   NEUROBIOLOGY OF AGING

Amyloid-β Deposition and Olfactory Dysfunction in an Alzheimer's Disease Model

(2018) Nan Wu et al.   JOURNAL OF ALZHEIMERS DISEASE

Depression in Alzheimer's Disease: Epidemiology, Mechanisms, and Management

(2018) Song Chi et al.   JOURNAL OF ALZHEIMERS DISEASE

Loss of Shp2 Rescues BDNF/TrkB Signaling and Contributes to Improved Retinal Ganglion Cell Neuroprotection

(2018) Nitin Chitranshi et al.   MOLECULAR THERAPY

Global, regional, and national burden of neurological disorders during 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015

(2017) Valery L Feigin et al.   LANCET NEUROLOGY

PTPN11 induces endoplasmic stress and apoptosis in SH-SY5Y cells

(2017) Nitin Chitranshi et al.   NEUROSCIENCE

A role for Tau protein in maintaining ribosomal DNA stability and cytidine deaminase-deficient cell survival

(2017) Elias Bou Samra et al.   Nature Communications

Glaucoma is associated with plasmin proteolytic activation mediated through oxidative inactivation of neuroserpin

(2017) Vivek Gupta et al.   Scientific Reports

Retinal vascular and structural changes are associated with amyloid burden in the elderly: ophthalmic biomarkers of preclinical Alzheimer’s disease

(2017) S.Mojtaba Golzan et al.   Alzheimers Research & Therapy

Intravitreal injection of β-crystallin B2 improves retinal ganglion cell survival in an experimental animal model of glaucoma

(2017) Fabian Anders et al.   PLoS One

Age-related neurodegenerative disease associated pathways identified in retinal and vitreous proteome from human glaucoma eyes

(2017) Mehdi Mirzaei et al.   Scientific Reports

Ocular indicators of Alzheimer’s: exploring disease in the retina

(2016) Nadav J. Hart et al.   ACTA NEUROPATHOLOGICA

Individual estimates of age at detectable amyloid onset for risk factor assessment

(2016) Murat Bilgel et al.   Alzheimers & Dementia

Crystallins and neuroinflammation: The glial side of the story

(2016) Jennifer E. Dulle et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

One protein, multiple pathologies: multifaceted involvement of amyloid β in neurodegenerative disorders of the brain and retina

(2016) Vivek Gupta et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Amyloid-β Increases Activity of Proteasomes Capped with 19S and 11S Regulators

(2016) Alexey V. Morozov et al.   JOURNAL OF ALZHEIMERS DISEASE

Cathepsin B Improves ß-Amyloidosis and Learning and Memory in Models of Alzheimer’s Disease

(2016) Christine M Embury et al.   Journal of Neuroimmune Pharmacology

Pathological Tau Promotes Neuronal Damage by Impairing Ribosomal Function and Decreasing Protein Synthesis

(2016) S. Meier et al.   JOURNAL OF NEUROSCIENCE

Tau Accumulation, Altered Phosphorylation, and Missorting Promote Neurodegeneration in Glaucoma

(2016) M. Chiasseu et al.   JOURNAL OF NEUROSCIENCE

Amyloid β accumulation and inner retinal degenerative changes in Alzheimer’s disease transgenic mouse

(2016) Vivek K. Gupta et al.   NEUROSCIENCE LETTERS

An integrated proteomics approach shows synaptic plasticity changes in an APP/PS1 Alzheimer's mouse model

(2016) Stefan J. Kempf et al.   Oncotarget

Regulation of global gene expression and cell proliferation by APP

(2016) Yili Wu et al.   Scientific Reports

Altered Machinery of Protein Synthesis in Alzheimer's: From the Nucleolus to the Ribosome

(2015) Karina Hernández-Ortega et al.   BRAIN PATHOLOGY

Early alterations in energy metabolism in the hippocampus of APPswe/PS1dE9 mouse model of Alzheimer's disease

(2014) Ignacio Pedrós et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Conditional inactivation of nicastrin restricts amyloid deposition in an Alzheimer's disease mouse model

(2013) Katia Sesele et al.   AGING CELL

Appropriate use criteria for amyloid PET: A report of the Amyloid Imaging Task Force, the Society of Nuclear Medicine and Molecular Imaging, and the Alzheimer's Association

(2013) Keith A. Johnson et al.   Alzheimers & Dementia

Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective cohort study

(2013) Victor L Villemagne et al.   LANCET NEUROLOGY

Light activation of the insulin receptor regulates mitochondrial hexokinase. A possible mechanism of retinal neuroprotection

(2013) Ammaji Rajala et al.   MITOCHONDRION

Crystallins in Retinal Ganglion Cell Survival and Regeneration

(2013) Natik Piri et al.   MOLECULAR NEUROBIOLOGY

Alzheimer disease in the United States (2010-2050) estimated using the 2010 census

(2013) L. E. Hebert et al.   NEUROLOGY

Hyperphosphorylation of tau protein by calpain regulation in retina of Alzheimer's disease transgenic mouse

(2013) Haikang Zhao et al.   NEUROSCIENCE LETTERS

Insulin receptor regulates photoreceptor CNG channel activity

(2012) Vivek K. Gupta et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Cerebrospinal Fluid Levels ofβ-Amyloid 1-42, but Not of Tau, Are Fully Changed Already 5 to 10 Years Before the Onset of Alzheimer Dementia

(2012) Peder Buchhave   ARCHIVES OF GENERAL PSYCHIATRY

Neurodegeneration of the retina in mouse models of Alzheimer’s disease: what can we learn from the retina?

(2011) Kin Chiu et al.   AGE

Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Reisa A. Sperling et al.   Alzheimers & Dementia

Binding of the Molecular Chaperone αB-Crystallin to Aβ Amyloid Fibrils Inhibits Fibril Elongation

(2011) Sarah L. Shammas et al.   BIOPHYSICAL JOURNAL

Amyloid Generation and Dysfunctional Immunoproteasome Activation with Disease Progression in Animal Model of Familial Alzheimer's Disease

(2011) Ester Aso et al.   BRAIN PATHOLOGY

Mutations in Nicastrin Protein Differentially Affect Amyloid β-Peptide Production and Notch Protein Processing

(2011) Annelie Pamrén et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Growth factor receptor-bound protein 14: a new modulator of photoreceptor-specific cyclic-nucleotide-gated channel

(2010) Vivek K Gupta et al.   EMBO REPORTS

Early onset amyloid lesions lead to severe neuritic abnormalities and local, but not global neuron loss in APPPS1 transgenic mice

(2010) Niels J. Rupp et al.   NEUROBIOLOGY OF AGING

Synaptic Plasticity in the Hippocampus of a APP/PS1 Mouse Model of Alzheimer's Disease Is Impaired in Old but Not Young Mice

(2010) Simon Gengler et al.   PLoS One

Amyloid-Peptide Vaccinations Reduce β-Amyloid Plaques but Exacerbate Vascular Deposition and Inflammation in the Retina of Alzheimer’s Transgenic Mice

(2009) Bingqian Liu et al.   AMERICAN JOURNAL OF PATHOLOGY

Tau inclusions in retinal ganglion cells of human P301S tau transgenic mice: Effects on axonal viability

(2009) Laura Gasparini et al.   NEUROBIOLOGY OF AGING

Empirical Bayes Analysis of Quantitative Proteomics Experiments

(2009) Adam A. Margolin et al.   PLoS One

 -Secretase Heterogeneity in the Aph1 Subunit: Relevance for Alzheimer's Disease

(2009) L. Serneels et al.   SCIENCE

Increased expression of the γ-secretase components presenilin-1 and nicastrin in activated astrocytes and microglia following traumatic brain injury

(2008) Yasmine Nadler et al.   GLIA

Inhibitors of Cathepsin B Improve Memory and Reduce β-Amyloid in Transgenic Alzheimer Disease Mice Expressing the Wild-type, but Not the Swedish Mutant, β-Secretase Site of the Amyloid Precursor Protein

(2008) Vivian Y. H. Hook et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Small heat shock proteins Hsp27 or αB-crystallin and the protein components of neurofibrillary tangles: Tau and neurofilaments

(2007) Cecilia Björkdahl et al.   JOURNAL OF NEUROSCIENCE RESEARCH